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*  Amyloid beta
Hiltunen M, van Groen T, Jolkkonen J (2009). "Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: ... Amyloid beta can be measured semiquantitatively with immunostaining, which also allows one to determine location. Amyloid beta ... By NMR-guided simulations, amyloid beta 1-40 and amyloid beta 1-42 also seem to feature highly different conformational states ... Amyloid beta (Aβ or Abeta) denotes peptides of 36-43 amino acids that are crucially involved in Alzheimer's disease as the main ...
*  Amyloid precursor protein
"An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease". Nature. 389 (6652 ... a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition". The ... Mutations in critical regions of amyloid precursor protein, including the region that generates amyloid beta (Aβ), cause ... Cleavage by gamma secretase within the membrane-spanning domain after beta-secretase cleavage generates the amyloid-beta ...
*  Alzheimer's disease research
It is believed to reduce the production of the toxic amyloid beta in favor of shorter forms of the peptide. Negative results ... The most widely used biomarker is the peptide beta-amyloid 1-42 (Aβ42), which is measured in cerebrospinal fluid. Levels of A ... Gamma secretase is a protein complex thought to be a fundamental building block in the development of the amyloid beta peptide ... One approach is to reduce amyloid beta, for example with bapineuzumab, an antibody in phase III studies for patients in mild to ...
*  Neprilysin
It also degrades the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a ... Iwata N, Higuchi M, Saido TC (November 2005). "Metabolism of amyloid-beta peptide and Alzheimer's disease". Pharmacol. Ther. ... Hama E, Saido TC (2005). "Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide". Med. ... Because neprilysin is thought to be the rate-limiting step in amyloid beta degradation, it has been considered a potential ...
*  Cabernet Sauvignon
Resveratrol has also been shown to promote the clearance of amyloid-beta peptides. It has also been shown that non-alcoholic ... The study showed that resveratrol found in Cabernet Sauvignon can reduce levels of amyloid beta peptides, which attack brain ... "Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides". J. Biol. Chem. 280 (45): 37377-82. doi:10.1074/ ...
*  RTN1
He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide ...
*  RTN3
2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959-65. doi: ...
*  Apoptosis-antagonizing transcription factor
Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". ... Xie J, Guo Q (Jun 2004). "AATF protects neural cells against oxidative damage induced by amyloid beta-peptide". Neurobiology of ... "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological ...
*  ANAVEX2-73
... which cleaves the amyloid precursor protein to produce the amyloid-beta peptide. These amyloid-beta peptides aggregate together ... Experiments in mice have found that M1 and M3 receptor agonists inhibit the formation of amyloid-beta and target GSK-3B.[ ... M1 receptor activation appears to decreases tau hyperphosphorylation and amyloid-beta accumulation. Sigma1 activation appears ... "Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production". J Cell Mol Med. 20: 1686- ...
*  HSD17B10
Oppermann UC, Salim S, Tjernberg LO, Terenius L, Jörnvall H (May 1999). "Binding of amyloid beta-peptide to mitochondrial ... "A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in ... "A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in ... "An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease". Nature. 389 (6652 ...
*  P3 peptide
PDB: 3MOQ​ McCandless, Gregory T. (2008). Synthesis of disubstituted amino acids and peptide inhibitors of amyloid beta ... p3 peptide also known as amyloid β- peptide (Aβ)17-40/42 is the peptide resulting from the α- and γ-secretase cleavage from the ... That is why p3 peptide represents the benign form of amyloid. Energy plays a very important role in p3 peptides. While Aβ ... p3 peptide generates from the 17-40 or 17-42 sequence of the amyloid precursor protein (APP), which is a type I integral ...
*  Joseph Buxbaum
"Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline". JAMA. 283 (12): 1571-1577. doi ... "Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation". ... In Alzheimer disease, Buxbaum has conducted several cell-biological and patient-based analyses of APP and A-beta and he and his ... that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid ...
*  Estrogen receptor beta
The pathology of AD is also associated with accumulation of amyloid beta peptide (Aβ). While a proper concentration of Aβ in ... Brandenberger AW, Tee MK, Jaffe RB (1998). "Estrogen receptor alpha (ER-alpha) and beta (ER-beta) mRNAs in normal ovary, ... and beta (ER-beta) mRNA in the midgestational human fetus". J. Clin. Endocrinol. Metab. 82 (10): 3509-12. doi:10.1210/jc.82.10. ... "The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and ...
*  Meningoencephalitis
Antibodies targeting amyloid beta peptide proteins which have been used during research on Alzheimer's disease. The fungus, ...
*  PLCD1
2003). "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site". Biochem. Biophys. Res ... Guo Y, Philip F, Scarlata S (2003). "The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation ... Keshamouni VG, Mattingly RR, Reddy KB (2002). "Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells ...
*  PSEN1
Phiel CJ, Wilson CA, Lee VM, Klein PS (May 2003). "GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides ... A 5-fold drop of amyloid peptide was observed, suggesting that deficiency of presenilin-1 can down regulate amyloid and ... from amyloid precursor protein (APP). Accumulation of amyloid beta is associated with the onset of Alzheimer's disease. ... These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid ...
*  NAD(P)H dehydrogenase (quinone 1)
"The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease". Progress in Neurobiology ... Dong GZ, Oh ET, Lee H, Park MT, Song CW, Park HJ (May 2010). "Beta-lapachone suppresses radiation-induced activation of nuclear ...
*  PAWR
Guo Q, Xie J, Chang X, Du H (May 2001). "Prostate apoptosis response-4 enhances secretion of amyloid beta peptide 1-42 in human ... Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". ...
*  SYNPR
2004). "Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic ...
*  Bapineuzumab
"Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation". Scientific ... Bapineuzumab is an antibody to the beta-amyloid (Aβ) plaques that are believed to underlie Alzheimer's disease neuropathology. ... In previous clinical trials for vaccination against human beta amyloid, called AN-1792, patients with Alzheimer's disease using ... Bapineuzumab has been shown to recognise the extreme N-terminal 5 residues of Aβ peptide in a helical conformation (4HIX.pdb) ...
*  Peroxidase
Atamna H, Boyle K (Feb 2006). "Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies ... Amyloid beta, when bound to heme, has been shown to have peroxidase activity. A typical group of peroxidases are the ...
*  Prevention of dementia
Alzheimer's disease causes inflammation in the neurons by its deposits of amyloid beta peptides and neurofibrillary tangles. ... Insulin in the bloodstream is a trigger of amyloid beta-production, so decreased insulin levels decrease the level of amyloid ... It has been theorized that a vaccine could activate the body's own immune system to combat the beta amyloid plaques in ... Lack of sleep may also increase risk of dementia by increasing beta-amyloid deposition. Being neurotic increases the risk of ...
*  Common degu
2004), "Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degus", Neurobiol. ... "Cloning of complementary DNA's encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, ...
*  Collagen, type XXV, alpha 1
2005). "CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 ... 2005). "Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide- ... 2005). "Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates". FEBS J. ... or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits". Am. J. Pathol. 165 ...
*  Sulfatide
Han, x. (2010). "The Pathogenic Implication of Abnormal Interaction Between Apolipoprotein E Isoforms, Amyloid-beta Peptides, ... Amyloidpeptide clearance is important so that this accumulation does not occur. Sulfatide facilitates amyloidpeptide ... Sulfatide is also involved in the clearance of amyloidpeptide. Amyloidpeptides are one of the hallmarks of Alzheimer's ... When they are not degraded properly, these peptides accumulate and create plaques, which are clumps of amyloidpeptide pieces ...
*  Ramakrishnan Nagaraj
"Organic solvent mediated self-association of an amyloid forming peptide from beta(2)-microglobulin: An atomic force microscopy ... He has done considerable work on signal peptides and peptide antibiotics and their structure-function relationships. He is ... Sowmya, B. L., Jagannadham, M. V., and Nagaraj, R. (2006). "Interaction of synthetic peptides corresponding to the scaffolding ... CS1 maint: Multiple names: authors list (link) Pallavi, B.; Nagaraj, R. (2003). "Palmitoylated peptides from the cysteine- rich ...
*  TREM2
... interacts with DAP12 in microglia to trigger phagocytosis of amyloid beta peptide and apoptotic neurons without ...