Anaphylatoxins, or complement peptides, are fragments (C3a, C4a and C5a) that are produced as part of the activation of the ... Anaphylatoxin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the ... Anaphylatoxins are able to trigger degranulation (release of substances) of endothelial cells, mast cells or phagocytes, which ... Anaphylatoxins indirectly mediate: smooth muscle cells contraction, for example bronchospasms increase in the permeability of ...
The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins. Members of this family ... "Anaphylatoxin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology ... "Characterization of receptors to the anaphylatoxins on isolated cells". Dermatologica. 179 Suppl 1: 35-40. doi:10.1159/ ...
The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is ... Moon KE, Gorski JP, Hugli TE (Aug 1981). "Complete primary structure of human C4a anaphylatoxin". The Journal of Biological ... Hugli TE (1987). "Biochemistry and biology of anaphylatoxins". Complement. 3 (3): 111-27. doi:10.1159/000467889. PMID 3542363. ...
"Anaphylatoxin Receptors: C5a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... Boulay F, Mery L, Tardif M, Brouchon L, Vignais P (March 1991). "Expression cloning of a receptor for C5a anaphylatoxin on ... Giannini E, Brouchon L, Boulay F (August 1995). "Identification of the major phosphorylation sites in human C5a anaphylatoxin ... Overview of all the structural information available in the PDB for UniProt: P21730 (C5a anaphylatoxin chemotactic receptor 1) ...
Davoust N, Jones J, Stahel PF, Ames RS, Barnum SR (May 1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and ... "Anaphylatoxin Receptors: C3a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... Kirchhoff K, Weinmann O, Zwirner J, Begemann G, Götze O, Kapp A, Werfel T (June 2001). "Detection of anaphylatoxin receptors on ... Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4 ...
C4a is an anaphylatoxin. C3 convertases are unstable (half-life 10 - 20 min) - respectively they are deactivated upon ...
Like other anaphylatoxins, C3a is regulated by cleavage of its carboxy-terminal arginine, which results in a molecule with ... C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large ... C3a, like other anaphylatoxins, has a C-terminal arginine residue. Serum carboxypeptidase B, a protease, cleaves the arginine ... Anaphylatoxins are small complement peptides that induce proinflammatory responses in tissues. C3a is primarily regarded for ...
C5a is a chemotactic agent and an anaphylatoxin; it is essential in the innate immunity but it is also linked with the adaptive ... C5a is an anaphylatoxin, causing increased expression of adhesion molecules on endothelium, contraction of smooth muscle, and ... C5a des-Arg is a much less potent anaphylatoxin. Both C5a and C5a des-Arg can trigger mast cell degranulation, releasing ... Gerard NP, Gerard C (February 1991). "The chemotactic receptor for human C5a anaphylatoxin". Nature. 349 (6310): 614-617. doi: ...
Li R, Coulthard LG, Wu MC, Taylor SM, Woodruff TM (Mar 2013). "C5L2: a controversial receptor of complement anaphylatoxin, C5a ...
"Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14". Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its ...
Li R, Coulthard LG, Wu MC, Taylor SM, Woodruff TM (Mar 2013). "C5L2: a controversial receptor of complement anaphylatoxin, C5a ...
Li R, Coulthard LG, Wu MC, Taylor SM, Woodruff TM (Mar 2013). "C5L2: a controversial receptor of complement anaphylatoxin, C5a ... a second C5a anaphylatoxin chemotactic receptor C5a2 (C5L2), a second C5a receptor of debated function which has the structure ...
Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology. 12 ( ...
Corporale, L. L H.; Tippett, P. S.; Erickson, B. W.; and Hugli, T. E. (1980) The Active Site of C3a Anaphylatoxin. J. Biol. ...
1995). "[Chemico-enzymatic synthesis, cloning and expression of a gene for an analog of human anaphylatoxin C5a]". Bioorg. Khim ... Oppermann M, Götze O (1995). "Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors". ... An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived ... Fernandez HN, Hugli TE (1978). "Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide ...
It inactivates proteins such as bradykinin and anaphylatoxins in the blood in order to prevent toxic buildup. Lysine ... This enzyme has also proven to be important in inactivating anaphylatoxins which are inflammation-inducing proteins used in ... Skidgel RA, Erdös EG (December 2007). "Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator ... carboxypeptidase is also known as: carboxypeptidase N arginine carboxypeptidase kininase I anaphylatoxin inactivator plasma ...
C5a anaphylatoxin chemotactic receptor 2 is a protein that in humans is encoded by the C5AR2 gene. It's a complement component ... 2007). "Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines". J. Biol ... In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is ... "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2". J. Biol. Chem. 280 (48): 39677-80. ...
This enzyme then cleaves C5 to C5a, a potent anaphylatoxin, and C5b. The C5b then recruits and assembles C6, C7, C8 and ... Both C3a and C5a have anaphylatoxin activity, directly triggering degranulation of mast cells as well as increasing vascular ...
"Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". J. Biol. ...
"Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". J. Biol. ...
"Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". J. Biol. ...
The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is ...
It is caused by the release (degranulation) of substances from mast cells or basophils under the influence of anaphylatoxins. ...
However, there are some differences between the two molecules, for example unlike C3, TEP1 lacks an anaphylatoxin domain. The ...
While the anaphylatoxin C3a interacts with its C3a receptor (C3aR) to recruit leukocytes, C3b contributes to further downstream ... Like C3a, C5a is also an anaphylatoxin that interacts with its cognate C5a receptor (C5aR) to attract leukocytes. Subsequent ...
Subsequent investigation demonstrated that complement, specifically the anaphylatoxin C5a, can drive the Arthus reaction ... "C5a anaphylatoxin is a major regulator of activating versus inhibitory FcγRs in immune complex-induced lung disease". The ...
The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and ... anaphylatoxin inactivator. This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic ...
The C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha ...
C5a anaphylatoxin, follicle-stimulating hormone [FSH], gonadotropin-releasing hormone [GnRH], neurokinin, thyrotropin-releasing ...
In 1914 Hirszfeld was made an academic lecturer on the basis of his work on anaphylaxis and anaphylatoxin and their ...