... is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an ... In all these tissues, the presence of inflammatory cells is physiologic and elafin expression is believed to protect against ...
... beta cells and acinar cells) the mammary gland the spleen (where bone marrow and lymphatic tissue undergo compensatory ... The growth can be a result of increased cell size (compensatory hypertrophy) or an increase in cell division (compensatory ... For instance, if one kidney is surgically removed, the cells of the other kidney divide at an increased rate. Eventually, the ...
EGFR Mutations K-ras Mutations EML4-ALK Fusions and Mutations Signet ring cell Acinar Papillary Micropapillary Squamous cell ... Clear cell variants Giant cell carcinomas HOHMS applied to certain lung cancer variants Undifferentiated large cell lung cancer ... EML4-ALK (+) lung cancers Acinar predominant adenocarcinoma and crizotinib Signet ring cell adenocarcinoma and crizotinib ... Rossi G, Marchioni A, Sartori G, Longo L, Piccinini S, Cavazza A (2007). "Histotype in non-small cell lung cancer therapy and ...
... which is then received by β1-adrenergic receptors on the acinar and ductal cells of the salivary glands, leading to an increase ... Since iron is a major component of bacterial cell walls, removal of iron breaks down the cell wall, which in turn breaks down ... Secretory cells are found in a group, or acinus. Each acinus is located at the terminal part of the gland connected to the ... Each acinus consists of a single layer of cuboidal epithelial cells surrounding a lumen, a central opening where the saliva is ...
Cystadenocarcinoma Islet cell tumors (neuroendocrine tumors) Papillary cystic neoplasms Lymphoma Acinar cell tumors Severe ... An experimental procedure called islet cell transplantation exists to help mediate the loss of endocrine function following ...
... or CD8-positive lymphocytes and IgG4-positive plasma cells, and exhibits interstitial fibrosis and acinar cell atrophy in later ... plasma cells), with rare ductal epithelial cells lacking atypia, favors the diagnosis of AIP. The sensitivity and the ... At the initial stages, typically, there is a cuff of lymphoplasma cells surrounding the ducts but also more diffuse ... It has been proposed that a cytologic smear primarily composed of acini rich in chronic inflammatory cells (lymphocytes, ...
... hormone within the pancreas that controlled blood sugar level would be to let the acinar cells secreted from the pancreas to ...
... acinar cell carcinomas account for 5% of exocrine pancreatic cancers and can be "functioning", and overproduce certain ... The second broad category of pancreatic tumor types are neuroendocrine tumors (also known as "endocrine" or "islet cell tumors ... Classification is based on cellular differentiation (ductal, acinar, neuroendocrine, other) and gross appearance (intraductal, ... "). These types of tumors arise from hormone-producing cells in the pancreas and account for only 1-2% of all pancreatic tumors ...
... and if it was the acinar cells but not the islets that degenerated after the ducts were ligated, and if two or three other ... Also in 1893, Édouard Laguesse suggested that the islet cells of the pancreas, described as "little heaps of cells" by Paul ... In 1893, Édouard Laguesse suggested that the islet cells of the pancreas, described as "little heaps of cells" by Paul ... particularly the relative changes in the acinar and islet cells... Nobody had either tried to prepare a graft or administer an ...
... cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells 1992 (1992): Ian M. Glynn - All hands to ...
... extranodal NK/T-cell lymphoma, nasal type, pancreatic acinar cell carcinoma, pheochromocytoma, paraganglioma, small cell lung ... also present on subset of CD4+ T cells and CD8+ T cells. In cell adhesion, CD56 contributes to cell-cell adhesion or cell- ... Τ cells and activated CD8+ T cells, as well as on dendritic cells. NCAM has been implicated as having a role in cell-cell ... Normal cells that stain positively for CD56 include NK cells, activated T cells, the brain and cerebellum, and neuroendocrine ...
Nevertheless, mouse ME-CRCs grown in a three-dimensional extracellular matrix gave rise to mammary acinar structures. ME-CRCs ... May 2013). "TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen- ... June 2014). "Human somatic cell nuclear transfer using adult cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03 ... June 2013). "Human embryonic stem cells derived by somatic cell nuclear transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell. ...
... expressed by β-cells and acinar cells respectively, have been shown to be linked with pancreatic β-cell regeneration in the ... This is related to the induction of Th17 cells by adjuvant treatment and these cells produce Interleukin-22 (IL-22). Pancreatic ... neural cells and epithelial cells in the digestive system. These C-type lectins contain a single carbohydrate recognition ... "The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes". Cell Regeneration. 2 (1): ...
An acinus (/ˈæsɪnəs/; PL: acini; adjective, acinar /ˈæsɪnər/ or acinous) refers to any cluster of cells that resembles a many- ... is acinar in form, as is the alveolar sac containing multiple alveoli in the lungs. Acinar exocrine glands are found in many ... p. 2. ISBN 978-0-323-52371-4. v t e (Cell anatomy, All stub articles, Anatomy stubs). ... glands The thyroid follicles can also be considered of acinar formation but in this case the follicles, being part of an ...
... atypical squamous cells of undetermined significance) on the Pap test. On a subsequent biopsy, given the diagnosis of ASAP, the ... In urologic pathology, atypical small acinar proliferation, is a collection of small prostatic glands, on prostate biopsy, ... Bostwick DG, Meiers I (July 2006). "Atypical small acinar proliferation in the prostate: clinical significance in 2006". Arch. ... Sensitivity Flury SC, Galgano MT, Mills SE, Smolkin ME, Theodorescu D (January 2007). "Atypical small acinar proliferation: ...
The histopathologic features of pancreatic acinar metaplasia are: (1) the presence of cell clusters that resembles a many-lobed ... Pancreatic acinar metaplasia (PAM) is a common incidental histopathologic finding present in approximately 20-25% of patients ... March 2010). "Pancreatic acinar metaplasia in the distal oesophagus and the gastric cardia: prevalence, predictors and relation ... Wang HH, Zeroogian JM, Spechler SJ, Goyal RK, Antonioli DA (December 1996). "Prevalence and significance of pancreatic acinar ...
... after squamous cell carcinoma). Adenocarcinomas are exceptionally heterogeneous neoplasms, occurring in four major tissue ... Acinar adenocarcinoma is a histological subtype of gland-forming cancer that is diagnosed when cuboidal and/or columnar shaped ... In Europe, acinar adenocarcinoma may comprise the dominant architectural pattern in as many as 50-60% of all adenocarcinomas. ... Acinar adenocarcinoma of the lung is a highly lethal disease. Overall five-year survival rates approximate 16% to 22%. ...
Relatively common and highly specific Multiple nucleoli Eccentric nucleoli Acinar adenocarcinoma with multiple nucleoli. Acinar ... "Papillary Urothelial (Transitional Cell) Carcinoma". Stanford University School of Medicine. Original posting/updates: 10/20/12 ... the numbers include cases where the pattern is found admixed with usual acinar adenocarcinoma. Numbers for usual acinar ... Acinar adenocarcinoma with intraluminal blue mucin. In uncertain cases, a diagnosis of malignancy can be discarded by ...
Combined with observations from the Mostov group, this work confirmed that cell polarity is indispensable for MDCK acinar ... MDCK cells are used for a wide variety of cell biology studies including cell polarity, cell-cell adhesions (termed adherens ... epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion". J Cell Biol. 108 (6): ... "Cell-cell interaction and polarity of epithelial cells: specific perturbation using a monoclonal antibody". Cell. 35 (3): 667- ...
tumour cells were reactive for Leu7 in 3 cases of 5, to vimentine in 4 of 6, to cytocheratin in 2 of 6, to epithelial membrane ... They show a uniform architecture of closely packed acinar or tubular structures of mature and bland appearance with scanty ... Cells are small with dark staining nuclei and inconspicuous nucleoli. Blastema is absent whereas calcospherites may be present ... stated that genetic analysis of chromosome 7, 17, and Y may facilitate discrimination of MA from papillary renal cell carcinoma ...
... such as acinar structures in healthy and cancerous breast tissue models. These techniques have been applied to in vitro disease ... cell-cell/cell-matrix interaction, and/or cell migration, but the available assays are not optimized for 3D cell culturing. ... Cell culture Cell lines Cell culture assay Hydrogel Madin-Darby Canine Kidney cell line Microphysiometry Fey S, Wrzesinski K ( ... In living tissue, cells exist in 3D microenvironments with intricate cell-cell and cell-matrix interactions and complex ...
... the non-small-cell lung cancers) are adenocarcinomas, squamous-cell carcinomas, and large-cell carcinomas. After diagnosis, ... Adenocarcinomas are classified as lepidic (growing along the surface of intact alveolar walls), acinar and papillary, or ... Their cells grow in three-dimensional clumps, resemble glandular cells, and may produce mucin. About 30% of lung cancers are ... The tumors consist of sheets of cells, with layers of keratin. A hollow cavity and associated cell death are commonly found at ...
... cell growth and division Proliferation, a phase of wound healing Atypical small acinar proliferation, a concept in urologic ... the challenge of dealing with large amounts of data Cell proliferation, ...
C) Clear cell carcinoma: clear cell cytoplasm identified in polygonal cells with a central nucleus, columnar cells with an ... prominent nucleoli and trabecular and pseudo-acinar growth pattern similar to hepatocarcinoma. H&E stained sections (A) ... If the mucus remains inside the tumor cell, it pushes the nucleus at the periphery, this occurs in "signet-ring cell." ... Tumor budding in colorectal cancer is loosely defined by the presence of individual cells and small clusters of tumor cells at ...
June 2008). "A betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with ... BTC is synthesized in a wide range of adult tissues and in many cultured cells, including smooth muscle cells and epithelial ... June 2007). "Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin". The American Journal of ... Immunohistochemistry has been used to look for betacellulin expression in Schwann cells. Treating cells with betacellulin ...
... present in all tissues in the mitochondria of the cell. Pancreatic acinar tissue has been found to carry the highest levels of ... BCATm is more sensitive to the redox environment of the cell, and can be inhibited by nickel ions even if the environment is ... BCAT from E. coli is typically engineered to be overexpressed and extracted from whole cells to be used for chemical synthesis ... BCATc regulates the mTORC1 signaling and TCR-induced glycolytic metabolism pathways during CD4+ T cell activation. In the brain ...
"The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell ... "p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/ ... Tikhmyanova N, Little JL, Golemis EA (2010). "CAS proteins in normal and pathological cell growth control". Cell. Mol. Life Sci ... allowing cells to respond to mechanical force changes in the cell environment. p130Cas/BCAR1 is a member of the Cas family (Crk ...
... and also stimulates acinar cells of the pancreas to produce their pancreatic enzyme. Acinar cells: Mainly responsible for ... Acinar cells are stimulated by cholecystokinin (CCK), which is a hormone/neurotransmitter produced by the intestinal cells (I ... increases secretion of the pancreatic ductal cells, as well as stimulating pancreatic acinar cells to release their zymogenic ... Parietal cells: Produce hydrochloric acid and intrinsic factor. Gastric chief cells: Produce pepsinogen. Chief cells are mainly ...
Lymphoid and plasma cells infiltrate the stroma. Clinically, mammary blood flow increases in this luteal phase. This increased ... The breast may become nodular because of interlobular edema and ductular-acinar growth. Milligan D, Drife JO, Short RV (1975 ...
Acinar cell neoplasms (8560-8580) Complex epithelial neoplasms The term carcinoma in situ (or CIS) is a term for cells that are ... Squamous cell carcinoma, NOS (8090-8110) Basal cell neoplasms (M8090/3) Basal cell carcinoma, NOS (8120-8130) Transitional cell ... Epithelial cells ⇨ carcinoma Non-hematopoietic mesenchymal cells ⇨ sarcoma Hematopoietic cells Bone marrow-derived cells that ... Certain combinations of mutations in the given progenitor cell ultimately result in that cell (also called a cancer stem cell) ...