Levonantradol
Howlett AC, Johnson MR, Melvin LS, Milne GM (March 1988). "Nonclassical cannabinoid analgetics inhibit adenylate cyclase: ... GPCRs modulate the inhibition of adenylyl cyclase and accumulation of the second messenger, cyclic adenosine monophosphate ( ...
Beta-adrenergic agonist
The activation of β1, β2 and β3 activates the enzyme, adenylate cyclase. This, in turn, leads to the activation of the ... β1 agonists stimulate adenylyl cyclase activity and opening of calcium channel (cardiac stimulants; used to treat cardiogenic ... Prenalterol Xamoterol β2 agonists stimulate adenylyl cyclase activity and closing of calcium channel (smooth muscle relaxants; ...
Dopamine receptor D1
I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase". The Journal of Pharmacology and ...
RTX toxin
Adenylate cyclase toxin (ACT or CyaA), is a primary virulence factor in Bordetella pertussis. CyaA is a multifunctional RTX ... The C-terminal domain of the adenylate cyclase toxin (ACT or CyaA; TC# 1.C.11.1.4) of Bordetella pertussis forms a small cation ... However, mutations in residues in an amphipathic α-helix (Glu509 and Glu516) in the pore-forming domain block adenylate cyclase ... Bumba, Ladislav; Jiri Masin; Radovan Fiser; Peter Sebo (2010). "Bordetella Adenylate Cyclase Toxin Mobilizes Its b2 Integrin ...
Slendertail lanternshark
As ACTH increases, cAMP levels indirectly increase which stimulates adenylate cyclase activity. When MT was injected, cAMP ...
Adenosine receptor
This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts ... is mediated by G proteins that activate adenylyl cyclase. It is abundant in basal ganglia, vasculature and platelets and it is ...
Adrenergic agonist
The G-protein receptor can affect the function of adenylate cyclase or phospholipase C, an agonist of the receptor will ... β receptors activate adenylate cyclase (via Gs), thus increasing the activity of PKA. Agonists of each class of receptor elicit ... α2 receptors inhibit adenylate cyclase (via Gi), decreasing the activity of protein kinase A (PKA); ...
Neuregulin 3
Lefkowitz RJ (September 1975). "Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta- ...
LSD
Green JP, Johnson CL, Weinstein H, Maayani S (December 1977). "Antagonism of histamine-activated adenylate cyclase in brain by ...
Protein-protein interaction
Battesti A, Bouveret E (December 2012). "The bacterial two-hybrid system based on adenylate cyclase reconstitution in ...
Psychosis
The increased adenylate cyclase activity affects genetic expression in the nerve cell, which takes time. Hence antipsychotic ... While dopamine receptor D2 suppresses adenylate cyclase activity, the D1 receptor increases it. If D2-blocking drugs are ...
Glucagon (medication)
The alpha subunit specifically activates the next enzyme in the cascade, adenylate cyclase. Adenylate cyclase manufactures ...
Dihydroalprenolol
possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase". The Journal of ... When 3H-dihydroalprenolol bound to beta-adrenoceptors, putrescine resulted in increased adenylyl cyclase activity, consequently ...
Methods to investigate protein-protein interactions
"The bacterial two-hybrid system based on adenylate cyclase reconstitution in Escherichia coli". Methods. 58 (4): 325-34. doi: ...
Glucagon
The alpha subunit specifically activates the next enzyme in the cascade, adenylate cyclase. Adenylate cyclase manufactures ... Gαs separates from Gβ𝛾 and interacts with the transmembrane protein adenylyl cyclase. Adenylyl cyclase catalyzes the conversion ...
George H. Dodd
Shirley, S G; Robinson, C J; Dickinson, K; Aujla, R; Dodd, G H (1986). "Olfactory adenylate-cyclase of the rat: stimulation by ...
Nicholas Lydon
Lydon, Nicholas B. (1982). Studies on the hormone-sensitive adenylate cyclase from bovine corpus luteum (PhD thesis). ...
Moscow International Medical Cluster
R. J. Lefkowitz (1975). "Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta- ...
Adenosine A2B receptor
This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts ... signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase". The Journal ...
Protein-ligand complex
The alpha subunit-GTP complex dissociates from the beta and gamma dimer and interacts with adenylate cyclase. Binding of ... Then, the alpha subunit activates the adenylate cyclase, which converts ATP to cAMP. The alpha subunit deactivates itself ...
Prostaglandin D2 receptor
Adenylate cyclase then catalyzes the change from ATP to cyclic AMP, or cAMP. The result of the PDG2 receptor signaling pathway ... Activation of the Gs alpha subunit prompts activation of the enzyme adenylate cyclase, which is located on the cell membrane. ...
Alpha-2A adrenergic receptor
Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation". The Journal of ...
Dinoxyline
Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). "Differential activation of adenylate cyclase and receptor ...
Smooth muscle
Nitric oxide and PGI2 stimulate soluble guanylate cyclase and membrane bound adenylate cyclase, respectively. The cyclic ... adenylate cyclase, phospholipase C), G proteins (RhoA, G alpha), kinases (rho kinase-ROCK, protein kinase C, protein Kinase A ... nucleotides (cGMP and cAMP) produced by these cyclases activate Protein Kinase G and Protein Kinase A and phosphorylate a ...
Oxyphenisatine
The Role of Adenylate Cyclase and Mucosal Permeability". Digestion. 30 (3): 191-194. doi:10.1159/000199105. PMID 6548720. Kotha ...
5-HT7 receptor
Gs in turn activates adenylate cyclase which increases intracellular levels of the second messenger cAMP. The 5-HT7 receptor ... positively linked to adenylate cyclase". The Journal of Biological Chemistry. 268 (31): 23422-6. doi:10.1016/S0021-9258(19) ...
Bradykinin receptor B2
Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the ...
RIC8A
2007). "Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor". Biochem J. 406 (3): 383-8. doi: ...
Cholera toxin
Subunit B binds while subunit A activates the G protein which activates adenylate cyclase. The three-dimensional structure of ... Increased Gαs activation leads to increased adenylate cyclase activity, which increases the intracellular concentration of 3',5 ...
Naphthylpiperazine
... positively linked to adenylate cyclase". The Journal of Biological Chemistry. 268 (31): 23422-6. doi:10.1016/S0021-9258(19) ... a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences ...