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*  Transmission disequilibrium test
The motivating idea for this modification is the fact that, while the transmissions of both allele from parents to a child are ... These can be represented by the transmitted and the non-transmitted alleles M 1 {\displaystyle M_{1}} and M 2 {\displaystyle M ... the number of times a parent transmits the same allele to both affected children with the number of times a different allele is ... A rewording of this statement would be that the type of the transmitted allele is not, in general, independent of the type of ...
*  Stepwise mutation model
These include number of alleles, observed and expected heterozygosity, and allele frequencies. The SMM model takes into account ... Variance in allele sizes are used to make inferences about the genetic distance between individuals or populations. By ... The original model assumes that if an allele has a mutation that causes it to change in state, mutations that occur in ... The SMM is distinguished from the Kimura-Crow model, also known as the infinite alleles model (IAM), in that as the population ...
*  Ancestry-informative marker
A person having this allele is thus more likely to have Sub-Saharan African ancestors. Examining a suite of these markers more ... As one example, the Duffy Null allele (FY*0) has a frequency of almost 100% of Sub-Saharan Africans, but occurs very ...
*  Tag SNP
... the alleles are assigned so their frequencies agree with the allele frequencies of t. When multiple tagging SNPs have the same ... Allele Specific PCR, Somatic cell hybrids). These methods distinguish which allele is present at which chromosome by separating ... If the alleles at those loci are non-randomly inherited then we say that they are at linkage disequilibrium (LD). LD is most ... The Affymetrix platform prints DNA probes on a glass or silicone chip that hybridize to specific alleles in the sample DNA. The ...
*  Pseudodeficiency alleles
A pseudodeficiency allele may indicate a deficiency of the enzyme assay method, or it may reflect incomplete understanding of ... A pseudodeficiency allele or pseudodeficiency mutation is a mutation that alters the protein product or changes the gene's ... Because of pseudodeficiency alleles, the results of enzyme assay testing in one population cannot be generalized to other ... One possible cause of false positive results is a pseudodeficiency allele. Disease may also be present, but at a subclinical ...
*  Infinite alleles model
Beyond this number of alleles, the selective advantage of presence of those alleles in heterozygous genotypes would be ... that there were a large enough number of alleles so that any mutation would lead to a different allele (that is the probability ... The infinite alleles model is a mathematical model for calculating genetic mutations. The Japanese geneticist Motoo Kimura and ... The effective number of alleles n maintained in a population is defined as the inverse of the homozygosity, that is n = 1 F = 4 ...
*  Allele
It is now known that each of the A, B, and O alleles is actually a class of multiple alleles with different DNA sequences that ... An allele (/əˈliːl/) is a variant form of a given gene. Sometimes, different alleles can result in different observable ... The term "wild type" allele is sometimes used to describe an allele that is thought to contribute to the typical phenotypic ... for the mutant allele. It is now appreciated that most or all gene loci are highly polymorphic, with multiple alleles, whose ...
*  Null allele
One example of a null allele is the 'O' blood type allele in the human A, B and O blood type system. The alleles for the A- ... Null alleles are difficult to identify because a heterozygous individual for one null allele and one active allele is ... Mice homozygous for a null allele for insulin die 48-72 hours after birth. A microsatellite null allele is an allele at a ... The allele for O blood type, however, is a mutated version of the allele for the A-antigen, with a single base pair change due ...
*  Allele age
Estimating allele age based on the allele's frequency is based on the fact that alleles in high frequency are older than ... Allele age (or mutation age) is the amount of time elapsed since an allele first appeared due to mutation. Estimating the time ... Allele age can be estimated based on (1) the frequency of the allele in a population and (2) the genetic variation that occurs ... This same study also used the allele frequency and the Kimura-Ohta model to estimate allele age. This method provided very ...
*  Lethal allele
Alleles that need only be present in one copy in an organism to be fatal are referred to as dominant lethal alleles. These ... Lethal alleles (also referred to as lethal genes or lethals) are alleles that cause the death of the organism that carries them ... Lethal alleles may be recessive, dominant, or conditional depending on the gene or genes involved. Lethal alleles can cause ... This was the first documented example of a recessive lethal allele. A pair of identical alleles that are both present in an ...
*  Allele frequency
For 3 alleles see Allele § Allele and genotype frequencies) Allele frequency can always be calculated from genotype frequency, ... Beneficial alleles tend to increase in frequency, while deleterious alleles tend to decrease in frequency. Even when an allele ... then the frequency p of the A-allele and the frequency q of the B-allele in the population are obtained by counting alleles. p ... Earth Human STR Allele Frequencies Database VWA 17 Allele Frequency in Human Population (Poster) Allele Frequencies in ...
*  Minor allele frequency
... (MAF) refers to the frequency at which the second most common allele occurs in a given population. SNPs ... allele frequency The International HapMap Consortium (2005). "A haplotype map of the human genome". Nature. 437 (7063): 1299- ... MAF/MinorAlleleCount: C=0.1506/754 (1000 Genomes) 3. what do those numbers mean?: a. C, is the minor allele for that particular ... with a minor allele frequency of 0.05 or greater were targeted by the HapMap project. It is widely used in population genetics ...
*  Allele-specific oligonucleotide
Samples 1 and 4 only have the normal "A" allele, while samples 3 and 5 have both the "A" and "S" alleles (and are therefore ... An allele-specific oligonucleotide (ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target ... It is designed (and used) in a way that makes it specific for only one version, or allele, of the DNA being tested. The length ... The PCR technique itself has been adapted to detect polymorphisms, as allele-specific PCR. However, the simplicity and ...
*  Allele frequency spectrum
The joint allele frequency spectrum (JAFS) is the joint distribution of allele frequencies across two or more related ... In this table, a 1 indicates that the derived allele is observed at that site, while a 0 indicates the ancestral allele was ... However, sometimes the ancestral allele cannot be determined, in which case the folded allele frequency spectrum may be ... is the distribution of the allele frequencies of a given set of loci (often SNPs) in a population or sample. Because an allele ...
*  Allele frequency net database
The allele frequency net database is a database containing the allele frequencies of immune genes and their corresponding ... Gonzalez-Galarza, Faviel F; Christmas Stephen; Middleton Derek; Jones Andrew R (Jan 2011). "Allele frequency net: a database ...
*  Kompetitive Allele Specific PCR (KASP)
If QC is to be used for mapping population non parental alleles are discarded and alleles for which more than 90% of SNPs are ... Kompetitive Allele Specific PCR (KASP) is a homogenous, fluorescence-based genotyping variant of Polymerase Chain Reaction. It ... In the first round of PCR, a KASP primer mix that contains the two allele-specific forward primers and the single reverse ... In the second round of PCR, the complementary strand to the allele-specific forward primer is generated when the common reverse ...
*  Earth Human STR Allele Frequencies Database
Allele Frequency Global Tracking (AFGT) - allows searching for allele frequency distribution at global and regional level. STR ... The Earth Human STR Allele Frequencies Database is a scientific project based on a dynamic web interface and a relational ... the allele frequencies gradient distribution over vast geographical areas. ... EHSTRAFD - Earth Human STR Allele Frequencies Database. c2009 [cited on 14 Jun 2009 - R1]. Available from http://www.ehstrafd. ...
*  List of human leukocyte antigen alleles associated with cutaneous conditions
There are many human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system ...
*  Phenotypic trait
Alleles can be significantly different and produce different product RNAs. Combinations of different alleles thus go on to ... Multiple alleles refers to the situation when there are more than 2 common alleles of a particular gene. Blood groups in humans ... and multiple alleles. Incomplete dominance is the condition in which neither allele dominates the other in one heterozygote. ... The ABO blood group proteins are important in determining blood type in humans, and this is determined by different alleles of ...
*  ABO (gene)
Other minor alleles have been found for this gene. There are six common alleles in individuals of European descent. Nearly ... The ABO locus encodes three alleles. The A allele produces α-1,3-N-acetylgalactosamine transferase (A-transferase), which ... Many rare variants of these alleles have been found in human populations around the world. In human cells, the ABO alleles and ... The O allele lacks both enzymatic activities because of the frame shift caused by a deletion of guanine-258 in the gene which ...
*  Cis AB
... one allele is AB and other is O When one parent carries a Cis AB allele, the other allele can be any of O, A or B and the ... The second allele is O: children are either AB or O Second allele is A: Children are either AB or A Second allele is B: ... A novel cis AB allele derived from a B allele through a single point mutation. Roubinet F1, Janvier D, Blancher A. Rev Fr ... Other parent is AO and second allele is O: The children are either AB or A or O Other parent is AA and the second allele is O: ...
*  Introduction to genetics
If one allele dominates the instructions from another, it is called the dominant allele, and the allele that is overridden is ... In this example you can call the allele for brown "B" and the allele for red "b". (It is normal to write dominant alleles with ... The effects of this mixing depend on the types (the alleles) of the gene. If the father has two copies of an allele for red ... Mutations create new alleles. These alleles have new DNA sequences and can produce proteins with new properties. So if an ...
*  MHC class I polypeptide-related sequence B
Fischer G, Pérez-Rodríguez M, Argüello JR, Cox ST, McWhinnie A, Travers PJ, Madrigal JA (Feb 2000). "Three novel MICB alleles ... alleles". Tissue Antigens. 51 (6): 649-52. doi:10.1111/j.1399-0039.1998.tb03008.x. PMID 9694358. Steinle A, Groh V, Spies T ( ...
*  Extramacrochaetae
Its Fly Base designation is Dmel_emc, and its location is at 3L:749,406..753,505 [+]. 86 alleles have been reported. The Emc ...
*  HLA-A
The A signifies which HLA gene the allele belongs to. There are many HLA-A alleles, so that classification by serotype ... due to the diversity amongst those alleles, it is difficult to classify each and every allele's impact upon immune regulation ... In other words, every single person can only express either one or two of the 2432 known HLA-A alleles. All HLAs are assigned a ... An HLA name looks something like this: HLA-A*02:01:01:02L All alleles receive at least a four digit classification (HLA-A*02:12 ...