2001). "Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas". Anticancer Res. 20 (5C): 3775-9. ... Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene. The transporter is responsible for ... "Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene ... Hofmann K, Duker M, Fink T, Lichter P, Stoffel W (Apr 1995). "Human neutral amino acid transporter ASCT1: structure of the gene ...
Competition studies indicated that SnatA transports various L-type neutral amino acids. It has also been noted that glycine ... The 6TMS Neutral Amino Acid Transporter (NAAT) Family (TC# 2.A.95) is a family of transporters belonging to the Lysine Exporter ... "2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family". Transporter Classification Database. Retrieved 2016-02-25. Drew ... Portal: Biology As of this edit, this article uses content from "2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family ...
... an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids". J Biol Chem. 274 ... Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene. Heterodimeric ... "Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8". Maruyama K, Sugano S (1994 ... 2000). "LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine". J. Biol. Chem. 274 (49 ...
"Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters". J ... Large neutral amino acids transporter small subunit 3 is a protein that in humans is encoded by the SLC43A1 gene. SLC43A1+ ...
2009). "L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas". J Surg ... Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that in ... 2009). "L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer". Pathol. Int. 59 (1 ... 2006). "L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors". Int. J. Cancer. 119 (3): ...
2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID ... Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene. Solute carrier ... 2003). "Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB". Biochem. Biophys. Res. Commun. ... 2004). "Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas". NeuroReport. 15 (4): 575-8. ...
SLC6A19 is a system B(0) transporter that mediates epithelial resorption of neutral amino acids across the apical membrane in ... "Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder". J. ... Sodium-dependent neutral amino acid transporter B(0)AT1 is a protein that in humans is encoded by the SLC6A19 gene. ... "Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19". Nat. Genet. 36 (9): ...
"Identification and characterization of a lysosomal transporter for small neutral amino acids". Proc Natl Acad Sci U S A. 98 (13 ... 2004). "H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat ... 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered ... Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene. This gene encodes a member ...
... proton-coupled amino acid transporter (38) System A & N, sodium-coupled neutral amino acid transporter Vesicular inhibitory ... An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier ... Solute carrier family Amino acid transport Amino acid transport, acidic Amino acid transport, basic Amino acid transport ... high affinity glutamate and neutral amino acid transporter (3) heavy subunits of heteromeric amino acid transporters (6) ...
2009). "Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3". J. Biol. Chem. 284 (30): 19953-60. doi: ... The SLC6 family of proteins, which includes SLC6A18, acts as specific transporters for neurotransmitters, amino acids, and ... Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249-86. doi: ... and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters". J. ...
Large+Neutral+Amino+Acid-Transporter+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Amino+Acid+ ... amino acids. LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues. A ... SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of ... Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at ...
"Selective expression of the large neutral amino acid transporter at the blood-brain barrier". Proceedings of the National ... Andruszkiewicz R, Silverman RB (December 1990). "4-Amino-3-alkylbutanoic acids as substrates for gamma-aminobutyric acid ... "Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2". European Journal of Pharmaceutical Sciences. 35 (3): 161 ... US 6197819B1, Silverman RB, Andruszkiewicz R, "Gamma amino butyric acid analogs and optical isomers", issued March 6, 2001, ...
... an aromatic amino acid), making tryptophan preferentially available to the large neutral amino acid transporter at the blood- ... This lowers the ratio of these branched-chain amino acids in the bloodstream relative to tryptophan ( ... "Selective expression of the large neutral amino acid transporter at the blood-brain barrier". Proceedings of the National ...
... is a glycoprotein that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter ... amino acids. LAT is highly expressed in brain capillaries (which form the blood-brain barrier) relative to other tissues. A ... Amino+Acid-Transporter+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Amino+Acid+Transport+System+L ... Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at ...
... penetrates the blood-brain barrier via the large neutral amino acid transporter 1. In the central nervous ... Alpha-Amino acids, Antidepressants, Chlorobenzenes, Excitatory amino acid reuptake inhibitors, Experimental drugs, NMDA ... Most of its therapeutic potential is believed to occur via 7-chlorokynurenic acid which inhibits the glycine co-agonist site of ... 4-Chlorokynurenine is prodrug of 7-chlorokynurenic acid (7-Cl-KYNA), which in turn is a halogenated derivative of L-kynurenine ...
... independent transporter for small neutral amino acids that transports D-serine with high affinity". Neurosci. Lett. 287 (3): ... Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene. Heterodimeric amino acid ... neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D ... 2004). "The amino acid transporter asc-1 is not involved in cystinuria". Kidney Int. 66 (4): 1453-64. doi:10.1111/j.1523- ...
SLC6A19 is a sodium-dependent and chloride-independent neutral amino acid transporter, expressed predominantly in the kidneys ... The defective gene controls the absorption of certain amino acids from the intestine and the reabsorption of those amino acids ... Nicotinamide is necessary for neutral amino acid transporter production in the proximal renal tubules found in the kidney, and ... "Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19". Nature Genetics. 36 ( ...
"Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19". Nature Genetics. 36 ( ... Reeds PJ (1 July 2000). "Dispensable and indispensable amino acids for humans" (Free full text). The Journal of Nutrition. 130 ... Hypertryptophanemia is a rare autosomal recessive metabolic disorder that results in a massive buildup of the amino acid ... a disorder of amino acid transport. However, the increase of tryptophan in that disorder is negligible when compared to that of ...
"Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal ... "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location". Genomics. 79 (1): 95 ...
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded ... dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na+- and Cl−-dependent ... dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem. 274 (34): 23740-5. doi:10.1074/jbc.274.34.23740. ... "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to ...
2005). "Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of ... Monocarboxylate transporter 10 (MCT 10), also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 ( ... Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid ... cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters". J ...
This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids ... b(0,+)-type amino acid transporter 1, also known as b(0,+)AT1, is a protein which in humans is encoded by the SLC7A9 gene. This ... Heterodimeric amino acid transporter Solute carrier family GRCh38: Ensembl release 89: ENSG00000021488 - Ensembl, May 2017 ... gene encodes a protein that belongs to a family of light subunits of amino acid transporters. ...
... via the large neutral amino acid transporter (LNAAT). If phenylalanine is in excess in the blood, it will saturate the ... The fact that CGMP is a peptide ensures that the absorption rate of its amino acids is prolonged compared to free amino acids ... The enzyme phenylalanine hydroxylase normally converts the amino acid phenylalanine into the amino acid tyrosine. If this ... 541 This enzyme is necessary to metabolize the amino acid phenylalanine (Phe) to the amino acid tyrosine (Tyr). When PAH ...
Gabapentinoids are absorbed from the intestines mainly by the Large neutral amino acid transporter 1 (LAT1, SLC7A5) and the ... Branched-chained amino acids like l-leucine, l-isoleucine, and l-valine have many functions in the central nervous system. They ... Excitatory amino acid transporter 3 (EAAT3). They are one of the few drugs that use these amino acid transporters. ... 3-hydroxycyclopent-1-enecarboxylic acid (HOCPCA) γ-hydroxycrotonic acid, trans-4-Hydroxycrotonic acid (GHC, T-HCA) Amisulpride ...
The neutral amino acid transporter SLC6A19 (affecting glycine, proline, and other neutral amino acids like cysteine and ... "Neutral amino acid transport mediated by ortholog of imino acid transporter SIT1/SLC6A20 in opossum kidney cells". American ... instead of the amino group found in amino acids. Proline is considered and usually referred to as an amino acid, but unlike ... "H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat". ...
Mackenzie B, Erickson JD (February 2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family ... Gasnier B (February 2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflügers ... cationic amino acid transporter/glycoprotein-associated cationic amino acid transporters (SLC7A1, SLC7A2, SLC7A3, SLC7A4) ... copper transporter (SLC31A1, SLC31A2) vesicular inhibitory amino acid transporter (SLC32A1) Acetyl-CoA transporter (SLC33A1) ...
"The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations ... the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2". ... The Cationic Amino Acid Transporter (CAT) Family 2.A.3.4: The Amino Acid/Choline Transporter (ACT) Family 2.A.3.5: The ... The Amino Acid Transporter (AAT) Family 2.A.3.2: The Basic Amino Acid/Polyamine Antiporter (APA) Family 2.A.3.3: ...
... that pregabalin is actively transported across the blood-brain barrier by the system L neutral amino acid transporter protein, ... which usually functions to transport certain amino acids, including leucine, valine and isoleucine, into the brain. This ... and also retained similar affinity for the system L transporter. This was tested in animals and as hoped, was found to have ... were found to also dramatically reduce binding to the system L transporter, and with no assisted transport into the brain, ...
Family 2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family 2.A.96 The Acetate Uptake Transporter (AceTr) Family 2.A.97 ... "The Transporter Classification Database". Nucleic Acids Research. 42 (D1): D251-D258. doi:10.1093/nar/gkt1097. PMC 3964967. ... Dicarboxylate Transporter Family 2.A.17 Proton-dependent Oligopeptide Transporter Family 2.A.18 The Amino Acid/Auxin Permease ( ... Family 2.A.120 The Putative Amino Acid Permease (PAAP) Family 2.A.121 The Sulfate Transporter (CysZ) Family 2.A.122 The LrgB/ ...
... are absorbed from the intestines by an active transport process mediated via the large neutral amino acid transporter 1 (LAT1, ... SLC7A5), a transporter for amino acids such as L-leucine and L-phenylalanine. Very few (less than 10 drugs) are known to be ... The endogenous α-amino acids L-leucine and L-isoleucine, which closely resemble the gabapentinoids in chemical structure, are ... and competition for binding by endogenous L-amino acids has been said to likely be responsible for this discrepancy. In one ...