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*  Adoptive cell transfer
... (ACT) is the transfer of cells into a patient. The cells may have originated from the patient or from ... Adoptive Transfer at the US National Library of Medicine Medical Subject Headings (MeSH) Adoptive Immunotherapy at the US ... The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant ... Marcus A, Eshhar Z (2011). "Allogeneic adoptive cell transfer therapy as a potent universal treatment for cancer". Oncotarget. ...
*  Adoptive immunity
adoptive transfer adoptive immunization adoptive immunotherapy Adoptive cell therapy adoptive tolerance Rosenberg, SA; Restifo ... 2003). "Adoptive transfer." [Dictionary for Keywords in Molecular Biology and Immunology], 2nd ed. Tokyo: Igakushoin, Ltd., p. ... Transfer of cells are made between allogeneic hosts but the new host is irradiated for preventing rejection or GVHD. Transfer ... Transferred components are immune cells and autologous as above. Transfer of immune cells is made between different individuals ...
*  Cancer immunotherapy
Adoptive T-cell therapy is a form of passive immunization by the transfusion of T-cells (adoptive cell transfer). They are ... Another approach is adoptive transfer of haploidentical γδ T cells or NK cells from a healthy donor. The major advantage of ... "Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells". Journal of Translational Medicine. 12: 45. ... The first 2 adoptive T-cell therapies, tisagenlecleucel and axicabtagene ciloleucel, were approved by the FDA in 2017. ...
*  Experiments in immunology
For example, adoptive transfer is used to study the effects of lymphocytes in the absence of other lymphoid cells. Ionizing ... 2009). "Adoptive transfer of virus-specific and tumor-specific T cell immunity." Current Opinion in Immunology 21(2): 224-232. ... The body is thus prepared for restoration of immune function by adoptive transfer of new lymphocytes. Another method is ... hematopoietic stem-cell transfer, used for studying lymphocyte development. Hematopoietic cells are killed by ionizing ...
*  MHC multimer
2005). "Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide ... "Multimer technologies for detection and adoptive transfer of antigen-specific T cells". Cancer Immunol Immunother. 2010 (59): ... Uhlin; Okas M; Gertow J; Uzunel M; Brismar TB; Mattsson J. (2009). "A novel haplo-identical adoptive CTL therapy as a treatment ... 2009 a special dispensation was granted for a team to use them for isolating EBV-specific T cells for mother-daughter transfer ...
*  Mikael Pittet
"In vivo imaging of T cell delivery to tumors after adoptive transfer therapy". Proc Natl Acad Sci U S A. 104: 12457-12461. doi: ...
*  Intrastructural help
and was also verified for HIV in the mouse model by adoptive transfer experiments. Non-human primate experiments also indicate ... Thus, the approach has also transferred well for the treatment of hepatitis B and HIV. One of the approaches for a protective ...
*  IBA Lifesciences
"Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer". Nat Med. 8 (6 ...
*  Autologous immune enhancement therapy
May 1995). "Prolonged disease-free period in patients with advanced epithelial ovarian cancer after adoptive transfer of tumor- ... Adoptive Immuno cell therapy of cancer was first introduced by Steven Rosenberg and his colleagues of National Institute of ... September 2000). "Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial ... July 2003). "Tumor-localization by adoptively transferred, interleukin-2-activated NK cells leads to destruction of well- ...
*  Immunotherapy
Adoptive cell transfer in vitro cultivates autologous, extracted T cells for later transfusion. The T cells may already target ... Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME (April 2008). "Adoptive cell transfer: a clinical path to effective ... Adoptive cell transfer has been tested on lung and other cancers. Dendritic cells can be stimulated to activate a cytotoxic ... "Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma". J. ...
*  Marcel R.M. van den Brink
"Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation ... and adoptive cell therapy with precursor T cells and b) novel insights in the pathophysiology of graft-versus-host disease ( ...
*  Chimeric antigen receptor
Although adoptive transfer of CAR-modified T-cells is a unique and promising cancer therapeutic, there are significant safety ... A CAR therapy for cancer, using a technique called adoptive cell transfer, has been approved by the US Food and Drug ... Adoptive transfer of T cells expressing chimeric antigen receptors is a promising anti-cancer therapeutic as CAR-modified T ... Adoption of suicide gene therapy to the clinical application of CAR-modified T cell adoptive cell transfer has potential to ...
*  Tumor-infiltrating lymphocytes
The use of TILs as an adoptive cell transfer therapy to treat cancer was pioneered by Dr. Steven Rosenberg at the National ... "Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in ... "Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma". ... Lion Biotechnologies is developing adoptive cell transfer with TILs as a cancer therapy. Several centres are currently working ...
*  ALECSAT
Research on adoptive transfer in melanoma patients laid the groundwork for companies focusing on adoptive transfer research in ... In a study run at the University de la Sante, the adoptive transfer of cloned T cells in "in vitro immunization" caused ... "Adoptive transfer of tumor-reactive Melan-A-specific CTL clones in melanoma patients is followed by increased frequencies of ... The latter method is utilized for ALECSAT to treat cancer by adoptive T-cell immunotherapy. Refer to the adjacent diagram for a ...
*  Artificial antigen presenting cells
Activated and stimulated T cells can be studied in this biomimetic contex and used for adoptive transfer as an immunotherapy. ... These T cells can be then re-infused or adoptively transferred into the patient for effective cancer therapy. This technology ...
*  Cancer
Approaches include antibodies, checkpoint therapy and adoptive cell transfer. Laser therapy uses high-intensity light to treat ...
*  Freund's adjuvant
"Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice ...
*  Immunity (medical)
Passive or "adoptive transfer" of cell-mediated immunity, is conferred by the transfer of "sensitized" or activated T-cells ... Passive immunity is also provided through the transfer of IgA antibodies found in breast milk that are transferred to the gut ... This type of transfer differs from a bone marrow transplant, in which (undifferentiated) hematopoietic stem cells are ... In unmatched donors this type of transfer carries severe risks of graft versus host disease. It has, however, been used to ...
*  Streptamer
... and adoptive transfer of defined antigen specific T cell populations. This may now be realized as very effective therapeutic ... Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nature ... Second, the amount of d-biotin that might be transferred with Streptamer isolated T-cells are far lower than d-biotin ... expanded T cell lines or clones can be easily purified from contaminating cells or cell debris before transfer to clinical ...
*  Tumor antigens recognized by T lymphocytes
Adoptive transfer of TILs can increase the survival of melanoma patients when it is used as an adjuvant therapy, i.e. after a ... Adoptive transfer involves either collecting from patients intratumoral or blood T cells, stimulate them in vitro against ... Adoptive TIL transfer in the adjuvant setting for melanoma: long-term patient survival ". Journal of Immunology Research. 2014 ... but also the adoptive transfer of T cells that recognize these antigens. Finally, antibodies that increase the general activity ...
*  Epstein-Barr virus nuclear antigen 1
Adoptive ex vivo transfer of EBNA-1-specific T cells is a feasible and well-tolerated therapeutic option, however for optimal ... "Adoptive transfer of epstein-barr virus (EBV) nuclear antigen 1-specific t cells as treatment for EBV reactivation and ...
*  Nicholas P. Restifo
The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant ... adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory ... and his therapeutic approaches employ adoptive T cell transfer, gene modification and cellular reprogramming. Basic aspects of ... Thus Cish represents a new class of T-cell intrinsic immunologic checkpoints with the potential to radically enhance adoptive ...
*  Gene therapy
Tisagenlecleucel is an adoptive cell transfer therapy for B-cell acute lymphoblastic leukemia; T cells from a person with ... Baum C, Düllmann J, Li Z, Fehse B, Meyer J, Williams DA, von Kalle C (March 2003). "Side effects of retroviral gene transfer ... The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was ... The first attempt, an unsuccessful one, at gene therapy (as well as the first case of medical transfer of foreign genes into ...
*  CISH
The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant ...
*  Nicholas Chiorazzi
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease" Blood 117 ...
*  Ma Shaohong
... while Emperor Zhuangzong's adoptive brother Li Siyuan had recently launched a successful surprise attack against Later Liang's ... and therefore tried to resign the chief of staff post and have it transferred to Li Shaohong, but Emperor Zhuangzong did not ...