ADP-ribosyl)ation and DNA methylation, an important epigenetic regulatory factor. A substantial body of preclinical and ... Roles of poly(ADP-ribosyl)ation in plant responses to DNA damage, infection, and other stresses have been studied. Plant PARP1 ... CCCTC-binding factor (CTCF) induces PAR accumulation. ADP-ribose polymers, either free or PARP1 bound, are able to inhibit DNA ... Zardo G, Reale A, De Matteis G, Buontempo S, Caiafa P (June 2003). "A role for poly(ADP-ribosyl)ation in DNA methylation". ...
ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene. ADP-ribosylation factor-like ... "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A". Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, ... Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG (1999). "ADP-ribosylation factor (ARF)-like 4, 6, and ... 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has ...
ADP-ribosylation (ADPr) defines the addition of one or more adenosine diphosphate ribose (ADP-ribose) groups to a protein. ADPr ... SUMOylation affects the chromatin status (looseness) of the histone and influences the assembly of transcription factors on ... Ryu KW, Kim DS, Kraus WL (March 2015). "New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose ... Hassa PO, Haenni SS, Elser M, Hottiger MO (September 2006). "Nuclear ADP-ribosylation reactions in mammalian cells: where are ...
... "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". The Journal of ... "beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis". The Journal of ... Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor". FEBS Letters. 402 (2 ... "Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G- ...
... works: By using NAD+ to synthesize poly ADP ribose (PAR) and transferring PAR moieties to proteins (ADP-ribosylation). In ... November 2009). "Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori". Proceedings ... Plants have a PARP1 with substantial similarity to animal PARP1, and roles of poly(ADP-ribosyl)ation in plant responses to DNA ... Briggs AG, Bent AF (July 2011). "Poly(ADP-ribosyl)ation in plants". Trends in Plant Science. 16 (7): 372-80. doi:10.1016/j. ...
Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (Jul 2000). "The GIT family of ADP-ribosylation factor GTPase-activating ... GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating ... "An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin ... a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proceedings of the National ...
... phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". J. Biol. Chem. ... Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2". Traffic. 8 (6): ... Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH (2002). "Phospholipase C gamma 1 is a ... 3 (1): 17-24. doi:10.1093/dnares/3.1.17. PMID 8724849. Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS (1997 ...
ADP-ribosylation factor regulates hPLD2". The Journal of Biological Chemistry. 273 (21): 12846-52. doi:10.1074/jbc.273.21.12846 ... "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor- ... "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor- ... 82 (1): 225-53. doi:10.1139/o03-079. PMID 15052340. Colley WC, Sung TC, Roll R, Jenco J, Hammond SM, Altshuller Y, et al. ( ...
ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of ... 22 (1): 88-93. doi:10.1006/geno.1994.1348. PMID 7959795. Ishii H, Kim DH, Fujita T, Endo Y, Saeki S, Yamamoto TT (Jul 1998). " ... 51 (1): 132-5. doi:10.1006/geno.1998.5339. PMID 9693042. v t e (Articles with short description, Short description matches ...
ADP-ribosylation factor 1 MeSH D12.776.543.990.300.300 - coatomer protein MeSH D12.776.543.990.400.100 - dynamin i MeSH D12.776 ... tumor necrosis factor, type i MeSH D12.776.543.750.705.852.760.798 - receptors, tumor necrosis factor, type ii MeSH D12.776. ... nerve growth factor MeSH D12.776.543.750.750.400.550.124 - glial cell line-derived neurotrophic factor receptors MeSH D12.776. ... platelet-derived growth factor alpha MeSH D12.776.543.750.750.400.630.400 - receptor, platelet-derived growth factor beta MeSH ...
1998). "β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor ... 1999). "G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain- ... 259 (1): 224-9. doi:10.1006/bbrc.1999.0758. PMID 10334944. Lazari MF, Liu X, Nakamura K, et al. (1999). "Role of G protein- ... 101 (1-2): 39-51. doi:10.1016/S0169-328X(02)00144-4. PMID 12007830. Portal: Biology v t e (Articles with short description, ...
ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, ... Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as ... Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene. This gene encodes poly(ADP-ribosyl) ... 2004). "Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function ...
In particular, the translocation of cytosolic ADP-ribosylation factor (ARF) to the plasma membrane is essential for PLD ... In animal cells, small protein factors are important additional regulators of PLD activity. These small monomeric GTPases are ... 1 (11): 789-800. PMID 14517341. Petersen EN, Gudheti M, Pavel MA, Murphy KR, William WJ, Jorgensen EM, Hansen SB (5 September ... 82 (1): 225-53. doi:10.1139/o03-079. PMID 15052340. Balboa MA, Firestein BL, Godson C, Bell KS, Insel PA (April 1994). "Protein ...
Shin OH, Exton JH (Aug 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and ... of rac1 specifies interaction with a subset of guanine nucleotide exchange factors". The Journal of Biological Chemistry. 276 ( ... 539 (1-3): 131-7. doi:10.1016/S0014-5793(03)00213-8. PMID 12650940. S2CID 27574424. Noda Y, Takeya R, Ohno S, Naito S, Ito T, ... 8 (1): 47-55. doi:10.1016/S0969-2126(00)00080-0. PMID 10673424. Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (Jan 1998 ...
"ARL14 ADP-ribosylation factor-like 14 [Homo sapiens (human)". Entrez Gene. "ARL14EP ADP-ribosylation factor-like 14 effector ... PSD4 as a guanine exchange factor, loads ARL14/ARF7 with GTP. Subsequently, ARF7EP interacts with MYO1E which binds itself to ... PSD4 (Pleckstrin and Sec7 Domain containing 4) is a GEF (Guanine nucleotide Exchange Factor) that loads ARL14/ARF7 with GTP. ... is due to mutations in the genes that code for transcription factors that regulate the expression of the MHC class II genes. It ...
BFA blocks the activation of some ADP-ribosylation factors (ARFs). ARFs are small GTPases which regulate vesicular trafficking ... BFA inhibits the function of several guanine nucleotide exchange factors (GEFs) that mediate GTP-binding of ARFs. Treatment of ... 44 (1): 56-72.e4. doi:10.1016/j.devcel.2017.12.014. PMC 5765772. PMID 29316441. Day KJ, Staehelin LA, Glick BS (September 2013 ... 13 (1): 316. Archived (PDF) from the original on 2018-04-07. Davidson MW (2004-12-13). "The Golgi Apparatus". Molecular ...
... a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proceedings of the National ... 521 (1-3): 140-4. doi:10.1016/S0014-5793(02)02858-2. PMID 12067742. S2CID 29467488. Portal: Biology v t e (Articles with short ... 275 (1): 390-7. doi:10.1074/jbc.275.1.390. PMID 10617630. Pronin AN, Morris AJ, Surguchov A, Benovic JL (Aug 2000). "Synucleins ... Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ (Jan 2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic ...
ADP-ribosylation-like factor 6 interacting protein 4 (ARL6IP4), also called SRp25 is the product of the ARL6IP4 gene located on ... However, due to sequence homology of its protein with SR splicing factors, it is widely believed that the protein is nuclear ... ADAR 1 and ADAR 2 are the only enzymatically active members. ADAR3 is thought to have a regulatory role in the brain. ADAR1 and ...
Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT (June 2002). "The association of ASAP1, an ADP ribosylation factor-GTPase ... "Entrez Gene: DDEF1 development and differentiation enhancing factor 1". Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, ... Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ASAP1 gene ... Furman C, Short SM, Subramanian RR, Zetter BR, Roberts TM (March 2002). "DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ...
ADP-ribosylation factor-like protein 8A is a protein that in humans is encoded by the ARL8A gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ARL8A ADP-ribosylation factor-like 8A". Human ARL8A genome location and ARL8A gene details page in the UCSC Genome ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 1, All stub articles, ...
It catalyzes the ADP ribosylation of the unusual amino acid diphthamide in eEF-2 by transferring the ADP-ribosyl group from ... C domain blocks protein synthesis by transfer of ADP-ribose from NAD to a diphthamide residue of eukaryotic elongation factor 2 ... The ADP ribosylation of diphthamide inactivates the eEF-2 protein, thus, inhibiting the translation of mRNA. The catalysed ... The A subunit ADP-ribosylates host eEF-2, which is required for protein synthesis; when it is inactivated, the host cannot make ...
"Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs)". EMBO J. 20 (22 ... AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene. This gene encodes a subunit of the ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. v t e (Articles with short description, Short description matches Wikidata, ... 402 (1): 57-61. doi:10.1016/S0014-5793(96)01500-1. PMID 9013859. S2CID 81844290. Dell'Angelica EC, Mullins C, Bonifacino JS ( ...
ADP-ribosylation of HMGB1 by PARP1 inhibits removal of apoptotic cells, thereby sustaining inflammation. TLR4 binding by HMGB1 ... HMGB1 is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released ... sustains ADP-ribosylation of HMGB1 by PARP1 thereby serving as an amplification loop for inflammation. HMGB1 has been proposed ... In the nucleus HMGB1 interacts with nucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA ...
"Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes". ... This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for ... Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic ... Peptide+Elongation+Factor+2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ...
"ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation". The ... including epidermal growth factor and transforming growth factor alpha (TGF-α). ErbB2 has no known direct activating ligand, ... "Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor". Biochemistry. ... interplay with the epidermal growth factor receptor". Growth Factors. 22 (2): 89-95. doi:10.1080/08977190410001700998. PMID ...
"Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs)". EMBO J. 20 (22 ... 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015. van der Weyden L, White JK, Adams DJ, Logan DW ( ... AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. The heterotetrameric adaptor protein ( ...
The life span of 13 mammalian species correlated with poly(ADP ribosyl)ation capability measured in mononuclear cells. ... An increase in cellular apoptosis may correlate to aging, but is not a 'cause of death'. Environmental factors and genetic ... ADP-ribosyl)ation capability than control cell lines from younger individuals. The cross-linking theory proposes that advanced ... Further support for the theory that DNA damage is the primary cause of aging comes from study of Poly ADP ribose polymerases ( ...
P. aeruginosa uses the virulence factor exotoxin A to inactivate eukaryotic elongation factor 2 via ADP-ribosylation in the ... An important factor found to be associated with antibiotic resistance is the decrease in the virulence capabilities of the ... Pyocyanin is a virulence factor of the bacteria and has been known to cause death in C. elegans by oxidative stress. However, ... Without elongation factor 2, eukaryotic cells cannot synthesize proteins and necrotise. The release of intracellular contents ...
ADP-ribosylation factor-like protein 8B is a protein that in humans is encoded by the ARL8B gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ARL8B ADP-ribosylation factor-like 8B". Human ARL8B genome location and ARL8B gene details page in the UCSC Genome ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. v t e (Articles with short description, Short description matches Wikidata, ...
August 2009). "Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler". Proceedings ... transcription factors, mediator complex and DNA loops in mammalian transcription). About 22% of transcription factors are ... ADP)-ribose polymerase) and its product poly(ADP)-ribose (PAR) accumulate at sites of DNA damage as part of the repair process ... Nuclear factor (NF)-κB inhibitor ε (NFKBIE) directly inhibits NF-κB1 activity and is significantly co-expressed with NF-κB1, ...