*  Germline mosaicism
2015). "A Case Report of a Fetus with Mosaic Autosomal Variegated Aneuploidies and Literature Review". Annals of Clinical & ...
*  Aneuploidy
However, mitotic aneuploidy may be more common than previously recognized in somatic tissues, and aneuploidy is a ... thus highlighting the role of somatic aneuploidy in carcinogenesis. It has been suggested that aneuploidy might directly ... Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes ... Germline aneuploidy is typically detected through karyotyping, a process in which a sample of cells is fixed and stained to ...
*  Chromosome instability
Because aneuploidy is a common feature in tumour cells, the presence of aneuploidy in cells does not necessarily mean CIN is ... CIN often results in aneuploidy. There are three ways that aneuploidy can occur. It can occur due to loss of a whole chromosome ... One way of differentiating aneuploidy without CIN and CIN-induced aneuploidy is that CIN causes widely variable (heterogeneous ... Segmental aneuploidy can occur due to deletions, amplifications or translocations, which arise from breaks in DNA, while loss ...
*  Autosome
Fetuses with aneuploidy of gene-rich chromosomes-such as chromosome 1-never survive to term, and fetuses with aneuploidy of ... Autosomal aneuploidy can also result in disease conditions. Aneuploidy of autosomes is not well tolerated and usually results ... Partial aneuploidy can also occur as a result of unbalanced translocations during meiosis. Deletions of part of a chromosome ... Autosomal Aneuploidy. Humana Press. pp. 133-164. ISBN 978-1-58829-300-8. Savva, George M.; Morris, Joan K.; Mutton, David E.; ...
*  SRC1
... mutant has aneuploidy tolerance. SRC1 at yeastgenome.org.. ...
*  Angelika Amon
Amon's aneuploidy research has potential applications to cancer research. "HHMI Scientist Abstract: Angelika Amon". Howard ... Williams, Bret; Amon, Angelika (2009). "Aneuploidy -Cancer's Fatal Flaw?". Cancer Research. 69 (2389): 5289-91. doi:10.1158/ ... growth and physiology and demonstrated that mammalian aneuploidy results in a stress response analogous to yeast aneuploidy. ... and effects of aneuploidy on normal physiology and tumorigenesis. As a student under Nasmyth, Amon demonstrated that CDC28 ...
*  BUB1
In vitro knockdown of Bub1 in p53 impaired cells (e.g. HeLa cells) caused aneuploidy. Whether aneuploidy alone is a sufficient ... Loss-of-function mutations or absence of Bub1 has been reported to result in aneuploidy, chromosomal instability (CIN) and ... Depletion of Bub1 results in increased CIMD in order to avoid aneuploidy caused by reduced SAC functioning. The transcriptional ... More precisely, mutations in the spindle checkpoint can lead to chromosomal instability and aneuploidy, a feature present in ...
*  Spindle checkpoint
In fact, aneuploidy is the most common characteristic of human solid tumors and thus the spindle assembly checkpoint might be ... Due to the fact that alterations in mitotic regulatory proteins can lead to aneuploidy and this is a frequent event in cancer, ... Weaver, B. A.A.; Cleveland, D. W. (2009). "The role of aneuploidy in promoting and suppressing tumors". The Journal of Cell ... Examples include: In cancer cells, aneuploidy is a frequent event, indicating that these cells present a defect in the ...
*  Polyploid
... the distinction between aneuploidy and polyploidy is that aneuploidy refers to a numerical change in part of the chromosome set ... Aneuploidy is more common. Polyploidy occurs in humans in the form of triploidy, with 69 chromosomes (sometimes called 69,XXX ...
*  Human genetic variation
Prenatal screening for aneuploidy". The New England Journal of Medicine. 360 (24): 2556-62. doi:10.1056/NEJMcp0900134. PMID ... Apart from sex chromosome disorders, most cases of aneuploidy result in death of the developing fetus (miscarriage); the most ...
*  Entosis
Aneuploidy, a condition in which non-disjunction gives rise to gametes with an abnormal number of chromosomes, is one of the ... The underlying cause of aneuploidy remains highly debated; however, entosis is shown to perturb cytokinesis (cytoplasmic ... Apoptosis Autoschizis Necrosis Janssen, Aniek; Rene H. Medema (1 March 2011). "Entosis: aneuploidy by invasion". Nature Cell ...
*  List of OMIM disorder codes
GLB1 Mosaic variegated aneuploidy syndrome; 257300; BUB1B Mowat-Wilson syndrome; 235730; ZEB2 Muckle-Wells syndrome; 191900; ...
*  Dicentric chromosome
Strains of S. cerevisiae that tolerate aneuploidy can stabilize products of broken chromosomes during proliferation, which can ... "Identification of Aneuploidy-Tolerating Mutations". Cell. 143 (1): 71-83. doi:10.1016/j.cell.2010.08.038. ISSN 0092-8674. PMC ... cerevisiae due to its known ability to tolerate aneuploidy, an abnormal number of chromosomes. ...
*  Uniparental disomy
Aneuploidy Robinson WP (May 2000). "Mechanisms leading to uniparental disomy and their clinical consequences". BioEssays. 22 (5 ...
*  Genetics of Down syndrome
Aneuploidy BBC News (22 September 2005). "Down's syndrome recreated in mice". Retrieved 2006-06-14. For a description of human ... "aneuploidy rescue". There is considerable variability in the fraction of cells with trisomy 21, both as a whole and tissue-by- ...
*  Paclitaxel
Bharadwaj, Rajnish; Yu, Hongtao (2004). "The spindle checkpoint, aneuploidy, and cancer". Oncogene. 23 (11): 2016-27. doi: ...
*  Mad1
Bharadwaj R, Yu H (2000). "The spindle checkpoint, aneuploidy, and cancer". Oncogene. 23 (11): 2016-27. doi:10.1038/sj.onc. ... Mismatches in chromosome number (aneuploidies) during meiosis are responsible for human diseases like Down's syndrome and also ...
*  Transmission electron microscopy DNA sequencing
2008). "Aneuploidy: Cells Losing Their Balance". Genetics. 179 (2): 737-46. doi:10.1534/genetics.108.090878. PMC 2429870 . PMID ...
*  Trisomy
A trisomy is a type of aneuploidy (an abnormal number of chromosomes). Most organisms that reproduce sexually have pairs of ... Chromosome abnormalities Aneuploidy Karyotype Sexual reproduction Monosomy "CRC - Glossary T". Retrieved 2007-12-23. Rieger, R ... O'Connor, Clare (2008). "Chromosomal Abnormalities: Aneuploidies". Nature Education. 1 (1): 172. ...
*  Diana W. Bianchi
Bianchi, DW; Platt LD; Goldberg JD; Abuhamad AZ; Sehnert AJ; Rava RP (2012). "Genome-wide fetal aneuploidy detection by ... 2002). "Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data". Prenatal ... February 27, 2014). "DNA sequencing versus standard prenatal aneuploidy screening". New England Journal of Medicine. 370 (9): ... February 27, 2014). "DNA sequencing versus standard prenatal aneuploidy screening". New England Journal of Medicine. 370 (9): ...
*  Nondisjunction
Cigarette smoke is a known aneugen (aneuploidy inducing agent). It is associated with increases in aneuploidy ranging from 1.5 ... Trisomy X is a form of sex chromosome aneuploidy where females have three instead of two X chromosomes. Most patients are only ... Shi Q, Ko E, Barclay L, Hoang T, Rademaker A, Martin R (2001). "Cigarette smoking and aneuploidy in human sperm". Mol. Reprod. ... Surveys of cases of human aneuploidy syndromes have shown that most of them are maternally derived. This raises the question: ...
*  Down syndrome
"Noninvasive prenatal diagnosis of fetal aneuploidy using cell-free fetal nucleic acids in maternal blood" (PDF). United ... "DNA sequencing versus standard prenatal aneuploidy screening". The New England Journal of Medicine. 370 (9): 799-808. doi: ...
*  Spermatozoon
Increased aneuploidy of spermatozoa often occurs in association with increased DNA damage. DNA fragmentation and increased in ... Aneuploidy Non-disjunction "Timeline: Assisted reproduction and birth control". CBC News. Retrieved 2006-04-06. Smith, D.J. ( ... Governini L, Guerranti C, De Leo V, Boschi L, Luddi A, Gori M, Orvieto R, Piomboni P (2014). "Chromosomal aneuploidies and DNA ... 3 (1): 1-7. Templado C, Uroz L, Estop A (2013). "New insights on the origin and relevance of aneuploidy in human spermatozoa". ...
*  Aneugen
Governini L, Guerranti C, De Leo V, Boschi L, Luddi A, Gori M, Orvieto R, Piomboni P (2015). "Chromosomal aneuploidies and DNA ... An aneugen is a substance that causes a daughter cell to have an abnormal number of chromosomes or aneuploidy. A substance's ... Templado C, Uroz L, Estop A (2013). "New insights on the origin and relevance of aneuploidy in human spermatozoa". Mol. Hum. ... Exposure of males to lifestyle, environmental and/or occupational hazards may increase the risk of spermatozoa aneuploidy. ...
*  Cell-free fetal DNA
Allyse, M.; Sayres, L. C.; King, J. S.; Norton, M. E.; Cho, M. K. (2012). "Cell-free fetal DNA testing for fetal aneuploidy and ... Fan, H. C.; Blumenfeld, Y. J.; Chitkara, U.; Hudgins, L.; Quake, S. R. (2008). "Noninvasive diagnosis of fetal aneuploidy by ... Point mutations, loss of heterozygosity and aneuploidy can be detected in a single PCR step. Digital PCR can differentiate ... Massive parallel sequencing and digital PCR for fetal aneuploidy detection can be used without restriction to fetal-specific ...