Resveratrol has also been shown to promote the clearance of amyloid-beta peptides. It has also been shown that non-alcoholic ... The study showed that resveratrol found in Cabernet Sauvignon could reduce levels of amyloid beta peptides, which attack brain ... "Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides". J. Biol. Chem. 280 (45): 37377-82. doi:10.1074/ ...
"Oxidative stress and the amyloid beta peptide in Alzheimer's disease". Redox Biology. 14: 450-464. doi:10.1016/j.redox.2017.10. ... significantly lowers brain levels of beta amyloid (1-42)". Alzheimer's & Dementia. 2 (3S_Part_4): S95. doi:10.1016/j.jalz. ... During phase I in 2000, the supplementary patent regarding its inhibitory mechanism upon β-amyloid precursor protein (APP) ... and Aβ peptide. The drug interaction with the APP gene mediates the expression of both APP and its following product, Aβ ...
"Amyloid-beta as a "difficult sequence" in solid phase peptide synthesis". Protein and Peptide Letters. 11 (4): 377-384. doi: ... Chemical peptide synthesis most commonly starts at the carboxyl end of the peptide (C-terminus), and proceeds toward the amino- ... The first protected peptide was synthesised by Theodor Curtius in 1882 and the first free peptide was synthesised by Emil ... The crude peptide can be purified using reversed-phase HPLC. The purification process, especially of longer peptides can be ...
"Alzheimer's disease beta-amyloid peptides are released in association with exosomes". Proceedings of the National Academy of ... "Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting". Science. 320 (5875): 520-523. Bibcode: ...
It also degrades the amyloid beta peptide whose abnormal folding and aggregation in neural tissue has been implicated as a ... Iwata N, Higuchi M, Saido TC (November 2005). "Metabolism of amyloid-beta peptide and Alzheimer's disease". Pharmacol. Ther. ... Because neprilysin is thought to be the rate-limiting step in amyloid beta degradation, it has been considered a potential ... Neprilysin-deficient knockout mice show both Alzheimer's-like behavioral impairment and amyloid-beta deposition in the brain, ...
Nelson TJ, Alkon DL (2007). "Protection against beta-amyloid-induced apoptosis by peptides interacting with beta-amyloid". J ... It has been shown to interact with a number of proteins, such as beta-amyloid, protein elongation factor 1alpha, and otoferlin ... Kwok SC, Liu X, Mangel P, Daskal I (2006). "PTX1(ERGIC2)-VP22 fusion protein upregulates interferon-beta in prostate cancer ...
Milner-White, JE; Watson, JD; Qi, G; Hayward, S (September 2006). "Amyloid formation may involve alpha- to beta sheet ... the type I and type II beta turns differ by a simple flip of the central peptide group of the turn. The significance of peptide ... many structures need correction by peptide-plane flips or peptide bond flips. Hayward, S. (2001). "Peptide-plane flipping in ... peptide flips have been described as significant in the catalytic cycle of flavodoxin and in the formation of amyloid ...
Alzheimer's is associated with toxic aggregations of the amyloid beta (Aβ) peptide, caused by Aβ misfolding and clumping ... "Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of ... "Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid". Proc Natl Acad Sci USA. ... "Rationally Designed Turn Promoting Mutation in the AmyloidPeptide Sequence Stabilizes Oligomers in Solution". PLOS ONE. 6 (7 ...
When Aβ peptide is released by proteolytic cleavage of amyloid-beta precursor protein, some Aβ peptides that are solubilized ... April 2008). "Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide ... will cleave amyloid-beta precursor protein (APP) into various types of amyloid beta (Aβ) protein. Most β-secretase activity ... Amyloid beta (Aβ) is composed of a family of peptides produced by proteolytic cleavage of the type I transmembrane spanning ...
Haass C; Selkoe DJ (2007). "Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide ... amyloid beta plaques or senile plaques) are extracellular deposits of the amyloid beta (Aβ) protein mainly in the grey matter ... Findeis MA (November 2007). "The role of amyloid beta peptide 42 in Alzheimer's disease". Pharmacology & Therapeutics. 116 (2 ... 2019). "Different aspects of Alzheimer's disease-related amyloid β-peptide pathology and their relationship to amyloid positron ...
... which cleaves the amyloid precursor protein to produce the amyloid-beta peptide. These amyloid-beta peptides aggregate together ... Experiments in mice have found that M1 and M3 receptor agonists inhibit the formation of amyloid-beta and target GSK-3B.[ ... M1 receptor activation appears to decreases tau hyperphosphorylation and amyloid-beta accumulation. Sigma1 activation appears ... September 2016). "Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production". Journal ...
PDB: 3MOQ​ McCandless, Gregory T. (2008). Synthesis of disubstituted amino acids and peptide inhibitors of amyloid beta ... p3 peptide also known as amyloid β- peptide (Aβ)17-40/42 is the peptide resulting from the α- and γ-secretase cleavage from the ... That is why p3 peptide represents the benign form of amyloid. Energy plays a very important role in p3 peptides. While Aβ ... p3 peptide generates from the 17-40 or 17-42 sequence of the amyloid precursor protein (APP), which is a type I integral ...
When proteins spontaneously aggregate they can form fibrous clumps known as amyloids. Amyloid-beta peptides are associated with ... Linse has demonstrated that the process of nucleation and growth of amyloid-beta peptide occurs in two phases; first the ... Her research makes use of a variety of analytical tools to study protein amyloid formation. In 2020 Linse and co-workers ... "New mathematical model for amyloid formation: Equations describe chemical reactions responsible for the formation of protein ...
He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide ...
Plaques are made up of small peptides, typically 39-43 amino acids in length, called amyloid beta (also written as A-beta or Aβ ... June 1990). "Cleavage of amyloid beta peptide during constitutive processing of its precursor". Science. 248 (4959): 1122-4. ... amyloid beta: the major component of amyloid plaques in Alzheimer's disease. prion: main component of prion diseases and ... One of these fragments gives rise to fibrils of amyloid beta which can self-assemble into the dense extracellular amyloid ...
Studies of dementia suggest decreased beta-amyloid deposition. Cerebrolysin is not a scheduled drug in the United States. ... Cerebrolysin (developmental code name FPF-1070) is a mixture of enzymatically treated peptides derived from pig brain whose ... "Neurotrophic activities and therapeutic experience with a brain derived peptide preparation". Ageing and Dementia. Journal of ...
Phiel CJ, Wilson CA, Lee VM, Klein PS (May 2003). "GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides ... from amyloid-beta precursor protein (APP). Accumulation of amyloid beta is associated with the onset of Alzheimer's disease. ... These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid ... Transgenic mice that over-expressed mutant presenilin-1 show an increase of beta-amyloid-42(43) in the brain, which suggest ...
Cho S, Hu Y (2007). "Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival ...
Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". ... Xie J, Guo Q (Jun 2004). "AATF protects neural cells against oxidative damage induced by amyloid beta-peptide". Neurobiology of ... "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological ...
2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959-65. doi: ...
2001). "Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain". Journal of Neurochemistry. 76 (1): ... In a mouse model of Alzheimer's disease, DAPT reduces the levels of beta-amyloid. Geling, A.; Steiner, H.; Willem, M.; Bally- ...
2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959-65. doi: ...
Buildup of beta amyloid (Aβ) peptides is shown to cause and/or trigger Alzheimer's disease. Aβ interferes with BDNF-induced ... which encodes a protein that is necessary for the last step of the sequential proteolytic processing of amyloid precursor ...
BACE1 is the major beta secretase for the generation of amyloidpeptides in the neurons. Generation of the 40 or 42 amino ... Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1 ... Drugs to block this enzyme (BACE inhibitors) in theory would prevent the buildup of beta-amyloid and (per the Amyloid ... However a single residue mutation in APP reduces the ability of BACE1 to cleave it to produce amyloid-beta and reduces the risk ...
Milner-White, EJ; Watson (2006). "Amyloid formation may involve alpha- to beta sheet interconversion via peptide plane flipping ... The synthesized peptide Ser-Gly-Ala-Gly-Lys-Thr, designed as a minimal peptide P-loop, was shown to bind inorganic phosphate ... A few have so little that the concavity is lost; these peptides often bind cations via their main chain CO groups, instead of ... It is a small recurring anion-binding feature of both proteins and peptides. Each consists of the main chain atoms of three ...
This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide ... Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive ... Lee Y, Chang DJ, Lee YS, Chang KA, Kim H, Yoon JS, Lee S, Suh YH, Kaang BK (2003). "Beta-amyloid peptide binding protein does ... The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of ...
... which is proteolysed into beta amyloid. Beta amyloid is one of the peptides which accumulate in the brains of people with ... "A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid". Nature Genetics. 1 ( ... this suggested that the amyloid protein itself could cause the disease. The idea that amyloid could cause the disease ... As a consequence, the mice can develop amyloid plaques at around 13 months old. It is thought that the Swedish mutation causes ...
... like beta-amyloid peptides, protein, inflammatory and lipid profiles); measures of amyloid and tau concentration in ... cerebrospinal fluid; changes detected with neuroimaging; PET studies of brain amyloid uptake; and genetic variations. She has ...
Alzheimer's disease causes inflammation in the neurons by its deposits of amyloid beta peptides and neurofibrillary tangles. ... Insulin in the bloodstream is a trigger of amyloid beta-production, so decreased insulin levels decrease the level of amyloid ... It has been theorized that a vaccine could activate the body's own immune system to combat the beta amyloid plaques in ... Lack of sleep may also increase risk of dementia by increasing beta-amyloid deposition. Some personality traits such as being ...
... relations to beta-amyloid peptides, cognition, and treatment strategies". Progress in Neurobiology. 68 (3): 209-45. doi:10.1016 ... Beta amyloid plaques and neurofibrillary tangles. The Beta amyloid plaques are high-molecular weight fibrils and are major ... It appears that Beta amyloid (1-42) mediates its cytotoxic action by affecting key proteins that play a role in apoptosis ... Most studies of Alzheimer's have used mice or rat brains with Beta amyloid plaque buildup as the disease model. In 2013, Dr. Su ...
Oppermann UC, Salim S, Tjernberg LO, Terenius L, Jörnvall H (May 1999). "Binding of amyloid beta-peptide to mitochondrial ... "A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in ... "A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in ... "An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease". Nature. 389 (6652 ...
Considerable interest in IDE has been stimulated due to the discovery that IDE can degrade amyloid beta (Aβ), a peptide ... April 2003). "Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor ... Kurochkin IV, Goto S (May 1994). "Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin ... November 2010). "Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of ...
Alzheimer's disease is characterized by build-ups of aggregates of the peptide beta-amyloid. Apolipoprotein E enhances ... "Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol". Proceedings of the National Academy of ... high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease". ... Recently, the amyloid hypothesis of Alzheimer's disease has been questioned, and an article in Science claimed that "Just as ...
"Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline". JAMA. 283 (12): 1571-1577. doi ... "Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation". ... In Alzheimer disease, Buxbaum has conducted several cell-biological and patient-based analyses of APP and A-beta and he and his ... that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid ...