... brown adipose tissue, white adipose tissue, placenta, macrophages, and demonstrated additional roles in diabetes and cancer. ... "Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge". Nature. 546 (7659): 544-548. Bibcode: ... The contributions of individual ERRs to physiology continue to be elucidated through the generation of sophisticated tissue- ... "ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes". Obesity. 21 (3): 516-24. doi:10.1002/oby.20067. ...
The second is non-shivering, which occurs in brown adipose tissue. Population studies have shown that the San tribe of Southern ... Brown, Douglas J. A.; Brugger, Hermann; Boyd, Jeff; Paal, Peter (2012-11-15). "Accidental Hypothermia". The New England Journal ...
Klingenberg M (March 1990). "Mechanism and evolution of the uncoupling protein of brown adipose tissue". Trends in Biochemical ...
Many studies support that the orexin neurons regulate brown adipose tissue (BAT) activity via the sympathetic nervous system to ... Although orexin knockout mice were reported to show maldevelopment of brown adipose tissue (BAT), subsequent report has shown ... Sellayah D, Bharaj P, Sikder D (October 2011). "Orexin is required for brown adipose tissue development, differentiation, and ... "An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis". ...
It functions in the differentiation between white and brown adipose tissue. It can also be a repressor of transforming growth ...
Notable papers: Mrosovsky, N. (1962). "Changes in multilocular brown adipose tissue in the rat following hypothermia." Nature ...
... and brown adipose tissue thermogenesis. It was recently identified as an important regulator of the mammalian circadian clock, ... brown adipose tissue, cerebellum, intestine, and skeletal muscle. Recently, ERRα has been detected in normal adrenal cortex ... "Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge". Nature. 546 (7659): 544-548. Bibcode: ... ERRα has wide tissue distribution but it is most highly expressed in tissues that preferentially use fatty acids as energy ...
... is produced primarily in the adipocytes of white adipose tissue. It also is produced by brown adipose tissue, placenta ( ... both of adipose tissues, as well as of the cartilage and other joint tissues. Alterations in these factors can be the ... Lönnqvist F, Arner P, Nordfors L, Schalling M (September 1995). "Overexpression of the obese (ob) gene in adipose tissue of ... This metabolic component related with the release of systemic factors, of a pro-inflammatory nature, by the adipose tissues, ...
"BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions". Cell. 149 (4): 871-85. doi: ... activation of thermogenesis in adipose tissue, molecular mechanisms controlling energy expenditure and brown fat activation, ... Novel concepts worked on by Vidal-Puig include: Adipose tissue expandability hypothesis. The concept was advanced by him in ... According to the hypothesis, the expansion of adipose tissue (AT) is a normal phenomenon when an individual undergoes sustained ...
... recently been found to augment the conversion of white adipose tissue to brown adipose tissue as well as increase brown adipose ... "Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning". The Journal of Experimental ...
BMPs are also involved in adipogenesis and functional regulation of adipose tissue. BMP4 favors white adipogenesis, whereas ... BMP7 activates brown fat functionality; BMP inhibitors are also involved in this regulation Originally, seven such proteins ... Bone morphogenetic protein signaling in adipose tissue". Obesity Reviews. 20 (5): 648-658. doi:10.1111/obr.12822. ISSN 1467- ... There are reports of this therapy causing swelling of soft tissue which in turn can cause life-threatening complications due to ...
Vagal activation also controls the generation of lipids in brown adipose tissue. Insulin. Vagal innervation of the pancreas ... and brown adipose tissue nonshivering thermogenesis. This regulation occurs through the sympathetic and parasympathetic system ... "Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue". AJP: Regulatory, ... from the rostral raphe pallidus to the spinal intermediolateral nucleus nonshivering thermogenesis by brown adipose tissue. ...
... until high GPD1 and GPD2 activity were demonstrated in mammalian brown adipose tissue and pancreatic ß-islets. In this shuttle ... "Glycerol-3-phosphate shuttle and its function in intermediate metabolism of hamster brown-adipose tissue". European Journal of ... "Unusually high mitochondrial alpha glycerophosphate dehydrogenase activity in rat brown adipose tissue". The Journal of Cell ... Koza RA, Kozak UC, Brown LJ, Leiter EH, MacDonald MJ, Kozak LP (December 1996). "Sequence and tissue-dependent RNA expression ...
... and in brown adipose tissue. Their role in gallbladder physiology is unknown, but they are thought to play a role in lipolysis ... Thermogenesis in skeletal muscle It is located mainly in adipose tissue and is involved in the regulation of lipolysis and ... Actions of the β3 receptor include Enhancement of lipolysis in adipose tissue. ... adiponectin receptors and tumor necrosis factor-alpha expressions in adipose tissues of obese diabetic KKAy mice". European ...
"Hibernation activates glyoxylate cycle and gluconeogenesis in black bear brown adipose tissue". Biochimica et Biophysica Acta ( ... While the DNA has been expressed in some tissues, including the liver and small intestine in test animals, the level of ... in some animal tissue has raised questions regarding the evolutionary relationship of enzymes in bacteria and animals and ... some studies show evidence of components of the glyoxylate cycle existing in significant amounts in the liver tissue of ...
"The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue". Biochimica et Biophysica Acta (BBA) - ... an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". ... UCP1 is highly expressed in brown adipocytes, UCP2 is variably expressed in many different tissues, and UCP3 is expressed ... Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I, Garvey WT (October 1998). "Effects of ...
2006). "Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory ... Brown SA, Hanscom HN, Vu H, et al. (2006). "TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located ... Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, ...
"BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality". PLOS ONE. 8 (9): e74083. ... BMP7 not only stimulates brown adipogenesis, it also stimulates the "browning" of brite or beige adipocytes, turning them from ... The epithelial tissue emerging from this MET process eventually forms the tubules and glomeruli of the nephron. BMP-7 is also ... Brown A, Stock G, Patel AA, Okafor C, Vaccaro A (2006). "Osteogenic protein-1 : a review of its utility in spinal applications ...
Thermogenin is primarily found in brown adipose tissue, or brown fat, and is responsible for non-shivering thermogenesis. Brown ... In humans, brown adipose tissue is present at birth and decreases with age. Mitochondrial fatty acid synthesis (mtFASII) is ... adipose tissue is found in mammals, and is at its highest levels in early life and in hibernating animals. ... Tissues from elderly humans show a decrease in enzymatic activity of the proteins of the respiratory chain. However, mutated ...
Alexson SE, Svensson LT, Nedergaard J (1989). "NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of ...
5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats". PLOS ONE. 10 (2): e0116498. Bibcode: ... It has agonistic (thyromimetic) effects at myocardial tissue and pituitary, which results in 3,5-T2 suppressing TSH release. 3, ... causes central hypothyroidism and stimulates thyroid-sensitive tissues". The Journal of Endocrinology. 221 (3): 415-27. doi: ...
Hutchinson defended adipose tissue against the viewpoint that it was a health risk. He commented that adipose "is really a most ... He disliked brown bread, especially Graham bread because he believed they were less nourishing than white bread and irritable ... harmless, healthful, innocent tissue." He argued against fashion and trends in which young women wanted to be thin and wrote ...
Alexson SE, Nedergaard J (1988). "A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue ... Alexson SE, Svensson LT, Nedergaard J (1989). "NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of ...
"Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance". Nat. Med. 21: 159-65. doi: ... Intestinal tissue-specific actions of fexaramine were suggested to be a possible new approach for the treatment of obesity and ...
... but not brown, adipose tissue". Proceedings of the National Academy of Sciences of the United States of America. 98 (22): 12532 ... show abnormal adipose tissue formation. Moreover, ectopic expression of C/EBPα in various fibroblast cell lines promotes ... Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells ... For example, mice lacking C/EBPα in all tissues except the liver (where it is needed to avoid postnatal lethality) ...
"Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue". American Journal of ...
"FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271-281. ... "Development of obesity in transgenic mice after genetic ablation of brown adipose tissue". Nature. 366 (6457): 740-2. Bibcode: ... Cited 2993 times, June 2022 Kershaw, Erin E.; Flier, Jeffrey S. (2004-06). "Adipose tissue as an endocrine organ". The Journal ... Much of his research has addressed the pathophysiology of obesity; In 1993, he described the dynamics of obesity in a brown-fat ...
Irisin promotes conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) by increasing UCP1 expression. A 2016 in ... May 2019). "Fndc5 loss-of-function attenuates exercise-induced browning of white adipose tissue in mice". The FASEB Journal. 33 ... June 2020). "Impacts of rat hindlimb Fndc5/irisin overexpression on muscle and adipose tissue metabolism". American Journal of ... of white and brown fat cell tissue found dose-related upregulation of a protein called UCP1 that contributes to the browning of ...
"FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271-281. ... "FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271-281. ...
The eyes are extremely reduced, and are embedded in a mass of adipose tissue. Extrinsic eye muscles are absent, and the ... the brown bullhead (Ameiurus nebulosus) and the Redeye Chub (Notropis harperi) are also likely predators. ...