"Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme ... Antibodies against adenylate cyclase toxin are also present in the serum of humans infected with B. pertussis. Adenylate ... Genetically detoxified adenylate cyclase toxin also serves in promoting the Th1/Th17 response, acting as an adjuvant. Adenylate ... also produce adenylate cyclase toxin. It is a toxin secreted by the bacteria to influence the host immune system. Adenylate ...

... is an adenylate cyclase produced by Bordetella pertussis. Kessin RH, Franke J (April 1986). " ... Ladant D, Brezin C, Alonso JM, Crenon I, Guiso N (December 1986). "Bordetella pertussis adenylate cyclase. Purification, ... "Secreted adenylate cyclase of Bordetella pertussis: calmodulin requirements and partial purification of two forms". J. ...

... has been shown to interact with secretin receptor. Adenylate cyclase Pituitary ... This gene encodes adenylate cyclase-activating polypeptide 1. Mediated by adenylate cyclase-activating polypeptide 1 receptors ... Both isoforms of pituitary adenylate cyclase-activating polypeptide (pituitary adenylate cyclase-activating polypeptide-38 and ... this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. Adenylate cyclase- ...

"Entrez Gene: ADCY2 adenylyl cyclase 2 (brain)". "Adenylate cyclase type 2". UniProt Consortium. Retrieved 28 May 2014. Stengel ... It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 ... "Adenylate Cyclase 2 (Brain)". Weizmann Institute of Science. Retrieved 28 May 2014. Xu W, Cohen-Woods S, Chen Q, Noor A, Knight ... Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase ...

Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with ... Wikimedia Commons has media related to Adenylate cyclase. Adenylyl Cyclases at the U.S. National Library of Medicine Medical ... Interactive 3D views of Adenylate cyclase at Proteopedia Adenylyl_cyclase Portal: Biology (Articles with short description, ... Cotta MA, Whitehead TR, Wheeler MB (July 1998). "Identification of a novel adenylate cyclase in the ruminal anaerobe, ...

Haga, T; Ross, EM; Anderson, HJ; Gilman, AG (1977). "Adenylate cyclase permanently uncoupled from hormone receptors in a novel ... Haga, T; Haga, K; Gilman, AG (1977). "Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild ... Gilman, AG (1984). "G proteins and dual control of adenylate cyclase". Cell. 36 (3): 577-9. doi:10.1016/0092-8674(84)90336-2. ... Sternweis, PC; Northup, JK; Smigel, MD; Gilman, AG (1981). "The regulatory component of adenylate cyclase. Purification and ...

"Entrez Gene: ADCY3 adenylate cyclase 3". "Gene Cards: ADCY3 Gene". Retrieved 2012-12-30. Human ADCY3 genome location and ADCY3 ... Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase ... Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene. This gene encodes adenylyl cyclase 3, which ... Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J (Jul 1994). "Chromosomal mapping of human adenylyl cyclase genes ...

"Entrez Gene: ADCY6 adenylate cyclase 6". Human ADCY6 genome location and ADCY6 gene details page in the UCSC Genome Browser. ... 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 ... Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene. This gene encodes adenylyl cyclase 6, which ... 1998). "Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity ...

"Entrez Gene: ADCY4 adenylate cyclase 4". Human ADCY4 genome location and ADCY4 gene details page in the UCSC Genome Browser. ... 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 ... along with adenylyl cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylyl cyclases may ... Adenylyl cyclase type 4 is an enzyme that in humans is encoded by the ADCY4 gene. This gene encodes a member of the family of ...

"Entrez Gene: ADCY9 adenylate cyclase 9". Human ADCY9 genome location and ADCY9 gene details page in the UCSC Genome Browser. ... 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 ... Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene. Adenylyl cyclase is a membrane bound enzyme ... Cumbay MG, Watts VJ (2004). "Novel regulatory properties of human type 9 adenylate cyclase". J. Pharmacol. Exp. Ther. 310 (1): ...

"Entrez Gene: ADCY7 adenylate cyclase 7". Human ADCY7 genome location and ADCY7 gene details page in the UCSC Genome Browser. ... 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 ... The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by ... Yan SZ, Tang WJ (2002). "Construction of Soluble Adenylyl Cyclase from Human Membrane-Bound Type 7 Adenylyl Cyclase". G Protein ...

"Entrez Gene: ADCY5 adenylate cyclase 5". Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (May 2003). "Identification of RGS2 and ... Wang SC, Lai HL, Chiu YT, Ou R, Huang CL, Chern Y (2007). "Regulation of type V adenylate cyclase by Ric8a, a guanine ... Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (1999). "Involvement of adenylate cyclase and p70(S6)-kinase ... Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene. ADCY5 has been shown to interact with RGS2. ...

Adenylate cyclase activity is unaffected by ras. Goodsell DS (1999). "The molecular perspective: the ras oncogene". The ... Other small GTPases may bind adaptors such as arfaptin or second messenger systems such as adenylyl cyclase. The Ras binding ...

"Entrez Gene: ADCY8 adenylate cyclase 8 (brain)". Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome ... Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase ... Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene. Adenylyl cyclase is a membrane bound enzyme ... Parma J, Stengel D, Gannage MH, Poyard M, Barouki R, Hanoune J (Aug 1991). "Sequence of a human brain adenylyl cyclase partial ...

Brandt DR, Ross EM (January 1985). "GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs ... "Purification of the regulatory component of adenylate cyclase". Proceedings of the National Academy of Sciences of the United ... individual subunits of the G protein complex were first identified in 1980 when the regulatory component of adenylate cyclase ... Tang WJ, Gilman AG (December 1991). "Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits". Science. ...

Another toxin that inhibits the immune response is the adenylate cyclase toxin. This toxin has an intrinsic adenylate cyclase ... The toxin, known as pertussis toxin (or PTx), inhibits G protein coupling that regulates an adenylate cyclase-mediated ... Sebo, Peter; Osicka, Radim; Masin, Jiri (2014-08-04). "Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines". ... Its virulence factors include pertussis toxin, adenylate cyclase toxin, filamentous hæmagglutinin, pertactin, fimbria, and ...

Adenylate cyclase toxin (CyaA) is released from bacterium Bordetella pertussis by the T1SS (Type 1 secretion system) and ... October 2008). "Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling". Journal of ... The toxin is a 1706 residue-long polypeptide that consists of an N-terminal ~400 residue-long adenylate cyclase (AC) enzyme ... Sebo P, Osicka R, Masin J (October 2014). "Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines". Expert Review ...

Edema factor is a calmodulin-dependent adenylate cyclase. Adenylate cyclase catalyzes the conversion of ATP into cyclic AMP ( ... The complexation of adenylate cyclase with calmodulin removes calmodulin from stimulating calcium-triggered signaling, thus ...

... diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. ... Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC1, is a protein that in humans is encoded ... "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I". Ogi K, Miyamoto Y, Masuda Y, ... Miampamba M, Germano PM, Arli S, Wong HH, Scott D, Taché Y, Pisegna JR (May 2002). "Expression of pituitary adenylate cyclase- ...

It does so by inhibiting the enzyme adenylate cyclase. The enzyme catalyzes the conversion of adenosine triphosphate (ATP) to 3 ... Liao H, Thorner J (April 1980). "Yeast mating pheromone alpha factor inhibits adenylate cyclase". Proceedings of the National ... Zhang G, Liu Y, Ruoho AE, Hurley JH (March 1997). "Structure of the adenylyl cyclase catalytic core". Nature. 386 (6622): 247- ...

August 1984). "Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine ... May DC, Ross EM, Gilman AG, Smigel MD (December 1985). "Reconstitution of catecholamine-stimulated adenylate cyclase activity ... activates hormone-sensitive adenylate cyclase. More than one type of G protein co-exist in the same tissue. For example, in ... The alpha subunit of a stimulatory G protein activated by receptors for stimulatory hormones could stimulate adenylyl cyclase, ...

EF is an adenylate cyclase that targets ATP. LF enzyme is a metalloprotease that confers the lethal phenotype associated with ...

Guanylyl imidodiphosphate is a potent stimulator of adenylate cyclase. It is often used in studies of protein synthesis. ...

The cya gene encodes adenylate cyclase, which produces cAMP. In a cya mutant, the absence of cAMP makes the expression of the ... which influences the activity of adenylate cyclase. (In addition, glucose transport also leads to direct inhibition of the ...

... activates adenylate cyclase in the absence of ligand. GPR3 was first described as a constitutive activator of adenylate ... August 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". The ... cyclase. This constitutive activity could be due to stimulation by a ubiquitous ligand that may be free, membrane-bound, or ...

Zhang ZH, Wu SD, Gao H, Shi G, Jin JZ, Kong J, Tian Z, Su Y (March 2006). "Expression of pituitary adenylate cyclase-activating ... Wei Y, Mojsov S (1997). "Tissue specific expression of different human receptor types for pituitary adenylate cyclase ... VIPR2 transduction results in upregulation of adenylate cyclase activity. Furthermore, VIPR2 mediates the anti-inflammatory ... Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) are homologous peptides that ...

Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylate ... Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs ... This occurs through inhibition of the cAMP-producing enzyme, adenylate cyclase, as a side-effect of glucose transport into the ... cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline. cAMP ...

... this protein is a stimulatory regulator of adenylate cyclase. Cells containing this mutant form of the Gs protein will continue ...

"Entrez Gene: CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)". Hubberstey, A; Yu G; Loewith R; Lakusta C; Young D (Jun ... Adenylyl cyclase-associated protein 1 is an enzyme that in humans is encoded by the CAP1 gene. The protein encoded by this gene ... Yu G, Swiston J, Young D (1994). "Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins ... Adenylyl cyclase GRCm38: Ensembl release 89: ENSMUSG00000028656 - Ensembl, May 2017 "Human PubMed Reference:". National Center ...

... a process regulator related to adenylate cyclase proteins; a profilin with a molecular weight of approximately 14 kDa that is ...

sAC is encoded in a single Homo sapiens gene identified as ADCY10 or Adenylate cyclase 10 (soluble). This gene packed down 33 ... "Identification of a haem domain in human soluble adenylate cyclase". Bioscience Reports. 32 (5): 491-499. doi:10.1042/ ... Soluble adenylyl cyclase (sAC) is a regulatory cytosolic enzyme present in almost every cell. sAC is a source of cyclic ... Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, Buck J (July 2000). "Soluble adenylyl cyclase as an ...