... is more concerning when there is weight loss or anemia, blood is present in the stool, there is a history of ... In refractory cases, procedures can be performed to help relieve constipation. Sacral nerve stimulation has been demonstrated ... "Pernicious Anemia Clinical Presentation: History, Physical Examination". emedicine.medscape.com. Retrieved 6 April 2023. ...
Jun 2018). "Five year follow-up after autologous peripheral blood hematopoietic stem cell transplantation for refractory, ... May 2013). "Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic ... patients with Fanconi's anemia and chronic granulomatous disease. Later on, introducing the concept of post-transplant deletion ... "Fludarabine-based reduced intensity conditioning for stem cell transplantation of Fanconi anemia patients from fully matched ...
"Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and ... side effects include aplastic anemia, pancreatitis, agranulocytosis, and angioedema. Metolazone, like other thiazide diuretics ...
... anemia), dry skin, dry eyes and hair loss. Other side effects include redness, swelling, peeling or tenderness on the hands or ... in Patients with Advanced or Refractory Solid Tumors". Clin. Cancer Res. 25 (16): 4888-97. doi:10.1158/1078-0432.CCR-18-3334. ...
The GI bleeding can result in anemia. It is often overlooked, but can be more common in elderly patients. It has been seen in a ... Saab S, Nieto JM, Lewis SK, Runyon BA (2006). "TIPS versus paracentesis for cirrhotic patients with refractory ascites". The ... Most patients who are eventually diagnosed with watermelon stomach come to a physician complaining of anemia and blood loss. ... The Genetic and Rare Diseases Information Center (GARD) states that pernicious anemia is one of the conditions associated with ...
July 2007). "Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo- ... The most common abnormalities detected during blood testing were anemia, lymphocytopenia, leukopenia, thrombocytopenia and ...
In refractory cases, plasma exchange may be used. Thrombolysis (removal of the blood clot with "clot buster" medication) has ... especially in combination with oral contraceptive use Sickle cell anemia Dehydration, primarily in infants and children ...
Thomé SD, Petz LD (2002). "Hemolytic Anemia: Hereditary and Acquired". In Mazza J (ed.). Manual of Clinical Hematology (3rd ed ... Jang DH, Nelson LS, Hoffman RS (December 2011). "Methylene blue in the treatment of refractory shock from an amlodipine ... Chudow M, Ferguson K (April 2018). "A Case of Severe, Refractory Hypotension After Amlodipine Overdose". Cardiovascular ... It causes hemolytic anemia in carriers of the G6PD (favism) enzymatic deficiency. Methylene blue is a formal derivative of ...
December 2004). "Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard ... Anaemia Increased iron binding capacity Monocytes decreased Thrombocytes increased TSH decreased Free T4 decreased Flushing ...
When used for anemia it is recommended that pernicious anemia as a cause be ruled out first. Folinic acid is a form of folic ... "Pyridoxine-Dependent Epilepsy and Antiquitin Deficiency Resulting in Neonatal-Onset Refractory Seizures". Brain Sciences. 12 (1 ... may be used to treat folate deficiency that results in anemia, and methanol poisoning. It is taken by mouth, injection into a ...
Rulten SL, Hodder E, Ripley TL, Stephens DN, Mayne LV (July 2008). "Alcohol induces DNA damage and the Fanconi anemia D2 ... for refractory cutaneous T-cell lymphoma (CTCL)". Blood. 109 (1): 31-9. doi:10.1182/blood-2006-06-025999. PMC 1785068. PMID ...
... anaemia, neutropenia and lymphopenia, in descending order of frequency. Omacetaxine mepesuccinate can cause fetal harm when ... and cytarabine combined with granulocyte colony-stimulating factor priming on the outcome of relapsed or refractory acute ...
However, if there is some essential heterogeneity of refractory period or if conduction is abnormally slow in some areas (for ... or anemia.[citation needed] Tachycardia that is not sinus tachycardia usually results from the addition of abnormal impulses to ...
Anaemia may develop in several ways: iron malabsorption may cause iron deficiency anaemia, and folic acid and vitamin B12 ... Refractory coeliac disease should not be confused with the persistence of symptoms despite gluten withdrawal caused by ... Between 0.3% and 10% of affected people have refractory disease, which means that they have persistent villous atrophy on a ... Further, many adults with subtle disease may only present with fatigue, anaemia or low bone mass. Many undiagnosed individuals ...
"Refractory" CLL is a disease that no longer responds favorably to treatment within six months following the last cancer therapy ... Enlargement of the spleen and low red blood cells (anemia) may also occur. It typically worsens gradually over years. Risk ... 2017-12-07). "Initial Results of Ibrutinib Plus Venetoclax in Relapsed, Refractory CLL (Bloodwise TAP CLARITY Study): High ... warm autoimmune hemolytic anemia in 10-15% of patients, and bone marrow failure. Chronic lymphocytic leukemia may also develop ...
Anaemia, caused by both chronic blood loss from the gastrointestinal tract and reduced absorption due to the up-regulation of ... Refractory ulcerative colitis. Patients with toxic megacolon (colonic dilation > 6 cm and toxic appearing) who do not respond ... The main symptom of active disease is usually diarrhea mixed with blood, of gradual onset which often leads to anaemia. ...
There were no reports of anemia nor changes in lipidemia. The company stated in their press release that filgotinib is the ... Clinical trial number NCT01384422 for "Safety and Preliminary Efficacy of GLPG0634 in Methotrexate-refractory Active Rheumatoid ... Nonetheless it is thought that JAK2 inhibition might lead to anemia and thrombopenia by interference with erythropoietin and ... "Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to ...
In February 2003 FDA granted fast-track status to lenalidomide for the treatment of relapsed or refractory MM. In 2006 it was ... Lenalidomide is also approved for transfusion-dependent anemia due to low or intermediate-1-risk myelodysplastic syndromes ... Schey, S.A. (15 August 2004). "Phase I Study of an Immunomodulatory Thalidomide Analog, CC-4047, in Relapsed or Refractory ... The major toxicities of approved IMiDs are peripheral neuropathy, thrombocytopenia, anaemia and venous thromboembolism. There ...
Mason C, Krueger GG (January 2001). "Thioguanine for refractory psoriasis: a 4-year experience". Journal of the American ... colitis Psoriasis Colorectal cancer in mice resistant to immunotherapy Leukopenia and neutropenia Thrombocytopenia Anemia ... "Tioguanine in the treatment of refractory coeliac disease--a single centre experience". Alimentary Pharmacology & Therapeutics ...
... can cause hypoxia (hypoxemic hypoxia), but hypoxia can also occur via other mechanisms, such as anemia. Hypoxemia is ... Cirrhosis can be complicated by refractory hypoxemia due to high rates of blood flow through the lung, resulting in ventilation ...
Clozapine is an effective treatment for those who respond poorly to other drugs ("treatment-resistant" or "refractory" ... Vitamin B12 serum and urinary MMA to role out pernicious anemia or vitamin B12 deficiency, Basic electrolytes and serum calcium ... Taylor DM, Duncan-McConnell D (2000). "Refractory schizophrenia and atypical antipsychotics". Journal of Psychopharmacology. 14 ...
the treatment of adults with relapsed or refractory classical Hodgkin lymphoma (cHL) who have failed autologous stem cell ... of people taking pembrolizumab have included anemia, decreased appetite, headache, dizziness, distortion of the sense of taste ... "FDA approves pembrolizumab for treatment of relapsed or refractory PMBCL". U.S. Food and Drug Administration (FDA) (Press ... relapsed or refractory solid tumors. In March 2023, Merck reported the results of NRG-GY018, a Phase III clinical trial in ...
2009). "Use of rituximab for refractory cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS)". Pediatric ... These include autoimmune hemolytic anemia, autoimmune neutropenia, and autoimmune thrombocytopenia. Other autoimmune ... refractory immune cytopenias in children with autoimmune lymphoproliferative syndrome". British Journal of Haematology. 129 (4 ...
The differential diagnoses include several kinds of anemia, including myelophthisis and aplastic anemia, and most kinds of ... They may be considered for refractory cases in younger, otherwise healthy individuals. "Minitransplants" are possible. People ... Consequently, patients may develop infections related to low white blood cell count, anemia and fatigue due to a lack of red ... and is used more frequently for refractory cases. Combining rituximab with cladribine or pentostatin may or may not produce any ...
These would enable a dipole to reach an area that had been refractory and is now able to be depolarised with continuation of ... and death results within six to eight minutes from anemia [ischemia] of the brain and spinal cord". Spontaneous conversion of ... The waves eventually meet and cancel each other out, but, if an area of transient block occurred with a refractory period that ... The length of the refractory period and the time taken for the dipole to travel a certain distance-the propagation velocity- ...
Eloctate (Factor VIII), for hemophilia A. Ferrlecit (Sodium ferric gluconate complex), for iron deficiency anemia. Fludara ( ... K-NK003 for relapsed or refractory acute myeloid leukemia, and K-NK-ID101 for COVID-19. In January 2021, Sanofi announced that ...
Harrison LB, Chadha M, Hill RJ, Hu K, Shasha D (2002). "Impact of tumor hypoxia and anemia on radiation therapy outcomes". The ... and they were approved for the treatment of refractory non-Hodgkin's lymphoma. Intraoperative radiation therapy (IORT) is ...
"Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors (AflacST1501)". www.clinicaltrials.gov. Retrieved 20 ... anemia (low red blood cell count), thrombocytopenia (low platelet count), stomach pain, infections, fatigue, decreased appetite ... in Patients with Refractory HR+/HER2- Metastatic Breast Cancer". Clinical Cancer Research. 23 (17): 5218-5224. doi:10.1158/1078 ...
... anemia, and/or, rarely, leukopenia), central nervous system defects, and peripheral neuropathies due to the invasion of these ... sPCL continues to be highly refractory to various treatment regimens (. ...
February 2019). "Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer". The New England Journal of ... The most common side effects include nausea, neutropenia, diarrhea, fatigue, anemia, vomiting, alopecia (hair loss), ... February 2019). "Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer". The New England Journal of ... "ASCENT-Study of Sacituzumab Govitecan in Refractory/Relapsed Triple-Negative Breast Cancer (ASCENT)" at ClinicalTrials.gov ...