They are common in protein-protein interaction motifs and are typically 20-29 amino acids in length. All major classes of LRRs ... The LRRN3 protein is 708 amino acids in length. The molecular weight of this protein is 79,424 Daltons, with an isoelectric ... Leucine-rich repeats are unusually rich in the hydrophobic amino acid leucine. ...

It contains a divalent cation tolerance protein CutA motif from amino acids 57-88. No transmembrane domains or N-terminal ... Chemically significant amino acid changes in conserved regions of the c4orf36 protein were found with NCBI SNPGeneView. GRCh38 ... C4orf36 encodes a 117 amino acid protein with a molecular weight of 13.28 kDa and an isoelectric point of 9.54. ... "GenomeNet MOTIF Search". GenomeNet. Archived from the original on 2011-08-17. "PSORTII Prediction". PSORTII. Archived from the ...

This recruitment takes place via a 4 amino acid motif in the Ste5 phosphosites. Ptc1 is also involved in regulating the osmotic ...

This 15-amino acid motif is one found by the original Dame et al., 1984 discovery of CSP which contains the 5-length CSP Region ... however the antibody's binding is inhibited by a particular CSP motif, suggesting antibody efficacy is due to its anti-CSP ...

A coronavirus cleavage site is predicted at the 235 amino acid position. There are also tyrosine motif locations between amino ... The full C16orf46 protein is 417 amino acids long. It has no isoforms, and its most distant ortholog, Rhincodon typus (whale ... acids 42-45 and 251-252. mRNA folding on the 5' UTR predicts a stem loop twice in the area between base pairs 47-90. C16orf46 ...

The WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was ... The WH2 motif or WH2 domain is an evolutionarily conserved sequence motif contained in proteins. It is found in WASP proteins ... The WH2 motif (for Wiskott-Aldrich syndrome homology region 2) has been shown in WAS and Scar1/WASF1 (mammalian homologue) to ... Human genes encoding proteins containing the WH2 motif include: COBL, COBLL1, ESPN, INF2, JMY LMOD1, LMOD2, LMOD3 MTSS1, PXK ...

Hemopoietic Growth Factor (type 1) family, whose members have certain conserved motifs in their extracellular amino-acid domain ... Structural motifs conserved between members of this family include: an extracellular fibronectin III-like domain, a ...

DUF 4587 is usually between 64 and 79 amino acids long and contains the two sequence motifs QNAQ and HHH. PRR29 is predicted to ... It contains one proline-rich region motif that extends from amino acid 39 to 107. The secondary structure is characterized by ... Its name is derived from the chain of 5 proline amino acids located toward the end of the protein. The primary domain within ... PRR29 contains a proline rich region within its sequence from amino acids 73 to 166. A domain of unknown function, DUF 4587, is ...

These amino acids form the DDE motif that coordinate divalent metal ions (Mg2+ or Mn2+). These metal ions are essential for the ... A loop containing amino acid residues 140-149 is located in the catalytic-core domain and is important for IN function as ... 2. The catalytic core domain (CCD), which encompasses amino acids 51- 212, contains the active site of IN but it can't catalyze ... 3. The C-terminal domain (CTD), which encompasses amino acids 213-288, binds DNA nonspecifically and its interaction with NTD ...

As predicted amino acids in the conserved WRKYGQK signature motif contact the W-box DNA. WRKY Transcription Factor Family at ... The W box is a deoxyribonucleic acid (DNA) cis-regulatory element sequence, (T)TGAC(C/T), which is recognized by the family of ... Nucleic Acids Research. 41 (21): 9764-9778. doi:10.1093/nar/gkt732. PMC 3834811. PMID 23975197. Yamasaki, K.; Kigawa T; ...

This motif is composed of four amino acids at the end of the protein sequence. The most common retention sequences are KDEL for ... The N-terminus (one end) of a polypeptide chain (i.e., a protein) contains a few amino acids that work as an address tag, which ... The first 5-30 amino acids polymerized encode a signal peptide, a molecular message that is recognized and bound by a signal ... either secreted constitutively with no tag or secreted in a regulatory manner involving clathrin and paired basic amino acids ...

Bernad A, Blanco L, Salas M (September 1990). "Site-directed mutagenesis of the YCDTDS amino acid motif of the phi 29 DNA ... Involvement of two amino acid residues highly conserved in proofreading DNA polymerases". EMBO J. 15 (5): 1182-92. doi:10.1002/ ... His61 and Phe69 of the highly conserved ExoII motif are essential for interaction with the terminal protein". Nucleic Acids Res ... Truniger V, Blanco L, Salas M (1999). "Role of the "YxGG/A" motif of Phi29 DNA polymerase in protein-primed replication". J Mol ...

The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. Fanconi anemia is an autosomal recessive ... Blom E, van de Vrugt HJ, de Vries Y, de Winter JP, Arwert F, Joenje H (January 2004). "Multiple TPR motifs characterize the ...

The predicted coiled-coil domain of CCDC142 is from amino acids 308-719. A RINT1_TIP1 motif is also present from amino acids ... The main isoform of the CCDC142 protein is 743 amino acids in length and the second isoform is 665 amino acids long. The ... Distant Ortholog Multiple Sequence Alignment of CCDC142 Purple=Similar Amino Acid Chemistry Blue=Same Amino Acid In the ... Conserved Region 1 contains mostly nonpolar amino acids. Conserved Region 2 contains mostly nonpolar and basic amino acids. ...

Tahiliani PD, Singh L, Auer KL, LaFlamme SE (March 1997). "The role of conserved amino acid motifs within the integrin beta3 ... A carboxy-terminal region of one hundred and fifty-nine amino acids, the focal adhesion targeting domain (FAT), has been shown ... The amino-terminal domains of FAK share a significant sequence similarity with the band 4.1 domain first identified in ... Between the amino and the carboxy regions lies the catalytic domain. Phosphorylation of the activation loop within this kinase ...

In 1975, it was shown that cAMP-dependent proteins kinases phosphorylate serine residues on specific amino acid sequence motifs ... aspartic acid, glutamic acid and cysteine, and these phosphorylated amino acids have recently been identified to be present in ... Phosphorylation of the amino acid Ser129 in the α-Synuclein protein has a profound effect on the severity of the disease. There ... For example, if amino acid Serine-473 ("S473") in the protein AKT is phosphorylated, AKT is, in general, functionally active as ...

... motif with three repeats from amino acids 183-202 and a motif of phenylalanine at every other residue from amino acids 409-416 ... from amino acids 21-28 and "PPSH" from amino acids 107-114. There is a periodic motif of four leucines spaced seven residues ... or highly conserved amino acids; changes in these amino acids may be more likely to have phenotypic effects. The table below ... The human TMEM39B protein isoform 1 is composed of 492 amino acids and has a predicted molecular weight of 56 kDa. The basal ...

The FIP1 motif of 40 amino acids on FIP1L1 is responsible for its binding to CPSF1. CPSF1 is an RNA processing protein that ... The fusion gene may produce a protein consisting of the first 233 amino acids of FIP1L1 joined to the last 523 amino acids of ... and codes for a complete protein consisting of 594 amino acids. However, alternative splicing of its Precursor mRNA results in ... RARA, the Retinoic acid receptor alpha gene, is located on human chromosome 17 at position q21.2 (i.e. 17q21.2), consists of 17 ...

Only the one located at amino acid 113 has been experimentally confirmed. There is also a high probability of a SASRP1 motif ... modification site at amino acid 280, N-glycosylation sites at amino acids 49 and 229, and a phosphorylation site at amino acid ... The human SPATS1 gene contains 1150 nucleotides, coding for 300 amino acids. It's located on the positive strand of chromosome ... that spans amino acids 51 - 288. Possible interacting proteins are listed in the table below. Note that these proteins have not ...

The C terminus contain a LPXTG sequence motif and hydrophobic amino acid segments attached to peptidoglycan. The C-terminal ... the wall-anchoring LPTXG motif, a hydrophobic transmembrane region and a cytoplasmic tail of positively charged amino acid ... SdrG stands for serine-aspartate dipeptide repeats, which as its name suggests, contains repeats of two amino acids, serine and ...

... s are a ~90 amino acid motif present only at the N-terminus of proteins. The core is made of highly conserved ... A pyrin domain (PYD, also known as PAAD/DAPIN) is a protein domain and a subclass of protein motif known as the death fold, the ... Bertin J, DiStefano PS (December 2000). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell ...

Lauberth SM, Rauchman M (Aug 2006). "A conserved 12-amino acid motif in Sall1 recruits the nucleosome remodeling and ... Through a 12-amino acid sequence in its N-terminus (N-12a.a.), SALL4 binds to retinoblastoma binding protein 4 (RBBP4), a ... SALL4 has at least one canonical nuclear localization signal (NLS) with the K-K/R-X-K/R motif in the N-terminal portion of the ... SALL4 contains one zinc finger in its amino (N-) terminus and three clusters of zinc fingers that each coordinates zinc with ...

2016). "Role of tetra amino acid motif properties on the function of protease-activatable viral vectors". ACS Biomater. Sci. ... A study to change out the tetra-aspartic acid blocking residues revealed that the negative charge of the residues is likely ... By inserting an infection blocking tetra-aspartic acid residue into the capsid flanked by MMP cleavable sequences, a lab has ...

When multiple amino acids within this motif were mutated, HOXB4 became resistant to CRL4A-mediated degradation. The substrate ... CUL4A protein is 759 amino acids long and forms an extended, rigid structure primarily consisting of alpha-helices. At the N- ... Sequence alignment studies showed that there is a highly conserved "LEXE" motif within helix one of the homeodomain. ...

It is a 70 kDa glycoprotein made up of 329 amino acids. Both CD80 and CD86 share a conserved amino acid motif that forms their ... This enzyme can metabolize amino acid tryptophan, which is an important component for successful proliferation and ...

Homo sapiens FAM237A amino acid composition is predicted to be relatively standard. It notably contains a repeat LFWD motif at ... Homo sapiens FAM237A contains two predicted fatty acid addition sites at amino acids 18 and 26; these sites overlap with one of ... amino acids 90 and 97. FAM237A's transmembrane domain is generally predicted to reside on amino acids 14-32 within the protein ... The last protein isoform of FAM237A is made up of 158 amino acids and contains a transmembrane domain; this isoform is ...

... is a member of the catenin family, since it contains a distinct repeating amino acid motif called the armadillo ... Troyanovsky SM, Troyanovsky RB, Eshkind LG, Leube RE, Franke WW (Nov 1994). "Identification of amino acid sequence motifs in ... Human plakoglobin is 81.7 kDa in molecular weight and 745 amino acids long. The JUP gene contains 13 exons spanning 17 kb on ... Franke WW, Goldschmidt MD, Zimbelmann R, Mueller HM, Schiller DL, Cowin P (Jun 1989). "Molecular cloning and amino acid ...

This protein domain contains six motifs and 70 amino acids and it folds into a five-stranded antiparallel beta barrel. The ... This suggests that they may both be derived from an ancient nucleic acid-binding protein. The S1 domain is an essential in ... This suggests that they may both be derived from an ancient nucleic acid-binding protein. Conserved residues on one face of the ... a member of an ancient nucleic acid-binding fold". Cell. 88 (2): 235-42. doi:10.1016/S0092-8674(00)81844-9. PMID 9008164. S2CID ...

For example, one well-known example is the dileucine motif, in which a leucine amino acid (aa) residue is followed immediately ... or amino acid "motifs" in the cargo proteins that interact with the adaptor proteins can be very short. ... The complete "dileucine based" motif is (D/E)XXXL(L/I), where X is any aa and D/E is either aspartic or glutamic acid residues ... The sort of sequence comparisons used, in part, to define these motifs. In some cases, post-translational modifications, such ...

The amino acid sequence of Cl6a contains the NaSpTx family 1 motif KHKWCK. Cl6a highly resembles a similar sequence with other ... Toxins of NaSpTx family 1 are characterized by containing the following motif present in the amino acid sequence of the toxins ... For instance, the amino acid sequence of Cl6a shows 67% sequence similarity with Hainantoxin (HNTX) III and 97% with huwentoxin ... Cl6a is a 33 amino acid residue peptide toxin with a molecular weight of 3775.6 Dalton. Its molecular structure encompasses six ...