... cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3',5'-cyclic ... Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): ... Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399-405. PMID ... cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320-5. doi:10.1038/sj.ijir ...
cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... Lincoln, TM; Cornwell TL (1991). "Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth ...
... and it is long-acting because it is resistant to degradation by cyclic AMP phosphodiesterase. 8-Bromoguanosine 3',5'-cyclic ... is a brominated derivative of cyclic adenosine monophosphate (cAMP). 8-Br-cAMP is an activator of cyclic AMP-dependent protein ... cyclic monophosphate at Sigma-Aldrich 8-Bromo Cyclic Adenosine Monophosphate at PubChem. ...
"Ontogenic development of a phosphodiesterase activator and the multiple forms of cyclic AMP phosphodiesterase of rat brain". ... A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ... as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases ...
... cyclic-AMP phosphodiesterase Phosphodiesterase PDE4 inhibitor. ... At least four types of the enzyme phosphodiesterase 4 (PDE4) ...
Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Molecular ... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic guanosine 3',5'- ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3',5'-phosphate phosphodiesterase. As of ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3',5'-cyclic phosphate ...
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso, G.D.; ...
"Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP". The ... Helfman DM, Kuo JF (Jan 1982). "A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- ... Nov 2003). "Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase ... selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium". ...
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. cAMP is a second messenger, used for intracellular ... such as cyclic adenosine monophosphate, cyclic AMP). Cyclic AMP is synthesized from ATP by adenylate cyclase located on the ... Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in ... In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally ...
Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current ... Némoz G, Zhang R, Sette C, Conti M (Apr 1996). "Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene ... "Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification ... "Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)". Gene. 138 (1-2): 253-6. doi: ...
Denis D, Riendeau D (February 1999). "Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 ... Phosphodiesterase inhibitor David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN ... Osinski MT, Schrör K (August 2000). "Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 ... 6 (3): 511-9. doi:10.1097/00005344-198405000-00021. PMID 6202980. Holck M, Thorens S, Muggli R, Eigenmann R (1984). "Studies on ...
Cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide (CDN) and the first to be found in metazoans. Other CDNs (c-di-GMP and c-di-AMP ... phosphodiesterases. Other advantages of the unique 2'-5' linkage may be that cGAMP is able to bind multiple allelic variants of ... Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). ... "Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses". Science 23 August 2013: Vol. 341 no. 6148 pp ...
Chapter 33 in Cyclic Nucleotide Phosphodiesterases in Health and Disease, Eds Joseph A. Beavo et al. CRC Press, Dec 5, 2006 ... Hannila SS, Filbin MT (Feb 2008). "The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury ... Nov 2012). "Phosphodiesterases as therapeutic targets for Alzheimer's disease". ACS Chem Neurosci. 3 (11): 832-44. doi:10.1021/ ... Apr 2013). "Phosphodiesterase 4-targeted treatments for autoimmune diseases". BMC Med. 11 (1): 96. doi:10.1186/1741-7015-11-96 ...
Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah ... 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): 671-80. doi:10.1067/mai ... Fertel, R. and Weiss, B.: Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung" Mol. ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), ...
... cyclic AMP 3',5'-cyclic dAMP 3',5'-cyclic IMP 3',5'-cyclic GMP 3',5'-cyclic CMP As per Andrew T. Bender and Joseph A. Beavo, ... 3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17, cyclic 3',5'-mononucleotide phosphodiesterase, PDE, cyclic 3',5'- ... monophosphate phosphodiesterase (cyclic CMP), cyclic 3',5-nucleotide monophosphate phosphodiesterase, nucleoside 3',5'-cyclic ... Kroll S, Phillips WJ, Cerione RA (March 1989). "The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the ...
PDE4 hydrolyzes cyclic adenosine monophosphate (cAMP) to inactive adenosine monophosphate (AMP). Inhibition of PDE4 blocks ... Moustafa, F; Feldman, SR (16 May 2014). "A Review of Phosphodiesterase-Inhibition and the Potential Role for Phosphodiesterase ... is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a ... "Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor" (pdf). British ...
Lugnier, C. (2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific ... into AMP and GMP. These second messengers control many physiological processes. The cAMP is formed from ATP by the enzyme ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ... Phosphodiesterase 5 (PDE5) is widely expressed in several tissues in the body for example brain, lung, kidney, urinary bladder ...
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic ... The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a ... "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family". Gene. 129 (2): 239-47. doi: ... Moustafa F, Feldman SR (May 2014). "A review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4- ...
Dransfield DT, Bradford AJ, Smith J, Martin M, Roy C, Mangeat PH, Goldenring JR (Jan 1997). "Ezrin is a cyclic AMP-dependent ... "mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module". The EMBO Journal. 20 (8): 1921-30. doi: ... Beebe SJ, Salomonsky P, Holroyd C, Becker D (Dec 1993). "Differential expression of cyclic AMP-dependent protein kinase ... "Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and ...
The activated OR in turn activates the intracellular G-protein, GOLF (GNAL), adenylate cyclase and production of cyclic AMP ( ... CaMKII will also activate phosphodiesterase, which will then hydrolyze cAMP. The effect of this negative feedback response ... "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons". Proc ... 5 (3): 243-66. PMID 9663551. Schacter, Daniel L. (2014). Psychology. p. 167. ISBN 1464106037. Cunningham, A.M.; Manis, P.B.; ...
... cyclic-AMP phosphodiesterase EC 3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D EC 3.1.5.1: dGTPase EC ... CMP-N-acylneuraminate phosphodiesterase EC 3.1.4.41: sphingomyelin phosphodiesterase D EC 3.1.4.42: glycerol-1,2-cyclic- ... glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase EC 3.1.4.52: cyclic-guanylate-specific phosphodiesterase EC 3.1.4.53 ... cyclic-nucleotide phosphodiesterase EC 3.1.4.18: now EC 3.1.16.1 EC 3.1.4.19: now EC 3.1.13.3 EC 3.1.4.20: now EC 3.1.13.1 EC ...
... for instance a bond in a molecule of cyclic AMP or cyclic GMP. An enzyme that plays an important role in the repair of ... Phosphodiesterase Phosphodiesterase inhibitor DNA replication, DNA, ATP Teichoic acid, DNase I PDE5 Nick (DNA) Even prions, the ... A phosphodiesterase is an enzyme that catalyzes the hydrolysis of phosphodiester bonds, ... phosphodiesterase. During the replication of DNA, there is a hole between the phosphates in the backbone left by DNA polymerase ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... alkylglycerophosphoethanolamine phosphodiesterase activity. • macromolecular complex binding. Cellular component. • ... Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.[5] ... This gene uses alternative polyadenylation signals.[5][6] Interactive pathway map[edit]. Click on genes, proteins and ...
Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by ... An example is adenylate cyclase, which produces the second messenger cyclic AMP.[6] For this discovery, they won the 1994 Nobel ... which produces the second messenger cyclic AMP.[6]. *The 1988 Nobel Prize in Physiology or Medicine to George H. Hitchings, Sir ... cyclic-GMP phosphodiesterase. *Protein kinase G. *G alpha subunit Gα *GNAO1 ...
... an effect mediated by decreased cyclic AMP-mediated phosphorylation-activation of the enzyme.[25] α2 receptors also cause ... Cashman JR, Ghirmai S (October 2009). "Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase ... decreased intracellular cyclic AMP expression which results in smooth muscle relaxation or decreased secretion.[26] TCAs ... 292 (5): R1775-81. doi:10.1152/ajpregu.00527.2006. PMID 17218444.. *^ a b Morishita S, Arita S (February 2003). "The clinical ...