Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and ... Khanna M, Qin KN, Cheng KC (Jun 1995). "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning ... Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R (Aug 2003). "Human 20alpha-hydroxysteroid dehydrogenase: ... Zhang Y, Dufort I, Rheault P, Luu-The V (Oct 2000). "Characterization of a human 20alpha-hydroxysteroid dehydrogenase". Journal ...

October 2004). "11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response". Endocrine ... of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of ... "Human 11 beta-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme ... "11 beta-Hydroxysteroid dehydrogenase type 2 complementary deoxyribonucleic acid stably transfected into Chinese hamster ovary ...

The 17α-estrogens in CEEs such as 17α-estradiol and 17α-dihydroequilin have low estrogenicity and are thought to contribute ... In addition, 17β-dihydroequilenin has shown a selective estrogen receptor modulator (SERM)-like profile of estrogenic activity ... On the other hand, the active forms of the equine estrogens in CEEs, such as equilin and 17β-dihydroequilin, have greater ... The transformation of estrone sulfate to estrone is catalyzed by steroid sulfatase, and of estrone into estradiol by 17β- ...

The human gene SRD5A2 encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), one of ... 327 (17): 1216-9. doi:10.1056/NEJM199210223271706. PMID 1406794. Labrie F, Sugimoto Y, Luu-The V, et al. (1992). "Structure of ... 1998). "The identification of 5 alpha-reductase-2 and 17 beta-hydroxysteroid dehydrogenase-3 gene defects in male ...

17-beta-estradiol (E2) is considered the most potent estrogen found in humans. E2 influences vascular function, apoptosis, and ... In an alternative pathway, androstenedione is aromatized to estrone, which is subsequently converted to estradiol via 17β- ... hydroxysteroid dehydrogenase (17β-HSD). During the reproductive years, most estradiol in women is produced by the granulosa ... and CYP2C8 via 17β-hydroxy dehydrogenation into estrone, with various other cytochrome P450 (CYP) enzymes and metabolic ...

May 2008). "17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent ... Poirier D (September 2010). "17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review". Expert Opin Ther Pat. 20 (9): ... 17β-HSD isoforms that are involved in the conversion of estrone into estradiol include 17β-HSD1, 17β-HSD3, 17β-HSD4, 17β-HSD7, ... Estrone, also known as estra-1,3,5(10)-trien-3-ol-17-one, is a naturally occurring estrane steroid with double bonds at the C1 ...

doi:10.1530/ERC-17-0153. PMID 28667081. Odlind V, Milsom I, Persson I, Victor A (June 2002). "Can changes in sex hormone ... 17 (3): 284-95. doi:10.1007/s11102-013-0504-2. PMID 23925896. S2CID 30697394. Shimon I, Barkan A (December 2012). "Estrogen ... 17 (Suppl 2): 34-7. doi:10.3109/13697137.2014.956717. PMID 25223916. S2CID 5084606. Bińkowska M (October 2014). "Menopausal ... 753-. ISBN 978-1-4511-4847-3. Stanczyk FZ, Archer DF, Bhavnani BR (2013). "Ethinyl estradiol and 17β-estradiol in combined oral ...

In patients with congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency 17α-hydroxypregnenolone is ... a prohormone for glucocorticosteroids and androstenedione through the activity of 3α-hydroxysteroid dehydrogenase. Measurements ... 17α-hydroxypregnenolone is a known neuromodulator as its acts in the central nervous system. Specifically, it is known to ... 17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. ...

It is transformed into androstenedione by 3β-hydroxysteroid dehydrogenase (3β-HSD), and into androstenediol by 17β- ... hydroxysteroid dehydrogenase (17β-HSD). Then, androstenedione and androstenediol can be converted into testosterone by 17β-HSD ... Hecker PA, Leopold JA, Gupte SA, Recchia FA, Stanley WC (February 2013). "Impact of glucose-6-phosphate dehydrogenase ... Schwartz AG, Pashko LL (April 2004). "Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity". Ageing ...

... is reported to act as an inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase. It has also been found ... 11β-Hydroxysteroid dehydrogenase inhibitors, GABAA receptor negative allosteric modulators, Pregnanes, Triketones, All stub ... 11-Dehydrocorticosterone (11-keto-21-hydroxyprogesterone) 21-Deoxycortisone (11-keto-17α-hydroxyprogesterone) Elks J (14 ... 11-keto-17α,21-dihydroxyprogesterone) that was formerly used in veterinary medicine in the treatment of bovine ketosis. It was ...

... hydroxysteroid epimerase". Biochimica et Biophysica Acta. 1520 (2): 124-30. doi:10.1016/s0167-4781(01)00247-0. PMID 11513953. ... Epiandrosterone, or isoandrosterone, also known as 3β-androsterone, 3β-hydroxy-5α-androstan-17-one, or 5α-androstan-3β-ol-17- ... Uralets VP, Gillette PA (September 1999). "Over-the-counter anabolic steroids 4-androsten-3,17-dione; 4-androsten-3beta,17beta- ... 17 beta-diol and 3 beta-hydroxy-5 alpha-androstan-17-one sulfates as quantitatively significant secretory products of porcine ...

It is also known as estradiol 17β-valerate or as estra-1,3,5(10)-triene-3,17β-diol 17β-pentanoate. Other common esters of ... 300 μg 17β-estradiol (Aerodiol®; Servier, Chambrayles-Tours, France) was administered via the nasal route by a gynecologist. ... 17 (2): 84-89. doi:10.1159/000179680. PMID 6220949. Düsterberg B, Schmidt-Gollwitzer M, Hümpel M (1985). "Pharmacokinetics and ... Leidenberger FA (17 April 2013). Klinische Endokrinologie für Frauenärzte. Springer-Verlag. pp. 527-. ISBN 978-3-662-08110-5. ...

... for the 3β-hydroxysteroid dehydrogenase (3βHSD) of endocrine system. It has been reported that both of these agents are ... On December 17, 2018, it was announced that Educational & Scientific, LLC (ESL), in conjunction with University of Maryland ... 17 (4): 29. doi:10.1007/s11934-016-0584-4. PMC 4888068. PMID 26902623. "Tokai Pharmaceuticals Announces Clinical Update" (Press ... As a CYP17A1 inhibitor, galeterone shows selectivity for 17,20-lyase over 17α-hydroxylase. Prostate cancer drug abiraterone and ...

17β-Hydroxysteroid dehydrogenase type 13 also known as 17β-HSD type 13 is an enzyme that in humans is encoded by the HSD17B13 ... 17β-HSD13 is significantly up-regulated in the liver of patients with non-alcoholic fatty liver disease (NAFLD) and enhances ... "Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease". Proceedings of the ...

DHEA is then converted to androstenedione by 3β-hydroxysteroid dehydrogenase (3β-HSD) and then finally converted to ... Eventually, when the follicle has fully matured, a spike in 17α-hydroxyprogesterone production by the follicle inhibits the ... Akhtar MK, Kelly SL, Kaderbhai MA (November 2005). "Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17 ... testosterone by 17β-hydroxysteroid dehydrogenase (HSD17B). The onset of puberty is controlled by two major hormones: FSH ...

... is an uncommon form of congenital adrenal ... 3β-hydroxysteroid dehydrogenase (3β-HSD) type II (HSD3B2). As a result, higher levels of 17α-hydroxypregnenolone appear in the ... "Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency". Semin. Reprod ... 3β-HSD II mediates three parallel dehydrogenase/isomerase reactions in the adrenals that convert Δ4 to Δ5 steroids: ...

Rižner, Tea Lanišnik; Lin, Hsueh K.; Penning, Trevor M. (2003). "Role of human type 3 3alpha-hydroxysteroid dehydrogenase ( ... Penning, Trevor M. (1997). "Molecular Endocrinology of Hydroxysteroid Dehydrogenases". Endocrine Reviews. 18 (3): 281-305. doi: ... and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate". J Biol Chem. 272 (25): 15959-66. doi:10.1074/jbc.272.25. ... via 3α-reduction by a 3α-hydroxysteroid dehydrogenase isozyme (AKR1C2 and AKR1C4) or HSD17B6, that also has 3α-reduction ...

Khanna M, Qin KN, Cheng KC (Jun 1995). "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning ... Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M (Aug 1996). "Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase ... "Entrez Gene: AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)". Theisen, J. ... "Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional ...

Raimondi SG, Olivier NS, Patrito LC, Flury A (1989). "Regulation of the 3 beta-hydroxysteroid dehydrogenase activity in tissue ... 17 (1): 111-33. doi:10.1016/0018-506X(83)90021-1. PMID 6862388. S2CID 29041025. Desprez D.1, Geraz E., Hoareau M.C., Melard C ... and 17 hydroxyprogesterone (17OHP) responses to low doses of (1-24)ACTH". J. Clin. Endocrinol. Metab. 83 (10): 3750-3. doi: ... 17-hydroxyprogesterone, cortisol, and cortisone during infancy and childhood". Pediatr. Res. 14 (1): 39-46. doi:10.1203/ ...

... , also known as estra-1,3,5(10)-trien-3-ol-17-one, is a naturally occurring estrane steroid with double bonds at the C1 ... Estrone can also be reversibly converted into estradiol by 17β-HSD. The blood half-life of estrone is about 10 to 70 minutes ... N. K. Adam suggested that this substance be named estrone because of the C-17-ketone group present (1933). Rooke T (1 January ... In addition to aromatization of androstenedione, estrone is also formed reversibly from estradiol by the enzyme 17β- ...

... and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to ... 3β-Hydroxysteroid dehydrogenase inhibitors, Androgens and anabolic steroids, Androstanes, Hepatotoxins, Ketones, Synthetic ... Because of its 17α-alkylated structure, oxymetholone is hepatotoxic. Long term use of the drug can cause a variety of serious ... Retrieved 17 December 2016. Karch SB (21 December 2006). Drug Abuse Handbook, Second Edition. CRC Press. pp. 30-. ISBN 978-1- ...

... estrogen metabolism Hydroxysteroid dehydrogenases (and ketosteroid reductases) 3α-Hydroxysteroid dehydrogenase - androgen, ... and neurosteroid synthesis and metabolism 3β-Hydroxysteroid dehydrogenase/Δ5-4-isomerase (1, 2) - androgen, progestogen, and ... and progestogen synthesis and metabolism 20α-Hydroxysteroid dehydrogenase - progestogen synthesis and metabolism 20β- ... Hydroxysteroid dehydrogenase - progestogen synthesis and metabolism Steroid reductases 5α-Reductase (1, 2, 3) - androgen and ...

... adrenal hyperplasia due to 11β-hydroxylase deficiency Congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase ... Retrieved 2021-01-17. "Caster Semenya takes new step in appeal". NBCSports. 2020-11-17. Retrieved 2021-01-17. "Caster Semenya ... "Francine Niyonsaba of OTC Elite opens up, and good for her: Oregon track & field rundown". 17 April 2019. "Fifth-placed runner ... 51 (17). doi:10.1136/bjsports-2017-097792. Bermon, Stéphane; Garnier, Pierre Yves; Hirschberg, Angelica Lindén; Robinson, Neil ...

Retrieved 17 February 2021. Official website Business data for Organon & Co.: Bloomberg Google Reuters SEC filings Yahoo! Merck ... a potentially first-in-class oral 17β-hydroxysteroid dehydrogenase type 1 inhibitor. Their products are divided into three main ...

Archived from the original on 17 November 2013. "World's first intersex mayor, Cr Tony Briffa does not want to be called he or ... 17 (3): 341-344. doi:10.1080/09505430802280784. S2CID 143528047. "Neither man nor woman". Sydney Morning Herald. 27 June 2010. ... Archived from the original on 17 September 2016. Retrieved 8 September 2016. Carpenter, Morgan (12 January 2013). "Ten years of ... where the parents were able to authorize the sterilization of their 5-year child with 17-beta-hydroxysteroid dehydrogenase III ...

Estradiol 17beta-dehydrogenase Testosterone 17beta-dehydrogenase 17β-Hydroxysteroid dehydrogenase (17β-HSD, HSD17B), also 17- ... 17beta dehydrogenase or 17β dehydrogenase may refer to: ... ketosteroid reductases (17-KSR) This set index page lists ...

... and function as 3α-HSDTooltip 3α-Hydroxysteroid dehydrogenases, 3β-HSDsTooltip 3β-Hydroxysteroid dehydrogenases, 5β-reductases ... and 20α-HSDsTooltip 20α-Hydroxysteroid dehydrogenases, respectively. The AKR1C enzymes act as 3-, 17- and 20-ketosteroid ... 11β-HSDsTooltip 11β-Hydroxysteroid dehydrogenases, 17β-HSDsTooltip 17β-hydroxysteroid dehydrogenases, ... Together with short-chain dehydrogenase/reductases (SDRs), these enzymes catalyze oxidoreductions, act on the C3, C5, C11, C17 ...

Due to inactivation by 3α-hydroxysteroid dehydrogenase (3α-HSD) in skeletal muscle, mestanolone is described as a very poor ... Like other 17α-alkylated AAS, mestanolone is hepatotoxic. Due to its C17α methyl group, unlike androstanolone, mestanolone is ... Mestanolone, also known as 17α-methyl-4,5α-dihydrotestosterone (17α-methyl-DHT) or as 17α-methyl-5α-androstan-17β-ol-3-one, is ... Arnold A, Potts GO, Beyler AL (December 1963). "The Ratio of Anabolic to Androgenic Activity of 7: 17-Dimethyltestosterone, ...

In addition, metribolone was identified in 2010 as a potent inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) 1 and 2 (IC50 ... Zheng F (2010). "Methyltrienolone (R1881) is a Potent Inhibitor of 3B-Hydroxysteroid Dehydrogenase (3B-HSD) Activity". ... 3β-Hydroxysteroid dehydrogenase inhibitors, Tertiary alcohols, Androgens and anabolic steroids, Antimineralocorticoids, ... More precisely, metribolone is the 17α-methylated derivative of trenbolone. It was investigated briefly for the treatment of ...

Other, more rare forms of CAH are caused by mutations in genes, including HSD3B2 (3β-hydroxysteroid dehydrogenase 2), CYP17A1 ( ... Ambiguous genitalia in XY males with 3β-hydroxysteroid dehydrogenase deficiency (3β-HSD2D). In females, hypogonadism can cause ... Hyperkalemia (due to hypoaldosteronism) Elevated 17α-hydroxyprogesterone Classic 21-hydroxylase deficiency typically causes 17α ... 17α-hydroxylase/17,20-lyase), CYP11A1 (P450scc; cholesterol side-chain cleavage enzyme), STAR (steroidogenic acute regulatory ...