Calcineurin will go on to activate the transcription factors NFAT 1-3, which will stimulate hypertrophy and growth of the ... Nonsulfated CCK peptides also occur, which consequently cannot activate the CCK-A receptor, but their biological role remains ... Gurda GT, Guo L, Lee SH, Molkentin JD, Williams JA (January 2008). "Cholecystokinin activates pancreatic calcineurin-NFAT ... Liddle RA (September 1995). "Regulation of cholecystokinin secretion by intraluminal releasing factors". The American Journal ...

The inflammatory transcription factor NF-κB and CD38 are mutually activating. Secretions from senescent cells induce high ... As a receptor, CD38 can attach to CD31 on the surface of T cells, thereby activating those cells to produce a variety of ... Zhao ZY, Xie XJ, Li WH, Zhao YJ (2016). "A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce ... The cytokine tumor necrosis factor strongly induces CD38 on airway smooth muscle cells inducing cADPR-mediated Ca2+, thereby ...

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. NFAT ... "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated ... "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated ... Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and ...

"Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors". J. Biol. Chem. 273 (23 ... "Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2". J. Biol. Chem. 277 (32): 29268- ... 1173 (3): 342-4. doi:10.1016/0167-4781(93)90135-z. PMID 7916637. Haga K, Kameyama K, Haga T, Kikkawa U, Shiozaki K, Uchiyama H ... 327 (3): 941-53. doi:10.1124/jpet.108.140350. PMC 2745822. PMID 18772318. Dencker D, Weikop P, Sørensen G, et al. (2012). "An ...

... cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region". Journal of ... a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate- ... SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene. PDEF is an ETS ... "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor". Chen H, Nandi AK, Li X, Bieberich CJ (January 2002 ...

TAK1 can then activate two transcription pathways, the nuclear factor-κB (NF-κB) pathway and the mitogen-activated protein ... IRF7 is a transcription factor that translocates into the nucleus when activated and initiates transcription of IFN-α. IRAK-1 ... Phosphorylated JNK/p38 can then translocate into the nucleus and phosphorylate and activate transcription factors such as c-Fos ... IL-10 transcription is activated by signal transducer and activator of transcription 3 (STAT3). IRAK-1 forms a complex with ...

... a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1". The Journal of Biological Chemistry ... by control of the upstream activator of insulin growth factor-1 (IGF-1) and mitogen-activated protein kinase (MAPK) signaling ... 30 (3): 129-37. doi:10.1016/j.tips.2008.12.003. PMID 19217170. Maghzal GJ, Leck MC, Collinson E, Li C, Stocker R (Oct 2009). " ... 8 (3): 221-5. doi:10.1038/84955. PMID 11224565. S2CID 42293456. Whitby FG, Phillips JD, Hill CP, McCoubrey W, Maines MD (Jun ...

These induce sensory interneurons by activating Sr/Thr kinases and altering SMAD transcription factor levels. Signals that ... Nerve Growth Factor (NGF): Rita Levi Montalcini and Stanley Cohen purified the first trophic factor, Nerve Growth Factor (NGF ... LIFRβ acts as a docking site for the STAT transcription factors. JAK kinase phosphorylates STAT proteins, which dissociate from ... CNTF: Ciliary neurotrophic factor is another protein that acts as a survival factor for motor neurons. CNTF acts via a receptor ...

IFNs activate signal transducer and activator of transcription (STAT) complexes; STATs are a family of transcription factors ... Type I IFNs further activate p38 mitogen-activated protein kinase (MAP kinase) to induce gene transcription. Antiviral and ... this receptor activates the transcription factors IRF3 and NF-κB, which are important for initiating synthesis of many ... Some STATs are activated by both type I and type II IFNs. However each IFN type can also activate unique STATs. STAT activation ...

When activated, YAP and TAZ can bind to several transcription factors including p73, Runx2 and several TEADs. YAP regulates the ... In its active state, Yki binds to the transcription factor Scalloped (Sd), and the Yki-Sd complex becomes localized to the ... Activated Wts can then go on to phosphorylate and inactivate the transcriptional coactivator Yorkie (Yki). Yki is unable to ... Fat activates Hpo through the apical protein Expanded (Ex; FRMD6/Willin in mammals). Ex interacts with two other apically- ...

June 1998). "Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B ... "Entrez Gene: TCF12 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)". Ganna A, Verweij KJ, Nivard MG, ... Transcription factor 12 is a protein that in humans is encoded by the TCF12 gene. The protein encoded by this gene is a member ... Bhandari RK, Sadler-Riggleman I, Clement TM, Skinner MK (2011-05-17). "Basic helix-loop-helix transcription factor TCF21 is a ...

Polarisation to a Th17 phenotype is triggered by IL-6 and TGF-β, which activate the Th17 transcription factor RORγt. IL-23 ... STATs dimerise and activate transcription of target genes in nucleus. STAT3 is responsible for key Th17 development attributes ... IL-23 is mainly secreted by activated dendritic cells, macrophages or monocytes. Innate lymphoid cells and γδ T cells also ... Re F, Strominger JL (October 2001). "Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells". The ...

SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of ... Gérard MA, Krol A, Carbon P (2007). "Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene". Gene ... Transcription factors, All stub articles, Human chromosome 11 gene stubs). ... Schuster C, Myslinski E, Krol A, Carbon P (1995). "Staf, a novel zinc finger protein that activates the RNA polymerase III ...

... nuclear factor-kappaB and Activating Transcription Factor 2 have also been implicated to be involved in EMT. Wnt signaling ... transcription factors such as grainyhead-like protein 2 homologue (GRHL2), and ETS-related transcription factors ELF3 and ELF5 ... Kruppel-like factor 8) can bind to the E-cadherin promoter and repress its transcription, whereas factors such as Twist, ... Many transcription factors (TFs) that can repress E-cadherin directly or indirectly can be considered as EMT-TF (EMT inducing ...

Pospelov VA, Pospelova TV, Julien JP (February 1994). "AP-1 and Krox-24 transcription factors activate the neurofilament light ... 93 (3): 825-831. doi:10.1093/jb/93.3.825. PMID 6135695. Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to ... 169 (3): 651-657. doi:10.1111/j.1432-1033.1987.tb13657.x. PMID 3121319. Nomata Y, Watanabe T, Wada H (March 1983). "Highly ... doi:10.1038/s41591-018-0304-3. PMC 6367005. PMID 30664784. Niemelä V, Landtblom AM, Blennow K, Sundblom J (27 February 2017). " ...

June 2012). "Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- ... This protein is deactivated by binding ATP, and activated by its dephosphorylation to ADP, which requires a potassium ion to ... Rauch JN, Gestwicki JE (January 2014). "Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates ... Rauch JN, Gestwicki JE (January 2014). "Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates ...

The AHR (i.e. the aryl hydrocarbon receptor) is a ligand-activated transcription factor that regulates xenobiotic-metabolizing ... platelet-activating factor, and PUFA metabolites including in particular leukotrienes (e.g. LTB4), hydroxyeicosatetraenoic ... by either activating or inhibiting cells through binding to and thereby activating or inhibiting the activation of specific ... These oxo metabolites directly activate the nuclear receptor peroxisome proliferator-activated receptor gamma and possess anti- ...

... believed to induce aberrant Ca2+-uptake in prostate cancer line and activate transcription factor Nuclear Factor of Activated T ... Mechanism wise, TRPV6 transcription is initiated in response to vitamin D Receptor (VDR)-mediated signaling, although other non ... TRPV6 has been reported to amplify Insulin-like growth factors (IGF)-induced PI3K-PDK1-Akt signaling in human colon cancer and ... Rodent studies suggest that the TRPV6 channel is regulated by a wide range of physiological factors such as diet, age, gender, ...

... phosphorylates specific tyrosine residues on the cytokine receptor subunits which then activate STAT transcription factors. ... It is a kinase that is activated only by cytokines whose receptors contain the common gamma chain subunit (IL-2, IL-4, IL-7, IL ... JAK3 (Janus kinase 3) deficiency is a dysfunction in cytokine receptor signalling and their production of cytokines. JAK3 is a ... "Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell ...

"Peroxisome proliferator-activated receptor subtypes differentially cooperate with other transcription factors in selective ... Under lipolytically stimulated conditions, PKA is activated and phosphorylates up to 6 Serine residues on Perilipin A (Ser81, ... Perilipin-null mice eat more food than wild-type mice, but gain 1/3 less fat than wild-type mice on the same diet; perilipin- ... 89 (3): 1352-8. doi:10.1210/jc.2003-031388. PMID 15001633. Arvidsson E, Blomqvist L, Rydén M (May 2004). "Depot-specific ...

"Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle ... FoxH1 is a transcription factor that contains a conserved function in chordates. FoxH1, acts in combination with other ... Forkhead transcription factors, All stub articles, Human chromosome 8 gene stubs). ... transcription factors, as a critical element of node formation in early embryo development. Specifically, FoxH1 plays a role in ...

Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate ... CREM transcription factors also play an important role in many physiological systems, such as cardiac function, circadian ... This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular ... Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". ...

ETS1 activates MET transcription in vitro. MET transcription is activated by hypoxia-inducible factor 1 (HIF1), which is ... "Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway". ... Hypoxia also activates transcription factor AP-1, which is involved in MET transcription. MET pathway plays an important role ... MET activates the STAT3 transcription factor directly, through an SH2 domain. The beta-catenin pathway, a key component of the ...

Glick E, Leshkowitz D, Walker MD (2000). "Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the ... PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox ... kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 ... 1995). "Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1". ...

Glick E, Leshkowitz D, Walker MD (January 2000). "Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate ... Neurogenic differentiation 1 (Neurod1), also called β2, is a transcription factor of the NeuroD-type. It is encoded by the ... Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, ... Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, ...

... differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus". ... leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO ... "Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)". Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins ... 37 (2): 111-2, author reply 112-3. doi:10.1038/ng0205-111. PMID 15678135. Park Y, Park S, Kang J, Yang S, Kim D (Feb 2005). " ...

IRF3 and IRF7 are themselves transcription factors that translocate into the nucleus and activate the transcription of type I ... phosphorylation by the activated JAK kinases of key transcription factors, namely STAT1 and STAT2, members of the family Signal ... After binding to its receptor, type I IFNs activate multiple cellular factors that transduce the signal from the cell surface ... enzymes which activate by phosphorylation the IFN regulatory factors (IRF), IRF3 and IRF7. ...

Transcription factor 'Signal inducer and activator of transcription 3' (STAT3) is continuously activated in cancer cells. It ... These adhesion molecules are essential factors in regulating the inflammatory process. It is linked to the inhibition of ... SK-OV-3, SK-MEL-2, A549, HCT-15 and XF498 (CNS) cell lines have been tested and resulted in a range between 0.29 and 1.37 μg/ml ... Another study has given values between 1.41 and 8.48 μg/ml for the SK-MEL-2, SK-OV-3, A549 and HCT cell lines. Additionally, ...

Nabel, Gary; Baltimore, David (1987-04-22). "An inducible transcription factor activates expression of human immunodeficiency ... "An inducible transcription factor activates expression of human immunodeficiency virus in T cells". Nature. 326 (6114): 711-713 ... a host transcription factor. He completed his Internal Medicine residency at Brigham and Women's Hospital. Nabel joined the ... Osborn, L.; Kunkel, S.; Nabel, G. J. (1989-04-01). "Tumor necrosis factor alpha and interleukin 1 stimulate the human ...

It acts as a transcription factor and activates several genes required for amino acid synthesis. Recently GCN2 has also been ... The molecular mechanisms governing this function are not yet known, but a basic zipper transcription factor called ATF4 is a ... Eukaryotic initiation factors The three subunits of eIF2: α - EIF2S1 β - EIF2S2 γ - EIF2S3 Kinases of eIF2 HRI (Heme-regulated ... Subsequently, GCN2 is activated. GCN2 activation results from a conformation that facilitates ATP binding, leading to ...