*Angiopoietin-related protein 2

Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted ... and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol ... Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 ... Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific ...

*Hes3 signaling axis

Activation of the Tie2 receptor by the ligand Angiopoietin 2. This has been shown in vitro and in vivo. Activation of the ... Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor ... Angiopoietin 2). Hes3, in turn, by regulating the expression of Shh and potentially other factors, can also exert an effect on ... Angiopoietin 2, insulin, or a combined treatment consisting of all three factors and an inhibitor of JAK) induce the increase ...

*Nesvacumab

It targets the protein angiopoietin 2. As of May 2017[update], it is in Phase II clinical trials for the treatment of diabetic ... "Anti-vasculaR Endothelial Growth Factor plUs Anti-angiopoietin 2 in Fixed comBination therapY: Evaluation for the Treatment of ... Clinical trial number NCT02713204 for "Anti-angiOpoeitin 2 Plus Anti-vascular eNdothelial Growth Factor as a therapY for ...

*Pericyte

Also, angiopoietin 2 can act as an antagonist to Tie-2. This destabilizes the endothelial cells, which accounts for less ... Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Platelet-derived growth ... Similar to the inhibition of the PDGF pathway, angiopoietin 2 reduces levels of pericytes, leading to diabetic retinopathy. ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...

*Thomas N. Sato

... and angiopoietins, that play the key roles in the blood vessel formation. "Laboratory of Biodynamics and Integrative Biology". ... "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell. 87 (7): 1171-1180. doi: ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ... October 1993). "Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic ...

*TEK tyrosine kinase

"Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization". Circulation Research. 83 (3): 233-40. ... Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (Nov 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent ...

*ANGPT4

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene. Angiopoietins are proteins with important roles in ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... "Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenet. Cell Genet. 94 (3-4): 147-54. ... "Entrez Gene: ANGPT4 angiopoietin 4". Human ANGPT4 genome location and ANGPT4 gene details page in the UCSC Genome Browser. ...

*Hedgehog signaling pathway

Activation of the Hedgehog pathway leads to an increase in Angiogenic Factors (angiopoietin-1 and angiopoietin-2), Cyclins ( ... Lee, SW; Moskowitz, MA; Sims, JR (2007). "Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin- ... 3.0.CO;2-G. PMID 9671939. Dorus, S.; Anderson, JR; Vallender, EJ; Gilbert, SL; Zhang, L; Chemnick, LG; Ryder, OA; Li, W; Lahn, ... Costal-2 is particularly important in Drosophila. The protein kinase Fused is a regulator of SUFU in Drosophila, but may not ...

*ANGPT2

Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K (2002). "Expression of angiopoietin-1, angiopoietin-2, and Tie2 ... Xu Y, Yu Q (September 2001). "Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its ... "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ... similar to angiopoietin-1 See Angiopoietin#Clinical_relevance ANGPT2 has been shown to interact with TEK tyrosine kinase. ...

*Vascular endothelial growth factor A

"Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy". ... 30 (2): 179-191. doi:10.1152/physiolgenomics.00047.2007. PMID 17426116. Huusko J, Merentie M, Dijkstra MH, Ryhänen MM, Karvinen ... Lamalice L, Houle F, Huot J (November 2006). "Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and ... Kobayashi M, Nishita M, Mishima T, Ohashi K, Mizuno K (February 2006). "MAPKAPK-2-mediated LIM-kinase activation is critical ...

*Angiopoietin 1

... is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in ... Dunk C, Shams M, Nijjar S (2000). "Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration ... Cheung AH, Stewart RJ, Marsden PA (1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): ... "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the ...

*Vascular endothelial growth factor

The expression of angiopoietin-2 in the absence of VEGF leads to endothelial cell death and vascular regression. Conversely, a ... Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in ... 13 (2 Pt 2): 741s-746s. doi:10.1158/1078-0432.CCR-06-2110. PMID 17255303. Jiang C, Zuo F, Wang Y, Lu H, Yang Q, Wang J (2016 ... 3.0.CO;2-E. Muller, YA; Li, B; Christinger, HW; Wells, JA; Cunningham, BC; de Vos, AM (8 July 1997). "Vascular endothelial ...

*Methaneseleninic acid

"Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin ... MeSeSeMe + H2O2 → 2 MeSeO2H Seleninic acids can be prepared by oxidation of selenoesters with one equivalent of ... 2". BMC Cancer. 12: 192. doi:10.1186/1471-2407-12-192. PMC 3517305 . PMID 22640261. Yan, L.; DeMars, L.C. (2012). "Dietary ... 2 RSeOH → RSeO2H + 1/2 RSeSeR Methaneseleninic acid, from decomposition of Se-methylselenocysteine Se-oxide but also available ...

*Ischemia-reperfusion injury of the appendicular musculoskeletal system

Tan, X., et al., Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of ... These tourniquets are often 1-2" in width, which concentrates the pressure to a narrow band of tissue. They can result in ... Surgical tourniquet times in excess of 2 hours have been associated with an increased risk of nerve damage (e.g., neuropraxia ... 23(10): p. 1305-19 Kapitsinou, P.P., et al., Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J ...

*Angiopoietin-related protein 1

... also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene ... Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this ... 2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein ...

*Schlemm's canal

In the combined absence of angiopoietin 1 and angiopoietin 2, Schlemm's canal and episcleral lymphatic vasculature completely ...

*Weibel-Palade body

Additional Weibel-Palade body components are the chemokines Interleukin-8 and eotaxin-3, endothelin-1, angiopoietin-2, ...

*List of MeSH codes (D12.776)

... angiopoietin-1 MeSH D12.776.467.100.100.200 - angiopoietin-2 MeSH D12.776.467.100.450.500 - angiostatins MeSH D12.776.467.100. ... cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin-related protein 2 MeSH D12.776.220.525. ... iron regulatory protein 2 MeSH D12.776.556.579.374.375.863 - electron transport complex i MeSH D12.776.556.579.374.375.863.500 ... muts homolog 2 protein MeSH D12.776.624.664.700.148 - myeloid-lymphoid leukemia protein MeSH D12.776.624.664.700.167 - proto- ...

*Endothelium

... hence the control of blood pressure Repair of damaged or diseased organs via an injection of blood vessel cells Angiopoietin-2 ...

*Vanucizumab

One arm of the antibody binds Angiopoietin-2 (Ang2) and the other is based on bevacizumab (Avastin), binding Vascular ...

*List of MeSH codes (D23)

... angiopoietins MeSH D23.348.479.311.100.100 --- angiopoietin-1 MeSH D23.348.479.311.100.200 --- angiopoietin-2 MeSH D23.348. ... h-2 antigens MeSH D23.050.301.500.400.370 --- HLA-A MeSH D23.050.301.500.400.370.372 --- HLA-A1 MeSH D23.050.301.500.400.370. ... h-2 antigens MeSH D23.050.705.552.400.370 --- hla-a antigens MeSH D23.050.705.552.400.370.372 --- hla-a1 antigen MeSH D23.050. ... erbb-2 MeSH D23.101.840.721 --- receptor, erbb-3 MeSH D23.101.840.800 --- synaptophysin MeSH D23.101.840.870 --- tissue ...

*List of MeSH codes (D12.644)

... angiopoietins MeSH D12.644.276.100.100.100 --- angiopoietin-1 MeSH D12.644.276.100.100.200 --- angiopoietin-2 MeSH D12.644. ... map kinase kinase 2 MeSH D12.644.360.440.300 --- map kinase kinase 3 MeSH D12.644.360.440.400 --- map kinase kinase 4 MeSH ... bcl-2 homologous antagonist-killer protein MeSH D12.644.360.075.718.937 --- bcl-x protein MeSH D12.644.360.075.718.968 --- bh3 ... leucine-2-alanine MeSH D12.644.468.281.381 --- enkephalin, methionine MeSH D12.644.468.281.381.300 --- d-ala(2),mephe(4),met(0 ...

*Angiopoietin

To be specific, angiopoietin levels provide an indication for sepsis. Research on angiopoietin-2 has shown that it is involved ... Angiopoietin-1 encodes a 498 amino acid polypeptide with a molecular weight of 57 kDa whereas angiopoietin-2 encodes a 496 ... Angiopoietin-1 and angiopoietin-2 can form dimers, trimers, and tetramers. Angiopoietin-1 has the ability to form higher order ... Angiopoietins at the US National Library of Medicine Medical Subject Headings (MeSH) "angiopoietin.de: endothelia activation ...

*PTPRB

The extracellular region was shown to interact with the angiopoietin receptor Tie-2 and with the adhesion protein VE-cadherin. ... "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2". Oncogene. 18 ...

*Inflammation

The fat-derived protein called angiopoietin-like protein 2 (Angptl2) elevates in fat tissues. Higher than normal Angptl2 level ... Kadomatsu T, Tabata M, Oike Y (Feb 2011). "Angiopoietin-like proteins: emerging targets for treatment of obesity and related ... 262 (2 Pt 1): C445-52. PMID 1371643. Lang, CH; Frost, RA; Bronson, SK; Lynch, CJ; Vary, TC (Jun 2010). "Skeletal muscle protein ... 179 (1/2): 159-168. doi:10.1023/A:1006828425418. PMID 9543358. Lang, Charles H.; Hong-Brown, Ly; Frost, Robert A. (10 November ...

*ELF2

2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a ... E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor. In humans ... 1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia". Leukemia. 11 ( ... 2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1- ...