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*  Zinc finger nuclease
Each zinc finger has an arginine (arg) amino acid protruding from the alpha helix, which forms a hydrogen bond with Nitrogen 7 ... August 2010). "TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain". Nucleic Acids ... Wayengera, M (2008). "Why bacteria derived R-M nucleic enzymatic peptides are efficient therapeutic molecules for use in the ... Chimeric nuclease Genome editing Gene targeting Zinc finger protein Zinc finger chimera Protein engineering Genome engineering ...
*  Signal peptide peptidase
Physiologically SPP processes signal peptides of classical MHC class I preproteins. A nine amino acid-long cleavage fragment is ... In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins ... which differ from mature pilin by virtue of containing a 6-8 residue leader peptide consisting of charged amino acids. Mature ... In mice, a nonamer peptide originating from the SPP protein serves as minor histocompatibility antigen HM13 that plays a role ...
*  Tetratricopeptide
It consists of a degenerate 34 amino acid sequence motif identified in a wide variety of proteins. It is found in tandem arrays ... It contains three 3-TPR repeats each with its own peptide-binding specificity. Its TPR1 domain is known to recognize the C- ... The other positions have a stronger preference for either small, large or aromatic amino acids rather than a specific residue. ... The PEX5 protein is a receptor for PTS1 (peroxisomal targeting signal tripeptide which directs proteins into peroxisomes). It ...
*  LdrD-RdlD toxin-antitoxin system
... a 35 amino acid peptide toxin (ldrD) and a 60 nucleotide RNA antitoxin. The 374nt toxin mRNA has a half-life of around 30 ... RdlD RNA (regulator detected in LDR-D) is a family of small non-coding RNAs which repress the protein LdrD in a type I toxin- ... sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in ... The Ldr peptide genes that have been discovered are thought to have evolved from a common ancestor. Four long direct repeat ( ...
*  Enfuvirtide
... with acquired resistance the result of a mutated 10 amino acid motif in viral gp41. Primary resistance, however, has yet to be ... HIV binds to the host CD4+ cell receptor via the viral protein gp120; gp41, a viral transmembrane protein, then undergoes a ... A biomimetic peptide, enfuvirtide was designed to mimic components of the HIV-1 fusion machinery and displace them, preventing ... By virtue of its peptide nature, enfuvirtide is marketed in injectable form. The lyophilised enfuvirtide powder must be ...
*  MIPEP
It contains a mitonchondria targeting peptide (Amino acid 1-35 of the peptide sequence). The mature protein has a theoretical ... The human protein Mitochondrial intermediate peptidase is 80.6 kDa in size and composed of 713 amino acids. ... The gene MIPEP encodes one metalloprotease that hydrolyzes peptide fragment of eight amino acids in lengths to process ... leader peptides cleaved by two matrix proteases share a three-amino acid motif". Proceedings of the National Academy of ...
*  Silk amino acid
... silk proteins into smaller peptide chains, typically 18 to 19 amino acids in length. Silk amino acids have a lower molecular ... Silk is made up of two primary proteins; a fibrous protein known as fibroin, and a sticky protein known as sericin, with the ... Silk amino acid (SAAs) also known as Sericin is a natural water-soluble glycoprotein extracted from raw silk. It is used as an ... weight than silk protein powders and are moisturizing to skin and hair. Silk amino acids are used in formulating shampoos, ...
*  Trichoderma
... produces small toxic peptides containing amino acids not found in common proteins, like alpha-aminoisobutyric acid, called ...
*  Protein sequencing
Each cycle releases and derivatises one amino acid from the protein or peptide's N-terminus and the released amino-acid ... Protein sequencing is the practical process of determining the amino acid sequence of all or part of a protein or peptide. This ... into proteins may also be determined. A generalized method often referred to as amino acid analysis for determining amino acid ... Hydrolyse a known quantity of protein into its constituent amino acids. Separate and quantify the amino acids in some way. ...
*  Peptide synthesis
... peptide/protein backbone modification, and the synthesis of D-proteins, which consist of D-amino acids. The established method ... Peptides can be chemically synthesized by coupling the carboxyl group of one amino acid to the amino group of another amino ... SPPS is limited by reaction yields, and typically peptides and proteins in the range of 70 amino acids are pushing the limits ... J. Peptide Res. Therap. 13 (1-2): 31-44. doi:10.1007/s10989-006-9059-7. Jones J (1992). Amino Acid and Peptide Synthesis. ...
*  Achlorhydria
... which is most important to digest the protein into smaller component like complex protein into simple peptides and amino acids ... VIPomas (vasoactive intestinal peptides) and somatostatinomas are both islet cell tumors of the pancreas. Pellagra, caused by ... The use of antacids or drugs that decrease gastric acid production (such as H2-receptor antagonists) or transport (such as ... Gastric bypass procedures such a duodenal switch and RNY, where the largest acid producing parts of the stomach are either ...
*  Protein structure
By convention, a chain under 30 amino acids is often identified as a peptide, rather than a protein. To be able to perform ... For example, insulin is composed of 51 amino acids in 2 chains. One chain has 31 amino acids, and the other has 20 amino acids ... A single amino acid monomer may also be called a residue indicating a repeating unit of a polymer. Proteins form by amino acids ... The sequence of amino acids in insulin was discovered by Frederick Sanger, establishing that proteins have defining amino acid ...
*  GBAS (gene)
... most common and malignant form of central nervous system tumor.The predicted 286-amino acid protein contains a signal peptide, ... Protein NipSnap homolog 2 is a protein that in humans is encoded by the GBAS gene. Chromosomal region 7p12, which contains GBAS ... GBAS protein might be involved in vesicular transport. GRCh38: Ensembl release 89: ENSG00000146729 - Ensembl, May 2017 GRCm38: ... 2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501 . ...
*  Papain
... and the mature peptide (134-345). The amino acid numbers are based on the mature peptide. The protein is stabilised by three ... The papain precursor protein contains 345 amino acid residues, and consists of a signal sequence (1-18), a propeptide (19-133) ... Amino acid residues within the pro-region mediate their membrane association, and play a role in the transport of the proenzyme ... This forms a covalent acyl-enzyme intermediate and frees the amino terminus of the peptide. The enzyme is deacylated by a water ...
*  Galanin
The second was galanin message-associated protein (GMAP), a 59- or 60-amino acid peptide also formed from the cleavage of ... Galanin is a peptide consisting of a chain of 29 amino acids (30 amino acids in humans) produced from the cleavage of a 123- ... In these animal forms, the first 15 amino acids from the N-terminus are identical, but amino acids differ at several positions ... amino acid protein known as prepro galanin, which is encoded by the GAL gene. The sequence of this gene is highly conserved ...
*  Thimet oligopeptidase
TOP2 helps with the degradation of these damaged proteins. The enzyme degrades peptides by targeting the amino acids residues ... Peptides that can be cleaved off are between 8 to 23 amino-acid residues. In addition, it has been suggested that TOP1 takes ... in the response to oxidative stress and degradation of oxidized proteins by breaking down peptides between 5 to 17 amino-acid ... similarity in the amino acid sequence, whereas TOPL is more similar to the mouse neurolysin with 34% similarity in the amino ...
*  CYR61
Full-length CYR61 protein contains 381 amino acids with an N-terminal secretory signal peptide followed by four structurally ... The first exon encodes 5'-UTR sequence and the first several amino acids in the secretory signal peptide. The remaining four ... CCN proteins function as matricellular proteins, which are extracellular matrix proteins that play regulatory roles, ... Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein ...
*  HADHB
... encodes a 51.2 kDa protein that is composed of 474 amino acids; 124 peptides have been observed through mass spectrometry ... 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides ... a catalyst of mitochondrial beta-oxidation of long chain fatty acids. The HADHB protein catalyzes the final step of beta- ... "Mitochondrial trifunctional protein deficiency: a severe fatty acid oxidation disorder with cardiac and neurologic involvement ...
*  SLC27A1
... encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass ... Long-chain fatty acid transport protein 1 is a protein that in humans is encoded by the SLC27A1 gene. The SLC27A1 gene is ... "Long-chain fatty acid transport protein 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Meirhaeghe A, Cottel D, ... "Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle ...
*  CYB5R3
... encodes a 34.2 kDa protein that is composed of 301 amino acids; 63 peptides have been observed through mass spectrometry ... Yubisui T, Miyata T, Iwanaga S, Tamura M, Yoshida S, Takeshita M, Nakajima H (Aug 1984). "Amino acid sequence of NADH- ... Yubisui T, Miyata T, Iwanaga S, Tamura M, Takeshita M (Feb 1986). "Complete amino acid sequence of NADH-cytochrome b5 reductase ... "Modification and identification of cytochrome b5 carboxyl groups involved in protein-protein interaction with cytochrome b5 ...
*  CYB5R1
... encodes a 34.1 kDa protein that is composed of 305 amino acids; 56 peptides have been observed through mass spectrometry ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ... "NADH-cytochrome b5 reductase 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Human CYB5R1 genome location and ... "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane ...
*  ACSL6
... encodes a 77.7 kDa protein that is composed of 697 amino acids; 10 peptides have been observed through mass spectrometry ... "Long-chain-fatty-acid--CoA ligase 6". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Human ACSL6 genome location and ... Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA. The ACSL6 ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355-64. doi: ...
*  MECR
... encodes a 21.2 kDa protein that is composed of 189 amino acids; 10 peptides have been observed through mass spectrometry ... An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II". J Biol Chem. 278 (22): 20154-61. doi: ... "Mitochondrial trans-2-enoyl-CoA reductase". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Maruyama K, Sugano S (1994 ... a protein interacting with a wide spectrum of nuclear hormone receptors". Gene. 221 (2): 225-33. doi:10.1016/S0378-1119(98) ...
*  ACSF3
ASCL4 encodes a 64.1 kDa protein that is composed of 576 amino acids; 20 peptides have been observed through mass spectrometry ... The disease is typically diagnosed by either genetic testing or higher levels of methylmalonic acid than malonic acid in the ... is a condition characterized by high levels of malonic acid and methylmalonic acid, because deficiencies in this gene cause ... This gene encodes a member of the acetyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation ...
*  Apolipoprotein A1
APOA1 encodes a 45.4 kDa protein that is composed of 396 amino acids; 21 peptides have been observed through mass spectrometry ... The protein, as a component of HDL particles, enables efflux of fat molecules by accepting fats from within cells (including ... Apolipoprotein A1 is a protein that in humans is encoded by the APOA1 gene. It has a specific role in lipid metabolism. The ... Apolipoprotein A1 is the major protein component of HDL particles in plasma. Chylomicrons secreted from the intestinal ...
*  Tachykinin receptor 1
... an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for ... The protein is the product of the TACR1 gene. Tachykinins are a family of neuropeptides that share the same hydrophobic C- ... doi:10.1016/j.peptides.2005.03.030. PMID 16042976 Datar P, Srivastava S, Coutinho E, Govil G (2004). "Substance P: structure, ... It is an undecapeptide with the amino acid sequence Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. SP binds to all three of ...
*  AGK (gene)
AGK encodes a 47.1 kDa protein that is composed of 422 amino acids; 32 peptides have been observed through mass spectrometry ... The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. It ... As phosphatidic acid is also involved in the synthesis of phospholipids, its loss will result in changes to the lipid ... The enzyme is involved in the more general pathway of fatty acid metabolism. AGK also has an implicated role in the assembly of ...