Galactoside acetyltransferase
It catalyzes the following reaction: acetyl-CoA + beta-D-galactoside → CoA + 6-acetyl-beta-D-galactoside The kinetics of the ... is an enzyme that transfers an acetyl group from acetyl-CoA to β-galactosides, glucosides and lactosides. It is coded for by ... Galactoside acetyltransferase (also known as Galactoside O-acetyltransferase, thiogalactoside transacetylase, β-galactoside ... Transacetylase Wang XG, Olsen LR, Roderick SL (April 2002). "Structure of the lac operon galactoside acetyltransferase". ...
GCAT
... which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded ... Glycine C-acetyltransferase is a protein that in humans is encoded by the GCAT gene. The degradation of L-threonine to glycine ... "Entrez Gene: Glycine C-acetyltransferase". Jacquot C, Lanco X, Carbonnelle D, Sevestre O, Tomasoni C, Briad G, Juget M, Roussis ...
ACAT
... see Glossary of military modeling and simulation KAAS Acetyl-coenzyme A acetyltransferase, an enzyme Acyl-CoA:cholesterol ...
List of MeSH codes (D08)
... acetyl-CoA C-acetyltransferase MeSH D08.811.913.050.134.105 - amino-acid n-acetyltransferase MeSH D08.811.913.050.134.150 - ... acetyl-CoA C-acyltransferase MeSH D08.811.913.050.134 - acetyltransferases MeSH D08.811.913.050.134.029 - acyl-carrier protein ... acetyl-CoA hydrolase MeSH D08.811.277.352.897.700 - palmitoyl-coa hydrolase MeSH D08.811.277.352.897.850 - ubiquitin ... acyl-coa dehydrogenase, long-chain MeSH D08.811.682.660.150.200 - acyl-CoA oxidase MeSH D08.811.682.660.150.300 - butyryl-coa ...
Histone acetylation and deacetylation
Glucose is converted to acetyl-CoA by the pyruvate dehydrogenase complex (PDC), which produces acetyl-CoA from glucose-derived ... The process is aided by factors known as histone acetyltransferases (HATs). HAT molecules facilitate the transfer of an acetyl ... Glucose availability affects the intracellular pool of acetyl-CoA, a central metabolic intermediate that is also the acetyl ... group from a molecule of acetyl-coenzyme A (Acetyl-CoA) to the NH3+ group on lysine. When a lysine is to be deacetylated, ...
KAT5
Excess acetyl CoA is necessary for acetylation of histones. The zinc finger domain has been shown to aid in the acetylation ... Histone acetyltransferase KAT5 is an enzyme that in humans is encoded by the KAT5 gene. It is also commonly identified as TIP60 ... The structure of KAT5 includes an acetyl CoA binding domain and a zinc finger in the MYST domain, and a CHROMO domain. ... Kim MY, Ann EJ, Kim JY, Mo JS, Park JH, Kim SY, Seo MS, Park HS (Sep 2007). "Tip60 histone acetyltransferase acts as a negative ...
CREB-binding protein
... when there are lower amounts of histone or acetyl-CoA available, CBP and p300 have different, preferred acetyltransferase ... CBP has intrinsic acetyltransferase functions; it is able to add acetyl groups to both transcription factors as well as histone ... CBP (and p300) have been shown to interact with E2F proteins as both a coactivator, and as an acetyltransferase, the latter of ... This relatively unique acetyltransferase activity is also seen in another transcription enzyme, EP300 (p300). Together, they ...
Cholinergic neuron
Szutowicz A, Bielarczyk H, Jankowska-Kulawy A, Pawełczyk T, Ronowska A (August 2013). "Acetyl-CoA the key factor for survival ... The problem with this therapy is that choline acetyltransferase is largely blocked by the blood-brain barrier. PTD-ChAT is a ... It is normal in aging for circadian rhythms to deteriorate as choline acetyltransferase (ChAT) fluctuations change in pattern ... Alzheimer's typically involves a decline in the activity of choline acetyltransferase and acetylcholinesterase, as well as a ...
KLF15
AceCS2 produces acetyl-CoA for oxidation through the citric acid cycle in the mitochondrial matrix. Fasting upregulated KLF15 ... Mice deficient in Klf15 develop heart failure and aortic aneurysms in a p53-dependent and p300 acetyltransferase-dependent ... The combination of KLF15 and Sp1 resulted in a synergistic activation of the acetyl-CoA synthetase 2 (AceCS2) promoter. ... "A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene ...
Zhimin Lu
He also demonstrated that generation of acetyl-CoA at the gene promoter regions by nuclear acetyl-CoA synthetase 2 (ACSS2) ... which known as a histone acetyltransferase. KAT2A gains a new function and acts as a histone H3 succinyltransferase to regulate ... gene expression by locally catalyzing succinyl-CoA generated by α-KGDH. ...
Curacin A
... the formation of hydroxymethylglutaryl acid by the addition of an malonyl-CoA unit to the terminal ketide of the aceto-acetyl- ... CurA contains a unique GCN5-related N-acetyltransferase (GNAT) loading domain and an associated acyl carrier protein (ACP). The ... Analysis of the pathway demonstrated the presence of one NRPS/PKS hybrid module located on CurF, one HMG-CoA synthase cassette ... The CurB (ACP), CurC (ketosynthase), and CurD (HMG-CoA reductase) are responsible for the formation of (S)HMG-ACP3. HaI, from ...
Oxidative decarboxylation
... transfer of acetyl group from acetyl-lipoamide to CoA) (4) oxidation of dihydrolipoamide to lipoamide (E3, FAD, NAD+) Acetyl ... as becomes clear upon subsequent transfer of the acetyl residue to coenzyme A, catalyzed by E2, an acetyltransferase and E3, ... At this time, the compound is acetyl dihydrolipoamide, which is then catalyzed by E2, and acetyl is transferred, to form acetyl ... The acetyl group is transferred from reduced lipoamide to coenzyme A (CoA) by the activity of the E2, or dihydrolipoyl ...
Fatty acid synthase
The fatty acids are synthesized by a series of decarboxylative Claisen condensation reactions from acetyl-CoA and malonyl-CoA. ... malonyl/acetyltransferase (MAT), and dehydrase (DH)), are separated by a core region (known as the interdomain) of 600 residues ... from acetyl-CoA and malonyl-CoA, in the presence of NADPH. ...
Beta-Hydroxy beta-methylbutyryl-CoA
... is converted into acetyl-CoA and thereby contributes to the synthesis of ketones, steroids, fatty acids, and other compounds ... 3-Hydroxyisovaleryl CoA is likely detoxified by carnitine acetyltransferase producing 3HIA-carnitine, which is transported ... Metabolic impairment diverts methylcrotonyl CoA to 3-hydroxyisovaleryl CoA in a reaction catalyzed by enoyl-CoA hydratase (22, ... MC-CoA). It can be metabolized into HMB, MC-CoA, and HMG-CoA in humans. This reaction is catalyzed by an unknown thioesterase ...
Carnitine palmitoyltransferase I
Acetyl-CoA carboxylase (ACC), the enzyme that catalyzes the formation of malonyl-CoA from acetyl-CoA, is important in the ... One such mechanism based upon a carnitine acetyltransferase model is shown below in which the His 473 deprotonates carnitine ... The "A site" or "CoA site" appears to bind both malonyl-CoA and palmitoyl-CoA, as well as other molecules containing coenzyme A ... the O site binds to malonyl-CoA via the dicarbonyl group of the malonate moiety of malonyl-CoA. The binding of malonyl-CoA to ...
Platelet-activating factor acetyltransferase
This enzyme is also called PAF acetyltransferase. Lee TC, Uemura Y, Snyder F (1992). "A novel CoA-independent transacetylase ... 1-alkyl-2-acetyl-sn-glycero-3-phospholipid Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3- ... In enzymology, a platelet-activating factor acetyltransferase (EC 2.3.1.149) is an enzyme that catalyzes the chemical reaction ... whereas its two products are 1-organyl-2-lyso-sn-glycero-3-phosphocholine and 1-alkyl-2-acetyl-sn-glycero-3-phospholipid. This ...
Index of molecular biology articles
... acetyl-CoA 1,2-dioxygenase - 3(or 17)a-hydroxysteroid dehydrogenase - 3110001I22Rik - 3alpha-hydroxyglycyrrhetinate ... ribosomal-protein-alanine N-acetyltransferase - ribosomal binding sequence - ribosome - ribosyldihydronicotinamide ... myristoyl-CoA 11-(E) desaturase - myristoyl-CoA 11-(Z) desaturase - N terminus - N-acetylhexosamine 1-dehydrogenase - N- ... 6-dideoxy-N-acetyl-alpha-D-glucosamine transaminase - undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase - ...
Carnitine palmitoyltransferase II deficiency
More specifically, this reaction proceeds as a general base-catalyzed nucleophilic attack of the thioester of acetyl-CoA by the ... 2003). "Structure of Human Carnitine Acetyltransferase: Molecular Basis For Fatty Acyl Transfer". J Biol Chem. 278 (15): 13159- ... to the acylation state of the mitochondrial pool of CoA despite the fact that the concentrations of both CoA and acyl-CoA found ... The carnitine binding site is made accessible by the conformational change induced in the enzyme by the binding of CoA. This ...
Pyruvate dehydrogenase (lipoamide) alpha 2
Overall the complex catalyzes five reactions, with the overall reaction being: Pyruvate + CoA + NAD+ → acetyl-CoA + CO2 There ... "Recombinant expression and evaluation of the lipoyl domains of the dihydrolipoyl acetyltransferase component of the human ... The E1 complex specifically uses the TPP cofactor to cleave the Calpha-C(=O) bond of pyruvate, and then transfer the acetyl ... with the final product being Acetyl CoA. ...
E3 binding protein
... a required complex for cellular respiration that catalyzes the dehydration of pyruvate to Acetyl-CoA. The entire complex is 9.5 ... "Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase". The ... complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex ...
Neuromuscular junction
Acetylcholine is a neurotransmitter synthesized from dietary choline and acetyl-CoA (ACoA), and is involved in the stimulation ... Other mutations, such as those affecting acetylcholinesterase and acetyltransferase, can also cause the expression of CMS, with ...
Β-Hydroxybutyric acid
Because oxaloacetate is crucial for entry of acetyl-CoA into the TCA cycle, the rapid production of acetyl-CoA from fatty acid ... 3-Hydroxyisovaleryl CoA is likely detoxified by carnitine acetyltransferase producing 3HIA-carnitine, which is transported ... This metabolic pathway is as follows: butyrate→butyryl-CoA→crotonyl-CoA→β-hydroxybutyryl-CoA→poly-β-hydroxybutyrate→D-β-(D-β- ... Metabolic impairment diverts methylcrotonyl CoA to 3-hydroxyisovaleryl CoA in a reaction catalyzed by enoyl-CoA hydratase (22, ...
Chromosome 11
ACAT1: acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) ACRV1: encoding protein Acrosomal protein SP-10 ... fatty acyl-coA reductase 1 FAT3: fat atypical cadherin 3 FHIP: FTS and Hook-interacting protein FNBP4: Formin-binding protein 4 ...
Leucine
MG-CoA), which is subsequently converted to HMG-CoA by methylglutaconyl-CoA hydratase. HMG-CoA is then cleaved into acetyl-CoA ... 3-Hydroxyisovaleryl CoA is likely detoxified by carnitine acetyltransferase producing 3HIA-carnitine, which is transported ... producing β-methylcrotonyl-CoA (MC-CoA) or hydroxymethylglutaryl-CoA (HMG-CoA) respectively. MC-CoA is then converted by the ... Isovaleryl-CoA is subsequently metabolized by isovaleryl-CoA dehydrogenase and converted to MC-CoA, which is used in the ...
List of enzymes
... acetyl-CoA synthase EC 6.2.1.39: (butirosin acyl-carrier protein)-L-glutamate ligase EC 6.2.1.40: 4-hydroxybutyrate-CoA ligase ... EC 2.3.1 Aminolevulinic acid synthase EC 2.3.1.37 Choline acetyltransferase EC 2.3.1.6 Category:EC 2.3.2 Factor XIII EC 2.3. ... Glutarate-CoA ligase EC 6.2.1.7: Cholate-CoA ligase EC 6.2.1.8: Oxalate-CoA ligase EC 6.2.1.9: Malate-CoA ligase EC 6.2.1.10: ... Acid-CoA ligase (GDP-forming) EC 6.2.1.11: Biotin-CoA ligase EC 6.2.1.12: 4-coumarate-CoA ligase EC 6.2.1.13: Acetate-CoA ...
List of EC numbers (EC 4)
... citryl-CoA lyase EC 4.1.3.35: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase EC 4.1.3.36: naphthoate synthase EC 4.1.3.37: Now EC ... sulfoacetaldehyde acetyltransferase EC 4.4.1.13: cysteine-S-conjugate β-lyase EC 4.4.1.14: 1-aminocyclopropane-1-carboxylate ... malyl-CoA lyase EC 4.1.3.25: (S)-citramalyl-CoA lyase EC 4.1.3.26: 3-hydroxy-3-isohexenylglutaryl-CoA lyase EC 4.1.3.27: ... 3-hydroxybutyryl-CoA dehydratase EC 4.2.1.56: itaconyl-CoA hydratase EC 4.2.1.57: isohexenylglutaconyl-CoA hydratase EC 4.2. ...
ETV6
... likewise binds to HTATIP, a histone acetyl transferase that regulates the expression of various genes involved in gene ... Nordentoft I, Jørgensen P (August 2003). "The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1- ... a Long-chain-fatty-acid-CoA ligase); h) transporter gene ARNT (binds to ligand-bound aryl hydrocarbon receptor to aid in its ...
List of EC numbers (EC 1)
... acetyl-CoA 1,5-monooxygenase EC 1.14.13.161: (+)-camphor 6-exo-hydroxylase EC 1.14.13.162: Now EC 1.14.14.108, 2,5- ... formate-C-acetyltransferase]-activating enzyme EC 1.97.1.5: Now EC 1.20.4.1, arsenate reductase (glutaredoxin EC 1.97.1.6: Now ... butyryl-CoA dehydrogenase. EC 1.3.99.3: now EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA ... cis-2-enoyl-CoA reductase (NADPH) EC 1.3.1.38: trans-2-enoyl-CoA reductase (NADPH) EC 1.3.1.39: trans-2-enoyl-CoA reductase ( ...