Loading...
*  Lifestyle causes of diabetes mellitus type 2
The obese therefore may have higher level of RBP4 but lower level of adiponectin, both of which increase the risk of developing ... Fat cells also secrete adiponectin which acts in an opposite way to RBP4 by improving the action of insulin, however, engorged ... adiponectin". Journal of Clinical Endocrinology & Metabolism. 86 (8): 3815-3819. doi:10.1210/jcem.86.8.7741. PMID 11502817. ...
*  Adiponectin
... is a 244-amino-acid-long polypeptide (protein). There are four distinct regions of adiponectin. The first is a ... Adiponectin is apparently able to cross the blood-brain-barrier. However, conflicting data on this issue exist. Adiponectin has ... Adiponectin in combination with leptin has been shown to completely reverse insulin resistance in mice. Adiponectin is secreted ... Adiponectin automatically self-associates into larger structures. Initially, three adiponectin molecules bind together to form ...
*  Adiponectin receptor
... which are bound and activated by adiponectin: Adiponectin receptor 1 (AdipoR1, PAQR1) Adiponectin receptor 2 (AdipoR2, PAQR2) ... The adiponectin receptors (AdipoRs) include the following two receptors, ...
*  Adiponectin receptor 1
Adiponectin ADP-355 ADP-399 AdipoRon (-)-Arctigenin Arctiin Gramine Matairesinol ADP-400 Adiponectin receptor Adiponectin ... The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate ... "Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order ... "The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in ...
*  Adiponectin receptor 2
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate ... Adiponectin ADP-355 ADP-399 AdipoRon Deoxyschizandrin Parthenolide Syringing Taxifoliol ADP-400 Adiponectin receptor ... Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene. It is a member of the progestin ... Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ...
*  List of OMIM disorder codes
ADSL Adiponectin deficiency; 612556; ADIPOQ Adrenal cortical carcinoma; 202300; TP53 Adrenal hyperplasia, congenital, due to 11 ...
*  AdipoRon
... small-molecule agonist of the adiponectin receptors to be identified. Adiponectin receptor agonists such as AdipoRon have ... Dysregulation of adiponectin expression has also been implicated in the pathology of mood disorders, anxiety disorders, eating ... As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. ... In addition, adiponectin has recently been elucidated to mediate the antidepressant, anxiolytic, and neurogenic effects of ...
*  RAB11FIP1
... has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the ... RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte ... potentially contributing to lower circulating levels of adiponectin observed in obese populations. RAB11FIP1 has been shown to ... "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLoS ONE. 8 (9): e74687. doi:10.1371/journal.pone.0074687. PMC 3770573 ...
*  TFAP2B
A negative regulator of adiponectin gene expression". J. Biol. Chem. 281 (42): 31245-53. doi:10.1074/jbc.M605132200. PMID ...
*  SOGA2
October 2010). "Adiponectin lowers glucose production by increasing SOGA". Am. J. Pathol. 177 (4): 1936-45. doi:10.2353/ajpath. ...
*  Brown adipose tissue
... and they have higher circulating adiponectin, suggesting a link between longevity and adiponectin production In addition, high ... Brown adipose tissue activation through cold exposure increases adiponectin levels, just two hours of cold exposure resulted in ... Centenarians (both men and women) and their offspring have been found to have genetics that boost adiponectin, ... Imbeault, Pascal; Dépault, Isabelle; Haman, François (2009-04-01). "Cold exposure increases adiponectin levels in men". ...
*  Silent stroke
Adiponectin: is a type of protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic ... Lower levels of s-adiponectin are associated with ischemic stroke. Aging: the prevalence of silent stroke rises with increasing ... Bang, OY; Saver, JL; Ovbiagele, B; Choi, YJ; Yoon, SR; Lee, KH (2007). "Adiponectin levels in patients with intracranial ...
*  Resistin
Stumvoll M, Häring H (November 2002). "Resistin and adiponectin--of mice and men". Obes. Res. 10 (11): 1197-9. doi:10.1038/oby. ... Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ (October 2003). "Plasma resistin, adiponectin and leptin levels ... Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME (April 2004). "Adiponectin differentially regulates ... "Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss". Obes. Res. 10 (11): 1095-103. doi: ...
*  Caloric restriction mimetic
Adiponectin (together with leptin, it regulates adipose tissue metabolism. It is activated by PPAR inhibitors such as ... It also blocks the beneficial actions of adiponectin. Rimonabant inhibits these and so it reduces appetite, balances energy, ... and increases adiponectin, which reduces intra-abdominal fat. It improves lipid profile, glucose tolerance, and waist ...
*  Maternal effect
Adiponectin has also been shown to increase the rate of fatty acid transport and oxidation in mice, which causes an increase in ... The adiponectin genes regulate glucose metabolism as well as fatty acid breakdown; however, the exact mechanisms are not ... Therefore, there was less adiponectin to help cells take up glucose and break down fat, as well as less leptin to cause a ... With a high fat diet during gestation, there was an increase in methylation in the promoter of the adiponectin gene accompanied ...
*  DNA Patterns
"An evolutionary perspective on adiponectin and insulin gene promoters". Adipobiology. 4: 111-115. Gagniuc, Paul; et al. "DNA ...
*  G protein-coupled receptor
Similar to GPCRs, the adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) also possess 7 transmembrane domains. However, ... "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762-9. doi:10.1038/ ...
*  Marrow adipose tissue
WAT is also the source of adipokines and inflammatory markers which have both positive (e.g., adiponectin) and negative effects ... Recently, MAT was noted to "produce a greater proportion of adiponectin - an adipokine associated with improved metabolism - ... Ye, Risheng; Scherer, Philipp E. (2013-04-19). "Adiponectin, driver or passenger on the road to insulin sensitivity?". ... "Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric ...
*  Orexin
It also inhibits lipolysis and stimulates the secretion of adiponectin. These effects are thought to be mostly conferred via ... lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes". Diabetologia. 54 (7 ...
*  ATF3
"Essential role of mitochondrial function in adiponectin synthesis in adipocytes". Diabetes. 56 (12): 2973-81. doi:10.2337/db07- ...
*  Abdominal obesity
But adiponectin which is found in lower concentration in obese and diabetic individuals has shown to be beneficial and ... Ghoshal, Kakali (2015). "Adiponectin: Probe of the molecular paradigm associating diabetes and obesity". World Journal of ... Vendrell J, Broch M, Vilarrasa N, Molina A, Gomez JM, Gutierrez C, Simon I, Soler J, Richart C (2004). "Resistin, adiponectin, ... Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ (2003). "Plasma resistin, adiponectin and leptin levels in lean ...
*  Maitree Bhattacharyya
Ghoshal, K; Bhattacharyya, M (2015). "Adiponectin: Probe of the molecular paradigm associating diabetes and obesity". World J ...
*  Peptides (journal)
... and adiponectin". Peptides. 27 (4): 911-6. doi:10.1016/j.peptides.2005.12.014. PMID 16476508. Steckelings, U; Kaschina, E; ...
*  Adipose-derived hormones
Like leptin, observations in both humans and animal models have shown that adiponectin is relevant to insulin sensitivity and ... Research into the adipose-derived hormones adiponectin and resistin is ongoing. Like leptin, these hormones also affect energy ... Adipose tissue is an endocrine organ that secretes numerous protein hormones, including leptin, adiponectin, and resistin. ...
*  APPL1
"APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function". Nature Cell Biology. 8 (5): 516-23. doi ... Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A (May 2007). "Adiponectin-induced endothelial nitric oxide ...