*  Alpha-1A adrenergic receptor
... a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype". J. Pharmacol. Exp. Ther. 274 (1): ... 1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic ... There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G- ...
*  Sympatholytic
They are primarily postsynaptic adrenergic receptor antagonists (alpha and beta adrenergic receptor antagonists, or "blockers ... Alpha2 adrenergic agonist can also be used to treat anxiety and panic, such as Generalized Anxiety Disorder, Panic Disorder or ... Alpha2-adrenergic receptor agonists, such as clonidine and guanfacine, act at noradrenergic autoreceptors to inhibit the firing ... However, there are exceptions: clonidine is an adrenergic agonist at the α2 receptor; since this receptor is located ...
*  Cell surface receptor
These receptors activate a G protein upon agonist binding, and the G-protein mediates receptor effects on intracellular ... Adrenergic receptor, Olfactory receptors, Receptor tyrosine kinases Epidermal growth factor receptor Insulin Receptor ... transmembrane alpha helices constitute most of the transmembrane component. In certain receptors, such as the nicotinic ...
*  Medifoxamine
Unlike many tricyclic antidepressants, medifoxamine lacks anticholinergic and alpha blocker properties (very low affinity for ... "Neurochemical and behavioral evidence for a central indirect dopaminergic agonist activity of the antidepressant medifoxamine ... the muscarinic acetylcholine receptors and 10-fold lower affinity for the α1-adrenergic receptor relative to 5-HT2 binding ...
*  Metabotropic glutamate receptor 1
Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. ... Desai MA, Burnett JP, Mayne NG, Schoepp DD (1995). "Cloning and expression of a human metabotropic glutamate receptor 1 alpha: ... A possible connection has been suggested between mGluRs and neuromodulators, as mGluR1 antagonists block adrenergic receptor ... highly potent and selective allosteric antagonist/inverse agonist A-841,720: potent non-competitive antagonist; minor hmGluR5 ...
*  Synephrine
... differences in activity at alpha-1 and alpha-2 adrenergic receptors." J. Pharmacol. Exp. Ther. 224 559-566. T. Hibino, M. ... F. Pellati, S. Benvenuti, M. Melegari, and F. Firenzuoli (2002). "Determination of adrenergic agonists from extracts and herbal ... An adrenergic antagonist selective for α1 receptors. Reversal of reserpine-induced hypothermia by a drug is a classical test ... Racemic synephrine has been shown to be an agonist of the TAAR1, although its potency at the human TAAR1 is relatively low ( ...
*  Pharmacology of antidepressants
"Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor ... as well as TNF-alpha and Interleukin-6 (IL-6). Antidepressants have also been shown to suppress TH1 upregulation. ... "Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor α and interleukin-6 ... The antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice". International ...
*  Prostaglandin EP1 receptor
Only one such agonist that is highly selective in stimulating EP1 has been synthesized and identified, ONO-D1-OO4. This ... EP1 mobilizes G proteins containing the Gq alpha subunit (Gαq/11)-G beta-gamma complex. These two subunits in turn stimulate ... "Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric ... genetically engineered to lack EP1 and supplemented by studies using treatment with EP1 receptor antagonists and agonists ...
*  Methylphenidate
... central alpha-adrenoreceptor agonists such as dexmedetomidine, or propofol. ... However, fatalities are rare with appropriate ... but limited evidence suggests that intake of β-adrenergic agonists with methylphenidate may increase the risk of liver toxicity ... Methylphenidate has been identified as a sigma-1 receptor agonist in rats. Methylphenidate taken orally has a bioavailability ... Methylphenidate is also a weak 5HT1A receptor agonist. Methylphenidate is a commonly prescribed psychostimulant and works by ...
*  Δ-opioid receptor
Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl- ... opioid receptors have been shown to interact with β2 adrenergic receptors, arrestin β1 and GPRASP1. K-opioid receptor μ-opioid ... Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80 ... Evidence for whether δ agonists produce respiratory depression is mixed; high doses of the δ agonist peptide DPDPE produced ...
*  Dexmethylphenidate
... central alpha-adrenoreceptor agonists such as dexmedetomidine, or propofol. ... However, fatalities are rare with appropriate ... but limited evidence suggests that intake of β-adrenergic agonists with methylphenidate may increase the risk of liver toxicity ... Roberts SM, DeMott RP, James RC (1997). "Adrenergic modulation of hepatotoxicity". Drug Metab. Rev. 29 (1-2): 329-53. doi: ... Shearer J (2008). "The principles of agonist pharmacotherapy for psychostimulant dependence". Drug Alcohol Rev. 27 (3): 301-8. ...
*  Adenosine A2A receptor
This protein is a member of the G protein-coupled receptor (GPCR) family which possess seven transmembrane alpha helices. The ... Lappas CM, Sullivan GW, Linden J (Jul 2005). "Adenosine A2A agonists in development for the treatment of inflammation". Expert ... the beta-2 adrenergic receptor and rhodopsin). The actions of the A2A receptor are complicated by the fact that a variety of ... Makujina SR, Sabouni MH, Bhatia S, Douglas FL, Mustafa SJ (Oct 1992). "Vasodilatory effects of adenosine A2 receptor agonists ...
*  Nicotine
Both drugs are agonists are nicotinic cholinergic receptors ... Robert L. Metcalf (2007), "Insect Control", Ullmann's ... Additionally, specific types of nicotinic acetylcholine receptors- eg, alpha 7 receptors, which are stimulated by nicotine-are ... Nicotine increases cholinergic signalling and adrenergic signalling in the case of colon cancer, thereby impeding apoptosis ( ... Nicotine acts as an agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits ( ...
*  Gaseous signaling molecules
The vasodilating antihypertensive drug minoxidil contains an NO moiety and may act as an NO agonist. Likewise, Sildenafil ... Endogenous sulfur dioxide also diminishes myocardial damage, caused by isoproterenol adrenergic hyperstimulation, and ... "Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine ... 3H)Naloxone displacement: evidence for nitrous oxide as opioid receptor agonist". Eur J Pharmacol. 89: 177-178. doi:10.1016/ ...
*  Stimulant
Adrenergic stimulants, such as ephedrine, may act by directly binding and activating the receptors that norepinephrine and ... Westfall DP, Westfall TC (2010). "Miscellaneous Sympathomimetic Agonists". In Brunton LL, Chabner BA, Knollmann BC. Goodman & ... Methamphetamine (contracted from N-methyl-alpha-methylphenethylamine) is a neurotoxin and potent psychostimulant of the ... Stimulants such as epinephrine, theophylline and salbutamol orally have been used to treat asthma, but inhaled adrenergic drugs ...
*  Apomorphine
Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor". The Journal ... α1-adrenergic, and α2-adrenergic. Though its efficacies at D1 and D5 are unclear, it is known to act as an agonist at these ... 10,000 nM affinity for β-adrenergic, H1, and mACh. Apomorphine behaves as a partial agonist at D2S (IA = 79%), D2L (IA= 53%), ... Apomorphine is an agonist, or activator, of both D1 and D2 type dopamine receptors with higher activity at D2. The members of ...
*  Prostaglandin DP1 receptor
2007). "Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human ... also known as β-Adrenergic receptor kinase 2 [BARK1]) and arrestin 2 (also known as Arrestin beta 1 [ARRB1]). These agents act ... a novel selective DP agonist". British Journal of Pharmacology. 123 (7): 1317-24. doi:10.1038/sj.bjp.0701708. PMC 1565289 . ...
*  Tramadol
Shen Q, Qian Y, Huang X, Xu X, Li W, Liu J, Fu W (2016). "Discovery of Potent and Selective Agonists of δ Opioid Receptor by ... tramadol's analgesic effects are also partially reversed by α2-adrenergic receptor antagonists like yohimbine, the 5-HT3 ... effects of tramadol on nicotinic acetylcholine receptors in adrenal chromaffin cells and in Xenopus oocytes expressing alpha 7 ... Tramadol has been found to possess the following actions: Agonist of the μ-opioid receptor (MOR) and to a far lesser extent of ...
*  PRKCE
A myriad of agonists have also been shown to induce the translocation of PKCε from the cytosolic to particulate fraction in ... Kooij V, Boontje N, Zaremba R, Jaquet K, dos Remedios C, Stienen GJ, van der Velden J (Mar 2010). "Protein kinase C alpha and ... PKCε translocation to sarcomeres and phosphorylation of cTnI and cMyBPC is involved in the κ-opioid- and α-adrenergic-dependent ... Hassouna A, Matata BM, Galiñanes M (Nov 2004). "PKC-epsilon is upstream and PKC-alpha is downstream of mitoKATP channels in the ...
*  Benzodiazepine
Gross ME (2001). "Tranquilizers, α2-adrenergic agonists, and related agents". In Adams RH. Veterinary Pharmacology and ... Binding also requires that alpha subunits contain a histidine amino acid residue, (i.e., α1, α2, α3, and α5 containing GABAA ... These long-acting metabolites are partial agonists. Short-acting compounds have a median half-life of 1-12 hours. They have few ... Ballenger JC (2000). "Benzodiazepine receptors agonists and antagonists". In Sadock VA, Sadock BJ, Kaplan HI. Kaplan & Sadock's ...
*  Sertraline
Agonists of the σ1 receptor such as igmesine have been found to inhibit intestinal secretion and bacteria-induced secretory ... Trauger JW, Jiang A, Stearns BA, LoGrasso PV (2002). "Kinetics of allopregnanolone formation catalyzed by human 3 alpha- ... Sertraline does not have significant affinity for the norepinephrine transporter (NET) or the serotonin, dopamine, adrenergic, ... Hindmarch I, Hashimoto K (2010). "Cognition and depression: the effects of fluvoxamine, a sigma-1 receptor agonist, ...
*  ADCY1
"Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition ... Osawa S, Dhanasekaran N, Woon CW, Johnson GL (Nov 1990). "G alpha i-G alpha s chimeras define the function of alpha chain ... Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP ...
*  Ephedrine
Pharmacological Effects of Ephedrine Alkaloids on Human {alpha}1- and {alpha}2-Adrenergic Receptor Subtypes Archived 2011-03-05 ... as alpha-agonists such as ephedrine constrict the internal urethral sphincter, mimicking the effects of sympathetic nervous ... Ephedrine works by turning on the α and β adrenergic receptors. Ephedrine was first isolated in 1885. It is on the World Health ... on adrenergic receptors. It is most usually marketed as the hydrochloride or sulfate salt. Ephedrine exhibits optical isomerism ...
*  Micro-g environment
Another countermeasure includes administration of Midodrine, which is a selective alpha-1 adrenergic agonist. Midodrine ... The use of beta-2 adrenergic agonists to increase muscle mass, and the use of essential amino acids in conjunction with ...
*  Adrenergic
... receptor Adrenergic transporter Regarding drugs: Adrenergic receptor agonist Adrenergic receptor antagonist ... ISBN 0-7817-6879-9. "The Physiology and Function of the Alpha-Adrenergic Nervous System". Medspace. Retrieved 10 December 2015 ... Adrenergic means "working on adrenaline (epinephrine) or noradrenaline (norepinephrine)". Adrenergic nervous system, a part of ... Adrenergic reuptake inhibitor Dopaminergic GABAergic Nootropic Serotonergic Glutamatergic Racetam Brunton, Laurence; Lazo, John ...