*CYR61

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded ... CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, ... Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein ... "The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and ...

*Soluble fms-like tyrosine kinase-1

... (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein that disables proteins that cause blood ... Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. Am J Obstet Gynecol 2005 ... In contrast, levels of the anti-angiogenic factor sFlt-1 remain stable during the early and middle stages of gestation and ... Both balance in circulating angiogenic factor and blood pressure modulation in pregnancy may be a continuum, with the diagnosis ...

*Vascular endothelial growth factor A

... family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that ... "The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice". Cardiovasc. Res. 86 ... leading to the activation of protein kinase C (PKC). PKC phosphorylates the mitogen-activated protein kinase (MAPK) ERK which ... Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. This gene is a member ...

*Basic fibroblast growth factor

Pereira RC, Economides AN, Canalis E (Dec 2000). "Bone morphogenetic proteins induce gremlin, a protein that limits their ... Orpana A, Salven P (Feb 2002). "Angiogenic and lymphangiogenic molecules in hematological malignancies". Leukemia & Lymphoma. ... Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Sep 1991). "Characterization and molecular cloning of a putative binding protein ... Skjerpen CS, Nilsen T, Wesche J, Olsnes S (Aug 2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with ...

*Vascular endothelial growth inhibitor

... is protein that in humans is encoded by the TNFSF15 gene. VEGI is an anti-angiogenic protein. It belongs to tumor necrosis ... Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) ... This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this ... It is the sole known ligand for death receptor 3, and it can also be recognized by decoy receptor 3. The protein encoded by ...

*Benjamin P. Sachs

Circulating angiogenic proteins trisomy 12 Am J Obstet Gynecol. 2006 Jan:194(1):239-45 Sachs BP, A Woman with Fetal Loss - ... Circulating Angiogenic Factors and the Risk of Preeclampsia. NEJM 2004; 350:672-83 Levine RJ, Thadhani R, Qian C, Lam C, Lim KH ... a novel circulating anti-angiogenic factor in preeclampsia. N Engl J Med 2006;355:992-1005 Nielsen P, Goldman M, Mann S, ...

*Angiogenesis

In contrast, pro-angiogenic protein therapy uses well-defined, precisely structured proteins, with previously defined optimal ... which angiogenic research began with, and pro-angiogenic therapies. Whereas anti-angiogenic therapies are being employed to ... Until 2007, three human clinical trials have been successfully completed with FGF-1, in which the angiogenic protein was ... Chemical stimulation of angiogenesis is performed by various angiogenic proteins, including several growth factors. The ...

*Placental growth factor

... an angiogenic protein, at 2.0 A resolution". The Journal of Biological Chemistry. 276 (15): 12153-61. doi:10.1074/jbc. ... Placental growth factor is a protein that in humans is encoded by the PGF gene. Placental growth factor (PGF) is a member of ... Placental growth factor (PGF) is a protein-coding gene and a member of the vascular endothelial growth factor (VEGF) family. ... Roberts-Clark DJ, Smith AJ (November 2000). "Angiogenic growth factors in human dentine matrix". Archives of Oral Biology. 45 ( ...

*Diabetic retinopathy

This protection appears to be due to the elevated levels of endostatin, an anti-angiogenic protein, derived from collagen XVIII ... An experimental study suggests that the pericyte death is caused by blood glucose persistently activating protein kinase C and ... mitogen-activated protein kinase (MAPK), which through a series of intermediates inhibits signaling through platelet-derived ...

*Pre-eclampsia

Angiogenic proteins such as vascular endothelial growth factor (VEGF) and placental growth factor (PIGF) and anti-angiogenic ... sFlt-1 is an anti-angiogenic protein that antagonizes vascular endothelial growth factor (VEGF) and placental growth factor ( ... Proteinuria ≥ 0.3 grams (300 mg) or more of protein in a 24-hour urine sample or a SPOT urinary protein to creatinine ratio ≥ ... Implicit in this generalized endothelial dysfunction may be an imbalance of angiogenic and anti-angiogenic factors. Both ...

*Asif Ahmed (scientist)

... as an inhibitor of anti-angiogenic proteins (soluble Flt-1 and soluble endoglin) Soluble Flt-1, the natural anti-VEGF factor in ... Professor Ahmed identified soluble Flt-1 as the single most important molecule responsible for the angiogenic imbalance in ... was amongst the first to signal the importance of vascular growth factors in pregnancy and pioneered the concept of angiogenic ... preeclampsia by demonstrating that the removal of soluble Flt-1 from preeclamptic samples restored angiogenic balance which was ...

*List of MeSH codes (D12.644)

... angiogenic proteins MeSH D12.644.276.100.100 --- angiopoietins MeSH D12.644.276.100.100.100 --- angiopoietin-1 MeSH D12.644. ... rap gtp-binding proteins MeSH D12.644.360.525.475.100 --- rap1 gtp-binding proteins MeSH D12.644.360.525.500 --- ras proteins ... grb2 adaptor protein MeSH D12.644.360.024.298 --- grb7 adaptor protein MeSH D12.644.360.024.300 --- grb10 adaptor protein MeSH ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ...

*CCN protein

The CCN protein family includes the following six proteins: CCN1: CYR61 (cysteine-rich angiogenic protein 61) CCN2: CTGF ( ... Together with three Wnt-induced secreted proteins, they comprise the CCN family of matricellular proteins. These proteins have ... CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. Due to their ... cysteine-rich angiogenic protein 61 or CCN1), CTGF (connective tissue growth factor or CCN2), and NOV (nephroblastoma ...

*List of MeSH codes (D23)

... angiogenic proteins MeSH D23.348.479.311.100 --- angiopoietins MeSH D23.348.479.311.100.100 --- angiopoietin-1 MeSH D23.348. ... hiv core protein p24 MeSH D23.050.327.520.330 --- hiv envelope protein gp41 MeSH D23.050.327.520.350 --- hiv envelope protein ... adenovirus e1 proteins MeSH D23.050.327.045.060 --- adenovirus e2 proteins MeSH D23.050.327.045.070 --- adenovirus e3 proteins ... ldl-receptor related protein 2 MeSH D23.050.422.500.750 --- ldl-receptor related protein-associated protein MeSH D23.050. ...

*Angiopoietin-related protein 1

... a unique angiopoietin-related protein with anti-angiogenic properties". Biochem. Biophys. Res. Commun. 333 (2): 308-15. doi: ... This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. GRCh38: Ensembl ... Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene ... 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein ...

*Proteases in angiogenesis

These effects are mediated by interacting and interfering with various angiogenic related proteins such as integrins and serine ... "Structure-function analysis of the ADAM family of diintegrin-like and metalloproteinase-containing proteins". J. Protein Chem. ... Native proteins which contain such domains with regulatory activity are normally inactive, most likely because they are cryptic ... Monocytes produce a variety of pro-angiogenic factors. There is also a population of CD34 positive cells that can express ...

*CXCL1

"The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma". J. Leukoc. Biol. 67 (1): 53-62. PMC 2669312 . PMID ... neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is ... for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins ...

*Syndecan 1

"HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Bonaldo MF, Lennon G, ... Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein encoded by this gene is a transmembrane (type ... The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and ... Indatuximab ravtansine targets this protein. It is a useful marker for plasma cells, but only if the cells tested are already ...

*Syndecan-4

"HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Kojima T, Katsumi A, ... The protein is found as a homodimer and is a member of the syndecan proteoglycan family. Syndecan-4 interacts with ... Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has ... Syndecan-4 activates protein kinase C (PKC), an enzyme involved in signal transduction. The variable domain of syndecan-4 could ...

*NOV (gene)

... cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV. These proteins, ... is a novel angiogenic regulator of the CCN protein family". The Journal of Biological Chemistry. 278 (26): 24200-8. doi:10.1074 ... The human NOV protein contains 357 amino acids with an N-terminal secretory signal peptide followed by four structurally ... Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb 1999). "The C-terminal domain of the regulatory protein NOVH ...

*Stem-cell niche

The angiogenic switch downregulates angiogenesis suppressor proteins, such as thrombospondin, angiostatin, endostatin and ... GSCs are easily identified through histological staining against vasa protein (to identify germ cells) and 1B1 protein (to ... Angiogenesis induced by hypoxic conditions is called an "Angiogenic switch". HIF-1 promotes expression of several angiogenic ... But there is evidence that the expression of angiogenic agens by cancer cells can also be HIF-1 independent. It seems that ...

*Syndecan-3

1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Chernousov MA, ... Hakansson S, Jacobs A, Caffrey M (2001). "Heparin binding by the HIV-1 tat protein transduction domain". Protein Sci. 10 (10): ... Syndecan-3 is a protein that in humans is encoded by the SDC3 gene. GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May ... "Entrez Gene: SDC3 syndecan 3". Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency ...

*Coronary artery disease

Numerous clinical trials were performed, either applying protein (angiogenic growth factor) therapies, such as FGF-1 or VEGF, ... Wagoner L.E.; Merrill W.; Jacobs J.; Conway G.; Boehmer J.; Thomas K.; Stegmann T.J. (2007). "Angiogenesis Protein Therapy With ... High levels of lipoprotein(a), a compound formed when LDL cholesterol combines with a protein known as apolipoprotein(a). ... Research efforts are focused on new angiogenic treatment modalities and various (adult) stem-cell therapies. A region on ...

*EGLN1

These gene products may include proteins such as glycolytic enzymes and angiogenic growth factors. In normoxia, HIF alpha ... 1996). "SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle". Lab. Invest. 74 ( ... Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme ... 2006). "Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia- ...

*Thrombospondin 1

"Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity". The Journal ... This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to ... "Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell ... the remaining anti-angiogenic domains have been shown to have decreased anti-angiogenic activity at low concentrations where ...

*Proto-oncogene tyrosine-protein kinase Src

Zan L, Zhang X, Xi Y, Wu H, Song Y, Teng G, Li H, Qi J, Wang J (2013). "Src regulates angiogenic factors and vascular ... The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by CSK. ... This protein phosphorylates specific tyrosine residues in other proteins. An elevated level of activity of c-Src tyrosine ... c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein ...

*Lee Byung-heon (biochemist)

Nam, J. O.; Jung, M. Y.; Thapa, N.; Lee, B. H.; Park, R. W.; Kim, I. S. (2008). "T-CAM, a fastatin-FIII 9-10 fusion protein, ... potently enhances anti-angiogenic and anti-tumor activity αvβ3 and α5β1 integrins". Experimental & Molecular Medicine. 40 (2): ... Nam, J. -O.; Son, H. -N.; Jun, E.; Cha, K.; Lee, B. -H.; Park, R. -W.; Kim, I. -S. (2012). "FAS1 Domain Protein Inhibits ... Thapa, N.; Lee, B. H.; Kim, I. S. (2007). "TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β". The ...