Daily rectal administration of progesterone is inconvenient and poorly accepted for long-term therapy. Nonetheless, rectal ... Hormone levels with rectal progesterone Progesterone levels with vaginal or rectal administration of a suppository containing ... Progesterone can be taken by rectal administration. A suppository sold under the brand name Cyclogest is indicated for rectal ... A number of studies have assessed progesterone by the rectal route. Levels of progesterone following rectal administration have ...

The Food and Drug Administration approved the vagus nerve stimulator in 1997 as a way to control seizures in some patients with ... Odeh M, Bassan H, Oliven A (February 1990). "Termination of intractable hiccups with digital rectal massage". Journal of ... epilepsy." Persistent digital rectal massage has also been proven effective in terminating intractable hiccups. There are many ...

"Low bioavailability of ergotamine tartrate after oral and rectal administration in migraine sufferers". British Journal of ... The low oral and rectal bioavailability is due to low gastrointestinal absorption and high first-pass metabolism. Ergotamine is ... "Approved Drug Products". FDA Orange Book (40th ed.). U.S. Food and Drug Administration. 2020. "CAFERGOT- ergotamine tartrate ... "Lists of: Scheduling Actions, Controlled Substances, Regulated Chemicals" (PDF). Drug Enforcement Administration, Diversion ...

Rectal use of lubricants is viewed by the agency as an off-label application.[citation needed] In 2012 it was reported that ... The US Food and Drug Administration (FDA) regulates lubricant as a medical device rather than as a cosmetic. Because of strict ... Enema nozzles and rectal thermometer tips should be lubricated before use to minimize friction while inserting through the ... As of December 2012, the U.S. Food & Drug Administration does not typically require testing of personal lubricants in humans.[ ...

Other non-invasive administration routes were investigated as a substitute for parenteral administration, reaching different ... van Laar T, Jansen EN, Neef C, Danhof M, Roos RA (July 1995). "Pharmacokinetics and clinical efficacy of rectal apomorphine in ... IV administration of apomorphine is highly discouraged, as it can crystallize in the veins and create a blood clot (thrombus) ... Toxicity depends on the route of administration; the LD50s in mice were 300 mg/kg for the oral route, 160 mg/kg for ...

For children less than six years old, if injected artesunate is not available the WHO recommends rectal administration of ... Therefore, it is typically administered via the digestive tract, either by oral or rectal administration. Artesunate however ... oral or rectal administration". Malaria Journal. 10 (1): 263. doi:10.1186/1475-2875-10-263. PMC 3180444. PMID 21914160. ... One derivative, SM934, was approved in 2015 by the Chinese National Medical Products Administration for a clinical trial as a ...

A suppository is a solid dosage form that fits for rectal administration. In hospice care, a specialized rectal catheter, ... Enteral/enteric administration usually includes oral (through the mouth) and rectal (into the rectum) administration, in the ... "Biopharmaceutics of rectal administration of drugs in man IX. Comparative biopharmaceutics of diazepam after single rectal, ... The rectal route is an effective route of administration for many medications, especially those used at the end of life. The ...

"Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects ... as a rectal suppository, or by injection into a muscle (IM). Common side effects of promethazine include confusion and ... Food and Drug Administration. 2013-08-15. "Promethazine". U.S. National Library of Medicine and National Institutes of Health ... approved by the US Food and Drug Administration (FDA), are deemed insufficient by state courts. On September 9, 2009, the FDA ...

In 2023, a Food and Drug Administration panel concluded that the drug was ineffective in tablet form. Phenylephrine is used as ... Hemorrhoids are caused by swollen veins in the rectal area. Phenylephrine can be used topically to prevent symptoms of ... "First Generic Drug Approvals 2023". U.S. Food and Drug Administration (FDA). 30 May 2023. Archived from the original on 30 June ... A common side effect during IV administration is reflex bradycardia. The low concentration eye drops do not cause blood ...

It has been studied for use by rectal administration in the treatment of prostate cancer in men as well. The medication was ... Rectal administration of estrogens in prostate carcinoma]. Minerva Urol (in Italian). 5 (1): 28-32. ISSN 0026-4989. PMID ...

... on the same date Nicolae Paulescu makes an apparently successful rectal administration of an insulin preparation. English ...

Rectal administration is an off-label use of vancomycin for the treatment of Clostridium difficile infection. Plasma level ... In the United States, vancomycin is approved by the Food and Drug Administration for either intravenous or oral administration ... Following oral administration, the fecal concentration of vancomycin is around 500 µg/mL (sensitive strains of Clostridium ... Importantly, the risk of AKI increases with co-administration of other known nephrotoxins, in particular, aminoglycosides. ...

Food and Drug Administration. 17 November 2010. Archived from the original on 27 February 2014. Retrieved 24 January 2014. ... Graham JR (June 1954). "Rectal use of ergotamine tartrate and caffeine alkaloid for the relief of migraine". The New England ... "CFR - Code of Federal Regulations Title 21". U.S. Food and Drug Administration. 21 August 2015. Archived from the original on ... In particular, the United States Food and Drug Administration has classified caffeine added to malt liquor beverages as an " ...

... has been available in oral, rectal, and injectable formulations, with bioavailability above 97% after oral ... administration. Many related compounds are known, although only propiram was ever commercialized. The addition of a 4-phenyl ...

The routes of administration include sublingual, oral, vaginal, and rectal with greatest efficacy from sublingual and vaginal ... Ergometrine has a relatively quick onset of action following intravenous administration (one minute) with the duration of ... administration. Vaginally administered misoprostol had improved outcomes of inducing labor within twenty four hours compared to ... action averaging 45 minutes (rhythmic contracts will persist for up to 3 hours following administration). Methylergonovine, a ...

It is well-known that other methods of administration include transdermal (skin lotion) as well as rectal suppositories. ...

Arend Langenberg, 63, Dutch voice-over and radio presenter, rectal cancer. Rita Levi-Montalcini, 103, Italian neurologist and ... Sonam Topgyal, 71, Tibetan politician, Kalön Tripa (Prime Minister) of the Central Tibetan Administration (1997-2001), stomach ... "Canadian Soccer League Powered by Goalline Sports Administration Software". www.canadiansoccerleague.ca. Archived from the ...

Due to its poor lipid solubility, lorazepam is absorbed relatively slowly by mouth and is unsuitable for rectal administration ... There is no evidence of accumulation of lorazepam on administration up to six months. On regular administration, diazepam will ... On regular administration, maximum serum levels are attained after three days. Longer-term use, up to six months, does not ... In September 2020, the U.S. Food and Drug Administration (FDA) required the boxed warning be updated for all benzodiazepine ...

Rectal administration in monkeys doubled bioavailability to 13.5% and achieved peak blood concentrations within 1 to 8 hours ... However, oral administration of CBD has a faster time to peak concentrations (2 hours) than THC. Due to the poor ... Smoking has been the means of administration of cannabis for many users, but it is not suitable for the use of cannabis as a ... Sublingual administration in rabbits yielded bioavailability of 16% and time to peak concentration of 4 hours. ...

Its rectal use was particularly favored for pediatrics, head or neck surgery, or in mentally unstable or anxious patients. ... Avertin was also used in humans as a general anesthetic or basal narcotic to induce unconsciousness prior to the administration ...

There have been reports of mistreatment in detention such as beatings, and forced rectal examinations,: 479 amounting to ... Involuntary medical and psychological "treatments", including administration of hormonal therapies, and detention for forced ...

"Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 ... Maloney N, Vargas HD (May 2005). "Acute intestinal pseudo-obstruction (Ogilvie's syndrome)". Clinics in Colon and Rectal ...

The rectal route of administration is highly effective as the rectal mucosa is highly vascularized tissue that allows for rapid ... The rectal route of administration is highly effective as the rectal mucosa is highly vascularized tissue that allows for rapid ... "Biophamacutics of rectal administration of drugs in man IX. Comparative biopharmaceutics of diazepam after single rectal, oral ... "Biophamacutics of rectal administration of drugs in man IX. Comparative biopharmaceutics of diazepam after single rectal, oral ...

2015). "Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A ... This route of administration is beneficial for mucosal administration and transmucosal administration. Buccal tablets are ... Sublabial administration Sublingual administration Route of administration Pharmacology Sattar, M; Sayed, OM; Lane, ME (Aug ... Buccal administration is a topical route of administration by which drugs held or applied in the buccal (/ˈbʌkəl/) area (in the ...

Routes of administration that progesterone has been used by include oral, intranasal, transdermal/topical, vaginal, rectal, ... A progesterone suppository which is marketed under the brand name Cyclogest is indicated for rectal administration in addition ... Rectal progesterone suppositories were first studied in men and women by Christian Hamburger in 1965. Vaginal and rectal ... Administration of as much as 500 mg progesterone by intravenous infusion in humans was uneventful in terms of toxicity, but did ...

Nasal, rectal, inhalation and smoking are safer. The oral route is one of the safest and most comfortable, but of little ... This route of administration is activated when chewing some forms of smokeless tobacco (e.g. dipping tobacco, snus). ... Drugs are often associated with a particular route of administration. Many drugs can be consumed in more than one way. For ... The "zero tolerance" climate of the Reagan and Bush administrations (1981-93) resulted in passage of strict laws and mandatory ...

The bioavailability of oral administration of oxycodone averages within a range of 60 to 87%, with rectal administration ... Therapeutic Goods Administration (June 2008). Standard for the uniform scheduling of drugs and poisons no. 23 (PDF). Canberra: ... When first introduced in Germany during World War I, both IV and IM administrations of oxycodone were commonly used for ... Drug Enforcerment Administration. Archived from the original on 21 November 2015. Retrieved 23 November 2015. "DEA Diversion ...

Rectal injection of either alcohol or a saline solution was used to ensure the participant did not know if he was being ... and because it was believed that alcohol would be absorbed more quickly into the bloodstream than by oral administration. In ... In the third study, Miles collaborated with T. M. Carpenter to examine the effects of alcohol administered via rectal injection ...

This requires administration of intravenous fluids and antibiotics. The transmission of cholera is closely linked to inadequate ... Cholera is diagnosed through a stool test or rectal swab, and today treatment takes the form of an oral rehydration solution ( ... Questions have been raised alluding to newer drugs, and whether the administration of these will be more useful than such ... health workers who were against the administration of the cholera vaccine based their opinion on the view that always limited ...

The CBD drug Epidiolex has been approved by the Food and Drug Administration for treatment of two rare and severe forms of ... or rectal suppository. Once in the body, most cannabinoids are metabolized in the liver, especially by cytochrome P450 mixed- ... Nabiximols (brand name Sativex) is an aerosolized mist for oral administration containing a near 1:1 ratio of CBD and THC. Also ... Some cannabis metabolites can be detected in the body several weeks after administration. These metabolites are the chemicals ...