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*  Pertussis toxin
The Gi subunits remain locked in their GDP-bound, inactive state, thus unable to inhibit adenylate cyclase activity, leading to ... Bagley K, Abdelwahab S, Tuskan R, Fouts T, Lewis G (2002). "Pertussis toxin and the adenylate cyclase toxin from Bordetella ... Carbonetti NH (2010). "Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell ...
*  Fluoride toxicity
Inorganic fluoride inhibits adenylate cyclase activity required for antidiuretic hormone effect on the distal convoluted tubule ...
*  Extracellular adenylate cyclase
... is an adenylate cyclase produced by Bordetella pertussis. Kessin RH, Franke J (April 1986). " ... Ladant D, Brezin C, Alonso JM, Crenon I, Guiso N (December 1986). "Bordetella pertussis adenylate cyclase. Purification, ... "Secreted adenylate cyclase of Bordetella pertussis: calmodulin requirements and partial purification of two forms". J. ...
*  Pituitary adenylate cyclase-activating peptide
... has been shown to interact with secretin receptor. Adenylate cyclase Pituitary ... This gene encodes adenylate cyclase-activating polypeptide 1. Mediated by adenylate cyclase-activating polypeptide 1 receptors ... this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. Adenylate cyclase- ... Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 ...
*  ADCY2
"Entrez Gene: ADCY2 adenylyl cyclase 2 (brain)". "Adenylate cyclase type 2". UniProt Consortium. Retrieved 28 May 2014. Stengel ... It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 ... "Adenylate Cyclase 2 (Brain)". Weizmann Institute of Science. Retrieved 28 May 2014. Xu W, Cohen-Woods S, Chen Q, Noor A, Knight ... Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase ...
*  Alfred G. Gilman
Haga, T; Ross, EM; Anderson, HJ; Gilman, AG (1977). "Adenylate cyclase permanently uncoupled from hormone receptors in a novel ... Haga, T; Haga, K; Gilman, AG (1977). "Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild ... Gilman, AG (1984). "G proteins and dual control of adenylate cyclase". Cell. 36 (3): 577-9. doi:10.1016/0092-8674(84)90336-2. ... Sternweis, PC; Northup, JK; Smigel, MD; Gilman, AG (1981). "The regulatory component of adenylate cyclase. Purification and ...
*  ADCY3
"Entrez Gene: ADCY3 adenylate cyclase 3". "Gene Cards: ADCY3 Gene". Retrieved 2012-12-30. Human ADCY3 genome location and ADCY3 ... Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase ... Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene. This gene encodes adenylyl cyclase 3, which ... Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J (Jul 1994). "Chromosomal mapping of human adenylyl cyclase genes ...
*  ADCY6
1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 ... Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene. This gene encodes adenylyl cyclase 6, which ... 1998). "Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity ... ADCY6 adenylate cyclase 6". Human ADCY6 genome location and ADCY6 gene details page in the UCSC Genome Browser. Nakajima D, ...
*  ADCY9
"Entrez Gene: ADCY9 adenylate cyclase 9". Human ADCY9 genome location and ADCY9 gene details page in the UCSC Genome Browser. ... 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 ... Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene. Adenylyl cyclase is a membrane bound enzyme ... Cumbay MG, Watts VJ (2004). "Novel regulatory properties of human type 9 adenylate cyclase". J. Pharmacol. Exp. Ther. 310 (1): ...
*  ADCY7
"Entrez Gene: ADCY7 adenylate cyclase 7". Human ADCY7 genome location and ADCY7 gene details page in the UCSC Genome Browser. ... 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 ... The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by ... Yan SZ, Tang WJ (2002). "Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase". Meth. ...
*  ADCY5
"Entrez Gene: ADCY5 adenylate cyclase 5". Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (May 2003). "Identification of RGS2 and ... Wang SC, Lai HL, Chiu YT, Ou R, Huang CL, Chern Y (2007). "Regulation of type V adenylate cyclase by Ric8a, a guanine ... Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (1999). "Involvement of adenylate cyclase and p70(S6)-kinase ... Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene. ADCY5 has been shown to interact with RGS2. ...
*  ADCY8
"Entrez Gene: ADCY8 adenylate cyclase 8 (brain)". Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome ... Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase ... Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene. Adenylyl cyclase is a membrane bound enzyme ... Parma J, Stengel D, Gannage MH, Poyard M, Barouki R, Hanoune J (Aug 1991). "Sequence of a human brain adenylyl cyclase partial ...
*  G beta-gamma complex
Brandt DR, Ross EM (January 1985). "GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs ... "Purification of the regulatory component of adenylate cyclase". Proceedings of the National Academy of Sciences of the United ... individual subunits of the G protein complex were first identified in 1980 when the regulatory component of adenylate cyclase ... Another example of Gβγ signaling is its effect of activating or inhibiting adenylyl cyclase leading to the intracellular ...
*  Anthrax
Edema factor is a calmodulin-dependent adenylate cyclase. Adenylate cyclase catalyzes the conversion of ATP into cyclic AMP ( ... The complexation of adenylate cyclase with calmodulin removes calmodulin from stimulating calcium-triggered signaling, thus ...
*  ADCYAP1R1
... diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. ... Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC1, is a protein that in humans is encoded ... Miampamba M, Germano PM, Arli S, Wong HH, Scott D, Taché Y, Pisegna JR (May 2002). "Expression of pituitary adenylate cyclase- ... Stoffel M, Espinosa R, Trabb JB, Le Beau MM, Bell GI (Oct 1994). "Human type I pituitary adenylate cyclase activating ...
*  Gs alpha subunit
A mnemonic for remembering this subunit is to look at first letter (Gαs = Adenylate Cyclase stimulator). The G protein-coupled ... However, each Gs activates only one adenylate cyclase. Second messenger system Ellis, Claire (Jul 2004). "The state of GPCR ... is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase. It is one of ... The general function of Gs is to activate adenylyl cyclase, which, in turn, produces cAMP, which, in turn activates cAMP- ...
*  Adenylyl cyclase
... (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with ... Interactive 3D views of Adenylate cyclase at Proteopedia Adenylyl_cyclase Molecular and Cellular Biology portal. ... Sodeman W, Sodeman T (2005). "Physiologic- and Adenylate Cyclase-Coupled Beta-Adrenergic Receptors". Sodeman's Pathologic ... These adenylyl cyclases are the most familiar based on extensive study due to their important roles in human health. They are ...
*  5'-Guanylyl imidodiphosphate
Guanylyl imidodiphosphate is a potent stimulator of adenylate cyclase. It is often used in studies of protein synthesis. ...
*  CyaA
Bifunctional hemolysin/adenylate cyclase is a protein that in B. pertussis (the bacteria that causes whooping cough) is encoded ... Carbonetti NH, Artamonova GV, Andreasen C, Bushar N (May 2005). "Pertussis toxin and adenylate cyclase toxin provide a one-two ... This protein in turn is cleaved into a calmodulin-sensitive adenylate cyclase (cyaA-ACD) and hemolysin. Both are virulence ... Ladant D, Ullmann A (April 1999). "Bordatella pertussis adenylate cyclase: a toxin with multiple talents". Trends Microbiol. 7 ...
*  GTPase
They always use the activation of adenylate cyclase as the next step in the signal chain. The s stands for stimulation. Their ... Among the target molecules of the active GTPase are adenylate cyclase and ion channels. The heterotrimeric G proteins can be ... The i stands for inhibition of the adenylate cyclase; another effector molecule for this protein family is phospholipase C. ...
*  Lac operon
The cya gene encodes adenylate cyclase, which produces cAMP. In a cya mutant, the absence of cAMP makes the expression of the ... which influences the activity of adenylate cyclase. (In addition, glucose transport also leads to direct inhibition of the ...
*  GPR3
... activates adenylate cyclase in the absence of ligand. GPR3 is expressed in mammalian oocytes where it maintains meiotic ... 1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J ... "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( ...
*  VIPR2
Zhang ZH, Wu SD, Gao H, Shi G, Jin JZ, Kong J, Tian Z, Su Y (March 2006). "Expression of pituitary adenylate cyclase-activating ... Wei Y, Mojsov S (1997). "Tissue specific expression of different human receptor types for pituitary adenylate cyclase ... VIPR2 transduction results in upregulation of adenylate cyclase activity. Furthermore, VIPR2 mediates the anti-inflammatory ... Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) are homologous peptides that ...
*  Heterotrimeric G protein
link) May, DC; Ross, EM; Gilman, AG; Smigel, MD (1985). "Reconstitution of catecholamine-stimulated adenylate cyclase activity ... 1984). "Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine ... activates hormone-sensitive adenylate cyclase. Gα subunits consist of two domains, the GTPase domain, and the alpha-helical ...
*  Bordetella
One of the most important of the regulated toxins is adenylate cyclase toxin, which aids in the evasion of innate immunity. The ... Fiser R, Masín J, Basler M, Krusek J, Spuláková V, Konopásek I, Sebo P (2007). "Third activity of Bordetella adenylate cyclase ... Gray MC, Donato GM, Jones FR, Kim T, Hewlett EL (2004). "Newly secreted adenylate cyclase toxin is responsible for intoxication ... Hewlett EL, Donato GM, Gray MC (2006). "Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: ...
*  Dinoxyline
Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). "Differential activation of adenylate cyclase and receptor ...
*  Cyclic adenosine monophosphate
Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylate ... Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs ... This occurs through inhibition of the cAMP-producing enzyme, adenylate cyclase, as a side-effect of glucose transport into the ... cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline. cAMP ...