... whose cytoplasmic domain is then able to bind the death domain of the adaptor protein FADD (Fas-associated protein with death ... and procaspase 8 together form a death-inducing signaling complex (DISC). Activated caspase 8 is released into the cytosol, ... However, overexpression of the protein CFLAR (caspase and FADD-like apoptosis regulator) inhibits Fas-mediated apoptosis. ... possibly indirectly by upregulating early growth response proteins. T cell activation-induced transcription of FasL is further ...
Ger M, Zitkus Z, Valius M (October 2011). "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates ... Chow A, Davis AJ, Gawler DJ (March 2000). "Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the ... RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human ... Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in ...
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology ... is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464-70. doi: ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through ...
Umeda M, Nishitani H, Nishimoto T (Jan 2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". ... Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M ... Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene. This gene encodes a protein that binds RAN, a ... Umeda M, Nishitani H, Nishimoto T (2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. ...
... it is brought to the site via protein-protein interactions that are the result of its different structural domains complexing ... CBP has two transitional adapter zinc finger (TAZ) domains that each consist of four alpha helices stabilized by zinc ions. ... Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational Techniques". The Protein Journal. 40 (1 ... CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding protein) is a ...
Cruciat CM, Hassler C, Niehrs C (2006). "The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nat. Cell Biol. 10 (3): ... Endoplasmic reticulum lectin 1 is a protein that in humans is encoded by the ERLEC1 gene. GRCh38: Ensembl release 89: ...
"Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex". Molecular and Cellular ... Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. Keap1 has four discrete protein ... Abed DA, Goldstein M, Albanyan H, Jin H, Hu L (July 2015). "Discovery of direct inhibitors of Keap1-Nrf2 protein-protein ... The N-terminal Broad complex, Tramtrack and Bric-à-Brac (BTB) domain contains the Cys151 residue, which is one of the important ...
Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein". The Journal of Biological Chemistry ... is a signaling adapter protein that in humans is encoded by the IRS1 gene. It is a 131 kDa protein with amino acid sequence of ... Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (March 2007). "Oncogenic transformation by the signaling adaptor proteins insulin ... Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (March 2007). "Oncogenic transformation by the signaling adaptor proteins insulin ...
The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport ... is a 38-kDa subunit that has a two-lobed structure with a polar core that resembles the arrestin family of trafficking adaptor ... Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene. This gene belongs to ... 2001). "Human Orthologs of Yeast Vacuolar Protein Sorting Proteins Vps26, 29, and 35: Assembly into Multimeric Complexes". Mol ...
The adapter protein Shc is specifically recruited to the oncostatin M receptor". The Journal of Biological Chemistry. 275 (52 ... Downstream signaling activation of the OSMR-gp130 complex along the JAK1 pathway leads to IL-6 signalling which is linked with ... This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with ... Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins ...
"Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Letters. 467 (1): 91-6. doi:10.1016/ ... Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from ... "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Letters. 467 (1): 91-6. doi:10.1016/ ... Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family ...
The SIP protein has a role as an adaptor protein, it links the E3 ubiquitin ligase activity of Siah-1 with Skp1 and Ebi F-Box ... analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex". J ... In molecular biology the protein domain, Siah interacting protein N-terminal domain is found at the N-terminal of the protein, ... Luo J, Yang J, Yu BY, Liu W, Li M, Zhuang SM (2010). "Identification of Siah-interacting protein as a potential regulator of ...
This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF- ... a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". ... The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins ... The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a ...
The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually ... SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, ... Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 ... Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. Gads, Grap2, Grf40, GrpL etc.). Other ...
Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (May 2001). "Stonin 2: an adaptor-like protein that interacts with ... SYT1 senses calcium ion concentrations as low as 10 ppm and subsequently signals the SNARE complex to open fusion pores. SYT1 ... Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene. Synaptotagmins are integral membrane proteins of ... homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C". Biochemistry. 31 ( ...
Activation of the complex is regulated by the attachment of the ubiquitin-like protein NEDD8 to a conserved Lys residue in the ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library ... Another substrate of CRL complex is a candidate tumour suppressor protein RhoBTB2. CUL3 has been shown to interact with: CAND1 ... Another protein that interacts with cullin is CAND1 which binds to deneddylated form of cullin protein and disrupts the ...
... which is also part of a protein complex. The autophagy-inducible Beclin-1 complex contains the proteins PIK3R4(p150), Atg14L ... Lipidated LC3 contributes to the closure of autophagosomes, and enables the docking of specific cargos and adaptor proteins ... protein family, was recently shown to physically bind ATG16L1. Atg16L1 is a member of an E3-like protein complex involved in ... substrate/chaperone complex. This complex then moves to the lysosomal membrane-bound protein that will recognise and bind with ...
Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". The Journal of Biological ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library ... Tight junction protein 1 has been shown to interact with: F11 receptor, GJA3, GJA8, Gap junction protein, alpha 1, KIRREL, ... Zonula occludens-1 ZO-1, also known as Tight junction protein-1 is a 220-kD peripheral membrane protein that is encoded by the ...
When serine 349 is phosphorylated, the binding affinity between protein complex p62 and the protein Keap1 is strengthened, ... and activation of the receptor activates a signaling pathway through enzymatic activity and interactions with adaptor proteins ... Protein phosphorylation is a reversible post-translational modification of proteins. In eukaryotes, protein phosphorylation ... protein A phosphorylates protein B, and B phosphorylates C. However, in another signaling pathway, protein D phosphorylates A, ...
"Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3". ... Lysosomal integral membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene. LIMP-2 is expressed ... Studies of the similar proteins in mice and rat suggested that this protein may participate in membrane transportation and the ... The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and ...
G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction". Journal of Biological ... Rho family GTP-binding protein family members Rac1 and Cdc42, activated via DHPH RhoGEF domain. The neuronal synapse adaptors ... βPIX is a multidomain protein that functions both as a signaling scaffold protein and as an enzyme. βPIX shares this domain ... βPIX has been reported to interact with over 120 proteins. Major interacting proteins include: Itself, or the highly-related ...
The complex of proteins which regulate the cell arrest are BUB1, BUB2, BUB3 (this protein), Mad1, Mad2, Mad3 and MPS1. At ... Cayrol C, Cougoule C, Wright M (November 2002). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint ... Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene. Bub3 is a protein involved with the ... BUB3 forms a complex with BUB1 (BUB1/BUB3 complex) to inhibit the anaphase-promoting complex or cyclosome (APC/C) as soon as ...
De Waard M, Liu H, Walker D, Scott VE, Gurnett CA, Campbell KP (1997). "Direct binding of G-protein betagamma complex to ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene. ... Yan K, Kalyanaraman V, Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of ...
Histones are protein complexes used to package DNA into structures known as nucleosomes. The level of coiling of the DNA around ... In its phosphorylated form, TrkB receptors recruit and bind adaptor proteins which result in the activation of MAPK. As ... Some of the kinase families currently linked to alcoholism are Ca2+/calmodulin-dependent protein kinases (CaMKs), protein ... Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism. Proc ...
AP2 adaptor complex Clathrin vesicles COPII vesicles Paczkowski JE, Richardson BC, Fromme JC (July 2015). "Cargo adaptors: ... Exomer is a heterotetrameric protein complex similar to COPI and other adaptins. It was first described in the yeast ... Articles with short description, Short description is different from Wikidata, Protein complexes). ... A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast". The ...
"Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking". ... "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis". Proceedings of the ... Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein- ... "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis". Proceedings of the ...
Buchsbaum RJ, Connolly BA, Feig LA (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library ... "Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation". The Journal of Biological ... Rho guanine nucleotide exchange factor TIAM1 is a protein that in humans is encoded by the TIAM1 gene. TIAM1 is tightly ...
"The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J Biol Chem. 270 (37): ... Vecchione A, Marchese A, Henry P, Rotin D, Morrione A (May 2003). "The Grb10/Nedd4 complex regulates ligand-induced ... Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is ... "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ...
Law SF, Zhang YZ, Fashena SJ, Toby G, Estojak J, Golemis EA (Oct 1999). "Dimerization of the docking/adaptor protein HEF1 via a ... Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex ... DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. The protein encoded by this gene ... Law SF, Zhang YZ, Fashena SJ, Toby G, Estojak J, Golemis EA (1999). "Dimerization of the docking/adaptor protein HEF1 via a ...
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library ... At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal ... Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly ...