Berni R, Malpeli G, Folli C, Murrell JR, Liepnieks JJ, Benson MD (September 1994). "The Ile-84-->Ser amino acid substitution in ... Rask L, Anundi H, Fohlman J, Peterson PA (1987). "The complete amino acid sequence of human serum retinol-binding protein". ... "Three-dimensional structure and active site of three hydrophobic molecule-binding proteins with significant amino acid sequence ... Nucleic Acids Research. 11 (22): 7769-76. doi:10.1093/nar/11.22.7769. PMC 326530. PMID 6316270. Newcomer ME, Jones TA, Aqvist J ...

"Secretion of a λ2 immunoglobulin chain is prevented by a single amino acid substitution in its variable region". Cell. 33 (1): ...

Additionally amino acid co-evolution is a challenging issue that needs to be addressed. For example, a substitution in a ... For example, substitutions at different amino acids results in varying levels of neutralization by antibodies. If mutation in a ... Mutations that lead to antigenic differences can be traced to the biochemical nature of the amino acid substitutions as well as ... These maps can show how changes in amino acids can alter the binding of an antibody to virus particle and help to analyze the ...

M10 is a mutated form of Rev and has a single amino acid substitution (Aspartic acid to Leucine). If delivered to cells, Rev ... Rev is a 13-kDa protein that is composed of 116 amino acids. Rev's sequence contains two specific domains which contribute to ... The arginine-rich motif (ARM) is located between amino acids 38-49 of the rev gene and forms an alpha-helical secondary ... Görlich D, Henklein P, Laskey RA, Hartmann E (April 1996). "A 41 amino acid motif in importin-alpha confers binding to importin ...

T substitution in the coding region of ADRB1 which causes a substitution of alanine to valine in amino acid position 507 of the ... C substitution in the coding region of DEC2 which results in a proline to arginine substitution at amino acid position 385 of ... This mutation consists of a substitution from tyrosine to histidine at amino acid position 206 of the gene. A mouse animal ... T which lead to an amino acid substitution of tyrosine to histidine. After deprivating them of sleep for over 38 hours, the ...

A single amino acid substitution, and in particular a single nucleotide substitution, is responsible for an activating mutation ... Normally amino acid position 12 of the KRAS protein is occupied by glycine but in G12D it is occupied by aspartic acid. As of ...

Nitta N, Ochiai M, Nagao M, Sugimura T (1987). "Amino-acid substitution at codon 13 of the N-ras oncogene in rectal cancer in a ... Mutations which change amino acid residues 12, 13 or 61 activate the potential of N-ras to transform cultured cells and are ... They differ significantly only in the C-terminal 40 amino acids. These Ras genes have GTP/GDP binding and GTPase activity, and ... Hall A, Brown R (1985). "Human N-ras: cDNA cloning and gene structure". Nucleic Acids Res. 13 (14): 5255-68. doi:10.1093/nar/ ...

... and intranuclear mobility of mutant androgen receptors carrying amino acid substitutions in the deoxyribonucleic acid-binding ... and intranuclear mobility of mutant androgen receptors carrying amino acid substitutions in the deoxyribonucleic acid-binding ... Missense mutations that result in a single amino acid substitution are known to produce the most phenotypic diversity. The ... Nucleocytoplasmic transport is in part facilitated by an amino acid sequence on the AR called the nuclear localization signal. ...

This variant of FLP only has 4 amino acid substitutions: P2S, L33S, Y108N, and S294P. Genetic mosaicism occurs within an ... Characterization of a mutant FLP protein with an alteration in a catalytic amino acid". The Journal of Biological Chemistry. ... While a base substitution of any of the aforementioned nucleotides in only one of the FRT sites led to a ten-fold, ten-fold, ... Every base substitution was performed on each of the thirteen nucleotides within the FRT site (example G to A, T, and C). First ...

SH3 binding specificity altered by single amino acid substitutions". Molecular and Cellular Biology. 15 (10): 5627-34. doi: ... The proline-rich region contains a high concentration of the amino acid Proline, and lies between amino acid residues 711-724. ... The ced-12 gene codes for an 82kDa large protein, which spans 731 amino acids in length. It is found on chromosome 2 on the L- ... The Pleckstrin Homology domain spans 100-200 amino acids in length. It is located close to the C-terminal and is necessary to ...

"Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids". J. Gen. Physiol. 132 (1): 85- ... of the Q/R site can effect inhibition of the channel by membrane fatty acids such as arachidonic acid and docosahexaenoic acid ... Editing results in a change in amino acid in the second membrane domain of the receptor. The editing site is found within the ... For Kainate receptors with only edited isoforms, these are strongly inhibited by these fatty acids. However, inclusion of just ...

"Switching from an esterase to a hydroxynitrile lyase mechanism requires only two amino acid substitutions". Chem. Biol. 17 (8 ... Key amino acid residues in this reaction are the lysine at position 236 and the threonine at position 11. Lys236 helps to ...

The first haplotype is seven amino acids in strong linkage disequilibrium. This haplotype is global and seems to be moving ... They specifically wanted to know how synonymous substitutions affected the evolutionary landscape of a protein. To do this, ... A synonymous protein has the same amino acid sequence but different nucleotide sequences. Thus, a synonymous protein has the ...

"Amino acid substitutions in the pore helix of GluR6 control inhibition by membrane fatty acids". J. Gen. Physiol. 132 (1): 85- ... The pre-mRNA of GLUR6 is edited at amino acid positions 567, 571, and 621. The Q/R position, which gets its name as editing ... Leuschner WD, Hoch W (1999). "Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor ... RNA editing of the Q/R site can affect inhibition of the channel by membrane fatty acids such as arachidonic acid and ...

"Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions". Genetics. 207 (1): 53-61. ... The mutation resulted in a change in specific amino acids and the effects of this mutation were analyzed. The site-directed ... generation of point mutations in cloned beta globin complementary dna at the positions corresponding to amino acids 121 to 123 ... approach is site saturation mutagenesis where one codon or a set of codons may be substituted with all possible amino acids at ...

In the case of Condylostoma, stop codons have been reassigned to code for an amino acid . For these new substitutions TAA and ... The answer seems to be that these codons can function both as stop codons and as normal amino acid encoders. In this case ...

Since the amino acid substitution can occur at different positions of the β-globin chain of the protein, there are several ... It showed glutamic acid to lysine substitution at position 11. The woman was suffering from a complicated blood conditions. The ... Hemoglobin O (HbO) is a rare type of hemoglobin in which there is a substitution of glutamic acid by lysine as in hemoglobin C ... It was later found that the amino acid replacement is at position 121 of the hemoglobin. The hemoglobin is now known as ...

... a conservative substitution at position 692 that is located seven amino acids downstream of the furin cleavage site; iii) ... a deletion of a histidine and valine at amino acid positions 69 and 70 in the N-terminal domain of the S1 subunit; ii) I692V - ... S1147L - a non-conservative substitution at position 1147 in the S2 subunit; and iv) M1229I - a conservative substitution ... and a non-conservative substitution S1147L. In North America, a mink-human spillover event in Michigan, resulting in four human ...

... a conservative substitution at position 692 that is located seven amino acids downstream of the furin cleavage site; iii) ... a deletion of a histidine and valine at amino acid positions 69 and 70 in the N-terminal domain of the S1 subunit; ii) I692V - ... S1147L - a non-conservative substitution at position 1147 in the S2 subunit; and iv) M1229I - a conservative substitution ... and a non-conservative substitution S1147L. Mink-related mutations that partially resemble the mutations discovered in Denmark ...

It contains 48 amino acid residues. Substitution of the 16th amino acid, asparagine (N), into an aspartic acid (D) is named ... It has two homologous amino acid substitutions (S17T and S19T) and one non-homologous substitution (V13S). This makes it 94% ... a replacement of the 14th amino acid, arginine (R), into histidine (H). Cangitoxin is to varying degrees homologous to the ... cangitoxin-II (CGTX-II). Cangitoxin-III (CGTX-III) contains in addition to the previous substitution, ...

... characterization of the amino acid substitution and the DNA mutation". Haemoglobin. 26 (1): 21-31. doi:10.1081/HEM-120002937. ... This results in the replacement of hydrophilic amino acid glutamic acid with the hydrophobic amino acid valine at the sixth ... It is 147 amino acids long and has a molecular weight of 15,867 Da. Normal adult human HbA is a heterotetramer consisting of ... HbC mutation is at the same position in HbS, but glutamic acid is replaced by lysine (β6Glu→Lys). The mutation is particularly ...

Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone N Engl J Med. 1992; 326(3): ...

... a 16-amino acid peptide structurally identical to human uroguanylin (with exception of a single-amino acid substitution. ... Plecanatide is a 16 amino acid peptide with the amino acid sequence: H-Asn1-Asp2-Glu3-Cys4-Glu5-Leu6-Cys7-Val8-Asn9-Val10-Ala11 ... apart from the substitution of Asp3 with Glu3. Disulfide bonds exist between Cys4 and Cys12, as well as Cys7 and Cys15. ...

Three amino acid substitutions distinguish the human FOXP2 protein from that found in mice, while two amino acid substitutions ... In mice it differs from that of humans by three substitutions, and in zebra finch by seven amino acids. One of the two amino ... The human gene differs from that in non-human primates by the substitution of two amino acids, a threonine to asparagine ... This mutation is due to an amino-acid substitution that inhibits the DNA-binding domain of the FOXP2 protein. Further screening ...

... identification of a nonfunctional clone resulting from a single amino acid substitution". Molecular and Cellular Biology. 5 (4 ... with high conservation of amino acid sequence. The high degree of amino acid sequence conservation suggests the crucial nature ... It has also been proposed that ADA, in addition to adenosine breakdown, stimulates release of excitatory amino acids and is ... ADA irreversibly deaminates adenosine, converting it to the related nucleoside inosine by the substitution of the amino group ...

Aminomethylbenzoic acid Anthranilic acid 4-Aminobenzoic acid Arene substitution pattern Non-proteinogenic amino acids m- ... 3-Aminobenzoic acid (also known as meta-aminobenzoic acid or MABA) is an organic compound with the molecular formula ... It consists of a benzene ring substituted with an amino group and a carboxylic acid. ... 3-aminobenzoic acid, Medical Subject Headings database. Haynes, William M., ed. (2016). CRC Handbook of Chemistry and Physics ( ...

The data provided for each amino acid substitution is a score and a qualitative prediction (either 'tolerated' or 'deleterious ... that predicts whether an amino acid substitution is likely to affect protein function based on sequence homology and the physic ... The score is the normalized probability that the amino acid change is tolerated so scores near 0 are more likely to be ... 12-22, 2011 C. Bult and J. Eppig, "The Mouse genome Database (MGD): mouse biology and model systems," Nucleic Acids Research, ...

... characterization of the amino acid substitution and the DNA mutation". Hemoglobin. 26 (1): 21-31. doi:10.1081/HEM-120002937. ...

DasSarma, Shiladitya; Capes, Melinda D.; Karan, Ram; DasSarma, Priya (2013-03-11). "Amino Acid Substitutions in Cold-Adapted ...

"Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein". ... Characterization of the Estrogenic Potencies and Receptor Interactions of a Series of Fungal β-Resorcylic Acid Lactones". ...