This protein may use the morpheein model of allosteric regulation. As of late 2007, two structures have been solved for this ...
This protein may use the morpheein model of allosteric regulation. As of late 2007, two structures have been solved for this ...
This protein may use the morpheein model of allosteric regulation. GRCh38: Ensembl release 89: ENSG00000062485 - Ensembl, May ...
This protein may use the morpheein model of allosteric regulation. PFK is about 300 amino acids in length, and structural ... Sola-Penna M, Da Silva D, Coelho WS, Marinho-Carvalho MM, Zancan P (November 2010). "Regulation of mammalian muscle type 6- ... one involved in ATP binding and the other housing both the substrate-binding site and the allosteric site (a regulatory binding ...
This protein may use the morpheein model of allosteric regulation. Ribonuclease Raines RT (1998). "Ribonuclease A". Chem. Rev. ...
This protein may use the morpheein model of allosteric regulation. As its name indicates, glyceraldehyde 3-phosphate ... Campanella ME, Chu H, Low PS (February 2005). "Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte ... However, researchers have reported different regulation of GAPDH under specific conditions. For example, the transcription ...
June 2019). "Mechanism of β2AR regulation by an intracellular positive allosteric modulator". Science. 364 (6447): 1283-1287. ... Johnson M (January 2006). "Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation". The Journal ...
This protein may use the morpheein model of allosteric regulation. TNF was thought to be produced primarily by macrophages, but ... Feng P, Jyotaki M, Kim A, Chai J, Simon N, Zhou M, Bachmanov AA, Huang L, Wang H (October 2015). "Regulation of bitter taste ... The primary role of TNF is in the regulation of immune cells. TNF, as an endogenous pyrogen, is able to induce fever, apoptotic ... Gaur U, Aggarwal BB (2003). "Regulation of proliferation, survival and apoptosis by members of the TNF superfamily". Biochem. ...
July 2012). "Structural basis for allosteric regulation of GPCRs by sodium ions". Science. 337 (6091): 232-6. Bibcode:2012Sci ... The A2A receptor is also expressed in the brain, where it has important roles in the regulation of glutamate and dopamine ... A novel mechanism for differential regulation of Fc gamma receptor function". Journal of Immunology. 151 (5): 2775-85. doi: ... allosteric) binding pocket. The crystal-structure of A2A bound to the antagonist ZM241385 (PDB code: 4EIY) showed that a sodium ...
"Allosteric initiation and regulation of catalysis with a molecular knot". Science. 352 (6293): 1555-1559. Bibcode:2016Sci... ...
This protein may use the morpheein model of allosteric regulation. As of late 2007, 3 structures have been solved for this ...
This protein may use the morpheein model of allosteric regulation. NADP-malic enzyme, as all other C4 decarboxylases, did not ... In addition to regulation at the longer time scale by means of expression control, regulation at the short-time scale can occur ... Rathnam CK (January 1979). "Metabolic regulation of carbon flux during C4 photosynthesis : II. In situ evidence for reffixation ... one at the active site and one at an allosteric site. However, the inhibitory effect exhibits pH-dependence - existent at a pH ...
This protein may use the morpheein model of allosteric regulation. Adenylosuccinate lyase (ASL) is an enzyme that catalyzes two ...
This protein may use the morpheein model of allosteric regulation. PNPase, together with adenosine deaminase (ADA), serves a ...
This protein may use the morpheein model of allosteric regulation. The systematic name of this enzyme class is biotin:apo-[ ...
This protein may use the morpheein model of allosteric regulation. As of late 2007, 7 structures have been solved for this ...
Bruser A, KirchbergerJ, Schoneberg T (Oct 2012). "Altered allosteric regulation of muscle 6-phosphofructokinase causes Tarui ... Allosteric activators such as AMP and ADP bind to the allosteric site as to facilitate the formation of the R state by inducing ... Brüser A, Kirchberger J, Schöneberg T (October 2012). "Altered allosteric regulation of muscle 6-phosphofructokinase causes ... PFK1 is an allosteric enzyme and has a structure similar to that of hemoglobin in so far as it is a dimer of a dimer. One half ...
November 2010). "Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle". Cell Metabolism. 12 (5): ... In addition to inhibition of GSK-3, it also inhibits other enzymes involved in the regulation of glucose metabolisms, such as ... However, these interactions have not been confirmed, as these pathways can be inhibited without the up-regulation of GSK-3. GSK ... Due to its importance across numerous cellular functions, GSK-3 activity is subject to tight regulation. The speed and efficacy ...
This protein may use the morpheein model of allosteric regulation. Glutamate racemase has emerged as a potential antibacterial ... As such it can proceed without needing an additional source, which would bind to an allosteric site, altering the enzyme shape ...
This protein may use the morpheein model of allosteric regulation. DBH is inhibited by disulfiram, tropolone, and, most ... and IAA are allosteric competitive. The systematic name of this enzyme class is 3,4-dihydroxyphenethylamine, ascorbate:oxygen ...
This protein may use the morpheein model of allosteric regulation. Selwood T, Jaffe EK (March 2012). "Dynamic dissociating homo ...
PAH is proposed to use the morpheein model of allosteric regulation. Mammalian PAH exists in an equilibrium consisting of ... Jaffe EK, Stith L, Lawrence SH, Andrake M, Dunbrack RL (February 2013). "A new model for allosteric regulation of phenylalanine ... Additional regulation is provided by Ser16; phosphorylation of this residue does not alter enzyme conformation but does reduce ... Regulation of flux through phenylalanine-associated pathways is critical in mammalian metabolism, as evidenced by the toxicity ...
Insights into allosteric regulation and mutations linked to a neurodegeneration disorder". The Journal of Biological Chemistry ... The regulation outlined above corresponds to PanK-II. PanK-III is resistant to feedback inhibition. In humans: PANK1, PANK2, ... This region allows for feedback inhibition by free CoA and acyl-CoA and regulation by acetyl-CoA and malonyl-CoA. On the other ... The regulation of pantothenate kinase is essential to controlling the intracellular CoA concentration. Pantothenate kinase is ...
March 2013). "Evidence for a common mechanism of SIRT1 regulation by allosteric activators". Science. 339 (6124): 1216-9. ...
This model for allosteric regulation of enzymes suggests that the subunits of multimeric proteins have two conformational ... Ronda, Luca; Bruno, Stefano; Bettati, Stefano (2013-09-01). "Tertiary and quaternary effects in the allosteric regulation of ...
Dombrauckas JD, Santarsiero BD, Mesecar AD (July 2005). "Structural basis for tumor pyruvate kinase M2 allosteric regulation ... "Regulation of glycolysis by Raf protein serine/threonine kinases". Advances in Enzyme Regulation. 42: 317-32. doi:10.1016/S0065 ... This regulation is termed metabolic budget system. Another activator of PKM2 is the amino acid serine. The thyroid hormone 3,3 ... It is able to bind to and phosphorylate the histone H3 of chromatin in cancer cells, thereby having a role in the regulation of ...
"Evidence for a common mechanism of SIRT1 regulation by allosteric activators". Science. 339 (6124): 1216-19. Bibcode:2013Sci... ... SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that ... Chung HT, Joe Y (2014). "Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation ... "Entrez Gene: SIRT1 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)". SIRT1 human gene location ...
Kashlan OB, Scott CP, Lear JD, Cooperman BS (2002). "A comprehensive model for the allosteric regulation of mammalian ... Kashlan OB, Cooperman BS (2003). "Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: ...
The DNA binding ability of lac repressor bound with allolactose is inhibited due to allosteric regulation, thereby genes coding ... When lactose is present, allolactose binds to the lac repressor, causing an allosteric change in its shape. In its changed ... Razo-Mejia M, Barnes S, Belliveau N, Chure G, Einav T, Lewis M, Phillips R (2018). "Tuning Transcriptional Regulation through ... an allosteric effector molecule) A linker that connects the DNA-binding domain with the core domain (sometimes called the hinge ...
Insights into allosteric regulation and mutations linked to a neurodegeneration disorder". J. Biol. Chem. 282 (38): 27984-93. ... It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation ... "PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression". J. Lipid Res. 45 ( ...