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*  Candesartan
As with other angiotensin II receptor antagonists, candesartan is indicated for the treatment of hypertension. Results from the ... Jul-Aug 1993). "Pilot study of a new angiotensin II receptor antagonist, TCV-116: effects of a single oral dose on blood ... Candesartan (rINN) /ˌkændɪˈsɑːrtən/ is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. The ... 1992). "Hypotensive activity of TCV-116, a newly developed angiotensin II receptor antagonist, in spontaneously hypertensive ...
*  Angiotensin-converting enzyme 2
... or the conversion of angiotensin II to angiotensin 1-7. ACE 2 has direct effects on cardiac functiona, and is expressed ... "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9". Circulation ... "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9". Circulation ... Lazartigues E, Feng Y, Lavoie JL (2007). "The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular ...
*  Angiotensin II receptor blocker
... s (ARBs), also known as angiotensin II receptor antagonists , AT1 receptor antagonists or ... They block the activation of AT1 receptors, preventing the binding of angiotensin II. Angiotensin II receptor blockers are used ... Kassler-Taub K, Littlejohn T, Elliott W, Ruddy T, Adler E (1998). "Comparative efficacy of two angiotensin II receptor ... Angiotensin II Type 1 Receptor Blockers at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Angiotensin II receptor type 1
... or AT1 receptor is the best characterized angiotensin receptor. It has vasopressor effects and ... The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II. The activated receptor in turn couples to ... "Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two ... Angiotensin II receptor type 1 has been shown to interact with Zinc finger and BTB domain-containing protein 16. The protein's ...
*  Angiotensin II receptor
The angiotensin II receptors, (AGTR1) and (AGTR2), are a class of G protein-coupled receptors with angiotensin II as their ... angiotensin II. The AT1 and AT2 receptors share a sequence identity of ~30%, but have a similar affinity for angiotensin II, ... The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II. The activated receptor in turn couples to ... The AT4 receptor is activated by the angiotensin II metabolite angiotensin IV, and may play a role in regulation of the CNS ...
*  Renin inhibitor
Ang I is broken down by the angiotensin-converting enzyme (ACE) to the active octapeptide angiotensin II (Ang II), which is the ... and similar to angiotensin II receptor antagonists. Ang II also functions within the RAAS as a negative feedback to suppress ... Ang II interacts with at least two classes of Ang II receptors, AT1 and AT2. This mechanism, which runs from renin through Ang ... design Angiotensin Angiotensin II receptor antagonist Beta blocker Circulatory system Discovery and development of angiotensin ...
*  Essential hypertension
Increased angiotensin II → Increased vasoconstriction, thirst/ADH and aldosterone → Increased sodium reabsorption in the ... Obesity can increase the risk of hypertension to fivefold as compared with normal weight, and up to two-thirds of hypertension ... Recent studies claim that obesity is a risk factor for hypertension because of activation of the renin-angiotensin system (RAS ... These mechanisms include the activation of the sympathetic nervous system as well as the activation of the renin-angiotensin- ...
*  Angiotensin II receptor type 2
... , also known as the AT2 receptor is a protein that in humans is encoded by the AGTR2 gene. ... Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector ... Angiotensin II receptor type 2 has been shown to interact with MTUS1. Angiotensin II receptor GRCh38: Ensembl release 89: ... The angiotensin II receptors". Pharmacological Reviews. 52 (3): 415-72. PMID 10977869. D'Amore A, Black MJ, Thomas WG (December ...
*  PRKCE
Inagaki K, Iwanaga Y, Sarai N, Onozawa Y, Takenaka H, Mochly-Rosen D, Kihara Y (Oct 2002). "Tissue angiotensin II during ... Paul K, Ball NA, Dorn GW, Walsh RA (Nov 1997). "Left ventricular stretch stimulates angiotensin II--mediated ... angiotensin II and diastolic stretch; adenosine; hypoxia and Akt-induced stem cell factor; ROS generated via pharmacologic ... Initially, PKCε was thought to protect mitochondria from MPT through its association with VDAC1, ANT, and hexokinase II; ...
*  Glucocorticoid remediable aldosteronism
Angiotensin is involved in regulating aldosterone and is the core regulator. Angiotensin II acts synergistically with potassium ... by increase in the plasma concentration of angiotensin III. by increased plasma angiotensin II, ACTH, or potassium levels. The ... Aldosterone synthase normally is not ACTH sensitive, and only activated by angiotensin II. Aldosterone causes the tubules of ... Control of aldosterone release from the adrenal cortex: The role of the renin-angiotensin system: ...
*  Tasosartan
... is an angiotensin II receptor antagonist. It was withdrawn from FDA review by the manufacturer after phase III ... ISBN 0-12-369417-5. Dina R, Jafari M (July 2000). "Angiotensin II-receptor antagonists: an overview". Am J Health Syst Pharm. ...
*  Endothelin 1
Cazaubon S, Deshayes F, Couraud PO, Nahmias C (2006). "[Endothelin-1, angiotensin II and cancer]". Med Sci (Paris). 22 (4): 416 ... Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48- ... 45 (2): 151-4. PMID 12855940. Doggrell SA (2006). "The endothelin system and its role in acute myocardial infarction". Expert ... 68 (2): 357-418. doi:10.1124/pr.115.011833. PMC 4815360 . PMID 26956245. This article incorporates text from the United States ...
*  Angiotensinamide
It is a derivative of angiotensin II. Angiotensin. ... Angiotensinamide (INN; BAN and USAN angiotensin amide) is a ...
*  Salvia elegans
... attributed to its action as an angiotensin II receptor antagonist and inhibitor of the angiotensin converting enzyme. ... Lamiaceae): ACE inhibition and angiotensin II antagonism". Journal of Ethnopharmacology. 130 (2): 340-346. doi:10.1016/j.jep. ... doi:10.2980/1195-6860(2006)13[23:TDOFUB]2.0.CO;2. Hanson, Beth (2001). Gourmet Herbs. Broolyn Botanic Garden. p. 90. ISBN 978-1 ...
*  Bradykinin receptor B2
Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48- ... The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk ... Cassano G, Susca F, Lippe C, Guanti G (1999). "Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response ... Alternate start codons result in two isoforms of the protein. Bradykinin receptor GRCh38: Ensembl release 89: ENSG00000168398 ...
*  Arnold Martin Katz
Katz AM (1990). "Angiotensin II: Hemodynamic regulator or growth factor?". J Mol Cell Cardiol. 22: 739-747. Katz AM, Katz PB ( ... Peptide separation by two-dimensional chromatography and electrophoresis. Katz AM, Chernoff AI (1959). "Structural similarities ... KATZ, AM; DREYER, WJ; ANFINSEN, CB (Nov 1959). "Peptide separation by two-dimensional chromatography and electrophoresis". The ... 180 (2): 392-402. PMID 14361747. KATZ, A. M.; KATZ, L. N.; WILLIAMS, F. L. (1 November 1955). "Registration of Left Ventricular ...
*  AGTRAP
The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. ... "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II ... Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene. This gene encodes ... "Entrez Gene: AGTRAP angiotensin II receptor-associated protein". Human AGTRAP genome location and AGTRAP gene details page in ...
*  CMA1
... is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been ... Jenne DE, Tschopp J (1991). "Angiotensin II-forming heart chymase is a mast-cell-specific enzyme". Biochem. J. 276 (2): 567-8. ... Urata H, Nishimura H, Ganten D (1996). "Chymase-dependent angiotensin II forming systems in humans". Am. J. Hypertens. 9 (3): ... Caughey GH, Raymond WW, Wolters PJ (2000). "Angiotensin II generation by mast cell alpha- and beta-chymases". Biochim. Biophys ...
*  Olmesartan
In studies of angiotensin II receptor antagonists such as olmesartan, patients with unilateral or bilateral renal artery ... Olmesartan medoxomil is an angiotensin II receptor antagonist which is used for the treatment of high blood pressure. It was ... "Angiotensin II receptor blocker induced fetopathy: 7 cases". Klin Padiatr. 223 (1): 10-4. doi:10.1055/s-0030-1269895. "BENICAR ... part II of II)". Int. J. Surg. Pathol. 22 (3): 202-11. doi:10.1177/1066896913502230. PMID 24021900. Rubio-Tapia, Alberto; ...
*  Complications of hypertension
Tanahashi N (April 2009). "[Roles of angiotensin II receptor blockers in stroke prevention]". Nippon Rinsho (in Japanese). 67 ( ... Once blood pressure is found to be high in diabetics, there are ways to treat it: Medications like the Angiotensin-converting ... Wachtell K, Devereux RB, Lyle AP (August 2007). "The effect of angiotensin receptor blockers for preventing atrial fibrillation ... 23 (2): 86-96. doi:10.1038/jhh.2008.80. PMID 18650838. Moretti R, Torre P, Antonello RM, Manganaro D, Vilotti C, Pizzolato G ( ...
*  Antagonism (chemistry)
Kalaitzidis, R; Bakris, G. L. (2009). "Effects of angiotensin II receptor blockers on diabetic nephropathy". Journal of ... For example, not only do angiotensin receptor blockers, and angiotensin-converting enzyme (ACE) inhibitors work to lower blood ... In chemistry, antagonism is a phenomenon wherein two or more agents in combination have an overall effect that is less than the ... 2-amidinopropane) dihydrochloride (AAPH)-induced oxidation: Synergistic and antagonistic effects". Journal of the American Oil ...
*  Cytokine storm
... suggesting a potential benefit for angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), ... Marshall and co-workers also found that angiotensin II was associated with cytokine-mediated lung injury and suggested a role ... Das published a review of ACE inhibitor and angiotensin-II receptor blocker use in a number of cytokine-mediated inflammatory ... Marshall RP, Gohlke P, Chambers RC, Howell DC, Bottoms SE, Unger T, McAnulty RJ, Laurent GJ (January 2004). "Angiotensin II and ...
*  Mikael Pittet
"Angiotensin II Drives the Production of Tumor-Promoting Macrophages". Immunity. 38 (2): 296-308. doi:10.1016/j.immuni.2012.10. ... "The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions". J Exp Med. 204 ... 13 (2): 125-38. doi:10.1038/nmat3780. PMID 24452356. Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, ...
*  MYOZ2
Overexpression of calsarcin-1 in mice (CS1Tg) was protective against Angiotensin II-induced pathologic cardiac hypertrophy, ... by Angiotensin II, phenylephrine and endothelin-1 agonists in neonatal cardiomyocytes. ... "Calsarcin-1 protects against angiotensin-II induced cardiac hypertrophy". Circulation. 116 (22): 2587-96. doi:10.1161/ ... Two missense mutations in MYOZ2, Ser48Pro and Ile246Met, have been shown to be causal for rare forms of familial hypertrophic ...
*  WASF1
Whitebread S, Mele M, Kamber B, de Gasparo M (1989). "Preliminary biochemical characterization of two angiotensin II receptor ... 1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly". EMBO ... Suetsugu S, Miki H, Takenawa T (1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules ... 219 (2): 509-14. doi:10.1006/bbrc.1996.0264. PMID 8605018. Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the ...
*  List of DuPont Experimental Station inventions
... intensifier phosphors and screens Building 400 Hyzaar combination drug to treat hypertension Cozaar Losartan angiotensin II ... 4-d 2,4-Dichlorophenoxyacetic acid herbicides Sulfonylurea herbicides and preemergent herbicides Ludox colloidal silica Vazo ... world's first synthetic rubbers Dacron polyester Polyethylene terephthalate fibers Teflon Polytetrafluoroethylene dispersions 2 ...
*  Sacubitril/valsartan
Valsartan blocks the angiotensin II receptor type 1 (AT1). This receptor is found on both vascular smooth muscle cells, and on ... Changing 100 people from an ACE inhibitor or angiotensin II receptor antagonist to sacubitril/valsartan for 2.3 years would ... Sacubitril/valsartan can be used instead of an ACE inhibitor or an angiotensin receptor blocker in people with heart failure ... August 30, 2014). "Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure". N Engl J Med. 371: 140830040023009. ...