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*  3T3-L1
... is a cell line derived from (mouse) 3T3 cells that is used in biological research on adipose tissue. 3T3-L1 cells have a ... 3T3-L1 cells of the adipocyte morphology increase the synthesis and accumulation of triglycerides and acquire the signet ring ... These cells are also sensitive to lipogenic and lipolytic hormones and drugs, including epinephrine, isoproterenol, and insulin ... Green H, Kehinde O (1975). "An established preadipose cell line and its differentiation in culture. II. Factors affecting the ...
*  Infections associated with diseases
Fusinski, Keith A (2008). Adenovirus 36 E4orf1 gene induces differentiation of 3T3-L1 cells (PhD Dissertation). Wayne State ... and Merkel cell polyomavirus (MCPyV) in non small cell lung cancer". Experimental and Molecular Pathology. 89 (3): 222-6. doi: ... Cell. 141 (7): 1135-45. doi:10.1016/j.cell.2010.05.009. PMC 2908380 . PMID 20602997. Mulholland, Selamawit; Gavranich, John B; ... February 2014). "Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes". Diabetes ...
*  GPR84
explored 3T3-L1 adipocytes cocultured with RAW264.7 cells to examine this potential interaction. RAW264.7 coculture increases ... There was also a GPR84 downregulation in dentritic cell derived from FcRgamma chain KO mice. In microglial cells, the GPR84 ... EST clones corresponding to hgpr84 were from B cells (leukemia), neuroendocrine lung as well as in microglial cells and ... Ly6G + MDSCs in Lal-/- mice show strong immunosuppression on T cells, which contributes to impaired T cell proliferation and ...
*  Vitisin A (stilbenoid)
"Vitisin a inhibits adipocyte differentiation through cell cycle arrest in 3T3-L1 cells". Biochemical and Biophysical Research ... and NF-κB activation in RAW 264.7 cells". International Immunopharmacology. 9 (3): 319-323. doi:10.1016/j.intimp.2008.12.005. ...
*  CEBPA
"Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev. 5 (9): 1538-52. doi:10.1101 ... "C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4". Mol. Cell. 8 (4): 817-28. doi:10.1016/S1097- ... CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain Blood cells. For ... and head and neck squamous cell carcinoma. A recent study has found that higher levels of CEBPA methylation are directly ...
*  CEBPB
Cao Z, Umek RM, McKnight SL (Oct 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells ... Cell. Biol. 18 (10): 5880-7. doi:10.1128/mcb.18.10.5880. PMC 109174 . PMID 9742105. Zhang F, Lin M, Abidi P, Thiel G, Liu J ( ... Cell. 4 (5): 735-43. doi:10.1016/s1097-2765(00)80384-6. PMID 10619021. Liu YW, Tseng HP, Chen LC, Chen BK, Chang WC (July 2003 ... Cell. Biol. 23 (12): 4066-82. doi:10.1128/mcb.23.12.4066-4082.2003. PMC 156132 . PMID 12773552. Mo X, Kowenz-Leutz E, Xu H, ...
*  CEBPD
"Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538-52. ... CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor. One study in mice ... Cell Biology. 29 (12): 1525-39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146. Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (Mar ... Cytogenetics and Cell Genetics. 70 (3-4): 188-91. doi:10.1159/000134030. PMID 7789168. Cleutjens CB, van Eekelen CC, van Dekken ...
*  Ccaat-enhancer-binding proteins
Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells ... In contrast, ectopic expression of C/EBPβ and δ in 3T3-L1 preadipocytes promotes adipogenesis, even in the absence of ... C/EBPβ plays a role in neuronal differentiation, in learning, in memory processes, in glial and neuronal cell functions, and in ... These proteins are found in hepatocytes, adipocytes, hematopoietic cells, spleen, kidney, brain, and many other organs. C/EBP ...
*  INSIG2
1,25-(OH)2D3 transiently but strongly induces Insig-2 expression in 3T3-L1 cells. This novel regulatory circuit may also play ... Ka SO, Kim KA, Kwon KB, Park JW, Park BH (May 2009). "Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a ... a functional vitamin D response element in the murine Insig-2 promoter and its potential role in the differentiation of 3T3-L1 ... March 2009). "Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of ...
*  BCKDHA
Expression of E1 alpha mRNA and subunit in maple-syrup-urine-disease and 3T3-L1 cells". J. Biol. Chem. 263 (18): 9007-14. PMID ... Cell Genet. 50 (4): 236-7. doi:10.1159/000132768. PMID 2805821. Fisher CW, Chuang JL, Griffin TA, et al. (1989). "Molecular ... "A T-to-A substitution in the E1 alpha subunit gene of the branched-chain alpha-ketoacid dehydrogenase complex in two cell lines ... phenotypes in cultured maple syrup urine disease cells. Complete E1 alpha cDNA sequence and mRNA and subunit contents of the ...
*  Sortilin 1
"Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin". Molecular Biology of the ... As a sorting receptor on the cell surface and on the endoplasmic reticulum-Golgi apparatus within the cell, sortilin is ... as it has been detected in several cancer cell lines. Notably, human cancerous epithelial cells exhibited increased levels of ... In addition, two hydrophobic loops have been detected in this domain and act to anchor the protein in the cell membrane. In ...
*  PTGFRN
"Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells". J. ... 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J. ... 2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. ...
*  Carboxyfluorescein succinimidyl ester
December 1997). "Insulin has a limited effect on the cell cycle progression in 3T3 L1 fibroblasts". Molecules and Cells. 7 (6 ... "High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro ... Also, due to this stable linkage, once incorporated within cells the dye is not transferred to adjacent cells. CFSE is commonly ... August 1998). "Helper T cell differentiation is controlled by the cell cycle". Immunity. 9 (2): 229-37. doi:10.1016/S1074-7613( ...
*  Avicularin
It suppresses lipid accumulation through repression of C/EBPα-activated GLUT4-mediated glucose uptake in 3T3-L1 cells. LC ... suppresses lipid accumulation through repression of C/EBPα-activated GLUT4-mediated glucose uptake in 3T3-L1 cells. Fujimori K ...
*  Chemerin
Studies with 3T3-L1 cells have shown chemerin expression is low in pre-differentiated adipocytes but its expression and ... Studies using mature human adipocytes, 3T3-L1 cells, and in vivo studies in mice showed chemerin stimulates the phosphorylation ... Interestingly, it was found incubation of 3T3-L1 cells with recombinant human chemerin protein facilitated insulin-stimulated ... "Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes". FEBS Lett. 582 (5 ...
*  Adenovirus serotype 36
AD-36 infection can induce cellular differentiation of 3T3-L1 preadipocytes and stem cells derived from human adipose tissue. ...
*  Streptomyces cinerochromogenes
"Cineromycin B isolated from Streptomyces cinerochromogenes inhibits adipocyte differentiation of 3T3-L1 cells via Krüppel-like ... "Cineromycin B isolated from Streptomyces cinerochromogenes inhibits adipocyte differentiation of 3T3-L1 cells via Krüppel-like ...
*  ALOXE3
... appears necessary and sufficient for the differentiation of mouse 3T3-L1 fibroblast cells into adipocytes (i.e. fat ... Finally, cultured human skin cells, which are rich in ALOXE3 readily convert arachidonic acid as well as 12S-hydroperoxy- ... is far greater in the skin cells isolated from subjects with psoriasis. These results suggest that ALOXE3 and its orthologs ... cells); the function of Aloxe3 in this differentiation appears to be to its metabolism 12R-HpETE into hepoxilins A3 or B3 which ...
*  FITM2
The overexpression of FITM2 was also displayed when the 3T3-L1 cells were combined with rosiglitazone (a PPAR γ agonist). This ... FITM2 has been identified as being overexpressed throughout the time 3T3-L1 (from the adipocyte cell line) is being ... when lipid droplets have been identified to build-up which results in the adipocyte phenotype that is seen in the 3T3-L1 cells ... Lastly, a shRNA-facilitated reduction in FITM2 in adipocytes (3T3-L1) or even a knockdown of it in the embryos of zebrafish ...
*  Carnitine palmitoyltransferase I
Brown NF, Hill JK, Esser V, Kirkland JL, Corkey BE, Foster DW, McGarry JD (Oct 1997). "Mouse white adipocytes and 3T3-L1 cells ... is found throughout the body on the mitochondria of all cells except for skeletal muscle cells and brown adipose cells. The ... Cell. 150 (5): 1068-81. doi:10.1016/j.cell.2012.08.011. PMC 3477804 . PMID 22939629. Shrivastav S, Zhang L, Okamoto K, Lee H, ... is highly expressed in heart and skeletal muscle cells and brown adipose cells. A third isoform, the brain isoform (CPT1C), was ...
*  KLF7
... suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells". ... Cell. Biol. 24 (3): 1058-69. doi:10.1128/MCB.24.3.1058-1069.2004. PMC 321422 . PMID 14729953. Ota T, Suzuki Y, Nishikawa T, et ... Cell Res. 291 (2): 340-51. doi:10.1016/S0014-4827(03)00408-7. PMID 14644156. Strausberg RL, Feingold EA, Grouse LH, et al. ( ... Suzuki S, Chuang LF, Doi RH, Chuang RY (2004). "Identification of opioid-regulated genes in human lymphocytic cells by ...
*  Phosphatidylinositol 3,5-bisphosphate
Acute insulin treatment increases PtdIns(3,5)P2 levels in 3T3L1 adipocytes, both in isolated membranes and intact cells to ... ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes. Exp ... The response to hyperosmotic challenge is not conserved in most tested mammalian cells except for differentiated 3T3L1 ... 5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway. J Biol Chem. 2005 ...
*  Ludwigia octovalvis
... system and AMPK pathway in 3T3-L1 cells". Food Chem. Toxicol. 48: 716-21. doi:10.1016/j.fct.2009.12.001. PMID 19963029. Lin, WS ...
*  David James (cell biologist)
"Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes". Cell Metab. 7 (4): 348-56. doi: ... "Insulin Increases Cell Surface GLUT4 Levels by Dose Dependently Discharging GLUT4 into a Cell Surface Recycling Pathway". Mol. ... Cell. Biol. 24 (14): 6456-66. doi:10.1128/MCB.24.14.6456-6466.2004. PMC 434240 . PMID 15226445. Larance M, Ramm G, Stöckli J, ... David Ernest James (born Sydney 1958) is a cell biologist who discovered the glucose transporter GLUT4. He has also been ...
*  C-jun
Overexpression of c-jun in 3T3-L1 cells (a preadipocytic non-tumoral cell line that resembles human liposarcoma) can block or ... and those cells exhibit cell cycle defect. Overexpression of c-jun in cells results in decreased level of p53 and p21, and ... In cells absent of c-jun, the expression of p53 (cell cycle arrest inducer) and p21 (CDK inhibitor and p53 target gene) is ... Studies have shown that c-jun is required for progression through the G1 phase of the cell cycle, and c-jun null cells show ...