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*  Phenoxybenzamine
It is also used in complex regional pain syndrome (CRPS) type 1 due to its anti-adrenergic affects. It has shown to be ... The main limiting side-effects of alpha antagonists is that the baroreceptor reflex is disrupted and thus this can cause ... As a non-selective alpha receptor antagonist, it will also affect both the postsynaptic alpha 1 and presynaptic alpha 2 ... Clinically, non-selective alpha antagonists block alpha receptors (but do not differentiate between alpha-1 and alpha-2). They ...
*  Sympatholytic
They are primarily postsynaptic adrenergic receptor antagonists (alpha and beta adrenergic receptor antagonists, or "blockers ... ICI-118,551 Highly selective β2-adrenergic receptor antagonist - No known clinical applications, but used in experiments due to ... preventing postsynaptic adrenergic receptor activation and downstream signaling. Another way to inhibit adrenergic receptor ... ganglion type receptor antagonist) Peripherally acting Guanethidine (Magnesium-ATPase inhibitor) Indoramin (α1 antagonist) ...
*  Phentolamine
... (Regitine) is a reversible nonselective α-adrenergic antagonist. Its primary action is vasodilation due to α1 ... In response, the β1 adrenergic receptors on the heart increase its rate, contractility, and dromotropy, which help to offset ... as they can cause unopposed α-adrenergic mediated coronary vasoconstriction, worsening myocardial ischemia and hypertension. It ...
*  Adrenergic agonist
... antagonists). From an overall perspective, α1 receptors activate phospholipase C (via Gq), increasing the activity of protein ... the adrenergic receptors). Directly acting adrenergic agonists act on adrenergic receptors. All adrenergic receptors are G- ... An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors. The five main categories of ... Indirectly acting adrenergic agonists affect the uptake and storage mechanisms involved in adrenergic signalling. Two uptake ...
*  Blonanserin
... antagonist and also exerts some blockade of α1-adrenergic receptors (Ki = 26.7 nM). Blonanserin also shows significant affinity ... α2-adrenergic, β-adrenergic, H1, and mACh receptors and the monoamine transporters, though it does possess low affinity for the ... a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties". The Journal of Pharmacology and ...
*  Primary polydipsia
... an alpha-2 adrenergic agonist Irbesartan, an angiotensin II receptor antagonist Propranolol, a sympatholytic beta blocker ... Vasopressin receptor antagonists, such as conivaptan Acetazolamide, a carbonic anhydrase inhibitor Lithium was previously used ...
*  Promethazine
... and α1-adrenergic receptors, where it acts as an antagonist at all sites, as well. Another notable use of promethazine is as a ... It acts primarily as a strong antagonist of the H1 receptor (antihistamine) and a moderate mACh receptor antagonist ( ... I: Antagonist correlation analysis". Psychopharmacology. 121 (3): 347-56. doi:10.1007/bf02246074. PMID 8584617. Seeman P, ... Paton DM, Webster DR (1985). "Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines)". Clinical ...
*  Carazolol
... is a high affinity antagonist/partial inverse agonist (also referred to as a beta blocker) of the β-adrenergic ... Innis RB, Corrēa FM, Synder SH (1979). "Carazolol, an extremely potent beta-adrenergic blocker: binding to beta-receptors in ...
*  List of MeSH codes (D16)
... adrenergic alpha-antagonists MeSH D27.505.519.625.050.200.200 --- adrenergic beta-antagonists MeSH D27.505.519.625.050.601 --- ... adrenergic alpha-antagonists MeSH D27.505.696.577.050.200.200 --- adrenergic beta-antagonists MeSH D27.505.696.577.050.601 --- ... adrenergic beta-agonists MeSH D27.505.519.625.050.200 --- adrenergic antagonists MeSH D27.505.519.625.050.200.100 --- ... adrenergic beta-agonists MeSH D27.505.696.577.050.200 --- adrenergic antagonists MeSH D27.505.696.577.050.200.100 --- ...
*  Tetrahydropalmatine
... including alpha-1 adrenergic receptors, at which it functions as an antagonist, and GABA-A receptors, through positive ... Additionally, l-THP displays significant binding to 5-HT1A and alpha-2 adrenergic receptors. In the case of 5-HT1A receptors, l ... alpha adrenergic and serotonin receptors. The Ki values for l-THP at D1 and D2 dopamine receptors are approximately 124 nM (D1 ...
*  Alpha-2A adrenergic receptor
... seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists ... The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the ... α2 adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in ... Handy DE, Gavras H (Nov 1992). "Promoter region of the human alpha 2A adrenergic receptor gene". The Journal of Biological ...
*  Dosulepin
It is also an antagonist of the histamine H1 receptor, α1-adrenergic receptor, serotonin 5-HT2 receptors, and muscarinic ... Guanethidine and other adrenergic neuron blocking drugs can have their antihypertensive effects blocked by dosulepin. ... reported relatively high Ki values of 12 and 15 nM for dosulepin and northiaden at the rat α2-adrenergic receptor and suggested ...
*  Glutamatergic
Examples include excitatory amino acid receptor agonists, excitatory amino acid receptor antagonists, and excitatory amino acid ... Adenosinergic Adrenergic Cannabinoidergic Cholinergic Dopaminergic GABAergic GHBergic Glycinergic Histaminergic Melatonergic ...
*  Mitragyna speciosa
Rhynchophylline is a non-competitive NMDA antagonist found in kratom. Mitragynine is metabolized in humans via phase I and ... and these may be responsible for the molecules observed in the serotonin and adrenergic systems. Mitragynine is structurally ... effects appear to be mediated via prevention of activation of serotonin 5-HT2A receptors and postsynaptic α2-adrenergic ...
*  Dichloroisoprenaline
It is non-selective for the β1-adrenergic and β2-adrenergic receptors. DCI has low potency and acts as a partial agonist/ ... antagonist at these receptors. Although DCI was of no clinical value itself, further developments from DCI eventually led to ...
*  Dopamine antagonist
... agonist Dopaminergic Serotonin antagonist Adrenergic antagonist Histamine antagonist Acetylcholine antagonist GABA antagonist ... Several other dopamine antagonists are antiemetics used in the treatment of nausea and vomiting. Dopamine receptor antagonists ... A dopamine antagonist (antidopaminergic) is a type of drug which blocks dopamine receptors by receptor antagonism. Most ... MeSH list of agents 82018492 Dopamine antagonists at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Clocapramine
... has been reported to act as an antagonist of the D2, 5-HT2A, α1-adrenergic, and α2-adrenergic receptors, and does ... "Effects of iminodibenzyl antipsychotic drugs on cerebral dopamine and alpha-adrenergic receptors". European Journal of ...
*  Pipamperone
... acts as an antagonist of the 5-HT2A, 5-HT2B, 5-HT2C D2, D3, D4, α1-adrenergic, and α2-adrenergic receptors. It ... receptor antagonist properties of compounds". Eur. J. Pharmacol. 388 (1): 57-67. doi:10.1016/s0014-2999(99)00859-6. PMID ...
*  Adrenergic
... receptor Adrenergic transporter Regarding drugs: Adrenergic receptor agonist Adrenergic receptor antagonist ... Adrenergic means "working on adrenaline (epinephrine) or noradrenaline (norepinephrine)". Adrenergic nervous system, a part of ... ISBN 0-7817-6879-9. "The Physiology and Function of the Alpha-Adrenergic Nervous System". Medspace. Retrieved 10 December 2015 ... Adrenergic reuptake inhibitor Dopaminergic GABAergic Nootropic Serotonergic Glutamatergic Racetam Brunton, Laurence; Lazo, John ...
*  Hypnotic
Zotepine Alpha-adrenergic agonist Clonidine Guanfacine Cannabinoids Cannabidiol Tetrahydrocannabinol Orexin receptor antagonist ... H1 antagonists are used to treat certain allergies. Sedation is a common side-effect, and some H1 antagonists, such as ... Examples include: Serotonin antagonists and reuptake inhibitors Trazodone Tricyclic antidepressants Amitriptyline Doxepin ...
*  Etoperidone
... is as an antagonist of several receptors in the following order of potency: 5-HT2A receptor (36 nM) > α1-adrenergic ... It is a phenylpiperazine related to trazodone and nefazodone in chemical structure and is a serotonin antagonist and reuptake ... Akritopoulou-Zanze, Irini (2012). "6. Arylpiperazine-Based 5-HT1A Receptor Partial Agonists and 5-HT2A Antagonists for the ... receptor (38 nM) > 5-HT1A receptor (85 nM) (may be a partial agonist) > α2-adrenergic receptor (570 nM); it has only very weak ...
*  Beta-2 adrenergic receptor
... denotes selective antagonist to the receptor. Beta-2 adrenergic receptor has been shown to interact with: AKAP12, OPRD1, Grb2, ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-3 adrenergic ... The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor ... "Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 ...
*  Vasoactivity
Various vasoactive agents, such as prostanoids, phosphodiesterase inhibitors, and endothelin antagonists, are approved for the ... Important vasoactive substances are angiotensin-11, endothelin-1, and alpha-adrenergic agonists. ...
*  Norepinephrine-dopamine disinhibitor
September 2003). "The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, ... blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways". The Journal of Pharmacology ... Noradrenergic and specific serotonergic antidepressant (NaSSA) Serotonin antagonist and reuptake inhibitor (SARI) Serotonin ...
*  Beta-1 adrenergic receptor
... β1-selective antagonists include: Acebutolol (in hypertension, angina pectoris and arrhythmias) Atenolol (in hypertension, ... Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-2 adrenergic receptor Beta-3 adrenergic ... The beta-1 adrenergic receptor (β1 adrenoreceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the ... "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation". The Journal ...
*  GNAQ
... has been shown to interact with: Beta adrenergic receptor kinase, Bruton's tyrosine kinase, RGS16, RGS4 RIC8A, and Sodium- ... characterization of new antagonists". Mol. Pharmacol. 50 (4): 923-30. PMID 8863838. Petit A, Geoffroy P, Bélisle S (1997). " ...
*  NAN-190
It was previously believed to act as a selective 5-HT1A receptor antagonist, but a subsequent discovery showed that it also ... potently blocks the α2-adrenergic receptor. The new finding has raised significant concerns about studies using NAN-190 as a ... Foong JP, Bornstein JC (2009). "5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig". ...