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*  Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
... is embedded in the smooth endoplasmic reticulum of the cells of the adrenal cortex. It catalyzes hydroxylation of 17α- ... Abnormalities of body image due to the effects of the disease likely play a role in the sexual development of these women, and ... 2007). "Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal ... Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest ...
*  Development of the endocrine system
The fetal adrenal cortex can be identified within four weeks of gestation. The adrenal cortex originates from the thickening of ... congenital heart disease, and improper organ development. The reproductive system begins development at four to five weeks of ... The gonadal ridge produces the steroidogenic cells for both the gonads and the adrenal cortex. The adrenal medulla is derived ... twice that of the adult adrenal glands) and are 0.5% of the total body weight. At 25 weeks, the adult adrenal cortex zone ...
*  Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency
Congenital adrenal hyperplasia (CAH) refers to any of several autosomal recessive diseases resulting from defects in steps of ... the hyperplastic adrenal cortex produces excessive amounts of DHEA, androstenedione, and especially testosterone. These ... Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency is a form of congenital adrenal hyperplasia (CAH) which ... Inborn errors of steroid metabolism Congenital adrenal hyperplasia Adrenal insufficiency Disorders of sexual development ...
*  Hypoadrenocorticism in dogs
Bilateral destruction of the adrenal cortex by neoplasia (e.g. lymphosarcoma), granulomatous disease, or arterial thrombosis ... The adrenal glands are located above the kidneys. The adrenal outer layer, or cortex, has three layers; each produces a ... It is possible not to see any signs of the disease until 90% of the adrenal cortex is no longer functioning. If hyponatremia ( ... All layers of the adrenal gland stop functioning; the problem is with the adrenal gland. This causes a deficiency of both ...
*  Lipoid congenital adrenal hyperplasia
The adrenals are large and filled with lipid globules derived from cholesterol. This inherited disease is autosomal recessive. ... of the adrenal cells and increases LDL receptors to amplify transport of cholesterol into the cells of the adrenal cortex which ... Congenital adrenal hyperplasias are a family of autosomal recessive diseases resulting from defects in steps of the synthesis ... Unlike in models of the disease in mice, patients with lipoid CAH do not always have enlarged adrenals due to lipid ...
*  Hyperplasia
Cushing's disease - Physiopathology of hyperplasia of adrenal cortex due to increased circulating level of ACTH ( ... "Cushing disease: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Retrieved 2015-05-30. "Congenital adrenal hyperplasia: ... adrenocorticotropic hormone). Congenital adrenal hyperplasia - Inherited disorder of gland (adrenal). Endometrial hyperplasia ... In regards to Cushing's disease, the diagnosis of salivary cortisol in an elevated level around "late-night" is a way to detect ...
*  PRKACA
Protein kinase A has been implicated in a number of diseases, including cardiovascular disease, tumors of the adrenal cortex, ... Mutations in the PRKACA gene that promote abnormal enzyme activity have been linked to disease of the adrenal gland. Several ... It has been speculated that abnormally high levels of PKA phosphorylation contributes to heart disease. This affects excitation ... Defective regulation of PKA holoenzyme activity has been linked to the progression of cardiovascular disease, certain endocrine ...
*  Autoimmune polyendocrine syndrome type 3
In Type 3, autoimmune thyroiditis and another endocrine autoimmune disease are present, but the adrenal cortex is not involved ... Autoimmune polyendocrine syndromes (APS) occur when more than one autoimmune disease occurs in endocrine glands. These ...
*  Anorexia nervosa (differential diagnoses)
Addison's disease is a disorder of the adrenal cortex which results in decreased hormonal production. Addison's disease, even ... Diagnosis of Crohn's disease was made within 5 to 13 years."(Blanchet C, Luton JP. 2002)"This disease should be diagnostically ... and radiologically and histopathologically as Crohn's disease". The Canadian journal of infectious diseases = Journal canadien ... Lyme disease is known as the "great imitator", as it may present as a variety of psychiatric or neurologic disorders including ...
*  Evelyn M. Anderson
Most notably she discovered with Webb E. Haymaker that Cushing's disease is caused by hyper function of the Adrenal cortex. ... She then moved to the National Institute of Arthritis and Metabolic Diseases (NIAMD) at the National Institute of Health where ... while continuing her research on hormone related diseases. ...
*  Adrenocortical hormone
Addison's disease is an autoimmune disorder that affects the adrenal cortex such that it is unable to efficiently secrete ... The immune system specifically targets the cells of the adrenal cortex and destroys them, but Addison's disease can also be ... the adrenocortical hormones are hormones produced by the adrenal cortex, the outer region of the adrenal gland. These ... The glucocorticoid family of hormones is synthesized in the middle layer of the adrenal cortex known as the zona fasciculata. ...
*  24-Dehydrocholesterol reductase
... of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland ... of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in ... 2006). "Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related ... 2007). "The association study between DHCR24 polymorphisms and Alzheimer's disease". Am. J. Med. Genet. B Neuropsychiatr. Genet ...
*  Cushing's syndrome
Excessive ACTH stimulates the adrenal cortex to produce high levels of cortisol, producing the disease state. Cushing's disease ... In adrenal Cushing's, excess cortisol is produced by adrenal gland tumors, hyperplastic adrenal glands, or adrenal glands with ... that affects the adrenal glands. This etiology is called ectopic or paraneoplastic Cushing's disease and is seen in diseases ... Cortisol is secreted by the cortex of the adrenal gland from a region called the zona fasciculata in response to ACTH. Elevated ...
*  Epinephrine
Failure of the adrenal cortex, as with Addisons disease, can suppress epinephrine secretion as the activity of the synthesing ... But the adrenal medulla, in contrast to the adrenal cortex, is not required for survival. In adrenalectomized patients ... Warren J (January 1986). "The adrenal medulla and the airway". British Journal of Diseases of the Chest. 80 (1): 1-6. doi: ... ACTH also stimulates the adrenal cortex to release cortisol, which increases the expression of PNMT in chromaffin cells, ...
*  Eating disorder
Addison's Disease is a disorder of the adrenal cortex which results in decreased hormonal production. Addison's disease, even ... Gastrointestinal diseases, such as celiac disease, Crohn's disease, peptic ulcer, eosinophilic esophagitis or non-celiac gluten ... It has been documented that some people with celiac disease, irritable bowel syndrome or inflammatory bowel disease who are not ... neurodegenerative diseases such as Parkinson's disease, neurotoxicity such as lead exposure, bacterial infection such as Lyme ...
*  Poodle
Addison's disease is characterized by insufficient production of glucocorticoid and/or mineralocortoid in the adrenal cortex ( ... In a UK survey, the most common causes of death were cancer (30%), old age (18%), GDV (6%), and cardiac disease (5%). Miniature ... Addison's disease is (as of 20 August 2007) the illness most commonly reported to the Poodle Health Registry. The number of ... juvenile renal disease, hip dysplasia, and cancer. Standard Poodles are also susceptible to some health issues usually too ...
*  Adrenal cortex
Adrenal insufficiency (e.g. due to Addison's disease) Cushing's syndrome Conn's syndrome Adrenal gland "Embryology of the ... Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of ... The adrenal cortex comprises three main zones, or layers. This anatomic zonation can be appreciated at the microscopic level, ... The adrenal cortex exhibits functional zonation as well: by virtue of the characteristic enzymes present in each zone, the ...
*  Primary pigmented nodular adrenocortical disease
used a mouse model to cre-lox knockout the Prkar1a gene specifically from cells of the adrenal cortex and observed that the ... PPNAD arises due to the enlargement of the cortex of the adrenal glands, resulting in Cushing's syndrome that is independent of ... The R1α loss caused the adult adrenal gland became hyperactive and hyperplastic on both sides, as seemingly the foetal adrenal ... "Cushing's Syndrome and Fetal Features Resurgence in Adrenal Cortex-Specific Prkar1a Knockout Mice". PLoS Genetics. 6 (6): ...
*  List of dog diseases
It is possible not to see any symptoms of the disease until the adrenal cortex is 90% dysfunctional. Addison's can occur when ... This list of dog diseases is a selection of diseases and other conditions found in the dog. Some of these diseases are unique ... The disease in dogs is usually nodular skin lesions of the head and trunk. Aspergillosis* is a fungal disease that in dogs is ... It is most commonly caused by destruction of adrenal tissue, probably by autoimmune disease. Signs include increased drinking ...
*  Etiocholanolone
... and is used to evaluate adrenal cortex function, bone marrow performance, and in neoplastic disease to stimulate the immune ...
*  Cholesterol side-chain cleavage enzyme
A study of the steroidogenic capacity of the adrenal cortex in infants with acute respiratory disease demonstrated that indeed ... In adrenal cortex cells from zona fasciculata, the expression of the mRNAs encoding all three P450scc proteins is induced by ... In the adrenal cortex, the concentration of adrenodoxin is similar to that of P450scc, but adrenodoxin reductase is expressed ... The highest level of the cholesterol side-chain cleavage system is found in the adrenal cortex and the corpus luteum. The ...
*  Israel Hanukoglu
... in regulating steroid hormone synthesis in the adrenal cortex, regulation of adrenal steroidogenic capacity in disease states, ... His Ph.D. thesis was on the "Mechanism of electron transport to cytochrome P-450 in adrenal cortex mitochondrial steroid ... Rapoport R, Sklan D, Hanukoglu I (10 March 1995). "Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 ... including the adrenal cortex, and the reproductive organs. The first step of steroidogenesis is dependent on the transfer of ...
*  Bearded Collie
It occurs when the adrenal cortex produces insufficient glucocorticoid and/or mineralocorticoid hormones. It affects ... Hypoadrenocorticism (also known as Addison's disease) is an inherited disease in Bearded Collies, although the mechanism of ... Morbidity in the two studies is not easily compared, however; the UK report grouped diseases, while the USA/Canada report ... Leading causes of death among Beardies in the UK are old age (26%), cancer (19%), cerebrovascular disease (9%), and chronic ...
*  List of incurable diseases
Adrenocortical carcinoma - A form of cancer that originates in the cortex of the adrenal gland and has no definitive cure.[ ... Creutzfeldt-Jakob disease - This is a neurodegenerative disease. There is no treatment or cure for this disease, although there ... Coeliac disease - Coeliac (or celiac) disease is an autoimmune disorder and chronic inflammatory disease. It is triggered by ... Lists of diseases - A list of lists for all the different kinds of diseases that are known. "Asthma". World Health Organization ...
*  Addison's disease
Autoimmune destruction of the adrenal cortex is caused by an immune reaction against the enzyme 21-hydroxylase (a phenomenon ... celiac disease, or vitiligo. Addison's disease may be the only manifestation of undiagnosed celiac disease. Both diseases share ... "Adrenal Insufficiency and Addison's Disease". National Endocrine and Metabolic Diseases Information Service. Archived from the ... This may be the result of either previously undiagnosed Addison's disease, a disease process suddenly affecting adrenal ...
*  LECT2
... and may be involved in various diseases. However, LECT2's relationships to these diseases requires much further study before ... They may have histological evidence of LECT2 amyloid deposition in the liver, lung, spleen, kidney, and adrenal glands of ... Kidney biopsy shows the presence of LECT2-based amyloid predominantly in the renal cortex interstitium, glomeruli, and ... It has been suggested that individuals with the disease have an increase in LECT2 production and/or a decrease in LECT2 ...
*  Edith E. Sproul
... on Nucleic Acids and Subcellular Elements of the Adrenal Cortex. The Journal of Biophysical and Biochemical Cytology, 2(2), 115 ... Diseases of the Chest, 33(4), 347. Fiala, A., Fiala, S., Sproul, E.E. (1956) The Action of Corticotropin (ACTH) ...