... but his daughters will be carriers of one copy of the mutated gene. A woman who is a carrier of an X-linked recessive disorder ... Examples of this type of disorder are albinism, medium-chain acyl-CoA dehydrogenase deficiency, cystic fibrosis, sickle cell ... On the other hand, hereditary defects in structural proteins (such as osteogenesis imperfecta, Marfan's syndrome and many ... When a couple where one partner or both are affected or carriers of a single-gene disorder wish to have a child, they can do so ...
Acyl-CoAs also mediate protein targeting to various membranes and regulation of G Protein α subunits, because they are ... and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers ... Duncan JA, Gilman AG (Jun 1998). "A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits ... Acyl-CoA thioesterase 13 is a protein that in humans is encoded by the ACOT13 gene. This gene encodes a member of the ...
Phosphorylation of a protein by a kinase can activate a cascade such as the mitogen-activated protein kinase cascade. ATP is ... However, it is also necessary to transport phosphate into the mitochondrion; the phosphate carrier moves a proton in with each ... Dozens of ATP equivalents are generated by the beta-oxidation of a single long acyl chain. In oxidative phosphorylation, the ... The protein has two binding sites for ATP - the active site is accessible in either protein conformation, but ATP binding to ...
Both proteins also mediate H+-dependent Fe2+ uptake. These proteins are of 575 and 549 amino acyl residues in length and are ... "Expansion of the APC superfamily of secondary carriers". Proteins. 82 (10): 2797-811. doi:10.1002/prot.24643. PMC 4177346. PMID ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... The yeast proteins may be localized to the vacuole and/or the plasma membrane of the yeast cell. Indirect and some direct ...
Protein families, Solute carrier family). ... and are roughly 460-565 amino acyl residues in length. ... The lactate permease (LctP) family (TC# 2.A.14) is a family of transport proteins belonging to the ion transporter (IT) ... The original text was at "2.A.14 The Lactate Permease (LctP) Family" (Protein pages needing a picture, Articles with imported ... and glycolate by the LldP and GlcA membrane carriers of Escherichia coli". Biochemical and Biophysical Research Communications ...
Medium-chain acyl-coenzyme A dehydrogenase deficiency (MCAD deficiency) Short-chain acyl-coenzyme A dehydrogenase deficiency ( ... If only one part of the gene is present then the individual is only a carrier and shows no symptoms of the disease. If both ... The enzyme or transport protein can be missing or improperly constructed, resulting in it not working. This leaves the body ... Like most autosomal recessive disorders, when both parents are carriers, there is a 25% chance for each child to inherit the ...
... which is attached to the peptidyl carrier protein (PCP) domain. The enzyme bound amino acids are then joined by amide bonds by ... These five structures differ by the identity of the fatty acyl side-chain attached to the sugar. The origin of these seven ... Teicoplanin contains 6 non-proteinogenic amino acids and three sugar moieties, N-acyl-β-D-glucosamine, N-acetyl-β-D-glucosamine ... Tei10* catalyses the addition of GlcNAc to residue 4, followed by deacetylation by Tei2*. The acyl chain (produced by the ...
... +protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Solute carrier family ... 2005). "Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not ... Long-chain fatty acid transport protein 3 is a protein that in humans is encoded by the SLC27A3 gene. In melanocytic cells ... Solute carrier family, All stub articles, Membrane protein stubs). ...
The cation-carrier effect is characterized by surfactin's ability to drive monovalent and divalent cations through an organic ... When surfactin penetrates the outer sheet, its fatty acid chain interacts with the acyl chains of the phospholipids, orienting ... Furthermore, when the environment is packed with proteins and lipids, surfactin faces a buffer effect lowering its antiviral ... Yeh MS, Wei YH, Chang JS (2005). "Enhanced production of surfactin from Bacillus subtilis by addition of solid carriers". ...
Protein translocation in ER SSR3 Translocon-associated protein TRAPG. Protein translocation in ER SUMO1 Protein targeting SUMO3 ... macrophage migration inhibitory factor TAPBP ADRBK1 can downregulate response to epinephrine AGPAT1 acyl 3 phosphoglycerol acyl ... 005415 SLC25A11 mitochondrial oxoglutarate/malate carrier SLC25A26 NM_173471 SLC25A28 NM_031212 SLC25A3 NM_002635 SLC25A32 NM_ ... 004582 CENPB Centromere protein B CTBP1 Centromere protein T CCNB1IP1 NM_021178 E3 ubiquitin-protein ligase. Modulates cyclin B ...
Known proteins in the AGCS family are between 445 and 550 amino acyl residues in length and possess 8 to 12 putative ... Kanamori M, Kamata H, Yagisawa H, Hirata H (March 1999). "Overexpression of the alanine carrier protein gene from thermophilic ... Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane proteins, All stub ... October 1992). "Primary structure of the alanine carrier protein of thermophilic bacterium PS3". The Journal of Biological ...
"A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity". Cell Chem Biol. 27 (9): 1130-1139.e4. doi:10.1016 ... NAGly respiration bioactivity can be also abrogated in the presence of serum albumin, which functions as an NAGly carrier in ... Kim JT, Terrell SM, Li VL, Wei W, Fischer CR, Long JZ (April 2020). "Cooperative enzymatic control of N-acyl amino acids by ... NaGly was shown to be endogenous ligand for the G-protein couple receptor GPR92 along with farnesyl pyrophosphate. In the ...
High levels of Malonyl-CoA will inhibit β-oxidation of fatty acids through deactivating the carrier of fatty acyl group, CPT1, ... The first mutation is the transversion of gene from C to G causing a premature stop signal in the protein. The second mutation ... Malonyl-CoA decarboxylase deficiency is extremely rare, evidence suggests that it is caused by the abnormality in the protein ... cellular Mal-CoA increases so dramatically that at the end it is instead broken down by an unspecific short-chain acyl-CoA ...
Incompletely processed proteins and fats can build up, leading to a dangerous chemical imbalance called acidosis. Individuals ... The parents of an individual with an autosomal recessive disorder are carriers of one copy of the defective gene, but do not ... "Multiple acyl-CoA dehydrogenase deficiency". Orphanet. INSERM and the European Commission. Retrieved 30 August 2018. "Glutaric ... Patients may be advised to follow a diet low in fat and protein and high in carbohydrates, particularly in severe cases. ...
... some lipid-binding proteins are able to insert themselves into membranes and could hypothetically recognize the type of acyl ... A major event in the budding of vesicles, such as transport carriers from the Golgi, is the creation and subsequent narrowing ... anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior". Proceedings of the National Academy of ... Perhaps the different acyl chains can affect the angle of the head-group in the membrane. If this is the case, it suggests that ...
Universal protein resource accession number Q9UNI1 at UniProt. "Elastase". Worthington Enzyme Manual. Largman C, Brodrick JW, ... it is possible that carriers of the polymorphism may be at greater risk of developing the common skin diseases such as ... followed by a nucleophillic attack that forms an acyl-enzyme intermediate (a pair of electrons from the double bond of the ... In fact, pancreatic elastase is expressed in basal layers of epidermis (at protein level). Hence pancreatic elastase 1 has been ...
... encoding protein Solute carrier family 39 member 11 SLFN11: encoding protein Schlafen family member 11 SLFN12: encoding protein ... acyl-coenzyme A dehydrogenase, very long chain (17p13.1) SHBG: Sex hormone binding globulin (17p13.1) TP53: tumor suppressor ... encoding protein Y-box-binding protein 2 ZNF207: encoding protein Zinc finger protein 207 ZNF830: encoding protein Zinc finger ... encoding protein Musashi RNA binding protein 2 MYBBP1A: encoding protein Myb-binding protein 1A MYCBPAP: encoding protein MYCBP ...
... encoding protein Solute carrier family 25 member 22 SMAP1: small acidic protein SMCO4: encoding protein SMCO4 SMPD1: ... fatty acyl-coA reductase 1 FAT3: fat atypical cadherin 3 FHIP: FTS and Hook-interacting protein FNBP4: Formin-binding protein 4 ... encoding protein Uncharacterized protein C11orf16 C11orf49: encoding protein UPF0705 protein C11orf49 C11orf52 encoding protein ... encoding protein Acrosomal protein SP-10 AKIP1: A kinase interacting protein 1 ALKBH3 encoding protein AlkB homolog 3, alpha- ...
"Protein Information: P24752". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 14 August ... Ge J, Zhai W, Cheng B, He P, Qi B, Lu H, Zeng Y, Chen X (September 2013). "Insulin induces human acyl-coenzyme A: cholesterol ... This disease is inherited in an autosomal recessive manner, meaning that carriers of the gene do not show symptoms of the ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
Riboflavin is generally ingested in the small intestine and then transported to cells via carrier proteins. Riboflavin kinase ( ... short/branched-chain acyl-CoA dehydrogenase), valine (isobutyryl-CoA dehydrogenase), and lysine (glutaryl-CoA dehydrogenase). ... Current research investigates proteins with the appended BLUF domain and how different external factors can impact the proteins ... FAD bound to proteins in the PDB FAD entry in the NIH Chemical Database (Articles with short description, Short description is ...
Sterol carrier proteins Phosphatidylinositol transfer proteins and STAR domains Oxysterol-binding protein These proteins are ... Protein association with membranes through the use of acylated residues is a reversible process, as the acyl chain can be ... Some proteins, such as G-proteins and certain protein kinases, interact with transmembrane proteins and the lipid bilayer ... Peripheral membrane proteins, or extrinsic membrane proteins, are membrane proteins that adhere only temporarily to the ...
Portal: Biology v t e (Protein families, Solute carrier family, All stub articles, Membrane protein stubs). ... They are usually 200-350 amino acyl residues long and exhibit 5-7 transmembrane segments (TMSs). The yeast golgi Gcr1-dependent ... CaCA2 family proteins are found in bacteria, archaea, yeast, plants and animals. This family, previously called the ... "Newly characterized Golgi-localized family of proteins is involved in calcium and pH homeostasis in yeast and human cells". ...
This end product acts as a carrier of N-Acetylglucosamine, which is the monomeric unit of chitin, a structural polymer that ... This proposed 3d structure of the protein shows that the specific parts of the substrates involved in this reaction - the ... since it involves the transfer of a general acyl group with a methyl as the substituent. The systematic name of this enzyme ... The general reaction mechanism postulated for protein N-end acetylation (inspired by lysine acetylation mechanism) with Acetyl- ...
Portal: Biology v t e (Protein families, Solute carrier family, All stub articles, Membrane protein stubs). ... This protein is 782 amino acyl residues in length and possesses 7 transmembrane segments (TMSs). It functions in inorganic ... These proteins belong to the EXS (Erd1/Xpr1/Syg1) superfamily. The generalized reaction catalyzed by Pho1 is: Pi (cells) → Pi ( ... protein". www.uniprot.org. Retrieved 2016-03-03. Versaw, W. K. (1995-02-03). "A phosphate-repressible, high-affinity phosphate ...
The alpha subunit of PCC contains the biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains. A domain ... November 2004). "Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate ... When multiple copies of a polypeptide encoded by a gene form an aggregate, this protein structure is referred to as a multimer ... a. Carbamazepine (antiepileptic drug): significantly lowers enzyme levels in the liver b. E. coli chaperonin proteins groES and ...
The proteins of the CPA2 family consist of between 333 and 900 amino acyl residues and exhibit 10-14 transmembrane α-helical ... The carrier-mediated mode) Some members may also catalyze: M+ (in) ⇌ M+ (out). (The channel-mediated mode) CPA superfamily ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ... The KefC ancillary protein is YabF while the KefB ancillary protein is YheR. These ancillary proteins stimulate transport ...
Acetylation of cellular proteins is a well-established phenomenon in the regulation of protein function at the post- ... The conjugate with the acetyl group intact is referred to as the acyl glucuronide; the deacetylated conjugate is the phenolic ... by diffusing from the inner membrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again ... Aspirin is known to displace a number of drugs from protein-binding sites in the blood, including the antidiabetic drugs ...
Protein pages needing a picture, Solute carrier family, Protein families, All stub articles, Membrane protein stubs). ... MntP proteins are of about 200 amino acyl residues with 6 putative transmembrane segments (TMSs). The Conserved Domain Database ... Martin JE, Waters LS, Storz G, Imlay JA (March 2015). "The Escherichia coli small protein MntS and exporter MntP optimize the ... A representative list of proteins belonging to the MntP family can be found in the Transporter Classification Database. At ...
... encoding protein Secretory carrier-associated membrane protein 2 SCAMP5: encoding protein Secretory carrier-associated membrane ... AAGAB: alpha- and gamma-adaptin binding protein ACSBG1: encoding enzyme Acyl-CoA Synthetase, Bubblegum Family, member 1 ADH1: ... encoding protein Zinc finger protein 280D SYNM: encoding protein Synemin TEX9: encoding protein Testis-expressed protein 9 ... encoding protein Unc-13 homolog C VPS39: encoding protein hVam6p/Vps39-like protein WDR76: encoding protein Wd repeat domain 76 ...
Biotin carboxylase (BC) activity, biotin carboxyl carrier protein (BCCP), and carboxyl transferase (CT) activity are each ... is produced which is a building block for new fatty acids and can inhibit the transfer of the fatty acyl group from acyl CoA to ... coli acetyl-CoA carboxylase Biotin carboxyl carrier protein subunit of E. coli acetyl-CoA carboxylase Carboxyl transferase ... Protein kinase A also has the ability to phosphorylate ACC, with a much greater ability to phosphorylate ACC2 than ACC1. Ser80 ...