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*  Adenovirus genome
Control protein E1B 19K suppresses apoptosis by mimicking the action of cellular protein Bcl-2. Control protein E1B 55K binds ... The functions of many adenovirus proteins are known: Structural proteins include capsid proteins II (hexon), III (penton base ... "Protein Details for Human adenovirus E". NCBI. Retrieved 2013-01-17. Russell, WC (Jan 2009). "Adenoviruses: update on structure ... and the terminal protein TP. Encapsidation proteins IVa2, 52K, and L1, and hexon assembly protein 100K are involved in assembly ...
*  Adenovirus E1B protein
... usually refers to one of two proteins transcribed from the E1B gene of the adenovirus: a 55kDa protein ... These two proteins are needed to block apoptosis in adenovirus-infected cells. E1B proteins work to prevent apoptosis that is ... E1B-55k also forms a complex with E4orf6, a viral protein. The E1B-55k/E4orf6 complex in infected cells assembles with other ... However, in adenovirus-infected cells, activated BAK and BAX are sequestered by E1B-19k, preventing the pathway. E1B-55k blocks ...
*  Oncovirus
The adenovirus E1B protein (55K) prevents p53 from regulating genes by binding to the site on p53 which binds to the genome. In ... HPV instead degrades p53: the HPV protein E6 binds to a cellular protein called the E6-associated protein (E6-AP, also known as ... DNA oncoviruses typically impair two families of tumor suppressor proteins: tumor proteins p53 and the retinoblastoma proteins ... SV40 uses the same protein for inactivating Rb, LT, to inactivate p53. HPV contains a protein, E7, which can bind to Rb in much ...
*  BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene. This gene is ... "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341-51. doi:10.1016/ ... "Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2". Low BC, Seow KT, Guy GR (December 2000). "The BNIP-2 and ... it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B ...
*  BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein that in humans is encoded by the BNIP3 gene. BNIP3 is a ... "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341-51. doi:10.1016/ ... As of this edit, this article uses content from "1.A.20 The BCL2/Adenovirus E1B-interacting Protein 3 (BNip3) Family", which is ... "Entrez Gene: BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3". Menyhárt O, Harami-Papp H, Sukumar S, Schäfer R, Magnani L ...
*  List of MeSH codes (D23)
... adenovirus e1a proteins MeSH D23.050.285.062.050 --- adenovirus e1b proteins MeSH D23.050.285.062.090 --- antigens, ... adenovirus e1 proteins MeSH D23.050.327.045.060 --- adenovirus e2 proteins MeSH D23.050.327.045.070 --- adenovirus e3 proteins ... adenovirus e1a proteins MeSH D23.050.327.062.050 --- adenovirus e1b proteins MeSH D23.050.327.062.090 --- antigens, ... hiv core protein p24 MeSH D23.050.327.520.330 --- hiv envelope protein gp41 MeSH D23.050.327.520.350 --- hiv envelope protein ...
*  HNRPUL1
This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA ... and its function is modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase ... "E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of ... 2005). "Protein arginine methylation during lytic adenovirus infection". Biochem. J. 383 (Pt 2): 259-65. doi:10.1042/BJ20040210 ...
*  BNIP3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like is a protein that in humans is encoded by the BNIP3L gene. This ... gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein ... "Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like". Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, ... The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function ...
*  Oncolytic adenovirus
E1B proteins produced by adenoviruses protect the infected cell by binding to and degrading the p53 transcription factors, ... Barker DD, Berk AJ (1987). "Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by ... Barker, Douglas D.; Berk, Arnold J. (1987). "Adenovirus proteins from both E1B reading frames are required for transformation ... and the knob domain of the adenovirus coat protein trimer. CAR is necessary for adenovirus infection. Although expressed widely ...
*  Bcl-2
"Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341-51. doi:10.1016/ ... These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its ... This is the first FDA approval of a protein-protein inhibitor of BCL-2. Bcl-2 has been shown to interact with: BAK1, BCAP31, ... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The ...
*  Transporter Classification Database
Tic110 family 1.A.19 Type A influenza virus matrix-2 channel family 1.A.20 BCL2/Adenovirus E1B-interacting protein 3 family 1.A ... HBV-S Protein) Family 1.G.7 The Reovirus FAST Fusion Protein (R-FAST) Family 1.G.8 The Arenavirus Fusion Protein (AV-FP) Family ... see also SecDF protein-export membrane protein 2.A.7 The Drug/Metabolite Transporter (DMT) Superfamily 2.A.8 The Gluconate:H+ ... Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family 3.A.8 The Mitochondrial Protein Translocase (MPT) Family ...
*  BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein is a protein that in humans is encoded by the BNIPL gene. BNIPL ... "Entrez Gene: BNIPL BCL2/adenovirus E1B 19kD interacting protein like". Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, ... "The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER". FEBS Letters. 540 ... a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Research. 59 (3): 533-7. PMID 9973195. Human BNIPL genome ...
*  TP53
... binding to mdm-2 and the adenovirus 5 E1B 55-kD protein". Genes & Development. 8 (10): 1235-46. doi:10.1101/gad.8.10.1235. PMID ... It delivers a functional copy of the p53 gene using an engineered adenovirus. Certain pathogens can also affect the p53 protein ... Mutant p53 proteins often fail to induce MDM2, causing p53 to accumulate at very high levels. Moreover, the mutant p53 protein ... In addition to the full-length protein, the human TP53 gene encodes at least 15 protein isoforms, ranging in size from 3.5 to ...
*  TAF9
... binding to mdm-2 and the adenovirus 5 E1B 55-kD protein". Genes Dev. 8 (10): 1235-46. doi:10.1101/gad.8.10.1235. PMID 7926727. ... TATA binding protein, Transcription initiation protein SPT3 homolog, and Transformation/transcription domain-associated protein ... TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in ... Lu H, Levine AJ (1995). "Human TAFII31 protein is a transcriptional coactivator of the p53 protein". Proc. Natl. Acad. Sci. U.S ...
*  Apoptosis
The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... Examples of viral Bcl-2 proteins include the Epstein-Barr virus BHRF1 protein and the adenovirus E1B 19K protein. Some viruses ... these inhibitory proteins target retinoblastoma tumor-suppressing proteins. These tumor-suppressing proteins regulate the cell ... HIV proteins decrease the amount of CD4 glycoprotein marker present on the cell membrane. Released viral particles and proteins ...
*  Vectors in gene therapy
It was found that in the absence of the E1B-55Kd viral protein, adenovirus caused very rapid apoptosis of infected, p53(+) ... Retroviruses and adeno-associated viruses have a single protein coating their membrane, while adenoviruses are coated with both ... or by chimeric proteins. Such chimera would consist of those parts of the viral protein necessary for incorporation into the ... entry into potential host cells requires a favorable interaction between a protein on the surface of the virus and a protein on ...
*  List of MeSH codes (D12.776)
... adenovirus e1a proteins MeSH D12.776.964.700.045.050.110 - adenovirus e1b proteins MeSH D12.776.964.700.045.060 - adenovirus e2 ... adenovirus E1B proteins MeSH D12.776.624.664.520.045.060 - adenovirus e2 proteins MeSH D12.776.624.664.520.045.070 - adenovirus ... adenovirus e3 proteins MeSH D12.776.964.700.045.080 - adenovirus e4 proteins MeSH D12.776.964.700.750.320 - fusion proteins, ... oncogene protein tpr-met MeSH D12.776.624.664.520.045 - adenovirus early proteins MeSH D12.776.624.664.520.045.050 - adenovirus ...
*  Adenoviridae
... replication of the adenovirus genome can occur. A terminal protein that is covalently bound to the 5' end of the adenovirus ... E1A (binds Retinoblastoma tumor suppressor protein) has been found to immortalize primary cells in vitro allowing E1B (binds ... Adenoviruses Stanford University - Adenoviruses Adenoviruses General Concepts General information on Adenovirus DNA virus ... Tupaia adenovirus (TAV) (Tree shrew adenovirus 1) has been isolated from tree shrews. Otarine adenovirus 1 has been isolated ...
*  CUL5
2002). "Analysis of the Adenovirus E1B-55K-Anchored Proteome Reveals Its Link to Ubiquitination Machinery". J. Virol. 76 (18): ... Cullin-5 is a protein that in humans is encoded by the CUL5 gene. The mammalian gene product was originally discovered by ... Since then, VACM-1 has been shown to be homologous to the Cullin family of proteins, and was subsequently dubbed cul5. Studies ... 2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ...
*  Bcl-2 homologous antagonist killer
"A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal ... "Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K". Nature. 374 (6524): 731-3. doi:10.1038/374731a0. PMID ... Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the BAK1 gene on chromosome 6. The protein encoded ... Cartron PF, Petit E, Bellot G, Oliver L, Vallette FM (Sep 2014). "Metaxins 1 and 2, two proteins of the mitochondrial protein ...
*  P73
The viral oncoproteins (e.g. Adenovirus E1B) that efficiently inhibit p53 function are unable to inactivate p73, and those that ... p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a ... p73, also known as tumor protein 73 (TP73), protein was the first identified homologue of the tumor suppressor gene, p53. Like ... A naturally occurring p73 mutation in a p73-p53 double-mutant lung cancer cell line encodes p73α protein with a dominant- ...
*  Bcl-2-interacting killer
Han J, Sabbatini P, White E (1996). "Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B ... "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal ... this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other ... The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the ...