Acetogenins inhibit NADH dehydrogenase, a key enzyme in energy metabolism. Li, N.; Shi, Z.; Tang, Y.; Chen, J.; Li, X. (2008 ... Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by ... Purified acetogenins and crude extracts of the common North American pawpaw (Asimina triloba) or the soursop (Annona muricata) ... Media related to Acetogenins at Wikimedia Commons (Articles with short description, Short description matches Wikidata, Commons ...

Several bioactive molecules known as acetogenins have been isolated from its bark including: bullatacin, which has pesticidal ... Gu, Zhe-Ming; Zhao, Geng-Xian; Oberlies, Nicholas H.; Zeng, Lu; McLaughlin, Jerry L. (1995). "Annonaceous Acetogenins". ... a novel bioactive acetogenin from Annona bullata (Annonaceae)". Tetrahedron. 45 (22): 6941-6948. doi:10.1016/S0040-4020(01) ... "New cytotoxic annonaceous acetogenins: Bullatanocin and cis- and trans-Bullatanocinone, from Annona bullata (Annonaceae)". ...

Fang, Xin-Ping; Rieser, Matthew J.; Gu, Zhe-Ming; Zhao, Geng-Xian; McLaughlin, Jerry L. (1993). "Annonaceous acetogenins: An ...

Alali, Feras Q.; Rogers, Lingling; Zhang, Yan; McLaughlin, Jerry L. (1998). "Unusual bioactive annonaceous acetogenins from ...

Terpenes and Acetogenins". American Scientist. 53 (4): 499A-500A. JSTOR 27836252. Singsaas, Eric L. (2000). "Terpenes and the ...

Tchen, T. T. (1965). "Reviewed Work: The Biosynthesis of Steroids, Terpenes & Acetogenins". American Scientist. Research ...

... was the first known example in a class of compounds known as acetogenins. Acetogenins, which are found in plants of ... Zafra-Polo, M. C.; González, M. C.; Estornell, E.; Sahpaz, S.; Cortes, D. (1996). "Acetogenins from Annonaceae, Inhibitors of ...

The bark, leaves, and roots of some species are used in folk medicines.[citation needed] The acetogenin compounds, which occur ... A large number of chemical compounds, including flavonoids, alkaloids, and acetogenins, have been extracted from the seeds and ... Experimental results indicate that acetogenins is responsible for this accumulation. Lancewood (Oxandra lanceolata) is a tough ... 2005-08-02). "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Movement ...

... s are a group of chemical compounds classified as acetogenins. They are found in the extracts of Annona seeds (A. ... and an isolated acetogenin against Helicoverpa armigera". Journal of Pest Science. 90 (2): 701-709. doi:10.1007/s10340-016-0817 ... an Insecticidal Acetogenin of the Pawpaw, Asimina triloba (Annonaceae)". Pesticide Biochemistry and Physiology. Volume 45, ...

It is a member of the class of compounds known as acetogenins. H. Naito; E. Kawahara; K. Maruta; M. Maeda; S. Sasaki (1995). " ... H.-W. Chih; H.-F. Chiu; K.-S. Tang; F.-R. Chang; Y.-C. Wu (2001). "Bullatacin, a potent antitumor annonaceous acetogenin, ... "The First Total Synthesis of (+)-Bullatacin, a Potent Antitumor Annonaceous Acetogenin, and (+)-(15,24)-bis-epi-Bullatacin". ... Two Highly Potent Bioactive Acetogenins from Annona bullata". Journal of Natural Products. 52 (3): 463-477. doi:10.1021/ ...

Other acetogenins have been isolated from the seeds, bark, and leaves.[citation needed] Annona squamosa is native to the ... Bayer AG has patented the extraction process and molecular identity of the annonaceous acetogenin annonin, as well as its use ... 1990). "Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa". Journal of ... 2012). "Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds". Journal of ...

He published his findings on the Annonaceous acetogenins in peer reviewed journals. These acetogenins have been identified as ... McLaughlin, Jerry L. (2008). "Paw Paw and Cancer: Annonaceous Acetogenins from Discovery to Commercial Products". Journal of ...

Mitregenin, an acetogenin, has been isolated from its leaves and twigs. Several members of the acetogenin family of compounds ... Zhang, Qiang; Di, Ying-Tong; He, Hong-Ping; Li, Shun-Lin; Hao, Xiao-Jiang (2010). "Mitregenin, a New Annonaceous Acetogenin ...

... is an acetogenin found in Uvaria chamae. (+)-Chamuvarinin was synthesized in 2010 by a research group from the ... Fall, D; Duval, RA; Gleye, C; Laurens, A; Hocquemiller, R (2004). "Chamuvarinin, an acetogenin bearing a tetrahydropyran ring ...

Bioactive molecules isolated from its bark, including acetogenins have been reported to have cytotoxic properties in tests with ... Wongsa, Nikhom; Kanokmedhakul, Somdej; Kanokmedhakul, Kwanjai (2011). "Cananginones A-I, linear acetogenins from the stem bark ...

Due to the presence of acetogenins, the leaves, twigs, and bark of pawpaw trees can be used to make an organic insecticide. The ... Pawpaw defends against herbivory by producing strong-smelling natural toxins known as acetogenins. Pawpaw leaves, twigs, and ... Phytochemical extracts of the bark, leaves, twigs, and seeds contain acetogenins, including the neurotoxin annonacin, as well ... Chemicals consumed by the caterpillars confer protection throughout the butterflies' lives, as trace amounts of acetogenins ...

Like other acetogenins, it is a mitochondrial complex I (NADH-dehydrogenase) inhibitor. As NADH-dehydrogenase is responsible ... It is a member of the class of compounds known as acetogenins. Annonacin-containing fruit products are regularly consumed ... "Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS". Journal of Agricultural and Food ... "Quantification of acetogenins in Annona muricata linked to atypical Parkinsonism in Guadeloupe". Movement Disorders. 20 (12): ...

"C15 acetogenins from the Laurencia complex: 50 years of research - an overview". Revista Brasileira de Farmacognosia. 25 (6): ...

Tantithanaporn, S.; Wattanapiromsakul, C.; Itharat, A.; Keawpradub, N. (2011). "Cytotoxic activity of acetogenins and styryl ...

... is a cytotoxic acetogenin derivate with the molecular formula C35H62O7 which has been isolated from the bark of the ... "Acetogenins as Selective Inhibitors of the Human Ovarian 1A9 Tumor Cell Line". Journal of Medicinal Chemistry. 46 (15): 3185- ... Two novel cytotoxic bis-tetrahydro-furanic γ-lactone acetogenins from Annona cherimolia". Tetrahedron. 47 (38): 8195-8202. doi: ...

Like other members of the family Annonaceae, the entire plant contains small amounts of neurotoxic acetogenins, such as ... December 2005). "Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe". Mov. Disord. ...

Isolated Acetogenins and Biological Activities". International Journal of Molecular Sciences. 16 (7): 15625-15658. doi:10.3390/ ...

The leaves, twigs, and bark of the common pawpaw tree contain natural insecticides known as acetogenins. Larvae of the zebra ...

The tetrahydrofuran ring is found in diverse natural products including lignans, acetogenins, and polyketide natural products. ...

... a new acetogenin inhibitor of mitochondrial electron transport from Xylopia emarginata Mart., Annonaceae". Revista Brasileira ...

November 2016). "Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen ...

Rolliniastatin-2, an acetogenin, is the first complex I inhibitor found that does not share the same binding site as rotenone. ... Acetogenins from Annonaceae are even more potent inhibitors of complex I. They cross-link to the ND2 subunit, which suggests ... Degli Esposti M, Ghelli A, Ratta M, Cortes D, Estornell E (July 1994). "Natural substances (acetogenins) from the family ... an acetogenin found in Asimina triloba fruit) is the most potent known inhibitor of NADH dehydrogenase (ubiquinone) (IC50=1.2 ...

Other acetogenins have been discovered with anti-malarial and anti-tumor properties, and some even inhibit HIV replication in ... The first acetogenin discovered was uvaricin, which has anti-leukemic properties when used in living organisms. ... Several members of the family Annonaceae are also under investigation for uses of a group of chemicals called acetogenins. ...

The compound annonacin and dozens of other acetogenins contained in the seeds and fruit of some members of Annonaceae such as ... Several annonaceous species have been found to contain acetogenins, a class of natural compounds with a wide variety of ... Esposti, M Degli; A Ghelli; M Ratta; D Cortes; E Estornell (1994-07-01). "Natural substances (acetogenins) from the family ...

Bioactive compounds extracted from its bark, including acetogenins, have been reported to be cytotoxic in tests with cultured ...