The Road to Alpha-Synuclein Oligomerization in PD". Parkinson's Disease. 2011: 693761. doi:10.4061/2011/693761. PMC 3026982. ... Mutations of synuclein alleles lead to lysosome pH increase and hydrolase inhibition. As a result, lysosomes degradative ... Parkinson's disease is characterized by inclusions of a protein called alpha-synuclien (Lewy bodies) in affected neurons that ...
... overexpression in human neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha- ... April 2008). "Formation of toxic oligomeric alpha-synuclein species in living cells". PLOS ONE. 3 (4): e1867. Bibcode:2008PLoSO ... In breast cancer cell line (MCF7) has been found that not only Hsp90 interacted with estrogen receptor alpha (ERα) but also ... C-terminal domain - rich in alpha helical structure acts as a 'lid' for the substrate binding domain. The helical subdomain ...
"Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications". Ann Neurol. 55 (2): 174-9. doi:10.1002/ ...
"Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy". Science. 305 (5688): 1292-5. Bibcode:2004Sci ...
It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. It interacts with Signal-regulatory protein ... and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein ... RA receptor alpha in acute promyelocytic leukemia cells". The Journal of Biological Chemistry. 276 (25): 22375-81. doi:10.1074/ ... alpha and directs integrin-activated cytoskeletal reorganization in macrophages. GRCh38: Ensembl release 89: ENSG00000005020 - ...
Junn E, Lee KW, Jeong BS, Chan TW, Im JY, Mouradian MM (August 2009). "Repression of alpha-synuclein expression and toxicity by ... Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of ...
In addition, alpha-synuclein activates the non-homologous end joining DNA repair pathway. The aggregation of alpha-synuclein in ... alpha-synuclein becomes misfolded and clump together with other alpha-synuclein. Cells are unable to remove these clumps, and ... Alpha-synuclein is produced in the gut and may migrate via the vagus nerve to the brainstem, and then to the substantia nigra. ... Alpha-synuclein, a protein encoded by SNCA gene mutations, is the main component of the Lewy bodies that accumulate in the ...
Esteves, AR; Arduíno, DM; Silva, DF; Oliveira, CR; Cardoso, SM (2011). "Mitochondrial Dysfunction: The Road to Alpha-Synuclein ... Additionally, in the microenvironment of cancer cells, there is an increase in hypoxia-inducible transcription factor 1-alpha ( ...
Vorinostat In an alpha-synuclein overexpressing Drosophila model of PD, vorinostat (as well as sodium butyrate) reduced alpha- ... miR-7 and miR-153 act to reduce alpha-synuclein levels (a hallmark of PD) but are reduced in PD brain. DNA methylation Neurons ... Histone marks alpha-synuclein, the protein encoded by SNCA, can associate with histones and prevent their acetylation in ... Hallmarks include mutations to the alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and ...
Chen, M.; Margittai, M.; Chen, J.; Langen, R. (2007). "Investigation of alpha-Synuclein Fibril Structure by Site-directed Spin ... to understand the structure of amyloid fibrils and the structure of membrane bound Parkinson's disease protein alpha-synuclein ...
DNA damages caused by oxidative stress can be repaired by processes modulated by alpha-synuclein. Alpha synuclein is expressed ... Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Sci Rep. 2019 Jul ... For one, dopaminergic neurons show abnormalities in mitochondrial complex 1, causing aggregation of alpha-synuclein; this can ... "Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain". The Journal of Biological Chemistry. ...
All known mammalian prion diseases were caused by the prion protein (PrP) until 2015, when a prion form of alpha-synuclein was ... Olanow CW, Brundin P (January 2013). "Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?". ... the misfolded form of a protein called alpha-synuclein. The endogenous, properly folded form of the prion protein is denoted ... Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein". Science. 349 (6248 ...
Singleton AB (August 2005). "Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin ... "Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein ...
Elkon H, Don J, Melamed E, Ziv I, Shirvan A, Offen D (June 2002). "Mutant and wild-type alpha-synuclein interact with ...
Payton JE, Perrin RJ, Clayton DF, George JM (November 2001). "Protein-protein interactions of alpha-synuclein in brain ... Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1A gene. Tubulin alpha-1A chain is an alpha-tubulin ... Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the ... There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and ...
Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and ...
In vitro studies utilizing purified kallikrein were also performed on alpha-synuclein, and it was effective in degrading alpha- ... Alpha-synuclein build-up is commonly found in Dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy ... Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N (October 2003). "Alpha-synuclein degradation by serine ... Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N (October 2003). "Alpha-synuclein degradation by serine ...
Elkon H, Don J, Melamed E, Ziv I, Shirvan A, Offen D (June 2002). "Mutant and wild-type alpha-synuclein interact with ...
The goal is through neuroanatomical and biochemical methods, to analyze the protein alpha-synuclein, which is fundamental for ... "Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles". Front Neurosci (published 23 ...
Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and ...
They also discovered a type of chaperone protein can reduce the death of neurons caused by alpha-synuclein built-up, and that ... In 2004, they associated alpha-synuclein in the brain with multiple system atrophy. Two years later, they showed for the first ... For Parkinson's disease, Lee and Trojanowski reported that another protein, alpha-synuclein, is a major component of Lewy ... healthy neurons may take up extracellular alpha-synuclein and become defective in function. Apart from these two relatively ...
... and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89-94. doi:10.1007/s00439-008-0525-5. PMID 18568448 ...
"DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation". PLOS Biology. 2 (11): e362. ... "The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein". Journal of Molecular Biology. 356 (4): ... Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus ... "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". The Journal of ...
"Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct". Science. 294 (5545): 1346-9. ... "Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein". Neuron. 34 (4): ... Wild-type alpha-synuclein fibrils are known to be the primary component of Lewy bodies, which are found in the brain of ... Alpha-synuclein has more than one known point-mutation, one being A53T where amino acid residue 53 is mutated from its native ...
"Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science. 317 (5837): 516-19. ...
Braak, E.; Sandmann-Keil, D.; Rüb, U.; Gai WP, R.A.I (2001). "Alpha-synuclein immunopositive Parkinson's disease-related ...
Sharma N, Brandis KA, Herrera SK, Johnson BE, Vaidya T, Shrestha R, Debburman SK (2006). "alpha-Synuclein budding yeast model: ... These β interactions are mediated mainly by salt bridges and hydrophobic interactions between conserved alpha helices whose ... which serve as docking domains for the regulatory particles and the alpha subunits N-termini (Pfam PF10584) form a gate that ... carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry". Molecular Cell. 27 (5): 731-44. doi: ...
Indeed, PARL-activated Skd3 is capable of disassembling alpha-synuclein fibrils in vitro. Even though the bacterial orthologue ...
In patients with PD, alpha synuclein is cut by AEP into toxic chunks., which are hypothesized to possibly play a role in the ... "Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease". Nature Structural & ...
Doxakis E (April 2010). "Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153". The Journal of ...