Glass TL, Lamppa RS (1985). "Purification and properties of 16 alpha-hydroxyprogesterone dehydroxylase from Eubacterium sp. ... The enzyme 16α-hydroxyprogesterone dehydratase (EC 4.2.1.98) catalyzes the chemical reaction 16α-hydroxyprogesterone = 16,17- ... 16α-hydroxyprogesterone dehydroxylase, 16α-dehydroxylase, and 16α-hydroxyprogesterone hydro-lyase. ... The systematic name of this enzyme class is 16α-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming). Other ...

11 alpha-Hydroxyprogesterone (11 alpha OH-P) was an order of magnitude more potent a competitive inhibitor of the 11 beta HSD-2 ... Souness GW, Latif SA, Laurenzo JL, Morris DJ (April 1995). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 ... Souness GW, Morris DJ (March 1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... 11α-Hydroxyprogesterone can therefore influence blood pressure regulation.12 Furthermore, 11α-hydroxyprogesterone exhibits an ...

5α-Reductase Steroidogenic enzyme Dorfman RI, Forchielli E (November 1956). "Separation of delta 4-5 alpha-hydrogenases from ... 17α-hydroxyprogesterone, androstenedione, and testosterone to 5β-reduced metabolites. It can also act on aldosterone, ... 17,21-dihydroxy-5β-pregnane-3,11,20-trione + NADP+ ⇌ {\displaystyle \rightleftharpoons } cortisone + NADPH + H+ The human ...

A potent mineralocorticoid antagonist with reduced affinity for the 5 alpha-dihydrotestosterone receptor of human and rat ... 7α-Acetylthio-17α-hydroxyprogesterone, a related derivative of progesterone and also of 17α-hydroxyprogesterone, has been found ...

MGA was the third synthetic derivative of progesterone to be developed for use as a medication, following hydroxyprogesterone ... hydroxyprogesterone caproate, medroxyprogesterone acetate, and nomegestrol acetate. MGA differs from medroxyprogesterone ... 17 (4): 367-371. doi:10.1002/jso.2930170409. PMID 7265976. S2CID 72595843. Geller J, Albert J, Yen SS, Geller S, Loza D (March ... 17α-Hydroxyprogesterone caproate is a depot progestogen which is entirely free of side actions. The dose required to induce ...

It is an alpha-globulin. This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major ... "Entrez Gene: SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6". E. Edward Bittar; ... allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency". Am J Hum Genet. 55 (1): 126-33. PMC ... Aldosterone - Approximately 17% of serum aldosterone is bound to transcortin, while another 47% is bound to serum albumin. The ...

This enzyme catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high ... "Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid ... Agapova OA, Yang P, Wang WH, Lane DA, Clark AF, Weinstein BI, Hernandez MR (Oct 2003). "Altered expression of 3 alpha- ... Khanna M, Qin KN, Cheng KC (Jun 1995). "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning ...

Zander J, Forbes TR, Von Munstermann AM, Neher R (April 1958). "Delta 4-3-Ketopregnene-20 alpha-ol and delta 4-3-ketopregnene- ... ISBN 978-1-259-64116-9. In addition to progesterone, 20α- and 20β-hydroxyprogesterone (20α- and 20β-hydroxy-4-pregnene-3-one) ... 20β-Dihydroprogesterone (20β-DHP), also known as 20β-hydroxyprogesterone (20β-OHP), is an endogenous metabolite of progesterone ... 20α-Dihydroprogesterone 17α-Hydroxyprogesterone 16α-Hydroxyprogesterone 5α-Dihydroprogesterone 11-Deoxycorticosterone Bertram G ...

... labeled alpha- and beta- subunits) that are non-covalently associated: The alpha subunits of LH, FSH, TSH, and hCG are ... The gene for the alpha subunit is located on chromosome 6q12.21. The luteinizing hormone beta subunit gene is localized in the ... In contrast to the alpha gene activity, beta LH subunit gene activity is restricted to the pituitary gonadotropic cells. It is ... Each monomeric unit is a glycoprotein molecule; one alpha and one beta subunit make the full, functional protein. Its structure ...

Souness GW, Latif SA, Laurenzo JL, Morris DJ (1995). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta- ... Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... alpha)-methyl-androsta-1,4-diene-11 (alpha), 17 (beta)-diol-3-one) in humans". J. Int. Med. Res. 4 (2): 96-105. doi:10.1177/ ... Indeed, 11α- and 11β-hydroxyprogesterone (formebolone and roxibolone being 11α- and 11β-hydroxylated (respectively) similarly) ...

Souness GW, Latif SA, Laurenzo JL, Morris DJ (1995). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta- ... Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... In accordance, 11α- and 11β-hydroxyprogesterone are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD ... Roxibolone (INN) (developmental code name BR-906), also known as 11β,17β-dihydroxy-17α-methyl-3-oxoandrosta-1,4-diene-2- ...

Sharquie KE, Noaimi AA, Saleh BO, Anbar ZN (December 2009). "The frequency of 21-alpha hydroxylase enzyme deficiency and ... two additional alpha helices, two sets of β-sheets, and a heme cofactor binding loop. Each subunit in the human enzyme consists ... This is in marked contrast to the evolutionarily and functionally related P450 enzyme 17-hydroxylase, which has a broad range ... It is one of three microsomal steroidogenic P450 enzymes, the others being 17-hydroxylase and aromatase. 21-hydroxylase is ...

Zander J, Forbes TR, Von Munstermann AM, Neher R (April 1958). "Delta 4-3-Ketopregnene-20 alpha-ol and delta 4-3-ketopregnene- ... ISBN 978-1-259-64116-9. In addition to progesterone, 20α- and 20β-hydroxyprogesterone (20α- and 20β-hydroxy-4-pregnene-3-one) ... Nowak FV (April 2002). "Distribution and metabolism of 20 alpha-hydroxylated progestins in the female rat". J. Steroid Biochem ... 20α-Dihydroprogesterone (20α-DHP), also known as 20α-hydroxyprogesterone (20α-OHP), is a naturally occurring, endogenous ...

Storbeck KH, Swart P, Africander D, Conradie R, Louw R, Swart AC (2011). "16α-hydroxyprogesterone: origin, biosynthesis and ... "Mutation of cytochrome P-45017 alpha gene (CYP17) in a Japanese patient previously reported as having glucocorticoid-responsive ... It has both 17α-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces ... CYP17A1 has both 17α-hydroxylase activity (EC 1.14.14.19) and 17,20-lyase activity (EC 1.14.14.32). The 17α-hydroxylase ...

Retrieved 2018-09-17. Štěrba, R. (1971). "On the Way to a More Physiological Hormonal Contraception". Current Problems in ... Retrieved 2018-09-17. Cekan Z, Horesovský O (February 1971). "Elimination and metabolism of 6-chloro-17-alpha-hydroxy-16- ... Shapiro EL, Weber L, Harris H, Miskowicz C, Neri R, Herzog HL (July 1972). "Synthesis and biological activity of 17-esters of 6 ... 17 (8): 898-900. doi:10.1021/jm00254a025. PMID 4845383. Topliss JG, Shapiro EL (June 1975). "Quantitative structure-activity ...

Souness GW, Latif SA, Laurenzo JL, Morris DJ (April 1995). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 ... Souness GW, Morris DJ (March 1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... 11β-Hydroxyprogesterone (11β-OHP), also known as 21-deoxycorticosterone, as well as 11β-hydroxypregn-4-ene-3,20-dione, is a ... van Rooyen D, Gent R, Barnard L, Swart AC (April 2018). "The in vitro metabolism of 11β-hydroxyprogesterone and 11- ...

On the progestational activity of 6-dehydro-16-methylene-17α-acetoxyprogesterone". Steroids. 4 (3): 415-42 1. doi:10.1016/0039- ... List of progestogen esters § Esters of 17α-hydroxyprogesterone derivatives 16-Methylene-17α-hydroxyprogesterone acetate Milne ... Stĕrba R (July 1967). "[3-Methylether-ethinylestradiol (Mestranol) and 6-dehydro-16-methylene-17-alpha-acetoxyprogesterone ( ... 16-Methylene-6-Dehydro-17-Alpha-Acetoxyprogesterone (MDAP)]". Zentralblatt Fur Gynakologie (in German). 86: 1327-1332. PMID ...

Marcus PI, Talalay P (February 1956). "Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases". The ... Also converts inactive 20α-hydroxyprogesterone into active progesterone. Preferential activity on androgens. Expressed widely ... 20α-Hydroxyprogesterone ↔ Progesterone DHEATooltip Dehydroepiandrosterone ↔ Androstenediol Androstenedione ↔ Testosterone ... Inhibitors of 17β-HSD type II are of interest for the potential treatment of osteoporosis. Some inhibitors of 17β-HSD type I ...

Ellsworth, K.; Harris, G. (1995). "Expression of the type 1 and 2 steroid 5 alpha-reductases in human fetal tissues". Biochem ... Hastings C, Hansson V (August 1981). "Kinetic properties of the soluble 3 alpha-hydroxysteroid dehydrogenase from rat testis ... 17alpha-diol-20-one as a key intermediate". Endocrinology. 144 (2): 575-80. doi:10.1210/en.2002-220721. PMID 12538619. Kinter, ... delta 4-3-ketosteroid 5 alpha-oxidoreductase of rat prostate". J Biol Chem. 246 (8): 2584-93. doi:10.1016/S0021-9258(18)62328-2 ...

Defects in the sterol 5-6 desaturase enzyme reduce the toxic effects of azole inhibition of the 14-alpha demethylation step. ... 17 (6): 1-4. PMID 22735503. Archived from the original on 12 December 2015. Piérard-Franchimont C, De Doncker P, Cauwenbergh G ... The cis-(2S,4R) isomer was more potent in inhibiting progesterone 17α,20-lyase than its enantiomer (IC50 values of 0.05 and ... It produces this effect through inhibition of 17α-hydroxylase and 17,20-lyase, which are involved in the synthesis and ...

PGA, also known as 17α-acetoxyprogesterone 3-cyclopentyl enol ether, is a synthetic pregnane steroid and a derivative of ... It is the 3-cyclopentyl enol ether of 17α-hydroxyprogesterone acetate. PGA, along with quingestrone (the 3-cyclopentyl enol ... cyclopentyl enol-ether of 17-alpha-acetoxy progesterone) for the treatment of threatened and habitual abortion and menstrual ... progesterone and 17α-hydroxyprogesterone. Pentagestrone Progesterone 3-acetyl enol ether Quingestrone J. Elks (14 November 2014 ...

"PAQR7 - Membrane progestin receptor alpha - Homo sapiens (Human) - PAQR7 gene & protein". www.uniprot.org. Retrieved 2015-10-30 ... "PAQR7 - Membrane progestin receptor alpha - Homo sapiens (Human) - PAQR7 gene & protein". www.uniprot.org. Retrieved 2015-10-27 ... Thomas P (May 2008). "Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor ... Membrane progesterone receptor alpha (mPRα) is a protein that in humans is encoded by the PAQR7 gene. It is a steroid receptor ...

Synthesis of 19-nor-17alpha-ethynyltestosterone and 19-nor-17alpha-methyltestosterone. 1954". American Journal of Obstetrics ... Chu YH, Li QA, Zhao ZF, Zhou YP, Cao DC (June 1985). "[Antiprogestational action of 5 alpha-dihydronorethisterone]". Zhongguo ... The others include progesterone, medroxyprogesterone acetate, megestrol acetate, and hydroxyprogesterone caproate, as well as ... "Suicide inactivation of aromatase in human placenta and uterine leiomyoma by 5 alpha-dihydronorethindrone, a metabolite of ...

Metabolism of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one after intravenous administration to bile duct-cannulated rats". J. Biol ... Schroepfer GJ, Parish EJ, Kisic A, Jackson EM, Farley CM, Mott GE (1982). "5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent ... 17 May 2017. pp. 88-. ISBN 978-0-12-802196-5. Francesco Clementi; Guido Fumagalli (9 February 2015). General and Molecular ... 17α-Hydroxylase/17,20-lyase (CYP17A1) inhibitors such as abiraterone acetate, etomidate, galeterone, ketoconazole, and ...

"DHEA metabolites activate estrogen receptors alpha and beta". Steroids. 78 (1): 15-25. doi:10.1016/j.steroids.2012.10.002. PMC ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". ... Thus, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed. Androstenedione is ... Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous ...

Rabe T, Kowald A, Ortmann J, Rehberger-Schneider S (August 2000). "Inhibition of skin 5 alpha-reductase by oral contraceptive ... being about 1,200-fold more potent than hydroxyprogesterone acetate, 12-fold more potent than medroxyprogesterone acetate, and ... Biochemical and biological studies with 4-aza-steroidal 5 alpha-reductase inhibitors". J. Steroid Biochem. 19 (1A): 385-90. doi ... 17 (4): 289-95. doi:10.1111/j.1447-0756.1991.tb00276.x. PMID 1801674. CPA is a progestogen which is anti-oestrogenic but also ...

Maleki, N; Kalantar Hormozi, M; Iranparvar Alamdari, M; Tavosi, Z (2013). "5-alpha-reductase 2 deficiency in a woman with ... 5-alpha-reductase 2 deficiency, pure gonadal dysgenesis, 17β-hydroxysteroid dehydrogenase deficiency, and mixed gonadal ... 16 (6): 15, 17. ISSN 0141-9536. PMID 12318872. Labbok M. "Physiology of lactational amenorrhea and its implications for spacing ... 2019-01-17. Retrieved 2022-02-21. Franik, Sebastian; Eltrop, Stephanie M.; Kremer, Jan Am; Kiesel, Ludwig; Farquhar, Cindy ( ...

It is said to be both more potent and longer-acting than the related progestogen hydroxyprogesterone caproate. The ... ISBN 978-0-85369-840-1. Lerner LJ, Brennan DM, Borman A (January 1961). "Biological activities of 16 alpha, 17 alpha ... hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, and segesterone acetate. Chemical syntheses of ... norethisterone and the acetophenone derivatives of 16 alpha, 17 alpha-dihydroxyprogesterone.(Abstr.). In Federation Proceedings ...

"Mutation of cytochrome P-45017 alpha gene (CYP17) in a Japanese patient previously reported as having glucocorticoid-responsive ... Some persons with 17α-hydroxylase deficiency develop hypertension in infancy, and nearly 90% do so by late childhood. The low- ... 17α-hydroxylase deficiency in genetic males (XY) results in moderate to severe reduction of fetal testosterone production by ... This form of CAH results from deficiency of the enzyme 17α-hydroxylase (also called CYP17A1). It accounts for less than 5% of ...

Azzouni F, Godoy A, Li Y, Mohler J (2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in ... 17alpha-diol-20-one as a key intermediate". Endocrinology. 144 (2): 575-80. doi:10.1210/en.2002-220721. PMID 12538619. Sumińska ... Fertig R, Shapiro J, Bergfeld W, Tosti A (2017). "Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome". ... Okeigwe I, Kuohung W (2014). "5-Alpha reductase deficiency: a 40-year retrospective review". Curr Opin Endocrinol Diabetes Obes ...