*ADAR

"RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR". The ... "Entrez Gene: ADAR Adenosine Deaminase Acting on RNA". Samuel CE (2012). Adenosine deaminases acting on RNA (ADARs) and A-to-I ... which stands for adenosine deaminase acting on RNA). Adenosine deaminases acting on RNA (ADAR) are enzymes responsible for ... Adenosine Deaminase Acting on RNA is one of the most common forms of RNA editing, and has both selective and non-selective ...

*Adenosine A2A receptor

... which functions primarily through protein kinase A to upregulate inhibitory cytokines such as transforming growth factor-beta ( ... The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it. This ... As a result, Adenosine receptor A2A decreases activity in the Dopamine D2 receptors. The adenosine A2A receptor has also been ... "Entrez Gene: ADORA2A adenosine A2A receptor". Ohta A, Sitkovsky M (2001). "Role of G-protein-coupled adenosine receptors in ...

*Adenosine kinase

The role of adenosine kinase in regulating adenosine concentration. Biochem J 1985, 226: 343-344. Boison D: Adenosine as a ... Gupta RS: Adenosine-AMP exchange activity is an integral part of the mammalian adenosine kinase. Biochem Mol Biol Int 1996, 39 ... Adenosine kinase (AdK; EC 2.7.1.20) is an enzyme that catalyzes the transfer of gamma-phosphate from Adenosine triphosphate ( ... Arch JR, Newsholme EA: Activities and some properties of 5'-nucleotidase, adenosine kinase and adenosine deaminase in tissues ...

*Gene therapy for epilepsy

The increase in adenosine kinase results in an increased metabolic rate for adenosine nucleosides. Due to the decrease in these ... The most prevalent theory is that upon brain injury there is an increased expression of the adenosine kinase (ADK). ... ISBN 978-88-470-1642-2. Boison, Detlev (October 2006). "Adenosine kinase, epilepsy, and stroke: mechanisms and theory". ... the effects can be counteracted and moderated by adenosine. Based on the properties afforded by adenosine in preventing ...

*ADK (gene)

Adenosine kinase is an enzyme that in humans is encoded by the ADK gene. This gene encodes adenosine kinase, an abundant enzyme ... "Entrez Gene: ADK adenosine kinase". Human ADK genome location and ADK gene details page in the UCSC Genome Browser. Klobutcher ... Singh B, Lin A, Wu ZC, Gupta RS (2001). "Gene structure for adenosine kinase in Chinese hamster and human: high-frequency ... 1997). "Cloning and expression of the adenosine kinase gene from rat and human tissues". Biochem. Biophys. Res. Commun. 231 (3 ...

*Ribokinase

Other members of this family (also known as the RK family) include adenosine kinase (AK), inosine-guanosine kinase, ... Park J, Gupta RS: Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci 2008, 65: 2875-2896. Bork P, ... Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS: Cloning of human adenosine kinase cDNA: sequence ... Maj MC, Singh B, Gupta RS: Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: ...

*Phosphofructokinase

... adenosine kinase (AK), inosine kinase, and 1-phosphofructokinase. The members of the PfkB/RK family are identified by the ... Park J, Gupta RS: Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci 2008, 65: 2875-2896. Bork P, ... Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS: Cloning of human adenosine kinase cDNA: sequence ... Maj MC, Singh B, Gupta RS: Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: ...

*1-phosphofructokinase

Park J, Gupta RS: Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci 2008, 65: 2875-2896. Bork P, ... Maj MC, Singh B, Gupta RS: Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: ... Sapico V, Anderson RL (1969). "D-fructose 1-phosphate kinase and D-fructose 6-phosphate kinase from Aerobacter aerogenes. A ... D-fructose-1-phosphate kinase, fructose 1-phosphate kinase, and 1-phosphofructokinase. This enzyme participates in fructose and ...

*Tagatose-6-phosphate kinase

Park J, Gupta RS: Adenosine kinase and ribokinase--the RK family of proteins. Cell Mol Life Sci 2008, 65: 2875-2896. Bork P, ... Maj MC, Singh B, Gupta RS: Pentavalent ions dependency is a conserved property of adenosine kinase from diverse sources: ... In enzymology, a tagatose-6-phosphate kinase (EC 2.7.1.144) is an enzyme that catalyzes the chemical reaction ATP + D-tagatose ... This enzyme belongs to the phosphofructokinase B (PfkB) or Ribokinase family of sugar kinases, specifically those transferring ...

*AICA ribonucleotide

... is an analog of adenosine that enters cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate ... "MECHANISMS OF ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE-INDUCED PRECONDITIONING IN ISCHEMIA/REPERFUSION." Department of ... AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity ... AICAR is able to enter the de novo synthesis pathway for adenosine synthesis to inhibit adenosine deaminase causing an increase ...

*List of EC numbers (EC 2)

... adenosine kinase EC 2.7.1.21: thymidine kinase EC 2.7.1.22: ribosylnicotinamide kinase EC 2.7.1.23: NAD+ kinase EC 2.7.1.24: ... subunit kinase EC 2.7.11.24: mitogen-activated protein kinase EC 2.7.11.25: mitogen-activated protein kinase kinase kinase EC ... EC 2.7.1.71: shikimate kinase EC 2.7.1.72: streptomycin 6-kinase EC 2.7.1.73: inosine kinase EC 2.7.1.74: deoxycytidine kinase ... UDP-N-acetylglucosamine kinase EC 2.7.1.177: L-threonine kinase EC 2.7.2.1: acetate kinase EC 2.7.2.2: carbamate kinase EC 2.7. ...

*List of MeSH codes (D08)

... adenosine kinase MeSH D08.811.913.696.620.155 --- choline kinase MeSH D08.811.913.696.620.175 --- deoxycytidine kinase MeSH ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ... map kinase kinase kinase 4 MeSH D08.811.913.696.620.682.700.559.500 --- map kinase kinase kinase 5 MeSH D08.811.913.696.620.682 ...

*Adenylyl-sulfate kinase

... adenosine 5'-phosphosulfate kinase, adenosine phosphosulfate kinase, adenosine phosphosulfokinase, adenosine-5'-phosphosulfate- ... MacRae IJ, Rose AB, Segel IH (October 1998). "Adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. site-directed ... Other names in common use include adenylylsulfate kinase (phosphorylating), 5'-phosphoadenosine sulfate kinase, ... In enzymology, an adenylyl-sulfate kinase (EC 2.7.1.25) is an enzyme that catalyzes the chemical reaction ATP + adenylyl ...

*Cardioprotection

ROS and adenosine acting on kinases such as PKCε and Src, which in turn activate gene transcription and upregulation of late PC ... "Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade". Cardiovascular research. 70 ... These signaling events act on the ROS-generating mitochondria, activate PKCε and the Reperfusion Injury Salvage Kinase (RISK) ... "Novel functional role of heat shock protein 90 in protein kinase C-mediated ischemic postconditioning". The Journal of surgical ...

*Susan S. Taylor

"Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): ... She is known for her research on protein kinases, particularly protein kinase A. She was elected to the Institute of Medicine ... Taylor's research group has focused on the structure and function of protein kinases, particularly protein kinase A, since ... Taylor, SS; Yang, J; Wu, J; Haste, NM; Radzio-Andzelm, E; Anand, G (11 March 2004). "PKA: a portrait of protein kinase dynamics ...

*Protein kinase domain

"Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): ... Hanks SK, Hunter T (May 1995). "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain ... Protein kinase function has been evolutionarily conserved from Escherichia coli to Homo sapiens. Protein kinases play a role in ... The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. ...

*PAPSS1

... kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains". Biochemistry. 43 ... Sekulic N, Konrad M, Lavie A (2007). "Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase ... In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 ... 1998). "cDNA cloning, expression, and characterization of the human bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate ...

*PAPSS2

"Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2 ...

*RHEB

... adenosine-monophospate-activated protein kinase (AMPK) has also been found to be an effector for RHEB. AMPK is a protein kinase ... Yee WM, Worley PF (Feb 1997). "Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase ... AMP-activated protein kinase (AMPK) RAF proto-oncogene serine/threonine-protein kinase (C-Raf) mammalian Target of Rapamycin ... Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (Apr 2005). "Rheb binds and regulates the mTOR kinase". Current Biology. 15 ( ...

*Cytidine monophosphate

CMP can be phosphorylated to cytidine diphosphate by the enzyme CMP kinase, with adenosine triphosphate or guanosine ...

*BIM-1

"Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): ... The protein kinase C inhibitor bis(indolyl)maleimide inhibitor BIM1 is clearly seen in the structure of PKCiota (residue 574- ... BIM-1 and the related compounds BIM-2, BIM-3, and BIM-8 are bisindolylmaleimide-based protein kinase C (PKC) inhibitors. These ... The bound BIM1 inhibitor blocks the ATP-binding site and puts the kinase domain into an intermediate open conformation. The ...

*STK11

LKB1 is a primary upstream kinase of adenosine monophosphate-activated protein kinase (AMPK), a necessary element in cell ... Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein ... that is capable of phosphorylating and activating AMPK and at least 12 other kinases that belong to the AMPK-related kinase ... LKB1 has a structure typical of other protein kinases, with two (small and large) lobes on either side of the ligand ATP- ...

*PRKACA

Induction by regulatory subunit and inhibition by catalytic subunit of adenosine 3':5'-monophosphate-dependent protein kinase ... Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family, and contributes to the control of cellular ... A-Kinase Anchoring Proteins (AKAPs) bind a surface formed between both R subunits and target the kinase to different locations ... They realized that a key metabolic enzyme called phosphorylase kinase was activated by another kinase that was dependent on the ...

*Myelin basic protein

1985). "Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent ... "Phosphorylation sites of bovine brain myelin basic protein phosphorylated with Ca2+-calmodulin-dependent protein kinase from ... protein kinase". J. Biol. Chem. 260 (23): 12492-9. PMID 2413024. Saxe DF, Takahashi N, Hood L, Simon MI (1985). "Localization ...

*Thromboregulation

cAMP, cyclic adenosine monophosphate, phosphorylate messengers via protein kinase A (PKA). These signaling elements include ... Nitric oxide (NO) stimulates cGMP production and therefore the activation cGMP-dependent protein kinase (G kinase). This kinase ... In vivo phosphorylation of thromboxane by cyclic GMP-dependent protein kinase" (PDF). Journal of the Salk Institute for ...

*Metabolism

Binding of the hormone to insulin receptors on cells then activates a cascade of protein kinases that cause the cells to take ... One central coenzyme is adenosine triphosphate (ATP), the universal energy currency of cells. This nucleotide is used to ... causing the active site of the synthase domain to change shape and phosphorylate adenosine diphosphate - turning it into ATP. ...

*Nucleic acid metabolism

Adenylate kinase is a specific nucleoside-monophosphate kinase that functions only on adenosine-monophosphate. Nucleic acid RNA ... The nucleoside, adenosine, is then deaminated and hydrolyzed to form hypoxanthine via adenosine deaminase and nucleosidase ... "Adenosine deaminase (ADA) deficiency". Learn.Genetics. Retrieved 31 October 2014. Nucleic Acids Book (free online book on the ... AMP and GMP can then be converted into ATP and GTP, respectively, by kinases that add additional phosphates. ATP stimulates ...