It is used as a long chain alkylating agent to improve the lipophilicity and hydrophobicity of organic molecules for biological ...

... with a new DNA-Alkylating agent acts on AML Cells. IMGN632, anti-CD123 SAR408701 in collaboration with Sanofi SAR428926 in ... Currently approved ADCs with ImmunoGen technology employ one of the company's maytansinoid cell-killing agents, either DM1 or ... with one of the company's potent cell-killing agents attached as a "payload". The antibody serves to deliver the cell-killing ... agent specifically to cancer cells bearing its target and the payload serves to kill these cells. In some cases, the antibody ...

... and chemical protection against radiation and alkylating agents. She focused on what caused cancer and what drugs could be used ... and chemical protection against radiation and alkylating agents. Kelly was a senior investigator in the National Cancer ... with laboratory animals showed that sulfhydryl compounds may protect against toxicity from x-irradiation and alkylating agents ...

Like any other alkylating agent it is expected to be carcinogenic, but such concerns are overshadowed by its serious acute ... The compound is a popular methylating agent in the laboratory, but it is too hazardous to be employed on an industrial scale ... Methylating agents, IARC Group 3 carcinogens, Reagents for organic chemistry, Explosive chemicals, 1894 in science, Gases with ...

... is a nitrogen mustard and alkylating antineoplastic agent (i.e., chemotherapy agent). It is a metabolite of a number of ... Alkylating antineoplastic agents, Carbamates, Human drug metabolites, Nitrogen mustards, Organochlorides, Chloroethyl compounds ... antineoplastic agents that have been developed for the treatment of tumors, including estramustine phosphate, alestramustine, ...

People who have previously been treated with an alkylating agent may have an excessive risk of cancers if treated with ... It is also an important therapy and steroid-sparing agent for inflammatory bowel disease (such as Crohn's disease and ... agent. Azathioprine is also used to maintain remission in people who have granulomatosis with polyangiitis. It can be very ...

Gonadal dysfunction seems to be the most severe endocrine long-term effect, especially after treatment with alkylating agents ...

... is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents ...

This is not true since fluoroalkanes do not act as alkylating agents under normal conditions and uneven fluoroalkane chains ... It has been speculated that the fluoropentane might function as an alkylating agent or is further metabolized into toxic ...

The aromatic ring in 6 is activated at positions ortho to the hydroxyl group, and is alkylated by 5, an alkylating agent. The ... Photosensitizing agents, Furanocoumarins, DNA intercalaters, Plant toxins, Dermatoxins). ...

... (INN, marketed under the tradename Cymerin; also known as MCNU) is a nitrosourea alkylating agent approved in Japan ... Alkylating antineoplastic agents, Nitrosamines, Nitrosoureas, Ureas, Chloroethyl compounds, All stub articles, Antineoplastic ...

... producing higher response rates than alkylating agents such as chlorambucil alone. Fludarabine is used in various combinations ... Fludarabine is a purine analogue and antineoplastic agent. It is generally used as its 5-O-phosphorylated form known as ...

They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity ...

Fischer-Speier esterification Transesterification reactions Alkyl tosylates are alkylating agents because tosylate is electron- ...

... notably benzene and alkylating chemotherapy agents for previous malignancies. Use of tobacco is associated with a small ... In resistant cases, single-agent treatments with nucleoside drugs such as fludarabine, pentostatin, or cladribine may be ... "Sidney Farber and the treatment of childhood acute lymphoblastic leukemia with a chemotherapeutic agent". Pediatric Hematology ...

A novel alkylating agent, Onrigin was evaluated in a Phase 2 trial in elderly de novo poor-risk acute myeloid leukemia (AML). ... Two anticancer agents, Onrigin (laromustine), formerly cloretazine (VNP40101M), and Triapine, a ribunucloetide reductase ...

Chemotherapeutic agents such as alkylating agents, antimetabolites, vinca alkaloids either singly or in combination can lead to ...

... and the alkylating agents (cyclophosphamide and busulfan).: 132 Skin lesion James, William; Berger, Timothy; Elston, Dirk (2005 ... Chemotherapy-induced hyperpigmentation is caused by many chemotherapeutic agents (especially the antibiotics bleomycin, and ...

A colorless, volatile liquid, it is an alkylating agent that is employed in organic synthesis, especially as a precursor to ( ...

... alkylating agents, carbon disulfide, and aldehydes and ketones. Because of its bifunctional nature, having two amines, it ... The derivative N,N-ethylenebis(stearamide) (EBS) is a commercially significant mold-release agent and a surfactant in gasoline ... A most prominent derivative of ethylenediamine is the chelating agent EDTA, which is derived from ethylenediamine via a ... chemicals for color photography developing, binders, adhesives, fabric softeners, curing agents for epoxies, and dyes. as a ...

took out and isolated SSCs from prepubertal and adult rhesus macaques before treating them with busulfan (an alkylating agent ...

The mechanism of antineoplastic activity of mannomustine, like for all other alkylating agents, lies in its ability to alkylate ... Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from ... Alkylating antineoplastic agents, Nitrogen mustards, Chloroethyl compounds). ...

... reacts with alkylating agents to give trithiocarbonate esters: K2CS3 + 2 RX → (RS)2CS + 2 KX (X = ...

Oral alkylating agents such as cyclophosphamide or chlorambucil have been administered for a median duration of 12 months with ... First-line treatment of choice is generally rituximab in combination with single alkylating agents or fludarabine, or a ...

... offering potential synergy between hydroxyurea and radiation or alkylating agents. Hydroxyurea has many pharmacological ... Antisickling Agents - Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle ... This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering ... Enzyme Inhibitors - Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme ...

Narayan S, He F, Wilson SH (August 1996). "Activation of the human DNA polymerase beta promoter by a DNA-alkylating agent ... present in the promoter of the POLB gene in response to exposure to alkylating agents. POLB gene expression is also regulated ... the promoter activator CREB-1 is upregulated in Chinese hamster ovary cells by DNA alkylating agent-induced stress". Biological ... whereas deficiencies in POLB results in hypersensitivity to alkylating agents, induced apoptosis, and chromosomal breaking. ...

... react with electrophilic alkylating agents, such as alkyl halides, to give esters. Anion availability can inhibit this reaction ... Other drying agents such as molecular sieves are also effective. Removal of water by physical means such as distillation as a ... Using a dehydrating agent: sulfuric acid not only catalyzes the reaction but sequesters water (a reaction product). ... which involves treating a carboxylic acid with an alcohol in the presence of a dehydrating agent: RCO2H + R'OH ⇌ RCO2R' + H2O ...

... with the oral alkylating agent melphalan. The four-drug combination helped in the increased overall remission rate, but was ...

In the treatment of malignancies, radiation therapy, alkylating antineoplastic agents, and epipodophyllotoxins are not used, ...

Chloroacetate is a good alkylating agent, serving as a reagent for affixing the -CH2CO2− group to a wide variety of even weak ...