... it was observed that the actin-binding protein actin depolymerisation factor (ADF)/cofilin, a factor that promotes actin ... Each myosin protein 'paddles' along the thin actin filament, repeatedly binding to myosin-binding sites along the actin ... It is thought that the function and form of the actin cytoskeleton is controlled largely by actin-binding proteins (ABP) that ... This binding causes the caldesmon protein to disengage from the actin filament, exposing the myosin-binding sites on the actin ...

Another shared protein, actin, is essential for phagocytosis in eukaryotes. Phagocytosis is the ability to engulf and consume ... These proteins included homologs of cytoskeleton proteins, GTPases, and the oligosaccharyltransferase (OST) protein complex. ... closely resemble archaeal proteins, and 29% correspond to bacterial proteins. This situation is consistent with: (i) proteins ... The presence of actin proteins and intracellular transport mechanisms provides evidence for the common ancestry between ancient ...

2001). "Interaction of ADP-ribosylated actin with actin binding proteins". FEBS Lett. 508 (1): 131-5. doi:10.1016/S0014-5793(01 ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene. Myosin is a hexameric ... Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ (2001). "A Nonerythroid Isoform of Protein 4.1R Interacts with Components of ...

AIF1L is an actin-binding protein that promotes actin bundling. It may neither bind calcium nor depend on calcium for function ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... Allograft inflammatory factor 1-like is a protein that is encoded by the AIF1L gene in humans. ...

Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to ... Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene. This gene encodes twinfilin, an actin monomer-binding ... "Entrez Gene: TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila)". "Eye morphology data for Twf1". Wellcome Trust ... 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel ...

Sasaki Y, Ohsawa K, Kanazawa H, Kohsaka S, Imai Y (August 2001). "Iba1 is an actin-cross-linking protein in macrophages/ ... Autieri MV, Kelemen SE, Wendt KW (May 2003). "AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular ... However complete functional profiles of all three proteins and how they overlap is unknown. IBA1 is a 17-kDa EF hand protein ... "Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity". Journal of ...

This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell ... "Entrez Gene: FSCN2 fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)". Hillier LD, Lennon G, ... Fascin-2 is a protein that in humans is encoded by the FSCN2 gene. ... close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146-56. doi:10.1006/geno.2000.6156. PMID ...

This binding remains after destabilizing actin with cytochalasin B. Like other surface-associated proteins that can bind ... thus its association with the cell surface may be via protein-protein interaction usually referred to as non-classic secretion ... "Protein diversity is generated within the motin family of proteins by alternative pre-mRNA splicing". Gene. 350 (2): 137-48. ... The PDZ-binding motif of angiomotin serves as a protein recognition site and deletion of as few as three amino acids from the C ...

In fact, annexin A-II is itself an actin-binding protein and therefore it can form a region of interaction with actin by means ... As of 2002 160 annexin proteins have been identified in 65 different species. The criteria that a protein has to meet to be ... The recognition that these proteins were members of a broad family first came from protein sequence comparisons and their cross ... Annexins can function as scaffolding proteins to anchor other proteins to the cell membrane. Annexins assemble as trimers, ...

"Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin ... "Protein sequence of human TPM2 (Uniprot ID: P07951)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Retrieved 1 July ... "Protein sequence of human TPM2 (Uniprot ID: P07951-2)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Retrieved 1 ... "Protein sequence of human TPM2 (Uniprot ID: P07951-3)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Retrieved 1 ...

This complex then binds to actin, leading to polymerization. For actin polymerization through the cadherin pathway, proteins of ... ROS also interacts with ERK pathway that leads to activation of Ras, MEK and MEK-like proteins. These proteins activate protein ... ILK activate the Rac and Cdc42 proteins and leading to actin polymerization. ERK also leads to actin polymerization through ... One example of a protein that binds to adaptor proteins and become activated is PLC that is very important in the lymphocyte ...

Other proteins that are known to interact with NM IIA include the actin binding protein tropomyosin 4.2 and a novel actin ... It encodes a protein of the same length, with 97.1% amino acid identity with the human MYH9 protein. Like all class II myosins ... "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin ... "Mapping of a myosin-binding domain and a regulatory phosphorylation site in M-protein, a structural protein of the sarcomeric M ...

... is adaptor protein. It interacts with c-Abl and WAVE2 which is an actin polymerization regulator. It is known that Abi1 ... "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras ... Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene. Abl ... In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as ...

"Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin ... Myosin-10 also known as myosin heavy chain 10 or non-muscle myosin IIB (NM-IIB) is a protein that in humans is encoded by the ... NM-IIB is 228.9 kDa protein composed of 1976 amino acids. NM-IIB has an N-terminal globular head that harbors the catalytically ... NM-IIB is part of the larger myosin II subfamily of proteins, which also includes skeletal muscle, cardiac muscle and smooth ...

Iota toxin is a protein produced by type E strands of C. perfringens. Iota toxins are made up of two, unlinked proteins that ... Iota toxins prevent the formation of filamentous actin. This causes the destruction of the cells cytoskeleton which in turn ... Epsilon toxin (ETX) is a protein produced by type B and type D strains of C. perfringens. This toxin is currently ranked the ... Beta toxins are a protein that causes hemorrhagic necrotizing enteritis and enterotoxaemia in both animals (type B) and humans ...

"Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin ... Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene. This isoform is distinct from ... The proposed mechanism for this is the expression of a more normalized ratio of α-myosin chain to β-myosin chain proteins. This ... Harris SP, Lyons RG, Bezold KL (Mar 2011). "In the thick of it: HCM-causing mutations in myosin binding proteins of the thick ...

Filamin B, beta (FLNB), also known as Filamin B, beta (truncated actin binding protein 278 homolog), is a cytoplasmic protein ... 1993). "Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease ... Xu W, Xie Z, Chung DW, Davie EW (1998). "A novel human actin-binding protein homologue that binds to platelet glycoprotein ... 1998). "Interaction of presenilins with the filamin family of actin-binding proteins". J. Neurosci. 18 (3): 914-22. doi:10.1523 ...

... derin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at ... Lueck A; Brown D; Kwiatkowski DJ (1999). "The actin-binding proteins adseverin and gelsolin are both highly expressed but ... In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are ... dependent actin filament-severing protein". Thromb. Haemost. 67 (2): 248-51. doi:10.1055/s-0038-1648420. PMID 1621245. ...

... unstructured proteins are cut more rapidly, while structured proteins are cut at a slower rate (sometimes by orders of ... "Impaired tropomyosin-troponin interactions reduce activation of the actin thin filament". Biochimica et Biophysica Acta (BBA ... is a method to determine the thermostability of proteins by measuring which fraction of protein resists rapid proteolytic ... "High-throughput characterization of intrinsic disorder in proteins from the Protein Structure Initiative". Journal of ...

Shaffer JF, Kensler RW, Harris SP (May 2009). "The myosin-binding protein C motif binds to F-actin in a phosphorylation- ... Bennett P, Craig R, Starr R, Offer G (Dec 1986). "The ultrastructural location of C-protein, X-protein and H-protein in rabbit ... "Protein Information - Myosin-binding protein C, cardiac-type". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). NHLBI ... protein kinase D (PKD), and protein kinase C (PKC). Furthermore, GSK3β was described as another protein kinase to phosphorylate ...

Dap160 is a molecular scaffolding protein and functions in actin recruitment. Dynamin is a GTPase involved in vesicle budding, ... Protein pages needing a picture, Genes on human chromosome 21, Genes on human chromosome 6, Peripheral membrane proteins, EC ... Synaptojanin is a protein involved in vesicle uncoating in neurons. This is an important regulatory lipid phosphatase. It ... The third is a C-terminal domain that is rich in the amino acid proline and interacts with several proteins also involved in ...

Park H, Teja K, O'Shea JJ, Siegel RM (May 2007). "The Yersinia effector protein YpkA induces apoptosis independently of actin ... YopO is a protein kinase also known as Yersinia protein kinase A (YpkA). YopO is a potent inducer of human macrophage apoptosis ... These T3SS-injected proteins, called Yersinia outer proteins (Yops), include Yop B/D, which form pores in the host cell ... Several proteins then contribute to the maintenance of the bacteria in the flea digestive tract, among them the hemin storage ...

Actin remodeling is generally modulated by the actin severing factor cofilin. Nef is able to associate with the cellular kinase ... HIV structure and genome Das SR, Jameel S (April 2005). "Biology of the HIV Nef protein" (PDF). Indian J. Med. Res. 121 (4): ... "HIV protein hides infected cells from immune system". MedPageToday.com. Retrieved 2008-09-26. (All articles with unsourced ... Lentiviruses such as HIV-1 have acquired proteins such as Nef which perform a wide array of functions including the ...

Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that ... 2002). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin ... Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238-46. doi: ... Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over ...

Positive: Glial fibrillary acidic protein (GFAP), pancytokeratin, and S100 protein. Smooth muscle actin may be positive in ...

Hishiya A, Ohnishi M, Tamura S, Nakamura F (September 1999). "Protein phosphatase 2C inactivates F-actin binding of human ... Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene. The protein encoded by this gene is a member ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... "A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein ...

... is a novel filamentous actin-binding protein". Biochemical and Biophysical Research Communications. 347 (1): 22-30. doi:10.1016 ... Dixin is a protein that in humans is encoded by the DIXDC1 gene. When active it stops cancer metastasis due to extreme ... Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC (September 2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N- ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (6): 347-55. ...

Hishiya A, Ohnishi M, Tamura S, Nakamura F (1999). "Protein phosphatase 2C inactivates F-actin binding of human platelet moesin ... Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene. The protein encoded by this gene is a member ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... "Entrez Gene: PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform". Cheng A, Kaldis P, Solomon MJ ( ...

... which target proteins to the plasma membrane; Calponin homology (CH) domain, which is an F-actin binding motif; Src homology 2 ... which mediate specific protein-protein binding. The literature-based adhesome contains enzymes, such as protein tyrosine and ... "A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells". The Journal of ... Whether these proteins are indeed an integral part of the adhesome or an artifact of the proteomic methods remains to be seen. ...

2003). "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300". Genomics ... 2003). "NUANCE, a giant protein connecting the nucleus and actin cytoskeleton". J. Cell Sci. 115 (Pt 15): 3207-22. doi:10.1242/ ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ... Nesprins are modular proteins with a central extended spectrin-repeat (SR) rod domain and a C-terminal Klarsicht/ANC-1/Syne ...