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*  Pyrimidinylpiperazine
It is known to act as an antagonist of the α2-adrenergic receptor (Ki = 7.3-40 nM) and, to a much lesser extent, as a partial ... and does not appear to have significant affinity for the α1-adrenergic receptors.[additional citation(s) needed] A number of ...
*  Nantenine
It is an antagonist at both the α1 adrenergic receptor and the 5-HT2A serotonin receptor, and blocks both the behavioural and ... Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW (May 2009). "(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) ... an antagonist of the behavioral and physiological effects of MDMA in mice". Psychopharmacology. 173 (3-4): 270-7. doi:10.1007/ ... "Serotonergic receptor antagonist from Nandina domestica Thunberg". Journal of Pharmaceutical Sciences. 73 (4): 568-70. doi: ...
*  Tremorine
Paul, V. (1986). "The role of adrenergic mechanism in tremorine-induced tremors in rats: Antitremor effect of beta-adrenoceptor ... antagonists". Indian journal of physiology and pharmacology. 30 (4): 307-312. PMID 2883120. Oxotremorine. ...
*  Adrenergic nerve fibre
The drug idazoxan blocks α2 autoreceptors and hence acts as an antagonist.) All adrenergic receptors are metabotropic, coupled ... Neurons in the central nervous system contain α1- and α2-adrenergic receptors and β1- and β2-adrenergic receptors. All four ... Adrenergic nerve terminals are found in the secondary neurons of the sympathetic nervous system, one of two deviations of the ... Adrenergic neurons, in particular the α2 autorecptors found in the brain, are also involved in sexual behavior and in the ...
*  Serotonin antagonist and reuptake inhibitor
These drugs act as antagonists or inverse agonists of the 5-HT2A, α1-adrenergic, and H1 receptors, as partial agonists of the 5 ... mCPP is an antagonist of the 5-HT2A and 5-HT2B receptors and an agonist of the 5-HT1A, 5-HT2C, and 5-HT3 receptors. Serotonin ... Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as ... Thomas DR, Gager TL, Holland V, Brown AM, Wood MD (1996). "m-Chlorophenylpiperazine (mCPP) is an antagonist at the cloned human ...
*  Aortic insufficiency
Aldosterone Antagonists, Selective, Alpha/Beta Adrenergic Agonists, Calcium Channel Blockers, Anticoagulants, Cardiovascular, ... Trials have shown a short term benefit in the use of ACE inhibitors or angiotensin II receptor antagonists, nifedipine, and ...
*  Parasympathomimetic drug
... β-receptor antagonist) atenolol (β1 antagonist) prazosin (α1 antagonist) Oxymetazoline (partial α2 adrenergic agonist) ... via blockade of the α adrenergic receptors Anti-adrenergics See also: alpha blocker and beta blocker clonidine (α-receptor ...
*  Maprotiline
It is also a strong antagonist of the H1 receptor, a moderate antagonist of the 5-HT2 and α1-adrenergic receptors, and a weak ... Maprotiline has also more recently been identified as a potent antagonist of the 5-HT7 receptor, with this action potentially ... von Coburg Y, Kottke T, Weizel L, Ligneau X, Stark H (2009). "Potential utility of histamine H3 receptor antagonist ... receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles". Bioorg. Med ...
*  Zolazepam
... is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the α2 adrenergic ...
*  Spiroxatrine
... is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is ... an analog of spiperone and also has some dopamine antagonist effects. Terrón, J. A.; Ibarra, M; Ransanz, V; Hong, E; Villalón, ...
*  Cannabigerol
CBG has been found to act as a high affinity α2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and ... It also binds to the CB2 receptor as an antagonist. CBG does not trigger THC-like activity in mice, rats, gerbils and non-human ... adrenoceptor agonist and moderately potent 5HT receptor antagonist". British Journal of Pharmacology. 159 (1): 129-141. doi: ... Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid ...
*  Glycinergic
Adenosinergic Adrenergic Cannabinoidergic Cholinergic Dopaminergic GABAergic Histaminergic Melatonergic Monoaminergic ... Examples include glycine receptor agonists, glycine receptor antagonists, and glycine reuptake inhibitors. ...
*  Anxiolytic
The alpha1 antagonist prazosin could be effective for PTSD The Alpha2 adrenergic agonists Clonidine and guanfacine have ... Jefferson, James W. (1974). "Beta-Adrenergic Receptor Blocking Drugs in Psychiatry". Archives of General Psychiatry. 31 (5): ... serotonin and adrenergic activity. Mebicar decreases the brain noradrenaline level, exerts no effect on the dopaminergic ...
*  Chlordiazepoxide
ACE inhibitors, Adrenergic neurone blockers, Angiotensin II receptor antagonists, Beta blockers, Calcium channel blockers, ...
*  Receptor antagonist
Phenoxybenzamine is an example of an irreversible alpha blocker-it permanently binds to α adrenergic receptors, preventing ... As for non-competitive antagonists and irreversible antagonists in functional assays with irreversible competitive antagonist ... A non-competitive antagonist is a type of insurmountable antagonist that may act in one of two ways: by binding to the active ... By definition, antagonists display no efficacy to activate the receptors they bind. Antagonists do not maintain the ability to ...
*  H1 antagonist
... antagonists as well. These agents also commonly have action at α-adrenergic receptors and/or 5-HT receptors. This lack of ... In common use, the term "antihistamine" refers only to H1 antagonists, also known as H1-receptor antagonists and H1- ... H1 antagonists, also called H1 blockers, are a class of medications that block the action of histamine at the H1 receptor, ... It has been discovered that some H1-antihistamines function as inverse agonists, as opposed to receptor antagonists, at the ...
*  Tiotixene
It is also an antagonist of the histamine H1, α1-adrenergic, and serotonin 5-HT7 receptors (low nanomolar affinity), as well as ... Tiotixene acts primarily as a highly potent antagonist of the dopamine D2 and D3 receptors (subnanomolar affinity). ...
*  Three-finger toxin
... antagonists for the beta-1 and beta-2 adrenergic receptors. There are known 3FTx proteins that target a variety of additional ... Recently, a new class of nAChR antagonist 3FTx proteins called omega-neurotoxins has been described. A smaller class of 3FTx ... Muscarinic toxins can be either receptor agonists or receptor antagonists, and in some cases the same 3FTx protein is an ... Novel Antagonists of Nicotinic Acetylcholine Receptors from Snake Venom". ACS Chemical Biology. 10 (12): 2805-2815. doi:10.1021 ...
*  Atropine
... a shorter-acting cholinergic antagonist) or phenylephrine (an α-adrenergic agonist) is preferred as an aid to ophthalmic ...
*  Adenosinergic
Adrenergic Cannabinoidergic Cholinergic Dopaminergic GABAergic Glycinergic Histaminergic Melatonergic Monoaminergic Opioidergic ... Examples include adenosine receptor agonists, adenosine receptor antagonists (such as caffeine), and adenosine reuptake ...
*  List of investigational antidepressants
5-HT1A receptor antagonist, 5-HT2A, α1A-adrenergic, and α1B-adrenergic receptor ligand TGBA01AD - serotonin reuptake inhibitor ... NR2B antagonist EVT-103 (ENS-103) - NR2B antagonist Hydroxynorketamine (2R,6R)-HNK - metabolite of ketamine which may be ... κ-opioid receptor antagonist CERC-501 (LY-2456302) - κ-opioid receptor antagonist Tramadol (ETS6103; Viotra) - μ-opioid ... non-competitive nicotinic acetylcholine receptor antagonist, uncompetitive NMDA receptor antagonist, and other actions ...
*  GABAergic
Some different classes of GABAergic drugs include the following: GABA receptor agonists, GABA receptor antagonists, and GABA ... Adenosinergic Adrenergic Cannabinoidergic Cholinergic Dopaminergic Glycinergic Histaminergic Melatonergic Monoaminergic ...
*  Generalized anxiety disorder
Clonidine - Sympatholytic, α2-adrenergic receptor agonist. Guanfacine - Sympatholytic, α2-adrenergic receptor agonist. Prazosin ... Hydroxyzine - Antihistamine, 5-HT2A receptor antagonist. Propranolol - Sympatholytic, beta blocker. ...
*  Histaminergic
H2 receptor antagonists, and H3 receptor antagonists. Adenosinergic Adrenergic Cannabinoidergic Cholinergic Dopaminergic ... Subdivisions of histamine antagonists include H1 receptor antagonists, ... Examples include histamine receptor agonists and histamine receptor antagonists (or antihistamines). ...
*  Anxiogenic
GABA antagonists such as DMCM, FG-7142 and ZK-93426, serotonergic agents such as mCPP and LY-293,284, adrenergic agents such as ... yohimbine, antipsychotics/dopamine antagonists such as ecopipam and reserpine, and cholecystokinin (CCK) (especially the ...
*  Chlorprothixene
von Coburg Y, Kottke T, Weizel L, Ligneau X, Stark H (2009). "Potential utility of histamine H3 receptor antagonist ... Bylund DB, Snyder SH (1976). "Beta adrenergic receptor binding in membrane preparations from mammalian brain". Mol. Pharmacol. ... Chlorprothixene is an antagonist of the following receptors: 5-HT2: antipsychotic effects, anxiolysis, weight gain D1, D2, D3: ... inhibition of extrapyramidal side effects α1-Adrenergic: hypotension, tachycardia Because of its potent serotonin 5-HT2A and ...