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*  Signal transducing adaptor protein
Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor ... phosphoinositide-3-kinase adaptor protein 1 SH2B1 - SH2B adaptor protein 1 SH2B2 - SH2B adaptor protein 2 SH2B3 - SH2B adaptor ... adaptor proteins.2C vesicular transport Signal Transducing Adaptor Proteins at the US National Library of Medicine Medical ... GRB2-related adaptor protein GRAP2 - GRB2-related adaptor protein 2 LDLRAP1 - low-density lipoprotein receptor adaptor protein ...
*  STAP2
Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene. This gene encodes the substrate ... 2007). "Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal ... "Entrez Gene: STAP2 signal-transducing adaptor protein-2". Rosenzweig BL, Imamura T, Okadome T, et al. (1995). "Cloning and ... 2003). "Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells ...
*  STAP1
Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene. The protein encoded by this gene ... A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. STAP1 has been shown to interact ... functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is ... an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem. 278 (13 ...
*  Lymphocyte cytosolic protein 2
SLP-76 signal Transducing adaptor proteins at the US National Library of Medicine Medical Subject Headings (MeSH). ... is a gene that encodes a signal-transducing adaptor protein. No full structure for SLP-76 has been solved. The PDB file 1H3H ... "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ... "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ...
*  Signal transducing adaptor molecule
Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene. This gene was identified by the ... has been found to bind and counteract the function of this protein. Signal transducing adaptor molecule has been shown to ... suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2". The Journal of Biological Chemistry ... signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc ...
*  Adaptor protein
... may refer to: Signal transducing adaptor protein Vesicular transport adaptor protein Clathrin adaptor protein, ...
*  STAM2
Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene. The protein encoded by this ... "Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2". Rual JF, Venkatesan K, Hao T, Hirozane- ... an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the ... "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain ...
*  MAPK/ERK pathway
Janus kinase Phosphatase Signal transducing adaptor protein G protein-coupled receptor Orton RJ, Sturm OE, Vyshemirsky V, ... Protein microarray analysis can be used to detect subtle changes in protein activity in signaling pathways. The developmental ... "extracellular signal-regulated kinases" (ERKs) and "microtubule associated protein kinase" (MAPK). One of the first proteins ... phosphorylates ribosomal protein S6. Mitogen-activated protein kinases that phosphorylate ribosomal protein S6 were the first ...
*  MADD (gene)
The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a ... Nakayama M, Kikuno R, Ohara O (2003). "Protein-Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a ... adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK ... MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene. Tumor necrosis factor alpha ...
*  NCK1
It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to ... Signal transducing adaptor protein Receptor tyrosine kinase Ras superfamily GRCh38: Ensembl release 89: ENSG00000158092 - ... The Nck (non-catalytic region of tyrosine kinase adaptor protein 1) belongs to the adaptor family of proteins. The nck gene was ... "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity". Cell. Signal. 23 (10): 1651 ...
*  Adapter (disambiguation)
Adapter pattern, a software design pattern used for computer programming Signal transducing adaptor protein, a type of protein ... Adapter may refer to: Adapter (device), used to match the physical or electrical characteristics of two different objects AC ... adapter, an electric power supply device Adapter (genetics), a small DNA molecule used in genetic engineering Adapter (rocketry ... a segment between rocket stages Adapter (computing), used to connect various hardware devices Adapter (piping), a short length ...
*  SH3 domain
Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 ... The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases SH3 proteins usually ... SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and ... In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction ...
*  STAP
... a signal-transducing adaptor protein encoded by the STAP1 gene STAP2, a signal-transducing adaptor protein encoded by the STAP2 ... STAP, or stap, may refer to: List of people with the surname Stap Space-time adaptive processing, a signal processing technique ...
*  TIMM8A
Deafness-dystonia peptide Deafness-dystonia protein TIMM8A has been shown to interact with Signal transducing adaptor molecule ... "Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1". Biochem. Biophys ... "Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1". Biochem. Biophys ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. England. 3 (1): 89. doi: ...
*  CD27
This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been ... CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the ... The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long ... Yamamoto H, Kishimoto T, Minamoto S (Nov 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated ...
*  STAMBP
The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role ... One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. ... STAM-binding protein is a protein that in humans is encoded by the STAMBP gene. Cytokine-mediated signal transduction in the ... Signal transducing adaptor molecule and GRAP2. GRCm38: Ensembl release 89: ENSMUSG00000006906 - Ensembl, May 2017 "Human PubMed ...
*  Apoptosis
... or directly transducing the signal via adaptor proteins to the apoptotic mechanisms. An extrinsic pathway for initiation ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... Examples of viral Bcl-2 proteins include the Epstein-Barr virus BHRF1 protein and the adenovirus E1B 19K protein. Some viruses ... apoptotic signals must cause regulatory proteins to initiate the apoptosis pathway. This step allows those signals to cause ...
*  List of MeSH codes (D12.644)
... adaptor proteins, signal transducing MeSH D12.644.360.024.264 --- caveolin 1 MeSH D12.644.360.024.272 --- caveolin 2 MeSH ... grb2 adaptor protein MeSH D12.644.360.024.298 --- grb7 adaptor protein MeSH D12.644.360.024.300 --- grb10 adaptor protein MeSH ... rap gtp-binding proteins MeSH D12.644.360.525.475.100 --- rap1 gtp-binding proteins MeSH D12.644.360.525.500 --- ras proteins ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ...
*  NKG2D
DAP10 functions as an adaptor protein and transduces the signal after the ligand binding by recruiting the p85 subunit of PI3K ... DAP12 bears ITAM motif and activates protein tyrosine kinases Syk and Zap70 signalling. NKG2D ligands are induced-self proteins ... By contrast, NKG2D-S associates with two adaptor proteins: DAP10 and DAP12. DAP10 recruits the p85 subunit of PI3K and a ... "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nature Immunology ...
*  Death receptor 4
2002). "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL- ... Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat ... and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death ... Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. ...
*  SH2 domain
... s are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways. ... conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 ... Phosphorylation of tyrosine residues in a protein occurs during signal transduction and is carried out by tyrosine kinases. In ... Koytiger G; Kaushansky A; Gordus A; Rush J; Sorger PK; Macbeath G (January 2013). "Phosphotyrosine signaling proteins that ...
*  Death receptor 5
... a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. DR5 has been shown to ... and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the ... a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL". Current Biology. 7 (9): 693-6. doi: ... The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This ...
*  Synaptic pruning
Reverse signaling between ephrin-B proteins and their Eph receptor tyrosine kinases have been found to initiate the retraction ... Ensuing binding of Ephrin-B3 to the cytoplasmic adaptor protein, Grb4, leads to the recruitment and binding of Dock180 and p21 ... Ephrin-B3 is observed to transduce tyrosine phosphorylation-dependent reverse signals into hippocampal axons that trigger ... Forward signaling between Ephrin-A and EphA, along the anterior-posterior axis, has been found to inhibit retinal axon branch ...
*  Interleukin-1 receptor family
The signal is transduced by cytoplasmatic kinases (such as IRAKs) and by other adaptors, such as tumor necrosis factor 6 (TRAF6 ... cytosolic adaptor proteins (such as MyD88 adaptor protein) and insect and nematode Toll. Each of these groups is involved ... When the receptor is activated TIR domain recruits downstream cytoplasmic signalization adaptor proteins (such as Myd88 adaptor ... May 2000). "IL-1 Signaling Cascade in Liver Cells and the Involvement of a Soluble Form of the IL-1 Receptor Accessory Protein ...
*  Co-receptor
They can also transmit signals through adaptor molecules through their cytoplasmic domain which bind to signalling motifs. ... First, cell surface receptors can directly transduce signals by possessing both serine and threonine or simply serine in the ... Co-receptors are proteins that maintain a three-dimensional structure. The large extracellular domains make up approximately 76 ... Secondly, certain surface receptors lacking a cytoplasmic domain can transduce signals through ligand binding. Once the surface ...
*  Pattern recognition receptor
NODs transduce signals in the pathway of NF-κB and MAP kinases via the serine-threonine kinase called RIP2. NODs signal via N- ... Interaction with other proteins (e.g. the adaptor molecule ASC) is mediated via N-terminal pyrin (PYD) domain. There are 14 ... BDCA2 signaling via ITAM and signaling through ITIM belong among the TLR-dependent signaling. TLR-independent signaling such as ... Among other proteins the most important are: the MHC Class II transactivator (CIITA), IPAF, BIRC1 etc. Some of these proteins ...