December 1994). "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by ... "Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK ... "The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta ... Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate TYK2. IL-10 is a ...
Currie RA (Dec 1997). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high ... show a cardiac hypertrophy and express low levels of the insulin receptor. HMGA1 has been shown to interact with CEBPB and Sp1 ... "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions ... and HMGI-Y controls human insulin receptor gene transcription". Molecular and Cellular Biology. 23 (8): 2720-32. doi:10.1128/ ...
This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist ( ... 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. ... 1987). "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical". Nature. 324 (6094): 266-8. ... Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. ...
... alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit ... "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and ... Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP ... It is inhibited by the G protein beta and gamma subunit complex. GRCh38: Ensembl release 89: ENSG00000164742 - Ensembl, May ...
... 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is ... The receptors can both bind all three forms of IL-1 (IL-1 alpha, IL-1 beta and IL-1 receptor antagonist). The crystal ... Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation of immune ... Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH (1998). "The interleukin-12/interleukin-12-receptor ...
... alpha subunit Interleukin 23 subunit alpha Interleukin 28 receptor, alpha subunit Interleukin 34 Interleukin 35 Interleukin 6 ... type II Interleukin 10 Interleukin 10 receptor, alpha subunit Interleukin 10 receptor, beta subunit Interleukin 12 Interleukin ... alpha Interleukin 8 receptor, beta Interleukin receptor Interleukin-1 receptor Interleukin-1 receptor family Interleukin-1 ... receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin-7 receptorInterleukin-8 receptor ...
... interleukin 6, interleukin-12 subunit alpha, and interleukin-12 subunit beta; and mouse helper and cytotoxic T cells from ... Free Fatty acid receptor 4 (FFAR4), also termed G-protein coupled receptor 120 (GPR120), is a protein that in humans is encoded ... Free fatty acid receptor Free fatty acid receptor 1 (CS1: long volume value, Articles with short description, Short description ... "Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human ...
Integrator complex subunit 12 KDR: Kinase insert domain receptor (Vascular endothelial growth factor receptor 2) KIAA1530: UV ... interleukin 8 (IL-8), scyb8 CXCL9: chemokine (C-X-C motif) ligand 9, scyb9 CXCL10: chemokine (C-X-C motif) ligand 10, scyb10 ... alpha (non A4 component of amyloid precursor) SPATA5: Spermatogenesis-associated protein 5 STATH: gene with protein product ... fibroblast growth factor receptor-like 1 FRG1: FSHD region gene 1 FRYL: encoding protein FRY like transcription coactivator ...
This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different ... 5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 ( ... "Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human ... Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: ...
Interleukin-2 is normally added to the extracted T cells to boost their effectiveness, but in high doses it can have a toxic ... Antitumor receptors genetically engineered into normal T cells can be used for therapy. T cells can be redirected by the ... The latter targets the epsilon subunit within the human CD3 complex of the TCR. 5-6 weeks after resecting the tumor, up to 1011 ... integration of genes encoding either conventional alpha-beta TCRs or CARs. CARs (Chimeric Antibody Receptors) were pioneered in ...
Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins ... transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, ... leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms". The Journal of Biological ... receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". The ...
This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription ... "Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and ... "A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death ... Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and ...
"Regulation of expression of human interleukin 1 alpha and beta genes." J. Immunol. 143:3556-3561. Hirano, T., Matsuda, T., ... Gray, P.W., Barrett, K., Chantry, D., Turner, M., and Feldmann, M. (1990). "Cloning of human tumour necrosis factor receptor ... A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. ... Buchan, G., Barrett, K., Turner, M., Chantry, D., Maini, R. N., and Feldmann, M. (1988). "Interleukin 1 and tumour necrosis ...
"HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and ... Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP ... that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase. GRCm38: Ensembl ... Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) ...
"14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor". The Biochemical Journal. 345 Pt 3 (3): 741-7. doi: ... "Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta". Blood. 91 (4): 1295- ... Each of the monomers are composed of 9 antiparallel alpha helices. Four alpha-helices (αC, αE, αG, and αI) form an amphipathic ... August 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and ...
... is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2 ... "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 ... Cytokine receptor common subunit gamma also known as interleukin-2 receptor subunit gamma or IL-2RG is a protein that in humans ... Interleukin+Receptor+Common+gamma+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of ...
... and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an ... "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". European Journal of Immunology ... a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". The Journal of ... Beecher MS, Baiocchi RA, Linett ML, Krajewski CA, Caligiuri MA (May 1994). "Expression of the zeta protein subunit in CD3- NK ...
Ueda T, Bruchovsky N, Sadar MD (March 2002). "Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK ... "Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin". ... Kim J, Kim D, Chung J (2000). "Replication protein a 32 kDa subunit (RPA p32) binds the SH2 domain of STAT3 and regulates its ... Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y (May 2003). "Opposing effects of PML and PML/RAR alpha ...
IL-26R heterodimer, a conventional receptor for IL-26, consists of two chains - IL-10R2, and IL-20R1. The IL-20R1 subunit ... IL-26 is a 171-amino acid protein that exhibits six alpha helices connected by loops and four conserved cysteine residues. ... "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor ... IL-26 signals through a receptor complex comprising two distinct proteins called IL-20 receptor 1 and IL-10 receptor 2. By ...
"Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels". The Journal of ... Wu D, LaRosa GJ, Simon MI (Jul 1993). "G protein-coupled signal transduction pathways for interleukin-8". Science. 261 (5117): ... "Differential coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G(o)alpha subunits". ... and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha". ...
... (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as ... CD11b binding to iC3b leads to a production of anti-inflammatory cytokines, e.g., interleukin 10 (IL-10) and tumour growth ... The switch into an active conformation follows quickly after the stimulation of toll-like receptors (TLR) of the leukocytes. ... Solovjov DA, Pluskota E, Plow EF (January 2005). "Distinct roles for the alpha and beta subunits in the functions of integrin ...
1992). "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester ... 1995). "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical ... Kunsch C, Ruben SM, Rosen CA (1992). "Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF- ... 207 (2): 362-8. doi:10.1006/viro.1995.1095. PMID 7886940. Mackman N (1994). "Protease inhibitors block lipopolysaccharide ...
The alpha 4 integrin on inflammatory cells interacts with these adhesion molecules to allow for migration. Integrin receptor ... Interleukins are a cytokine that play a major role in the immune system. IL-12 and IL-23 help with the activation and ... inhibit the action of IL-12 and IL-23 by binding to the p40 protein subunit that is found on both of these cytokines. ... Natalizumab is a humanized IgG4 monoclonal antibody that inhibits the alpha 4 integrin. It was the first integrin receptor ...
Ciliary+Neurotrophic+Factor+Receptor+alpha+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t ... This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell ... The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its ... Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD (1991). "The receptor for ciliary ...
The IL-17 receptor family consists of five, broadly distributed receptors (IL-17RA, B, C, D and E) that present with individual ... Each subunit of the homodimer is approximately 15-20 KDa. The structure of IL-17 consists of a signal peptide of 23 amino acids ... Cytokines released from DCs stimulate dying keratinocytes to secrete TNF-alpha, IL-1 and IL-6 leading to the chemotaxis of T ... Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 receptors". Cytokine & Growth ...
The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. 278 (11): 9528-35. doi:10.1074/jbc. ... of leukemia inhibitory factor and ciliary neurotrophic factor with the different subunits of their high affinity receptors". J ... Ciliary neurotrophic factor receptor Interleukin 6 George Yancopoulos GRCh38: Ensembl release 89: ENSG00000242689 - Ensembl, ... 2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharmaceutica Acta Helvetiae. 74 (2-3): 265-72. doi: ...
... interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor ... "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in ... DDX5 and Estrogen receptor alpha, Glucocorticoid receptor, NFKB1, PCAF, PPARGC1A, Peroxisome proliferator-activated receptor ... Na SY, Lee SK, Han SJ, Choi HS, Im SY, Lee JW (May 1998). "Steroid receptor coactivator-1 interacts with the p50 subunit and ...
... the common gamma-chain is an indispensable subunit of the IL-21 receptor complex". Journal of Immunology. 167 (1): 1-5. doi: ... Strengell M, Julkunen I, Matikainen S (August 2004). "IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells ... The IL-21 receptor (IL-21R) is expressed on the surface of T, B and NK cells. IL-21r is similar in structure to the receptors ... Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. Interleukin-21 is a cytokine that has potent ...
Wang LH, Yang XY, Mihalic K, Xiao W, Li D, Farrar WL (Aug 2001). "Activation of estrogen receptor blocks interleukin-6- ... "Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of ... Sentis S, Le Romancer M, Bianchin C, Rostan MC, Corbo L (2005). "Sumoylation of the estrogen receptor alpha hinge region ... "Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of ...
The Bb' subunit is aberrant in SLE T cells, controls IL-2 deprivation-induced cell death, and probably accounts for the ... Decreased Interleukin-2 production in humans and mice with SLE is multifactorial. Decreased binding of pCREB to the IL-2 ... Increased expression of CREM Alpha in SLE T cells is controlled through the SP1 binding to the P1 promoter; CREM expression in ... Deficient expression of the T cell receptor zeta chain". The Journal of Clinical Investigation. 101 (7): 1448-57. doi:10.1172/ ...