... recruits germ plasm components such as the protein Vasa and the RNA-binding proteins of the Piwi family, among many others. The ... The former is structurally related to SGNH hydrolases but lack the active site residues. The latter is a winged helix-turn- ... long isoform of oskar (Long oskar) has been implicated in creating an actin network on the posterior pole end. A second role ... Kim-Ha J, Kerr K, Macdonald PM (May 1995). "Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is ...

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 is a protein that ... "Entrez Gene: SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H ... 1993). "The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene related to Drosophila and yeast transcriptional ... 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. Gerhard DS, Wagner L, Feingold EA, et al. (2004 ...

ERM proteins are highly regulated proteins. They exist in two forms: the FERM domain is able to interact with the F-actin ... The ERM protein family consists of three closely related proteins, ezrin, radixin and moesin. The three paralogs, ezrin, ... ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament-plasma membrane ... ERM proteins are inactive for the folding prevents either integral protein binding, or actin-binding. if this head-to-tail ...

... but autophagocytosis associated protein Atg3 and other proteins are required. Additionally, collections of thin tubules at the ... Actin is also believed to be important. It has been observed that various pathogen infections that lead to the induction of ... and related to a process of autophagy. It is a subdomain of the Endoplasmic Reticulum (ER), and has a morphology resembling the ... Kruppa AJ, Kendrick-Jones J, Buss F (2016). "Myosins, Actin and Autophagy". Traffic. 17 (8): 878-90. doi:10.1111/tra.12410. PMC ...

Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene. GRCh38: Ensembl ... Brett TJ, Legendre-Guillemin V, McPherson PS, Fremont DH (Feb 2006). "Structural definition of the F-actin-binding THATCH ... "Entrez Gene: HIP1R huntingtin interacting protein 1 related". Parker JA, Metzler M, Georgiou J, et al. (2007). "Huntingtin- ... 2005). "Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for ...

RhoA directly stimulates actin polymerization through activation of diaphanous-related formins, thereby structurally changing ... Signaling proteins like RhoA, regulate polymerization of actin. Due to differences proteins exhibited between normal and ... are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation ... Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of ...

2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7-16. doi:10.1042/ ... Yarar D; Waterman-Storer CM; Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for ... This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the ... 2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in ... Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene. ... 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci ...

"The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)". ... Horisberger MA (1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins". J. ... Tubulin beta-2A chain is a protein that in humans is encoded by the TUBB2A gene. GRCh38: Ensembl release 89: ENSG00000137267 - ... 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693-707. doi: ...

Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (September 1998). "Five SWI/SNF-related, matrix-associated, actin- ... The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase ... "Entrez Gene: SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2". ... The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine ...

Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene. The product of this gene belongs to the ... "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal ... family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and ... The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is ...

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and ... Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42- ... "Cofilin Phosphorylation by Protein Kinase Testicular Protein Kinase 1 and Its Role in Integrin-mediated Actin Reorganization ... Maciver SK, Hussey PJ (2002). "The ADF/cofilin family: actin-remodeling proteins". Genome Biol. 3 (5): reviews3007. doi:10.1186 ...

Ras-related protein R-Ras, RRAS, belongs to the Ras family and is involved in the organization of actin filaments within the ... The glutamine and serine-rich protein 1 (QSER1) is the only closely related paralog to PRR12 (NCBI accession: EAW68214). QSER1 ... Jianping Chen lists PRR12 as an "extremely vulnerable protein". These proteins have regions rich in amino acids that are "poor ... ISBN 978-0-8153-4111-6. "PRR12 protein [Homo sapiens] - Protein - NCBI". Ncbi.nlm.nih.gov. 2013-08-12. Retrieved 2014-01-26. ...

... and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator- ... Zyxin is a protein that in humans is encoded by the ZYX gene. Focal adhesions are actin-rich structures that enable cells to ... Zumbrunn J, Trueb B (January 1997). "A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts". ... Degenhardt YY, Silverstein S (2001). "Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human ...

eEF1A also binds actin. Various species of green algae, red algae, chromalveolates, and fungi lack the EF-1α gene but instead ... In eukaryotes, a related GTPase called eRF3 participates in translation termination. The archaeal EF-1α, on the other hand, ... Peptide+Elongation+Factor+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Protein pages needing a ... divergent EF-1α genes co-occur with EFL genes in diverse distantly related eukaryotes". BMC Evolutionary Biology. 13: 131. doi: ...

... and the Chlamydial TC0437 protein (TC# 1.C.57.2.2) are of 3169 aas and 3255 aas, respectively. The distantly related ToxA toxin ... factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin ... The toxins thus induce redistribution of actin filaments and cause the cells to round up. The catalytic domains of CCTs ... A representative list of these proteins is available in the Transporter Classification Database. Homologues are found in a ...

"LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321-5. Bibcode:2001Natur.411..321M. ... Beta-actin, and UNC13B. GRCh38: Ensembl release 89: ENSG00000173898 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Nakayama M, Kikuno R, Ohara O (2003). "Protein-Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a ... Spectrin beta chain, brain 2 is a protein that in humans is encoded by the SPTBN2 gene. Mutations in this gene is associated ...

"Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". The Journal of ... Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has ... Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 ... Kv1.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH) KCNA2+protein,+human at the U. ...

... including the FAK-related protein kinase PTK2B/FAK2/PYK2, and alpha-catenin, vinculin, Programmed cell death protein 10 (PDCD10 ... Focal adhesions are multi-protein intracellular signalling complexes that link the cellular actin microfilament cytoskeleton, ... repeat motif peptides in the related focal adhesion proteins paxillin (PXN), leupaxin (LPXN) and TGFB1I1/Hic-5. FAT domains ... In structural and cell biology, the focal adhesion targeting domain is a conserved protein domain that was first identified in ...

RhoV (or Chp or Wrch2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family ... RhoV/Chp delineates with RhoU/Wrch a Rho subclass related to Rac and Cdc42, which emerged in early multicellular organisms ... activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton". Curr Biol. 8 (20): 1125-8. doi:10.1016/ ... S0960-9822(98)70468-3. ISSN 0960-9822. PMID 9778532. Boureux A, Vignal E, Faure S, Fort P (2007). "Evolution of the Rho family ...

These target molecules include RhoA, Rac, and Cdc42, which are regulatory proteins of the eukaryotic actin cytoskeleton and ... TcdA can induce the physiological changes that occur in C. difficile related pseudomembranous colitis (PMC), a severe ... F-actin), and an increase in globular actin. Disorganization of actin filaments and the cytoskeleton leads to increased ... "Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia". Proceedings of the ...

PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein BRICK1 v t e (Articles ... Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin ... "Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location". Human Mutation. ... BRICK1 is a putative micropeptide protein that in humans is encoded by the C3orf10 gene. GRCh38: Ensembl release 89: ...

A MAP6-related protein, TbSAXO, has been discovered in Trypanosoma brucei. The domains of the protein responsible for ... Instead, the phosphorylated MAP6 binds and stabilizes synaptic F-actin. The large number of calmodulin-binding domains ... Microtubule-associated protein 6 (MAP6) or stable tubule-only polypeptide (STOP or STOP protein) is a protein that in humans is ... showing that a MAP6-related protein can play a role in flagellum motility as well. MAP6 functions as a neuronal protein that ...

Wikimedia Commons has media related to Lipid rafts. Database of proteins involved in lipid rafts "Lipid Rafts, Signalling and ... Caroni, P. (2001). "NEW EMBO MEMBERS' REVIEW: Actin cytoskeleton regulation through modulation of PI(4,5)P2 rafts". The EMBO ... Syk can, in turn, activate other proteins such as LAT. Through crosslinking, LAT can recruit other proteins into the raft and ... Finally, while lipid rafts are believed to be connected in some way to proteins, Edidin argues that proteins attract the lipids ...

Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (1998). "Five SWI/SNF-related, matrix-associated, actin-dependent ... The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase ... "Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1". ... The encoded protein is part of the large ATP-dependent chromatin remodeling complex SWI/SNF and contains a predicted leucine ...

Profilin as a ubiquitous actin-binding protein is associated with most actin monomers in cells. Interactions between profilin- ... Media related to MDia1 at Wikimedia Commons Protein Database (Articles with short description, Short description is different ... The formin homology protein mDia1 is a Rho GTPase effector protein, which appears to be universally present in eukaryotic cells ... mDia1 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments. The ...

Endoplasmic reticulum (ER)-resident protein 57 (ERp57), a protein in the ER that promotes folding of nascent proteins and is ... However, none of these diseases are related to an enzyme deficiency. Indeed, thus far no disease has been attributed to the ... actin, and spectrin. Evidence shows that intracellular tTG crosslinks itself to myosin. It is also believed that tTG may ... Moreover, its specificity for TG2 was also markedly higher than those of other secreted redox proteins, including protein ...

Ma L, Li N, He X, Zhang Q (February 2011). "[miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins ... Mercey O, Kodjabachian L, Barbry P, Marcet B (2016). ""MicroRNAs as new regulators of GTPase-mediated apical actin ... "miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways"". Nature ... 143 (3): 811-820.e15. doi:10.1053/j.gastro.2012.05.033. PMID 22641068. Bao J, Li D, Wang L, Wu J, Hu Y, Wang Z, Chen Y, Cao X, ...

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene. RAB4A has been shown to interact with: ... Valentijn JA, LaCivita DQ, Gumkowski FD, Jamieson JD (Jan 1997). "Rab4 associates with the actin terminal web in developing rat ... Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related ... Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (Feb 2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 ...

... these amino acid substitutions in Act5C and Act42A did not occur in regions of the actin molecule where actin binding proteins ... In Drosophila testicles, the Leukocyte-antigen-related (LAR) receptor tyrosine phosphatase targets selection and synapse ... Mahowald focused on cytoplasmic actin genes instead of muscular actin due to the multifunctional nature of cytoplasmic actin ... Indeed, Mahowald established that there is a need for multiple forms of actin due to the large quantity of actin needed in a ...

Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).[citation needed] ... Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene. TMSB10 is a member of the beta-thymosin family of ... Condon MR, Hall AK (1992). "Expression of thymosin beta-4 and related genes in developing human brain". J. Mol. Neurosci. 3 (3 ... Maelan AE, Rasmussen TK, Larsson LI (2007). "Localization of thymosin beta10 in breast cancer cells: relationship to actin ...

Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M (Nov 2002). "Brain-specific expression of the nuclear actin-related protein ... The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of ... "Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2". Wang W ... "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM ...

... a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J. Cell Biol. ... Lee S, Park JB, Kim JH, Kim Y, Kim JH, Shin KJ, Lee JS, Ha SH, Suh PG, Ryu SH (July 2001). "Actin directly interacts with ... including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized ... The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively ...