In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule ... Ensemble models of allosteric regulation enumerate an allosteric system's statistical ensemble as a function of its potential ... allosteric regulation is also expected to play an increasing role in drug discovery and bioengineering. The AlloSteric Database ... whereas those that decrease the protein's activity are called allosteric inhibitors. Allosteric regulations are a natural ...

Stadtman, E.R. (1966). "Allosteric regulation of enzyme activity". Advances in Enzymology and Related Areas of Molecular ... ISBN 978-0-374-29912-5. Sauro, H.M. (2017). "Control and regulation of pathways via negative feedback". Journal of the Royal ... Monod, J.; Changeux, J.-P.; Jacob, F. (1963). "Allosteric Proteins and Cellular Control Systems". J. Mol. Biol. 6 (4): 306-329 ... Nonetheless, despite these positive assessments by leading biochemists of the time, the discovery of feedback regulation is ...

Allosteric regulation is the binding of an effector to a site on the protein other than the active site, causing a ... Jurica MS, Mesecar A, Heath PJ, Shi W, Nowak T, Stoddard BL (February 1998). "The allosteric regulation of pyruvate kinase by ... Valentini G, Chiarelli L, Fortin R, Speranza ML, Galizzi A, Mattevi A (June 2000). "The allosteric regulation of pyruvate ... Dombrauckas JD, Santarsiero BD, Mesecar AD (July 2005). "Structural basis for tumor pyruvate kinase M2 allosteric regulation ...

Allosteric regulation by metabolites. The regulation of the citric acid cycle is largely determined by product inhibition and ... There is no known allosteric mechanism that can account for large changes in reaction rate from an allosteric effector whose ... Regulation by calcium. Calcium is also used as a regulator in the citric acid cycle. Calcium levels in the mitochondrial matrix ... Stryer L, Berg JM, Tymoczko JL (2002). "Section 18.6: The Regulation of Cellular Respiration Is Governed Primarily by the Need ...

A common mechanism is allosteric regulation. This is when a substrate binds a repressor protein and causes it to undergo a ...

Kern, Dorothee; Zuiderweg, Erik RP (2003). "The role of dynamics in allosteric regulation". Current Opinion in Structural ... Kern, Dorothee; Zuiderweg, Erik RP (2003). "The role of dynamics in allosteric regulation". Current Opinion in Structural ... of her research include the activation of proteins and changes in protein shape and the connection to allosteric regulation. ...

In biochemistry, allosteric regulation (or allosteric control) is the regulation of a protein by binding an effector molecule ... has become another good example of allosteric regulation. The kinetic properties of allosteric enzymes are often explained in ... whereas those that decrease the protein's activity are called allosteric inhibitors.[citation needed] Allosteric regulations ... Allosteric regulation is also particularly important in the cell's ability to adjust enzyme activity. The term allostery comes ...

Valentini G, Chiarelli L, Fortin R, Speranza ML, Galizzi A, Mattevi A (June 2000). "The allosteric regulation of pyruvate ... Localization In animals, regulation of blood glucose levels by the pancreas in conjunction with the liver is a vital part of ... The details of regulation for some enzymes are highly conserved between species, whereas others vary widely. Gene Expression: ... Thus, the relevance of ATP as an allosteric effector is questionable. An increase in AMP is a consequence of a decrease in ...

Giladi, Moshe; Khananshvili, Daniel (2013-01-01). "Molecular Determinants of Allosteric Regulation in NCX Proteins". Sodium ... Allosteric activation of NCX involves the binding of cytosolic Ca2+ to regulatory domains CBD1 and CBD2. The generalized ... A large central loop is not required for transport function and plays a role in regulation. In the preferred 9 TMS model for ... DiPolo, Reinaldo; Beaugé, Luis (2006-01-01). "Sodium/calcium exchanger: influence of metabolic regulation on ion carrier ...

Mechanisms of Cooperativity and Allosteric Regulation in Proteins. Cambridge. Cambridge University Press ISBN 0-521-38648-9 ...

Differences occur in ligand binding and allosteric regulation. Myoglobin is found in vertebrate muscle cells and is a water- ... ISBN 1-57259-153-6. Frazer, David M.; Anderson, Gregory J. (March 2014). "The regulation of iron transport: The Regulation of ...

... allosteric regulation]. RopB regulation speB is a key determinant in the expression of the speB proteinase which is a primary ... erythrogenic toxins allosteric regulation alpha helix PDB: 5DL2​; Makthal N, Gavagan M, Do H, Olsen RJ, Musser JM, Kumaraswami ... Functional studies suggest that the ropB multigene regulon is responsible for not only global regulation of virulence but also ... The location of the ropB gene is directly and sequentially proximal to the subject of its transcriptional regulation (speB) ...

The concerted model (the Monod, Wyman and Changeux (MWC) model) of allosteric regulation requires all subunits to be in the ... Interconversion of morpheein forms can be a structural basis for allosteric regulation, an idea noted many years ago, and later ... De Riel, Jon K.; Paulus, Henry (1978). "Subunit dissociation in the allosteric regulation of glycerol kinase from Escherichia ... De Riel, Jon K.; Paulus, Henry (1978). "Subunit dissociation in the allosteric regulation of glycerol kinase from Escherichia ...

... intrinsic dynamics and allosteric regulation". Nat. Struct. Mol. Biol. 26 (7): 545-556. doi:10.1038/s41594-019-0253-7. PMC ... Regulation of NET has been linked to MAPKs, insulin, PKC, and angiotensin II. SERT is responsible for the reuptake of ... Regulation of SERT has been linked to acute depletion of intracellular Ca Na 2+, calmodulin inhibition, CaMKII, Src, p38 MAP ... NET regulation is linked to altered dopamine transmission and schizophrenia-like behaviors. Nisoxetine is a NET inhibitor and ...

Aspartokinases may use the morpheein model of allosteric regulation. In Escherichia coli, aspartokinase is present as three ... This allows the independent regulation of the rates of methionine, lysine, and threonine production. The forms that produce ...

Allosteric regulation Haldane effect Root effect Chloride shift Bohr; Hasselbalch, Krogh. "Concerning a Biologically Important ... The Bohr effect hinges around allosteric interactions between the hemes of the haemoglobin tetramer, a mechanism first proposed ...

RNR1 contains both allosteric sites, mediating regulation of substrate specificity and activity. Depending on the allosteric ... Elledge SJ, Zhou Z, Allen JB (March 1992). "Ribonucleotide reductase: regulation, regulation, regulation". Trends in ... RNR may use the morpheein model of allosteric regulation. Generally Class I RNR inhibitors can be divided in three main groups ... Eliasson R, Pontis E, Jordan A, Reichard P (October 1996). "Allosteric regulation of the third ribonucleotide reductase (NrdEF ...

Goodey, N. M. and Benkovic, S. J. (2008) Allosteric regulation and catalysis emerge via a common route, Nat. Chem. Biol. 4, 474 ... Goodey, Nina M.; Benkovic, Stephen J. (2008-08-01). "Allosteric regulation and catalysis emerge via a common route". Nature ... Pedley, Anthony M.; Benkovic, Stephen J. (2017-02-01). "A New View into the Regulation of Purine Metabolism - The Purinosome". ... allosteric effects are a consequence of creating or inhibiting such networks and drugs can be designed that target such ...

... may use the morpheein model of allosteric regulation. Mast cell tryptase-6 is involved in Trichinella spiralis ...

This protein may use the morpheein model of allosteric regulation. Lipoic acid GRCh38: Ensembl release 89: ENSG00000091140 - ... Wynn RM, Kato M, Machius M, Chuang JL, Li J, Tomchick DR, Chuang DT (December 2004). "Molecular mechanism for regulation of the ...

This protein may use the morpheein model of allosteric regulation. Glycerol Kinase (alternative name, ATP:glycerol 3- ...

This protein may use the morpheein model of allosteric regulation. Human CBS performs a crucial step in the biosynthetic ... AdoMet is an allosteric activator that increases the Vmax of the CBS reaction but does not affect the Km for the substrates. In ... Allosteric activation of CBS by adoMet determines the metabolic fate of homocysteine. Mammalian CBS is activated 2.5-5-fold by ... The C-terminal domain of cystathionine β-synthase regulates its activity via both intrasteric and allosteric effects and is ...

This protein may use the morpheein model of allosteric regulation. Hu Y, Komoto J, Huang Y, et al. (June 1999). "Crystal ...

CTP is also subject to various forms of allosteric regulation. GTP acts as an allosteric activator that strongly promotes the ... Since the discovery of this novel mode of enzyme regulation in CTP synthase, multiple other enzymes have been shown to exhibit ... The reaction product CTP also serves as an allosteric inhibitor. The triphosphate binding site overlaps with that of UTP, but ... Endrizzi JA, Kim H, Anderson PM, Baldwin EP (October 2005). "Mechanisms of product feedback regulation and drug resistance in ...

This protein may use the morpheein model of allosteric regulation. Ethanol is dehydrogenated to acetaldehyde by alcohol ... LDH undergoes transcriptional regulation by PGC-1α. PGC-1α regulates LDH by decreasing LDH A mRNA transcription and the ...

This protein may use the morpheein model of allosteric regulation. As of late 2007, two structures have been solved for this ...

This protein may use the morpheein model of allosteric regulation. As of late 2007, two structures have been solved for this ...

This protein may use the morpheein model of allosteric regulation. GRCh38: Ensembl release 89: ENSG00000062485 - Ensembl, May ...

This protein may use the morpheein model of allosteric regulation. PFK is about 300 amino acids in length, and structural ... Sola-Penna M, Da Silva D, Coelho WS, Marinho-Carvalho MM, Zancan P (November 2010). "Regulation of mammalian muscle type 6- ... one involved in ATP binding and the other housing both the substrate-binding site and the allosteric site (a regulatory binding ...

This protein may use the morpheein model of allosteric regulation. Ribonuclease Raines RT (1998). "Ribonuclease A". Chem. Rev. ...