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*  The androgen receptor and DXS15-134 markers show a high rate of discordance for germline X chromosome inactivation | Journal of...
The X chromosome inactivation mechanism results in site specific cytosine methylation of the inactive chromosome. This renders ... Non-random X chromosome inactivation was defined as a relative loss of one allele band intensity in the digested DNA lane while ... 1998) X Chromosome inactivation and the XIST gene. Cell Mol Life Sci 54:104-112. ... 1970) X-chromosome inactivation and the Xg locus. Am J Hum Genet 22:460-463. ...
http://jmg.bmj.com/content/38/7/474
*  June | 2011 | Rett Syndrome Research Trust Blog
The male mice are missing the Mecp2 protein completely and are called knockouts; the females, due to X chromosome inactivation ...
https://rettsyndrome.wordpress.com/2011/06/
*  Researchers discover protein responsible for X chromosome inactivation
Researchers have discovered that the structural protein SMCHD1 is required to prevent genes from both X chromosomes being ... However, little is known about the factors that regulate the process of X chromosome inactivation. ... It was thus hypothesized that this protein may play a role in X chromosome inactivation. ... The SMCHD1 protein influenced chromosome folding by preventing Xist from spreading across the chromosome. ...
https://www.news-medical.net/news/20180607/Researchers-discover-protein-responsible-for-X-chromosome-inactivation.aspx
*  Live Imaging of X-Chromosome Inactivation and Reactivation Kinetics | SpringerLink
X-chromosome inactivation (XCI) is an epigenetic phenomenon that equalizes the number of X-linked gene products between male ... and female eutherian mammals by inactivating one of the two X chromosomes.... ... Live Imaging of X-Chromosome Inactivation and Reactivation Kinetics. In: Sado T. (eds) X-Chromosome Inactivation. Methods in ... X-chromosome inactivation (XCI) is an epigenetic phenomenon that equalizes the number of X-linked gene products between male ...
https://link.springer.com/protocol/10.1007%2F978-1-4939-8766-5_7
*  Conformation Regulation of the X Chromosome Inactivation Center: A Model
XCI is governed by a region on the X, the X Inactivation Centre (Xic), which undergoes a sequence of conformational ... Author Summary In mammal female cells X-Chromosome Inactivation (XCI) is the vital process whereby one X, randomly chosen, is ... X chromosomes Is the Subject Area "X chromosomes" applicable to this article? Yes. No. ...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002229
*  X-chromosome Inactivation, Epigenetics and the Transcriptome - Tabular View - ClinicalTrials.gov
X-chromosome Inactivation, Epigenetics and the Transcriptome. Official Title X-chromosome Inactivation, Epigenetics and the ... The silencing is controlled by a part of the X-chromosome designated XIC (X-inactivation center). The inactivation/silencing of ... In healthy women with to normal X-chromosomes, the one of the X-chromosomes is switched off (silenced). The X-chromosome which ... The human genetic material consists of 46 chromosomes of which two are sex chromosomes. The sex-chromosome from the mother is ...
https://clinicaltrials.gov/ct2/show/record/NCT01678261?term=%22High+Blood+Pressure%22&lup_s=03%2F13%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14
*  Extreme skewing of X chromosome inactivation in mothers of homosexual men | SpringerLink
Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here,... ... Androgen Receptor Sexual Orientation Sexual Attraction Chromosome Inactivation Androgen Receptor Gene These keywords were added ... Brown CJ, Robinson WP (2000) The causes and consequences of random and non-random X chromosome inactivation in humans. Clin ... Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without ...
https://link.springer.com/article/10.1007%2Fs00439-005-0119-4
*  X-chromosome Inactivation, Epigenetics and the Transcriptome - Full Text View - ClinicalTrials.gov
The silencing is controlled by a part of the X-chromosome designated XIC (X-inactivation center). The inactivation/silencing of ... In healthy women with to normal X-chromosomes, the one of the X-chromosomes is switched off (silenced). The X-chromosome which ... The human genetic material consists of 46 chromosomes of which two are sex chromosomes. The sex-chromosome from the mother is ... X-chromosome Inactivation, Epigenetics and the Transcriptome. This study has been completed. ...
https://clinicaltrials.gov/ct2/show/NCT01678261?recr=Open&cond=%22Klinefelter+Syndrome%22&rank=4
*  PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation | Science
The Polycomb complexes PRC1 and PRC2 are also known to be involved in X chromosome inactivation. Almeida et al. elucidate a key ... PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation Message Subject. (Your Name) has forwarded a page to ... PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. By Mafalda Almeida, Greta Pintacuda, Osamu Masui, ... PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. By Mafalda Almeida, Greta Pintacuda, Osamu Masui, ...
http://science.sciencemag.org/content/356/6342/1081
*  X chromosome inactivation in human cells | HSTalks
Barbara Migeon on X chromosome inactivation in human cells, part of a collection of online lectures. ... about how the mouse inactivates one X chromosome, I will be talking about the version of X chromosome inactivation in our own ... I will talk to you about X chromosome inactivation, the way mammals carry out X dosage compensation. This has been the subject ... X chromosome inactivation in human cells. *Prof. Barbara Migeon - The Johns Hopkins University, USA ...
https://hstalks.com/t/1676/x-chromosome-inactivation-in-human-cells/?biosci
*  X chromosome inactivation in the cycle of life | Development
2005). Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice. Nature 438, 369- ... 2009). The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome ... imprinted or random X chromosome inactivation (XCI) is initiated, and both processes lead to an inactive X chromosome that is ... female somatic cells transcriptionally silence one of the two X chromosomes in a process named X chromosome inactivation (XCI ...
http://dev.biologists.org/content/139/12/2085
*  Recent insights into the regulation of X-chromosome inactivation | AGG
Skewing of XCI in favor of one chromosome can result in increased severity of disease symptoms, if the X chromosome with a gene ... In all these cases, a single active X chromosome is present. However, in those cases with two or more X chromosomes, some genes ... Dosage compensation can also mask some aspects of sex chromosome aneuploidies. X-chromosome aneuploidies include Klinefelter, ... X-chromosome inactivation (XCI) is the mechanism by which mammals compensate gene dosage differences between males and females ...
https://www.dovepress.com/recent-insights-into-the-regulation-of-x-chromosome-inactivation-peer-reviewed-article-AGG
*  REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice | Nature Communications
... through random X chromosome inactivation (rXCI). Later during development, the inactive X (Xi) chromosome is reactivated in ... REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice. *Cristina Gontan1. na1, ... The trans-activator RNF12 and cis-acting elements effectuate X chromosome inactivation independent of X-pairing. Mol. Cell 53, ... Imprinted X chromosome inactivation (iXCI) takes place during pre-implantation development in the embryo and in the ...
https://www.nature.com/articles/s41467-018-07060-w?error=cookies_not_supported&code=103a91e4-9469-4e5f-9aad-a3f4e42c4ec2
*  Incomplete meiotic sex chromosome inactivation in the domestic dog | BMC Genomics | Full Text
In addition to PAR synapsis between X and Y, we observed extensive self-synapsis of part of the dog X chromosome, and rapid ... This may be partially explained by extensive, but transient, self-synapsis of the X chromosome, in association with rapid ... In male mouse meiosis, the largely heterologous X and Y chromosomes synapse only in their short pseudoautosomal regions (PARs ... of these arms and the persistent DSBs then trigger transcriptional silencing through meiotic sex chromosome inactivation (MSCI ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1501-9
*  Low oxygen levels prevent X chromosome inactivation in human embryonic stem cells - Healthcanal.com : Healthcanal.com
X inactivation is vital for proper development in a female cell. If both X chromosomes are left active in an adult cell, the ... For example, after early random inactivation, female human ES cells always have the same X chromosome inactivated while mouse ... Low oxygen levels prevent X chromosome inactivation in human embryonic stem cells. ... "When human ES cells are isolated at 20% oxygen, they are stressed and they inactivate one X chromosome in female cells," says ...
https://www.healthcanal.com/medical-breakthroughs/7832-low-oxygen-levels-prevent-x-chromosome-inactivation-in-human-embryonic-stem-cells.html
*  Dosage compensation in human pre‐implantation embryos: X‐chromosome inactivation or dampening? | EMBO Reports
... chromosomes during embryonic development, a phenomenon known as X‐chromosome inactivation [1]. Studies have shown that like ... Dosage compensation in human pre‐implantation embryos: X‐chromosome inactivation or dampening?. Roni Saiba, Maniteja Arava, ... chromosomes along with the inactivation of X‐linked genes in pre‐implantation female embryos [3]. In contrast, another study ... inactivation [2]. However, X‐chromosome dynamics in human pre‐implantation embryos remains elusive, largely due to the ...
http://embor.embopress.org/content/19/8/e46294
*  Polycomb recruitment in X chromosome inactivation - Wikipedia
Recruitment of Polycomb proteins in X chromosome Inactivation X chromosome inactivation (XCI) is the phenomenon that has been ... Chow, J; Heard, E (June 2009). "X inactivation and the complexities of silencing a sex chromosome". Current Opinion in Cell ... During the establishment phase of X Chromosome Inactivation (XCI), Xist RNA, the master regulator of this process, spreads in ... Nora, EP; Heard, E (25 November 2009). "X chromosome inactivation: when dosage counts". Cell. 139 (5): 865-7. doi:10.1016/j. ...
https://en.wikipedia.org/wiki/Polycomb_recruitment_in_X_chromosome_inactivation
*  No correlation between X chromosome inactivation pattern and autistic spectrum disorders in an Italian cohort of patients
Willard, H.F. (1995) The sex chromosome and X-chromosome inactivation. In: Scriver, C.R., Beaudet, A.L., Sly, W.S. and Valle, D ... suggesting a major pathogenic role for genes located on the X-chromosome. The analysis of X chromosome inactivation (XCI) ... Plenge, R.M., Stevenson, R.A., Lubs, H.A., Schwartz, C.E. and Willard, H.F. (2002) Skewed X-chromosome inactivation is a common ... 1998) X chromosome inactivation in carriers of Barth syndrome. American Journal of Human Genetics, 63, 1457-1463. doi:10.1086/ ...
https://file.scirp.org/Html/2-1370014_8888.htm
*  RePub, Erasmus University Repository: REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice
REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice. Publication. Publication. Nature ... In mice, imprinted X chromosome inactivation (iXCI) of the paternal X in the pre-implantation embryo and extraembryonic tissues ... REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice. Nature Communications, 9(1). doi:10.1038/ ...
https://repub.eur.nl/pub/112124
*  Skewed X-chromosome inactivation is a common feature of X-linked mental retardation disorders. - Semantic Scholar
To explore the relationship between skewed X-chromosome inactivation and X-linked mental retardation (XLMR) disorders, we used ... Of the 20 distinct XLMR disorders, 4 demonstrate a strong association with skewed X inactivation, since all carriers of these ... The XLMR mutations are present on the preferentially inactive X chromosome in all 20 informative female subjects from these ... Among XLMR carriers, approximately 50% demonstrate markedly skewed X inactivation (i.e., patterns , or =80:20), compared with ...
https://www.semanticscholar.org/paper/Skewed-X-chromosome-inactivation-is-a-common-of-Plenge-Stevenson/e1cd1f6f3a729867581fd165aa0e48227f0c17df
*  Role of G(-43)A polymorphism in the promoter region of the Xist gene in non-random x-chromosome inactivation in intraspecific...
A polymorphism in the promoter region of the Xist gene in non-random x-chromosome inactivation in intraspecific hybrid voles, ... Role of G(-43)A polymorphism in the promoter region of the Xist gene in non-random x-chromosome inactivation in intraspecific ... Role of G(-43)A polymorphism in the promoter region of the Xist gene in non-random x-chromosome inactivation in intraspecific ... Role of G(-43)A polymorphism in the promoter region of the Xist gene in non-random x-chromosome... Orischenko, K.; Elisaphenko ...
https://www.deepdyve.com/lp/springer-journals/role-of-g-43-a-polymorphism-in-the-promoter-region-of-the-xist-gene-in-G0cZHJtFkj
*  X Chromosome Inactivation in Opioid Addicted Women - Basic and Clinical Neuroscience
Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is ... Vousooghi N, Sadat Shirazi M, Goodarzi A, Hassani Abharian P, Zarrindast M. X Chromosome Inactivation in Opioid Addicted Women ... gene located on the X chromosome. XCI skewness was studied in 3 ranges: 50:50-64:36 (random inactivation), 65:35-80:20 ( ... X Chromosome Inactivation in Opioid Addicted Women. مجله علوم اعصاب پایه و بالینی. 1394; 6 (3) :179-184. URL: http://bcn.iums. ...
http://bcn.iums.ac.ir/browse.php?a_id=598&sid=1&slc_lang=fa
*  EAMCET Zoology: X Chromosome Inactivation
The inactivation is random - one X chromosome may be inactivated in one cell and the other X chromosome inactivated in another ... The inactivation is random - one X chromosome may be inactivated in one cell and the other X chromosome inactivated in another ... Female mammals have two X chromosomes and one of these in every cell is inactivated. The inactivation occurs early in ... Female mammals have two X chromosomes and one of these in every cell is inactivated. The inactivation occurs early in ...
http://eamcetzoology.blogspot.com/2008/09/x-chromosome-inactivation.html
*  FAMILIAL SIDEROBLASTIC ANÆMIA: PROBLEM OF Xg AND X CHROMOSOME INACTIVATION - MRC Weatherall Institute of Molecular Medicine
FAMILIAL SIDEROBLASTIC ANÆMIA: PROBLEM OF Xg AND X CHROMOSOME INACTIVATION Weatherall DJ., Pembrey ME., Hall EG., Sanger R., ...
https://www.imm.ox.ac.uk/publications/634790
*  Scientific Protocols - Clonality - X Chromosome Inactivation Assay
Investigators can utilize X chromosome inactivation (methylation) to determine the clonality status of a tumor or premalignant ... and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. ... The technique is based on a methylation-sensitive restriction enzyme and analysis of a polymorphic locus on the X chromosome. ...
https://protocols.scienceexchange.com/protocols/clonality-x-chromosome-inactivation-assay