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*  Fetal hemoglobin
Hemoglobinopathies Transport across the placenta American Sickle Cell Anemia Association SCDAA: Break The Sickle Cycle ... May 1995). "Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter ... Study of Hydroxyurea in Sickle Cell Anemia". The New England Journal of Medicine. 332 (20): 1317-22. PMID 7715639. doi:10.1056/ ... Hydroxyurea promotes the production of fetal hemoglobin and can thus be used to treat sickle-cell disease. The fetal ...
*  Red blood cell
Eryptosis is increased in a wide variety of diseases including sepsis, haemolytic uremic syndrome, malaria, sickle cell anemia ... Aplastic anemia is caused by the inability of the bone marrow to produce blood cells. Pure red cell aplasia is caused by the ... Red blood cells in mammals anucleate when mature, meaning that they lack a cell nucleus. In comparison, the red blood cells of ... The red blood cell cell membrane comprises a typical lipid bilayer, similar to what can be found in virtually all human cells. ...
*  Beta thalassemia
Reductions in HbA available overall to fill the red blood cells in turn leads to microcytic anemia. Microcytic anemia ... A study aimed at detecting the genes that could give rise to offspring with sickle cell disease. Patients diagnosed with beta ... "washed red cells" or "cryopreserved red cells." Washed red cells have been removed of plasma proteins that would have become a ... Cryopreserved red cells are used to maintain a supply of rare donor units for patients with unusual red cell antibodies or ...
*  Autoimmune hemolytic anemia
Diagnosis is made by first ruling out other causes of hemolytic anemia, such as G6PD, thalassemia, sickle-cell disease, etc. ... A hemolytic state exists whenever the red cell survival time is shortened from the normal average of 120 days. Hemolytic anemia ... Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed against the person's own ... Although MeSH uses the term "autoimmune hemolytic anemia", some sources prefer the term "immunohemolytic anemia" so drug ...
*  Sickle Cell Anemia, a Molecular Disease
Hemoglobin and Sickle Cell Anemia - Oregon State University Library Sickle Cell Anemia, a Molecular Disease - reproduction of ... "Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and ... Pauling, Linus; Harvey A. Itano; S. J. Singer; Ibert C. Wells (1949-11-01). "Sickle Cell Anemia, a Molecular Disease". Science ... Strasser, Bruno J. (1999-11-19). "Perspectives: Molecular Medicine: "Sickle Cell Anemia, a Molecular Disease"". Science. 286 ( ...
*  Erythrocyte fragility
... iron deficiency anemia, thalassemia, hyponatremia, polycythemia vera, and sickle cell anemia after splenectomy. New approaches ... "A comparison of hemolysis and red cell mechanical fragility in blood collected with different cell salvage suction devices". ... It can be thought of as the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to ... When multiple levels of stress are applied to a given population/sample of cells, a fragility profile can be obtained by ...
*  Hemoglobinopathy
Some well-known hemoglobin variants such as sickle-cell anemia and congenital dyserythropoietic anemia are responsible for ... Anemia due to reduced life span of the red cells of reduced production of the cells e. g. hemoglobin S, C and E. Increased ... Common hemoglobinopathies include sickle-cell disease. It is estimated that 7% of world's population (420 million) are carriers ... In patients predisposed for rapid clearance of red blood cells, this may lead to early destruction of cells infected with the ...
*  Sickle-cell disease
If one parent has sickle-cell anaemia and the other has sickle-cell trait, then the child has a 50% chance of having sickle- ... In sickle-cell disease, low oxygen tension promotes red blood cell sickling and repeated episodes of sickling damage the cell ... When both parents have sickle-cell trait, a child has a 25% chance of sickle-cell disease, 25% do not carry any sickle-cell ... In sickle cell anaemia, a common form of sickle cell disease, haemoglobin S replaces both ╬▓-globin subunits in the haemoglobin ...
*  Point mutation
... results in the disease known as Sickle Cell Anemia. Sickle-Cell Anemia is an autosomal recessive disorder that affects 1 in 500 ... Sickle-cell anemia is caused by a point mutation in the ╬▓-globin chain of hemoglobin, causing the hydrophilic amino acid ... "Anemia, Sickle Cell". Genes and Disease. Bethesda MD: National Center for Biotechnology Information. 1998. NBK22183. Clancy S ( ... These sickle-shaped cells cannot carry nearly as much oxygen as normal red blood cells and they get caught more easily in the ...
*  Distal renal tubular acidosis
Sickle cell anemia. Toxins, including ifosfamide (more commonly causing pRTA than dRTA), toluene, lithium carbonate and ... Cell Biol. 37 (6): 1151-61. doi:10.1016/j.biocel.2005.01.002. PMID 15778079. Buckalew VM Jr (1989). "Nephrolithiasis in renal ... Distal RTA is characterized by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct of ... 1997). "Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene ...
*  Joseph Lennox Pawan
... sickle-cell anaemia; and the mosquito transmission of Venezuelan Equine Encephalomeyelitis Virus in Trinidad. But he will best ...
*  Hematology
Sickle Cell Anemia ...thalassemia == Blood disorders Hematologists Hematology topics http://www.austincc.edu/mlt/clin1/ ... Anemias (lack of red blood cells or hemoglobin) Hematological malignancies Coagulopathies (disorders of bleeding and ... It involves treating diseases that affect the production of blood and its components, such as blood cells, hemoglobin, blood ... Blood Venous blood Venipuncture Hematopoiesis Blood tests Cord blood Red blood cells Erythropoiesis Erythropoietin Iron ...
*  Balancing selection
A well-studied case is that of sickle cell anemia in humans, a hereditary disease that damages red blood cells. Sickle cell ... The sickle-cell and Haemoglobin C genes in some African populations. Ann. Human Genet. 21, 67-89. Sickle cell anemia. 2009. ... A person who inherits the sickle cell gene from one parent and a normal hemoglobin allele (HgbA) from the other, has a normal ... Malaria versus sickle-cell trait distributions Frequency-dependent selection occurs when the fitness of a phenotype is ...
*  New York Blood Center
"FDA Approves Immucor's PreciseType HEA Test to Screen for Sickle Cell Trait". Sickle Cell Anemia News. Retrieved 22 November ... Through its work with cord blood, stem cells and sickle cell treatments, NYBC is a leader in precision medicine, which takes ... The PreciseType HEA test screens blood donors for sickle cell trait (SCT), an inherited blood disorder that affects 1 million ... "FDA approves Immucor's PreciseType® HEA Test to be used for screening blood donors for Sickle Cell Trait (SCT)". Nasdaq. 21 ...
*  HBB
Luzzatto L (2012). "Sickle cell anaemia and malaria". Mediterr J Hematol Infect Dis. 4 (1): e2012065. doi:10.4084/MJHID. ... are resistant to malaria and develop minimal effects of the anaemia. Sickle cell disease is closely related to another mutant ... The most common is HbS, which causes sickle cell disease. HbS is produced by a point mutation in HBB in which the codon GAG is ... Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell ...
*  Tutankhamun
Pays, JF (December 2010). "Tutankhamun and sickle-cell anaemia". Bull Soc Pathol Exot. 103 (5, number 5): 346-347. doi:10.1007/ ... In June 2010, German scientists said they believed there was evidence that he had died of sickle cell disease. Other experts, ... however, rejected the hypothesis of homozygous sickle cell disease based on survival beyond the age of 5 and the location of ... which is characteristic of Freiberg-Kohler syndrome rather than sickle-cell disease.[citation needed] Research conducted in ...
*  Borris Miles
Miles has sickle cell anemia. http://www.fyi.legis.state.tx.us/fyiwebdocs/PDF/house/dist146/m1.pdf "Simpson Withdraws, Straus ...
*  Genetic carrier
Sickle cell anemia is the most common genetic disorder among African Americans in the United States. While approximately 8% are ... doi:10.1111/j.1745-7599.2004.tb00426.x. B., G. (October 5, 1956). "Malaria and Sickle-Cell Anemia". Science. 124: 619-624. doi: ... The test looks at a person's DNA, which is taken from cells in a blood sample or from cells that are gently scraped from inside ...
*  Verne Mason
Mason VR: Sickle cell anemia. JAMA 1922;79:1318-1320. Frank Capra. The Name Above the Title. Macmillan. New York. 1971. p. 174 ... As a medical resident at Hopkins in 1922 Mason gave the disease sickle cell anemia its name. When motion picture director Frank ...
*  Nosology
This was introduced in November 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, ... "Sickle Cell Anemia, a Molecular Disease". Science, 25 November 1949, vol. 110, no. 2865, pp. 543-548. http://www.mayo.edu/ ...
*  Kings County Hospital Center
Working with populations in which sickle cell anemia was endemic, in 1966, KCH physicians Drs. Margaret G. Robinson and R. ... "Pneumococcal Meningitis in Sickle-Cell Anemia". New England Journal of Medicine. 274: 1006-1008. doi:10.1056/ ... These results proved paramount in establishing the practice of vaccinating patients suffering from sickle-cell anemia against ... Janet Watson observed a high incidence of pneumococcal meningitis in sickle cell patients - a similar rate to that of post- ...
*  Linus Pauling
His success with sickle cell anemia led Pauling to speculate that a number of other diseases, including mental illnesses such ... It was the first proof of a human disease caused by an abnormal protein, and sickle cell anemia became the first disease ... Pauling, L.; Itano, H. A.; Singer, S. J.; Wells, I. C. (25 November 1949). "Sickle Cell Anemia, a Molecular Disease". Science. ... In November 1949, Pauling, Harvey Itano, S. J. Singer and Ibert Wells published "Sickle Cell Anemia, a Molecular Disease" in ...
*  Molecular medicine
"Sickle Cell Anemia, a Molecular Disease". Science, 25 November 1949, vol. 110, no. 2865, pp. 543-548. BJ Strasser, Perspectives ... In November 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, Linus Pauling, Harvey ... "Sickle Cell Anemia, a Molecular Disease"] Science, 19 November 1999, vol. 286, no.5444, pp. 1488 - 1490. RJ Williams (1956) ... The concept of the distribution of medicine to each individual cell just as oxygen would be an example of the practice of ...
*  Harvey Itano
While at Caltech, Itano joined the lab of Linus Pauling and began working on sickle cell anemia, a genetic disease that Pauling ... recognizing his sickle cell work. Pauling, Linus; Harvey A. Itano; S. J. Singer; Ibert C. Wells (1949-11-01). "Sickle Cell ... Ingram, V. M. (1956-10-13). "A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anaemia ... Pauling was convinced that sickle cell disease was caused by defective hemoglobin, and set Itano to find out what made sickle ...
*  Bibliography of biology
Pauling, Linus; Harvey A. Itano; S. J. Singer; Ibert C. Wells (1949). "Sickle Cell Anemia, a Molecular Disease". Science. 110 ( ... which are defined as any microscopic organism that comprises either a single cell (unicellular), cell clusters or no cell at ... This section contains a list of works on cell biology, the study of cells - their physiological properties, their structure, ... 2001). Landmark papers in cell biology : selected research articles celebrating forty years of the American Society for Cell ...
*  Brain ischemia
Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. Sickle shaped blood cells clot ... Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood ... The causes of brain ischemia vary from sickle cell anemia to congenital heart defects. Symptoms of brain ischemia can include ... Focal brain ischemia reduces blood flow to a specific brain region, increasing the risk of cell death to that particular area. ...
*  Host-parasite coevolution
One example is sickle cell anemia. It is due to a mutation in the hemoglobin gene leading to sickle shape formation of red ... The alternative homozygote, which does not carry the sickle cell disease allele, is susceptible to infection by Plasmodium. As ... CS1 maint: Multiple names: authors list (link) "What Is Sickle Cell Disease?". National Heart, Lung, and Blood Institute. June ... Hence, homozygote and heterozygote genotypes for the sickle-cell disease allele show malaria resistance, while the homozygote ...