YKL-40 promotes angiogenesis through VEGF-dependent and independent pathways. YKL-40 is a migration factor for primary ... Houston DR, Recklies AD, Krupa JC, van Aalten DM (August 2003). "Structure and ligand-induced conformational change of the 39- ... a potential therapeutic agent in cancers". Molecular Cancer Therapeutics. 10 (5): 742-51. doi:10.1158/1535-7163.MCT-10-0868. ... Faibish M, Francescone R, Bentley B, Yan W, Shao R (May 2011). "A YKL-40-neutralizing antibody blocks tumor angiogenesis and ...

However, one in vitro study in 2007 and later an in vivo study in 2008 have shown that tamoxifen induces apoptosis in growth ... ISBN 978-1-84816-959-3. Cole MP, Jones CT, Todd ID (June 1971). "A new anti-oestrogenic agent in late breast cancer. An early ... Clinical trials on angiogenesis inhibitors have been underway since 1992 using many different drugs. The Harvard researchers ... However, tamoxifen induces the metabolism of letrozole and significantly reduces its concentrations. Tamoxifen acts as a ...

Apoptosis was successfully induced and mitophagy was inhibited in glioma cells. This is an example of how SDT can be used with ... Due to their ability to oscillate with exposure to low-frequency ultrasound, microbubbles have been used as contrast agents in ... showed that SDT is capable of inhibiting angiogenesis through the production of ROS. This hindered the proliferation, migration ... Outside of ROS induced apoptosis, cavitation is another factor involved within apoptosis of surrounding cells. Both cavitation ...

A number of agents are currently being investigated in Phase II clinical trials for IPF, including the monoclonal antibodies ... angiogenesis and vascular remodelling, growth factors, surfactant and matrix regulatory factors), and that through further ... mir-29 microRNA precursor investigations in mice have produced reversal of induced IPF. MRG-201 is currently being tested as-of ... Spagnolo P, Del Giovane C, Luppi F, Cerri S, Balduzzi S, Walters EH, D'Amico R, Richeldi L (2010). "Non-steroid agents for ...

Both agents also display anti-tumor effects in animal studies. Metabolites such as Alanine, Saturated lipids, Glycine, Lactate ... p53 inhibits the glycolytic pathway by upregulating the expression of TP53-induced glycolysis and apoptosis regulator. Wild- ... July 1998). "Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis". Nature. 394 (6692 ...

van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces ... The preclinical agent, KTN0182A, is an anti-KIT, pyrrolobenzodiazepine (PBD)-containing antibody-drug conjugate which shows ... in mice high levels of c-KIT in mast cells as well as its presence in the tumor microenvironment promote angiogenesis, leading ... Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine ...

The induced heat stress resulted in the phosphorylation of ATF-2 (dATF-2) which is required for heterochromatin assembly. This ... Evidence has been forwarded that environmental stimuli are important agents in the alteration of epigenes. Ironically, ... and angiogenesis. The increase in DNA methylation and its phenotypic affects were carried over to multiple subsequent ... Environmental factors can induce the epigenetic marks (epigenetic tags) for some epigenetically influenced traits. These can ...

... chemotherapeutic agent - chemotherapy - chemotherapy-induced peripheral neuropathy - chest x-ray - chiasma - child-life worker ... angiogenesis - angiogenesis inhibitor - angioimmunoblastic T-cell lymphoma - angiosarcoma - angiostatin - angiotensin- ... antimicrotubule agent - antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ...

... induces synovial angiogenesis, and recruits and stimulates immune cells. X-rays of the hands and feet are generally performed ... Biological agents should generally be used only if methotrexate and other conventional agents are not effective after a trial ... The most commonly used agent is methotrexate with other frequently used agents including sulfasalazine and leflunomide. ... No infectious agent has been consistently linked with RA and there is no evidence of disease clustering to indicate its ...

Fong GH (2008). "Mechanism of adaptative angiogenesis to tissue hypoxia". Angiogenesis. 11 (2): 121-140. doi:10.1007/s10456-008 ... "Trichina agent". Washington University School of Medicine. Archived from the original on 2008-02-14. Fluorescence image of ... spiralis larva to enter the myocyte and induce the transformation into the nurse cell. VEGF expression is detected surrounding ...

To some extent, adult neurogenesis in rodents may be induced by selective disruption of Notch signalling in astrocytes: this ... This response is amplified by concomitant angiogenesis. Planarian are one of the earliest model organisms used to study ... A common pharmacological inhibitor for adult neurogenesis is methylazoxymethanol acetate (MAM), a chemotherapeutic agent. Other ... August 2006). "Evidence for stroke-induced neurogenesis in the human brain". Proc. Natl. Acad. Sci. U.S.A. 103 (35): 13198-202 ...

These chemical factors induce all associated inflammatory symptoms by sensitizing pain receptors, causing vasodilation of the ... The gradient signal of the chemokinetic agent is received through specific receptors on the cell surface and is transduced ... to regions of necrosis and angiogenesis in human glioblastoma". Clin Cancer Res. 6 (1): 102-111. PMID 10656438. Zou, W; et al ... In this manner, the chemorepellant reverses the polarity of the PtdIns(3,4,5)P3 gradient and induces chemorepulsion. Recent ...

Matou-Nasri S, Gaffney J, Kumar S, Slevin M (2009). "Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 ... "Dressings and topical agents containing hyaluronic acid for chronic wound healing". Cochrane Database of Systematic Reviews. ... In addition, recent studies showed hyaluronan fragments, not the native high-molecular weight molecule, can induce inflammatory ... and angiogenesis, which are phases of wound repair. As of 2023, however, reviews of its effect on healing for chronic wounds ...

There is also evidence that Akt is involved in angiogenesis and vascular maturation. Activation of the PI3K/AKT/mTOR pathway ... This allows for decreased dosages of each single agent with an increased apoptotic response.[citation needed] All advances in ... Pathan, N; Aime-Sempe, C; Kitada, S; Basu, A; Haldar, S; Reed, JC (2001). "Microtubule-Targeting Drugs Induce Bcl-2 ... The best physicians could do was try existing chemotherapeutic agents. With no evidence of the clinical benefit of chemotherapy ...

In particular, these studies demonstrated that peroxynitrite induces breaks in the strands of the genetic material, DNA, which ... and angiogenesis in colon cancer". Proceedings of the National Academy of Sciences. 110 (30): 12474-12479. Bibcode:2013PNAS.. ... Potent cytoprotective and antishock agents*". Critical Care Medicine. 30 (5): 1071-1082. doi:10.1097/00003246-200205000-00019. ... "Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase ...

This suggests a role for ceramide in the biological responses of all these agents. Because of its apoptosis-inducing effects in ... "Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis". The American ... "Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide ... Ceramides induce insulin resistance in many tissues by inhibition of Akt/PKB signaling. Aggregation of LDL cholesterol by ...

In 2015, the US Food and Drug Administration (FDA) approved the anti-PD-1 agent nivolumab for advanced or metastatic SCC. In ... August 2005). "Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells". American ... in the circulation and functions as an angiogenesis inhibitor. Multiple phase 3 clinical trials utilizing immunotherapy in the ... These agents include both traditional chemotherapies, such as cisplatin, which indiscriminately target all rapidly dividing ...

mda-7 has been used in several clinical trials because of its ability to induce apoptosis, prevent tumor angiogenesis, cause ... Animal tumor models and apoptin-transgenic mice have shown apoptin to be a safe and effective anticancer agent which causes a ... In the context of cancer, E4orf4 is even more efficient at inducing cell death than in healthy cells, which could be an ... As a p53 inducible gene, NOXA is transcribed and translated to Noxa in response to DNA damage and hypoxia induced apoptosis. A ...

The water moisture induced by the hookah makes the smoke less irritating and may give a false sense of security and reduce ... ISBN 978-0-521-78719-2. Feng Z, Hu W, Hu Y, Tang MS (October 2006). "Acrolein is a major cigarette-related lung cancer agent: ... Also, cigarette smoking interferes with folliculogenesis, embryo transport, endometrial receptivity, endometrial angiogenesis, ... Like PAH metabolites, acrolein is also an electrophilic alkylating agent and permanently binds to the DNA base guanine, by a ...

... carcinoma cells to fibronectin enhances tumorigenicity and confers resistance to apoptosis-inducing chemotherapeutic agents. ... "CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis". The Journal of Clinical ...

One way to overcome this difficulty is to artificially induce other cells such as stem cells into SC-like phenotypes. Eguchi et ... MC has been successfully used as a delivery agent for intra-optical and oral pharmaceutical therapies. Some disadvantages of MC ... HA is also known to support angiogenesis because its degradation products stimulate endothelial cell proliferation and ... PSA shows stability under cell culture conditions and allows for induced degradation by enzymes. It has also been discovered ...

A contrast agent is always required to be injected into the patient in the CT scanner. CTA serves as an alternative to MRA. ... For patients that are undergoing anti-angiogenesis cancer therapy, pMRI can give the doctors a better sense of efficacy of the ... The majority of radiation-induced brain cancers are caused by ionizing radiation from medical sources such as CT scans. ... Contrast agent uptake, sometimes in characteristic patterns, can be demonstrated on either CT or MRI scans in most malignant ...

... angiogenesis and tumor angiogenesis and improve survival in mice infected with H5N1. Anti-cancer effects have been also ... The potential of Dz13 as a therapeutic agent derives from the fact that inactivation of c-Jun can have an effect on downstream ... Gozar, M.M. et al (2008) Dz13, a DNAzyme Targeting c-jun, Induces Off-Target Cytotoxicity in Endothelial Cells with Features of ... Krug, N. et al (2015) Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med. 372(21):1987-95 ...

"FAS1 Domain Protein Inhibits VEGF165-Induced Angiogenesis by Targeting the Interaction between VEGFR-2 and v 3 Integrin". ... label substances and liposomes containing a therapeutic agent for preventing, treating or therapeutically diagnosing apoptosis- ... Nam, J. -O.; Jeong, H. W.; Lee, B. H.; Park, R. W.; Kim, I. S. (2005). "Regulation of Tumor Angiogenesis by Fastatin, the ... Thapa, N.; Lee, B. H.; Kim, I. S. (2007). "TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β". The ...

Miao RQ, Agata J, Chao L, Chao J (November 2002). "Kallistatin is a new inhibitor of angiogenesis and tumor growth". Blood. 100 ... In animal models, gene targeting in induced pluripotent stem cells has been successfully used to correct an antitrypsin ... "Serpin genes AtSRP2 and AtSRP3 are required for normal growth sensitivity to a DNA alkylating agent in Arabidopsis". BMC Plant ... One, SRP-6, performs a protective function and guards against stress-induced calpain-associated lysosomal disruption. Further, ...

... preventing the development and complications of dietary-induced and/or genetically induced diabetes, adipose cell/tissue ... and angiogenesis; c) maintaining normal renal, neurological, and brain function; and d) the development of Alzheimer's disease ... HETE metabolic pathway has dual functions in promoting or inhibiting platelet responses depending on the stimulating agent and ... Hematological Agents in Medicinal Chemistry. 9 (3): 154-64. doi:10.2174/187152511797037619. PMC 3171607. PMID 21838667. ...

Where classes of agents are listed, there may be exceptions within the class. CYP2E1 exhibits structural motifs common to other ... Zhang G, Kodani S, Hammock BD (Jan 2014). "Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and ... Kessova I, Cederbaum AI (Sep 2003). "CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury ... inhibit angiogenesis, endothelial cell migration and endothelial cell proliferation; and inhibit the growth and metastasis of ...

The agents that are competent to edit genetic codes are viruses or subviral RNA-agents. Although GEEN has higher efficiency ... It is also possible to fuse a protein constructed in this way with the catalytic domain of an endonuclease in order to induce a ... It has been demonstrated that this strategy can be used to promote a process of angiogenesis in animals. ... In Zea mays, disruption of the target locus was achieved by ZFN-induced DSBs and the resulting NHEJ. ZFN was also used to drive ...

The lipoxins and epi-lipoxins are potent anti-inflammatory agents and may contribute to the overall activities of the two COX's ... Xiao G, Tsai AL, Palmer G, Boyar WC, Marshall PJ, Kulmacz RJ (February 1997). "Analysis of hydroperoxide-induced tyrosyl ... The overexpression of PTGS2 (COX-2) along with increased angiogenesis and SLC2A1 (GLUT-1) expression is significantly ... but also neutralized the changes of the retina and the choroid thickness caused by the injection of pro-inflammatory agents. ...

The only known side effect of most telomerase inhibitors is dose-induced neutropenia. Neuropsychological deficits can result ... Wright, KD; Gajjar, A (2009). "New chemotherapy strategies and biological agents in the treatment of childhood ependymoma". ... receptor tyrosine kinase and phospho-KIT were found to be present in pediatric ependymomas and may be involved in angiogenesis ... Increased intracranial pressure can induce vomiting, headache, irritability, lethargy, changes in gait, and in children less ...

HIF1 is known to induce transcription of more than 60 genes, including genes involved in vascularization and angiogenesis, ... It is also available as a flavoring agent, contributing a somewhat sour and astringent component to umami taste. As an ... High concentrations of succinate will mimic the hypoxia state by suppressing PHDs, therefore stabilizing HIF1α and inducing the ... Activation of inflammatory macrophages through toll-like receptors induces a metabolic shift towards glycolysis. In spite of a ...