Von Willebrand Disease Pancytopenia due to leukemia Drug induced: Use of progestin-only contraceptives, such as Depo Provera ... Cervicitis Endometritis Vaginitis Sexually Transmitted Infections Pelvic inflammatory disease Endometrial abnormalities: ... Hormone imbalance Dysfunctional uterine bleeding Diets which induce ketosis, such as the Atkins diet polycystic ovarian ...

"Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". U.S. Food and Drug Administration (FDA ... It induces CYP1A2[medical citation needed] and inhibits the major P450 isoforms 3A4 and 2D6.[medical citation needed] ... Asthenia, malaise Diarrhea Nausea and vomiting Abdominal pain Dizziness Insomnia Kidney failure Sweating Taste abnormality ... "First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on January 26, 2021. ...

A new chapter about OCD in the DSM-5 (2013) now specifically includes drug-induced OCD.[citation needed] Atypical ... Similar to OCD, these disorders also exhibit abnormalities in the basal ganglia. This portion of the brain is responsible for ... Rapoport, J. L.; Ryland, D. H.; Kriete, M. (1992). "Drug treatment of canine acral lick: an animal model of obsessive- ... This understanding is frequently cited as evidence that abnormality in these neuroanatomical regions may cause OCD. The OFC and ...

... from an intrinsic abnormality in the elastin and collagen components of the aortic wall. While definite genetic abnormalities ... New lesions should not form at all when using this drug. Screening for an aortic aneurysm so that it may be detected and ... In short, raising HDL cholesterol is beneficial because it induces programmed cell death. The walls of a failing aorta are ...

Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral ... "Effect of weight reduction on hepatic abnormalities in overweight patients". Gastroenterology. 99 (5): 1408-1413. doi:10.1016/ ... assessment and management of suspected acute drug-induced liver injury occurring during clinical trials in adults with chronic ... assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic ...

... or drug-induced hallucinations. Fusiform gyrus Fusiform gyrus animation Cerebrum.Inferior view. Deep dissection Fusiform gyrus ... Abnormalities of the fusiform gyrus have also been linked to Williams syndrome. Fusiform gyrus has also been involved in the ...

... "the Agency has concluded that the totality of the scientific evidence no longer supports the conclusion that a drug-induced ... It is less commonly used compared than statins because it treats a different type of cholesterol abnormality to statins. While ... Multiple chemicals in Infobox drug, Multiple chemicals in an infobox that need indexing, Drug has EMA link, Drugboxes which ... These drug interactions with fenofibrate are considered major and may need therapy modifications: Bile acid sequestrants (e.g. ...

"Genetic risk factors associated with lipid-lowering drug-induced myopathies". Muscle & Nerve. 34 (2): 153-62. doi:10.1002/mus. ... Functional and metabolic abnormalities associated with disruption of the purine nucleotide cycle". Journal of Clinical ... MADD causes an increase of free adenosine during heavy activity which may cause exercise-induced muscle pain. Over time, excess ... There is an increased risk that statin (cholesterol-reducing drugs) will cause myopathy (muscle weakness) in individuals with ...

... such as drugs that slow heart rate and which induce hyperkalemia. Complete atrioventricular block in acute myocardial ... "ECG Conduction Abnormalities". Retrieved 2009-01-07. "Heart Block". NHS Choices. National Health Service (UK). Retrieved 25 ... Other drugs may be utilized such as epinephrine or dopamine which have positive chronotropic effects and may increase the heart ...

Historically, pharmacological, or drug-induced models were the most widely used. These involve the manipulation of various ... enduring prepulse inhibition abnormalities, and cognitive abnormalities associated with the prefrontal cortex including ... Abnormalities in PPI are seen in patients with schizophrenia. Latent inhibition Anomalies in latent inhibition have been linked ... Tests using the Morris water maze have found that reeler mice do not have the abnormalities in spatial reference memory which ...

On the other hand, related to the antiarrhythmic drugs, the cardiotoxicity is associated to the risk of induce a potential ... The typical changes, called repolarization abnormalities, in the action potential morphology that are considered pro-arrhythmic ... Indeed, the pharmacological cardiotoxicity of anti-arrhythmic compounds is related to the action of these drugs to induce ... Lancaster, M Cummins; Sobie, Ea (October 2016). "Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of ...

Various preclinical drug trials using other HDAC inhibitors have also been performed, with most drugs targeting HDAC classes I ... Traumatic experiences can induce epigenetic changes at the gene loci that are immune-related which can lead to immune ... and functional abnormalities in cortico-amygdala circuitry that mediates fear extinction. Trichostatin-a was normalized BDNF ... Valproate is a drug that acts as an HDACi on class I and II HDACs. Six clinical trials surrounding its use as an anxiolytic ...

... is one of the most common drugs that cause drug-induced lupus, along with hydralazine, procainamide, isoniazid, ... the use of diltiazem should be avoided in patients with SA or AV nodal abnormalities, because of its negative chronotropic and ... Solhjoo M, Ho CH, Chauhan E (2019). "article-24529". Drug-Induced Lupus Erythematosus. Treasure Island (FL): StatPearls ... "Drug interactions: Interactions between fentanyl and drugs that inhibit CYP3A4". Archived from the original on 3 December 2017 ...

Discovered by Yellapragada Subbarow, the drug was first used by Sidney Farber in 1947 to induce remissions among children with ... Similar congenital abnormalities have been documented with methotrexate, and collectively their teratogenic effects have become ... Subsequent doses of 20 mg (which may be taken orally) should be given at 6 hour intervals until hematological abnormalities are ... Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive ...

Pfeiffer syndrome: abnormalities of the skull, hands, and feet; wide-set, bulging eyes, an underdeveloped upper jaw, beaked ... Hyperthyroid induced craniosynostosis is a hormone mediated premature closure. It is thought that the bone matures faster due ... Environmental factors refer for example to maternal smoking and the maternal exposure to amine-containing drugs. Several ... The neurocranium will not grow when the forces induced by brain growth are not there. This will occur for example when the ...

In a cohort study of previously treated patients, ibrutinib induced responses in 91% of patients, and at 2 years 69% of ... Coagulation abnormalities may be present. Prothrombin time, activated partial thromboplastin time, thrombin time, and ... Based on this study, the Food and Drug Administration approved ibrutinib for use in Waldenström macroglobulinemia in 2015. ... Mensah-Osman, E.; Al-Katib, A.; Dandashi, M.; Mohammad, R. (2003). "XK469, a topo IIbeta inhibitor, induces apoptosis in ...

... allergic-drug reactions, drug overdose, toxic exposure (e.g. herbicides, tetanus), C7 radiculopathy, and coarctation of the ... There are numerous ways in which the long thoracic nerve can sustain trauma-induced injury. These include, but are not limited ... and structural abnormalities (e.g. rotator cuff pathology, shoulder instability, etc.). In addition to history and exam, it has ... Non-traumatic induced injury to the long thoracic nerve includes, but is not limited to, causes such as viral illness (e.g. ...

Animal model studies also find that the 15-lipoxygenase 1 / 13-HODE axis inhibits the development of drug-induced colon cancer ... One of the abnormalities found in the APC disease is progressive reductions in 15-lipoxygenase 1 along with its product, 13- ... In a mouse model of allergen-induced asthma, 13-HODE levels are elevated, in the latter mouse model, the injection of antibody ... The 13(S)-HODE/PPARγ axis also causes macrophages to self-destruct by activating apoptosis-inducing pathways;, this effect may ...

High Otx2 levels induce photoreceptor cell fate but not bipolar cell fate. Low levels of Otx2 impair bipolar cell maturation ... Other defects that occur due to a mutation of the Otx2 gene include pituitary abnormalities and mental retardation. Abnormal ... The VTA is involved in drug reinforcement, reward processing, and addiction in the adult. Ethanol consumption during ... Apart from anophthalmia and microphthalmia, other abnormalities such as aplasia of the optic nerve, hypoplasia of the optic ...

In addition, chlornaphazine induces chromosomal abnormalities in erythrocytes in both mouse and rat bone marrow. It has been ... "Alkylating Agents", LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, Bethesda (MD): National Institute ... Like in humans, 2-naphthylamine induces bladder tumors in dogs, monkeys, and hamsters. Bladder cancer can be induced in rats, ... Chlornaphazine was discontinued as a clinical drug due to sufficient evidence for carcinogenicity in humans. The drug caused ...

This must be distinguished from the situation in which the abnormality of mind causes a craving for drink or drugs . R v Tandy ... held that where a defendant could show that she was suffering from an abnormality of the mind, that it was induced by disease ( ... can become a relevant factor where a craving for drink or drugs causes an abnormality of mind. ... The sub-section does not require the abnormality of mind to be the sole cause of the defendant's acts; even if the defendant ...

Lack of ODC causes cell apoptosis in embryonic mice, induced by DNA damage. ODC is the most well-characterized cellular protein ... Inhibitors of ODC such as eflornithine have been shown to effectively reduce cancers in animal models, and drugs targeting ODC ... and behavioral abnormalities. BABS is typically caused by an autosomal dominant de novo ODC1 variant. ODC gene expression is ... ODC is also an enzyme indispensable to parasites like Trypanosoma, Giardia, and Plasmodium, a fact exploited by the drug ...

Mansford KR, Opie L (March 1968). "Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by ... The drug was discovered in a strain of the soil microbe Streptomyces achromogenes by scientists at the drug company Upjohn (now ... U.S. Patent 3,027,300 FDA drug details (Articles with short description, Short description matches Wikidata, Drugs with non- ... as well as induce a nearly complete recovery of cognitive impairment in the STZ-induced SAD mouse model. Streptozotocin is now ...

To prevent drug-induced esophagitis, drink plenty of liquids when taking medicines, take an alternative drug, and do not take ... The barium makes the organs more visible and can detect if there is any narrowing, inflammation, or other abnormalities that ... Types include: Fungal Candida (Esophageal candidiasis) Viral Herpes simplex (Herpes esophagitis) Cytomegalovirus Drug-induced ... Drug Safety Update 7 (10), A1. Moayyedi, P., Santana, J., Khan, M., et al., 2011. Medical treatments in the short-term ...

Benzodiazepines are drugs that act on the GABA receptors and are believed to be the most effective medication for treating ... They have properties that result in the reduction of anxiety, are relaxant in muscles, reduce excitement, and sleep inducing. A ... According to research, the underlying mechanisms are linked to abnormalities in certain neurotransmitters, especially GABAergic ... Catatonia can also occur as a result of autoimmune, paraneoplastic, infectious, metabolic, and specific drug exposures and ...

Class II recalls refer to drugs that induce temporary and/or medically reversible health effects. Class III recalls occur when ... The Third Generation of people exposed to DES are just now entering into an age where reproductive problems and abnormalities ... Drug recalls in the United States are made by the FDA or the creators of the drug when certain criteria are met. When a drug ... the drug is removed from the market and potential legal action can be taken depending on the severity of the drug recall. Drug ...

Drug induced immune mediated hemolytic anemia Penicillin (high dose) Methyldopa Hemoglobinopathies (where these is an unstable ... Hemoglobinopathies (congenital abnormality of the hemoglobin molecule or of the rate of hemoglobin synthesis) Sickle cell ... Heparin-induced thrombocytopenia (HIT) Myeloproliferative disorders (Increased numbers of cells) Polycythemia vera (increase in ...

Gartland, Fiona (27 May 2013). "Fall in seizures of drugs that induce abortion". The Irish Times. Archived from the original on ... when there is a fatal foetal abnormality, 61% when there is a significant foetal disability or non-fatal foetal abnormality, 59 ... The same survey also showed that 75% of women believed the morning-after pill should be an over-the-counter (OTC) drug, as ... In 2002, a woman pregnant with a foetus with fatal foetal abnormalities travelled to the UK for a termination. Her letter in ...

The signalling cascade induced by metabotropic receptor activation means that even a relatively brief or small synaptic signal ... By regulating the drugs which interact with those glutamate receptors, regulating glutamate binding may be possible, and ... we show that different abnormalities in synaptic glutamate receptor expression can cause alterations in social interactions and ... Inducing experimental autoimmune encephalomyelitis in animals as a model for multiple sclerosis(MS) has targeted some glutamate ...

... may also lead to drug fever and other allergic responses. There is also a chance that drug-induced lupus ... and is also known for causing gastrointestinal disturbances and aggravating pre-existing abnormalities in impulse initiation ... p. 1. US Food and Drug Administration. "Drugs at FDA: FDA Approved Drug Products". USA: U.S. Food and Drug Administration (FDA ... It induces rapid block of the batrachotoxin (BTX)-activated sodium channels of the heart muscle and acts as antagonist to long- ...