Arf-related proteins) and the remotely related Sar (Secretion-associated and Ras-related) proteins. Arf proteins cycle between ... Amor JC, Harrison DH, Kahn RA, Ringe D (1994). "Structure of the human ADP-ribosylation factor 1 complexed with GDP". Nature. ... They function as regulators of vesicular traffic and actin remodelling. The small ADP ribosylation factor (Arf) GTP-binding ... ARF requires assistance from other proteins in order to switch between binding to GTP and GDP. GTPase activating proteins (GAPs ...
Protein N-terminal acetylation has also been proved to relate with cell cycle regulation and apoptosis with protein knockdown ... "Lysine acetylation targets protein complexes and co-regulates major cellular functions". Science. 325 (5942): 834-840. Bibcode: ... "NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility". Proc Natl Acad Sci U S A ... Ribosome proteins play an important role in the protein synthesis, which could also be N-terminal acetylated. The N-terminal ...
2000). "LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation ... 2001). "A WASp-VASP complex regulates actin polymerization at the plasma membrane". EMBO J. 20 (20): 5603-14. doi:10.1093/emboj ... 2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins ... and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator- ...
... transmembrane low-density lipoprotein receptor-related protein), preventing constitutive degradation of β-catenin. The ... For the Rho branch, Wnt signals induce DVL to form a complex with Daam1 (Dishevelled associated activator of morphogenesis 1). ... which activates actin and cytoskeleton architecture in the cell. For the Rac branch, DVL activates the Rac GTPase. Activating ... These regions mediate protein-protein interactions and help DVL channel signals into either the β-catenin or the β-catenin ...
N-acetyltransferases modify proteins by transferring acetyl groups from acetyl-CoA to the N-termini of protein substrates. The ... "Entrez Gene: N-acetyltransferase 6 (GCN5-related)". Drazic A, Aksnes H, Marie M, Boczkowska M, Varland S, Timmerman E, et al. ( ... provided by RefSeq, Jan 2011]. Naa80 acetylates the N-terminus of mature actin. This N-terminal acetylation affects the rates ... "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with ...
In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA). HLAs corresponding to ... MYO1E is a protein that controls MHC-II compartments with an actin-based mechanism. PIK3R2 and PIP5K1A are two kinases that ... MHC class II genes and molecules are related to a multitude of different diseases, one of which being Type I diabetes. HLA ... Subsequently, ARF7EP interacts with MYO1E which binds itself to actin myofibers. Altogether, this complex contributes to ...
Alpha-actinin is an actin-bundling protein known to regulate several types of ion channels. Planer lipid bilayer ... The PKD2L1-PKD1L3 complex perceives sour taste. Disruption of the PKD2-PKD1 complex, responsible for mechanosensation, leads to ... development of ADPKD (autosomal-dominant polycystic kidney disease). Besides modulating channel activity and related signaling ... Protein families, Membrane proteins, Transmembrane proteins, Transmembrane transporters, Transport proteins, Integral membrane ...
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought ... Yayoshi-Yamamoto S, Taniuchi I, Watanabe T (September 2000). "FRL, a novel formin-related protein, binds to Rac and regulates ... Mahoney NM, Janmey PA, Almo SC (1997). "Structure of the profilin-poly-L-proline complex involved in morphogenesis and ... Miki H, Suetsugu S, Takenawa T (December 1998). "WAVE, a novel WASP-family protein involved in actin reorganization induced by ...
SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene. The protein encoded by this gene is ... Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (1998). "Five SWI/SNF-related, matrix-associated, actin-dependent ... The encoded protein is part of the large ATP-dependent chromatin remodeling complex SWI/SNF and contains a predicted leucine ... "Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1". ...
... expressed in smooth muscle Other proteins and enzymes related to MLC function have been described. Among them are, for example ... neck region of MHCs is necessary for the assembly of the macromolecular complexes that result in the functional motor protein, ... MLC1, in contrast with MLC2, has a N-terminal sequence able to bind actin, contributing to force production. MLCs are ... The interaction of MLCs with the α-helical neck region of MHC molecule stabilizes the complex . To this day, eight genes ...
2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7-16. doi:10.1042/ ... Lundmark R; Carlsson SR (2002). "The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding ... Yarar D; Waterman-Storer CM; Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for ... This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at ...
The encoded protein is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for ... "Entrez Gene: SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4". Kim Y ... The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of ... In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. BRG1 works to ...
Palmer RH, Ridden J, Parker PJ (1995). "Cloning and expression patterns of two members of a novel protein-kinase-C-related ... which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related ... shear stress stimulates the tyrosine phosphorylation of alpha-actinin associated with the glycoprotein Ib-IX complex". ... Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene. The protein encoded by this gene ...
Olson MF, Pasteris NG, Gorski JL, Hall A (December 1996). "Faciogenital dysplasia protein (FGD1) and Vav, two related proteins ... "Faciogenital dysplasia protein (FGD1) regulates export of cargo proteins from the golgi complex via Cdc42 activation". Mol. ... The prolin-rich domain interacts with cortactin and actin-binding protein 1. FYVE-finger domains are conserved through ... The mature human protein contains several characteristic motifs and domains that are involved in the protein's function. The ...
The eEF1A1 protein is an isoform of the eEF-1 complex alpha subunit, an elongation factor protein, a GTPase, and an actin ... Its role in heat shock response presents it as a target for treating related diseases like spinal and bulbar muscular atrophy ( ... This protein colocalizes with filamentous actin (F-actin) and is just as abundantly expressed. eEF1A putatively binds actin and ... This protein can also act as a membrane receptor for the cryptic antiadhesive site of fibronectin, thus inhibiting cell ...
... is a protein which is part of the troponin complex. It contains four calcium-binding EF hands, although different ... It is a component of thin filaments, along with actin and tropomyosin. It contains an N lobe and a C lobe. The C lobe serves a ... In cardiac muscle, they are related to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). These known point ... Protein pages needing a picture, Genes on human chromosome 3, Genes on human chromosome 20, Troponin). ...
The five of them share a C- terminal VCA (verprolin, central, acidic) domain where they interact with actin nucleating complex ... Many of these, such as phagocytosis and podosome formation, related to its role in regulating the polymerization of actin ... a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells ... These proteins, directly or indirectly, associate with the small GTPase CDC42, known to regulate formation of actin filaments, ...
These proteins included homologs of cytoskeleton proteins, GTPases, and the oligosaccharyltransferase (OST) protein complex. ... Another shared protein, actin, is essential for phagocytosis in eukaryotes. Phagocytosis is the ability to engulf and consume ... The analysis revealed several genes with cell membrane-related functions. The presence of such genes support the hypothesis of ... closely resemble archaeal proteins, and 29% correspond to bacterial proteins. This situation is consistent with: (i) proteins ...
Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to ... Sastry L, Cao T, King CR (January 1997). "Multiple Grb2-protein complexes in human cancer cells". Int. J. Cancer. 70 (2): 208- ... Chen-Hwang MC, Chen HR, Elzinga M, Hwang YW (May 2002). "Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A ... This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique ...
... organelles and protein complexes along the actin filaments. In humans it is coded for by the MYO5A gene. In the presence of ... "Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family ... a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science ... The GB of MYO5A can form a complex with Rab3A. The involvement of this complex is important for the synaptic vesicles (SVs) ...
It was identified as an F-actin binding protein. Six years later, the anillin gene was cloned from cDNA originating from a ... Saha S, Pollard TD (October 2012). "Characterization of structural and functional domains of the anillin-related protein Mid1p ... It has been observed that anillin proteolysis is triggered after mitotic exit by the Anaphase Promoting Complex (APC). Most ... Anillin specifically binds F-actin, rather than G-actin. Binding of F-actin by anillin only occurs during cell division. ...
Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene. TC10 is a member of the RAS ... 2003). "Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 ... 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF). Nature. 422 (6932): ... 2002). "Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin- ...
... and as strict as closely related mammals like the Gorilla, which has 99% sequence identity to the human protein. The ... and serves as an actin binding domain. WH2 binds actin monomers enabling the production of actin filaments. The predicted post- ... including transporting the viral capsid to the nuclear pore complex, and linking the inner and outer viral tegument capsids ... Protein interaction screenings have showed C15orf39 to interact with many proteins, including RPLP1 and EIF4ENIF1. C15orf39 was ...
2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by ... Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout ... The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene ... 2002). "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad". Eur. J. Immunol. 32 (7): 1847- ...
... but autophagocytosis associated protein Atg3 and other proteins are required. Additionally, collections of thin tubules at the ... Actin is also believed to be important. It has been observed that various pathogen infections that lead to the induction of ... and related to a process of autophagy. It is a subdomain of the Endoplasmic Reticulum (ER), and has a morphology resembling the ... "Dynamic association of the ULK1 complex with omegasomes during autophagy induction". Journal of Cell Science. 126 (Pt 22): 5224 ...
... hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl transferase V, B-Raf ... However, IPA-3's pharmacokinetic properties as well as undesirable redox effects in cells, due to the continuous reduction of ... Ku GM, Yablonski D, Manser E, Lim L, Weiss A (February 2001). "A PAK1-PIX-PKL complex is activated by the T-cell receptor ... Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R (September 2002). "Filamin is essential in actin cytoskeletal ...
Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been ... Westendorf JJ (December 2001). "The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription ... a novel nuclear export receptor that is specific for profilin.actin complexes". The EMBO Journal. 22 (21): 5928-40. doi:10.1093 ... Protein diaphanous homolog 1 is a protein that in humans is encoded by the DIAPH1 gene. This gene is a homolog of the ...
"Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science. 285 (5429): 895-8. doi: ... Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42- ... "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex ... Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. ...
"Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin ... Edwards JC (1999). "A novel p64-related Cl− channel: subcellular distribution and nephron segment-specific expression". Am. J. ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...
The small G protein carries an essential role in the activation of the oxidase by switching between a GDP-bound (inactive) and ... The NADPH oxidase complex is dormant under normal circumstances, but is activated to assemble in the membranes during ... These subunits are: a Rho GTPase, usually Rac1 or Rac2 (Rac stands for Rho-related C3 botulinum toxin substrate) Five ... depolymerized the actin, broke the adhesions, and allowed foam cells to migrate out of the intima. One study suggests a role ...