Loading...
*  Protein primary structure
Amino acids are polymerised via peptide bonds to form a long backbone, with the different amino acid side chains protruding ... "Normalization of nomenclature for peptide motifs as ligands of modular protein domains". FEBS Letters. 513 (1): 141-144. doi: ... Protein sequencing Nucleic acid primary structure Translation Pseudo amino acid composition SANGER F (1952). "The arrangement ... listing the amino acids starting at the amino-terminal end through to the carboxyl-terminal end. Either a three letter code or ...
*  Armadillo repeat
Peifer M, Berg S, Reynolds AB (1994). "A repeating amino acid motif shared by proteins with diverse cellular roles". Cell. 76 ( ... Eukaryotic Linear Motif resource motif class TRG_NLS_Bipartite_1 Eukaryotic Linear Motif resource motif class TRG_NLS_MonoCore_ ... 2 Eukaryotic Linear Motif resource motif class TRG_NLS_MonoExtC_3 Eukaryotic Linear Motif resource motif class TRG_NLS_MonoExtN ... An armadillo repeat is the name of a characteristic, repetitive amino acid sequence of about 40 residues in length that is ...
*  Beta-catenin
Peifer M, Berg S, Reynolds AB (March 1994). "A repeating amino acid motif shared by proteins with diverse cellular roles". Cell ... Liu J, Xing Y, Hinds TR, Zheng J, Xu W (June 2006). "The third 20 amino acid repeat is the tightest binding site of APC for ... First, they might reach or even surpass the length of 30 amino acids in length, and contact the ARM domain on an excessively ... There is one requirement, though: substrates of GSK3 need to be pre-phosphorylated four amino acids downstream (C-terminally) ...
*  Cyclic di-GMP
These proteins have either an EAL or an HD-GYP amino acid motif. Processes that are known to be regulated by cyclic di-GMP, at ... These proteins typically have a characteristic GGDEF motif, which refers to a conserved sequence of five amino acids. ... Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid P. Ross Nature, 1987 Benach, J; Swaminathan ... "Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid". Nature. 325 (6101): 279-81. doi:10.1038/ ...
*  RGS18
This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of ...
*  Gluten immunochemistry
McLachlan A, Cullis PG, Cornell HJ (October 2002). "The use of extended amino acid motifs for focussing on toxic peptides in ... The IRP lies within a 25 amino-acid long region that is resistant to pancreatic proteases. The 25mer is also resistant to Brush ... HLA-DQ proteins present polypeptide regions of proteins of about 9 amino acids and larger in size (10 to 14 residues in ... Α2-gliadin differs from the other α-gliadins, specifically because it contains an insert of 14 amino acids. This particular ...
*  List of open-source health software
Wregex is an amino acid motif searching software for weighted regular expressions. It is available under the GNU GPL. Glucosio ...
*  Ptc1
This recruitment takes place via a 4 amino acid motif in the Ste5 phosphosites. Ptc1 is also involved in regulating the osmotic ...
*  TGF alpha
The EGF receptor is characterized by having an extracellular domain that has numerous amino acid motifs. EGFR is essential for ... TGF-α is synthesized internally as part of a 160 (human) or 159 (rat) amino acid transmembrane precursor. The precursor is ... 50 amino acids of TGF-α, and a 35-residue-long cytoplasmic domain. In its smallest form TGF-α has six cysteines linked together ... TGF-α has been shown to inhibit gastric acid secretion. TGF-α can be produced in macrophages, brain cells, and keratinocytes. ...
*  Protein inhibitor of activated STAT
Each SAP domain contains an LXXLL amino acid motif. L = leucine, and X = any amino acid. This motif is used to bind to nuclear ... motif, the RING-finger-like zinc-binding domain (RLD), the highly acidic domain (AD), the SUMO-interacting motif (SIM), and the ... contains a SUMO-interacting motif (SIM). The SIM motif may be needed for PIAS proteins to accurately recognize and interact ... The Pro-Ile-Asn-Ile-Thr (PINIT) motif was discovered in PIAS3L, an isoform of PIAS3. PIAS proteins tend to go back and forth ...
*  Φ29 DNA polymerase
Bernad A, Blanco L, Salas M (September 1990). "Site-directed mutagenesis of the YCDTDS amino acid motif of the phi 29 DNA ... Involvement of two amino acid residues highly conserved in proofreading DNA polymerases". EMBO J. 15 (5): 1182-92. PMC 450017 ... His61 and Phe69 of the highly conserved ExoII motif are essential for interaction with the terminal protein". Nucleic Acids Res ... Truniger V, Blanco L, Salas M (1999). "Role of the "YxGG/A" motif of Phi29 DNA polymerase in protein-primed replication". J Mol ...
*  SALL4
Lauberth SM, Rauchman M (Aug 2006). "A conserved 12-amino acid motif in Sall1 recruits the nucleosome remodeling and ... Through a 12-amino acid sequence in its N-terminus (N-12a.a.), SALL4 binds to retinoblastoma binding protein 4 (RBBP4), a ... SALL4 has at least one canonical nuclear localization signal (NLS) with the K-K/R-X-K/R motif in the N-terminal portion of the ... SALL4 contains one zinc finger in its amino (N-) terminus and three clusters of zinc fingers that each coordinates zinc with ...
*  GPX4
... shares the amino acid motif of selenocysteine, glutamine, and tryptophane (catalytic triad) with other glutathione ... In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of ... During the catalytic cycle of GPx4, the active selenol (-SeH) is oxidized by peroxides to selenenic acid (-SeOH), which is then ... Grim JM, Hyndman KA, Kriska T, Girotti AW, Crockett EL (2011). "Relationship between oxidizable fatty acid content and level of ...
*  PTK2
Tahiliani PD, Singh L, Auer KL, LaFlamme SE (March 1997). "The role of conserved amino acid motifs within the integrin beta3 ... A carboxy-terminal region of one hundred and fifty-nine amino acids, the focal adhesion targeting domain (FAT), has been shown ... The amino-terminal domains of FAK share a significant sequence similarity with the band 4.1 domain first identified in ... Between the amino and the carboxy regions lies the catalytic domain. Phosphorylation of the activation loop within this kinase ...
*  SETDB1
The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. ...
*  Karyopherin alpha 1
"RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A ... 1994). "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in ...
*  RGS17
This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein ...
*  Molecular mimicry
For example, the QKRAA sequence is an amino acid motif in the third hypervariable region of HLA-DRB1*0401. This motif is also ... Assuming five to six amino acid residues are used to induce a monoclonal antibody response, the probability of 20 amino acids ... This motif occurs 37 times in the database. This would suggest that the linear amino acid sequence may not be an underlying ... The probability of finding a perfect match with a motif of 5 amino acids in length is 1 in 3.7 X 10−7 (0.055). Therefore, ...
*  Cytochrome c
All cytochrome c proteins contain a characteristic CXXCH (cysteine-any-any-cysteine-histidine) amino acid motif that binds heme ... Its primary structure consists of a chain of about 100 amino acids. Many higher-order organisms possess a chain of 104 amino ... Its amino acid sequence is highly conserved in eukaryotes, differing by only a few residues. In more than thirty species, 34 of ... The dipole moment of cytochrome c is a result from a cluster of negatively charged amino acid side chains at the "back" of the ...
*  Rev (HIV)
The arginine-rich motif (ARM) is located between amino acids 38-49 of the rev gene and forms an alpha-helical secondary ... Gorlich, D; Henklein, P; Laskey, RA; Hartmann, E (April 1996). "A 41 amino acid motif in importin-a confers binding to importin ... M10 is a mutated form of Rev and has a single amino acid substitution (Aspartic acid to Leucine). If delivered to cells, Rev ... Rev is a 13-kDa protein that is composed of 116 amino acids. Rev's sequence contains two specific domains which contribute to ...
*  KPNB1
Görlich D, Henklein P, Laskey RA, Hartmann E (1996). "A 41 amino acid motif in importin-alpha confers binding to importin-beta ... Weis K, Ryder U, Lamond AI (1996). "The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import ...
*  Importin α
Görlich, D; Henklein, P; Laskey, R A; Hartmann, E (1996-04-15). "A 41 amino acid motif in importin-alpha confers binding to ... NLS sequences can be monopartite (single cluster of basic amino acids) or bipartite (two clusters of basic amino acids with a ... This sequence occurs within the first 20 amino acid positions of the viral nucleoprotein and contains clusters of basic amino ... The IBB domain of importin α molecules contain many basic amino acid residues, similar to those found in NLS sequences. This ...
*  RNA polymerase II holoenzyme
The CTD consists of repetitions of an amino acid motif, YSPTSPS, of which Serines and Threonines can be phosphorylated. The ... It has a kinase activity that phosphorylates the C-terminal domain (CTD) of Pol II at the amino acid serine. This switches the ... Major studies in which knockout of particular amino acids was achieved in the CTD have been carried out. The results indicate ... TFIIE may be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single-stranded DNA. TFIIE ...
*  BDP1
... contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1". Genomics. 70 (3): 315-26. doi:10.1006/geno. ...
*  Mating of yeast
Presence of α-factor induces recruitment of Ptc1 to Ste5 via a 4 amino acid motif located within the Ste5 phosphosites. Ptc1 ...
*  Phage display
PelB (an amino acid signal sequence that targets the protein to the periplasm where a signal peptidase then cleaves off PelB) ... "Comparison of bacterial and phage display peptide libraries in search of target-binding motif". Appl. Biochem. Biotechnol. 127 ... Usually peptides that can be fused to pVIII are 6-8 amino acids long. The size restriction seems to have less to do with ... Moreover, pIII allows for the insertion of larger protein sequences (>100 amino acids) and is more tolerant to it than pVIII. ...
*  Plakoglobin
... is a member of the catenin family, since it contains a distinct repeating amino acid motif called the armadillo ... Troyanovsky SM, Troyanovsky RB, Eshkind LG, Leube RE, Franke WW (Nov 1994). "Identification of amino acid sequence motifs in ... Human plakoglobin is 81.7 kDa in molecular weight and 745 amino acids long. The JUP gene contains 13 exons spanning 17 kb on ... Franke WW, Goldschmidt MD, Zimbelmann R, Mueller HM, Schiller DL, Cowin P (Jun 1989). "Molecular cloning and amino acid ...