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*  Werner syndrome
Unfortunately there is no cure for Werner syndrome at this time. If you or a loved one has been diagnosed with Werner syndrome ... "Werner syndrome" (open studies are recruiting volunteers) and 1 "Werner syndrome" studies with "all" status. Visit ... Adult-onset Werner syndrome (WS) and childhood-onset Hutchinson-Gilford progeria syndrome are the best known examples. The ... Werner syndrome (WS) is an autosomal recessive genetic instability and progeroid ('premature aging') syndrome which is ...
http://www.diseaseinfosearch.org/result/7471
*  A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging | Science
Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater understanding of both premature and normal ... Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a ... A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging ... A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging ...
http://science.sciencemag.org/content/348/6239/1160
*  Metabolism of acetylated low density lipoproteins by monocyte-derived macrophages from patients with Werner's syndrome. |...
Metabolism of acetylated low density lipoproteins by monocyte-derived macrophages from patients with Werner's syndrome.. S Mori ... Therefore, for determination of the mechanism of accelerated atherogenesis in Werner's syndrome, studies were carried out on ... These results indicate that in monocyte-derived macrophages of patients with Werner's syndrome, the uptake, lysosomal ... Metabolism of acetylated low density lipoproteins by monocyte-derived macrophages from patients with Werner's syndrome. ...
http://atvb.ahajournals.org/content/9/5/644
*  The Werner Syndrome Helicase-Nuclease--One Protein, Many Mysteries -- Fry 2002 (13): 2 -- <i>Science</i...
Key Words: Werner helicase exonuclease progeroid progeria DNA replication DNA repair. Abstract: Werner syndrome (WS) is an ... The Werner Syndrome Helicase-Nuclease--One Protein, Many Mysteries Michael Fry The author is in the Department of Biochemistry ... Werner Syndrome Protein--Unwinding Function to Explain Disease.. R. J. Monnat Jr. and Y. Saintigny (2004). Sci. Aging Knowl. ... Identification and Biochemical Characterization of a Werner's Syndrome Protein Complex with Ku70/80 and Poly(ADP-ribose) ...
http://sageke.sciencemag.org/cgi/content/abstract/2002/13/re2
*  CellNEWS: Establishment of Induced Pluripotent Stem Cells from Werner Syndrome Fibroblasts
... cells from the fibroblasts of Werner Syndrome patients. ... Werner syndrome is characterized by the premature appearance of ... This advantage will be help in the development of new gene and cell therapies for Werner syndrome," Dr. Shimamoto said. ... The iPS cells that we have established will provide an opportunity for drug discovery for the treatment of Werner syndrome and ... Establishment of Induced Pluripotent Stem Cells from Werner Syndrome Fibroblasts Milestone for understanding diseases and for ...
http://cellnews-blog.blogspot.se/2014/11/establishment-of-induced-pluripotent.html
*  Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest | EMBO Reports
Fry, M. and Loeb, L.A. (1999) Human Werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome ... Yamagata, K., Kato, J., Shimamoto, A., Goto, M., Furuichi, Y. and Ikeda, H. (1998) Bloom's and Werner's syndrome genes suppress ... Kamath‐Loeb, A.S., Shen, J.C., Loeb, L.A. and Fry, M. (1998) Werner syndrome protein: II. Characterization of the integral 3′-5 ... Lebel, M., Spillare, E.A., Harris, C.C. and Leder, P. (2000) The Werner syndrome gene product co‐purifies with the DNA ...
http://embor.embopress.org/content/1/1/80
*  Progeroid syndromes - Wikipedia
Some segmental progeroid syndromes, such as Werner syndrome (WS), Bloom syndrome (BS), Rothmund-Thomson syndromes (RTS) and ... Examples of PS include Werner syndrome (WS), Bloom syndrome (BS), Rothmund-Thomson syndrome (RTS), Cockayne syndrome (CS), ... Werner syndrome[edit]. Werner syndrome is inherited in an autosomal recessive manner, which means both parents must contribute ... Main article: Werner syndrome. Werner syndrome (WS) is a rare autosomal recessive disorder.[9][10] It has a global incidence ...
https://en.wikipedia.org/wiki/Accelerated_aging_disease
*  International Journal of Pharmaceutical Sciences and Drug Research 2014; 6(4): 253-262
Kieras FJ, Brown WT, Houck GE, Zebrower M. Elevation of urinary hyaluronic acid in Werner syndrome and progeria. Biochem Med ... Mian IS, Kennedy BK, Oshima J. LMNA mutations in atypical Werner's syndrome. Lancet 2003; 362(9382): 440-445. ... 128-129] Hutchinson-Gilford progeria syndrome is a rare, segmental premature aging syndrome of accelerated atherosclerosis, ... Hutchinson-Gilford progeria syndrome. Autopsy some genetic defect causes progeroid syndrome that reports have described varying ...
http://spotidoc.com/doc/318324/international-journal-of-pharmaceutical-sciences-and-drug...
*  Hutchinson-Gilford Progeria Syndrome: A Rare Aging Disorder in Children
the Hutchinson-Gilford progeria syndrome is a rare genetic condition that affects an estimated 1 in 8 million children. It is ... Werner syndrome. *Cockayne syndrome. *Xeroderma pigmentosum. Treatment of Progeria Syndrome. There is no known treatment for ... Characteristics of Progeria Syndrome. The major characteristic of progeria syndrome is that a young infant or child has all the ... Tags:aging disease in children, causes of progeria syndrome, diagnosis of progeria syndrome, Hutchinson-Gilford progeri ...
http://www.healthfitnessresource.com/de/hutchinson-gilford-progeria-syndrome-rare-aging-disorder-children/
*  The Bloom Syndrome Protein Limits the Lethality Associated with RAD51 Deficiency | Molecular Cancer Research
The Werner and Bloom syndrome proteins catalyze regression of a model replication fork. Biochemistry 2006;45:13939-46. ... Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry. Hum Mutat 2007;28:743-53. ... Bloom's syndrome. I. Genetical and clinical observations in the first twenty-seven patients. Am J Hum Genet 1969;21:196-227. ... Bloom's syndrome is caused by mutations in the BLM gene, which encodes BLM, a RecQ 3′-5′ DNA helicase (1). The hallmark of ...
http://mcr.aacrjournals.org/content/8/3/385
*  Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins |...
Werner et al. [63]. Cross-sectional. Young sedentary (26),. young athletes (25),. older sedentary (26), and. older athletes (25 ... muscle telomere length by comparing healthy athletes to chronically overtrained athletes with fatigued-myopathic syndrome (FAMS ... Werner et al. [63, 117] performed a thorough series of experiments to elucidate how exercise produced adaptations in cells that ... Werner C, Fürster T, Widmann T, et al. Physical exercise prevents cellular senescence in circulating leukocytes and in the ...
http://circleofdocs.com/do-telomeres-adapt-to-physiological-stress-exploring-the-effect-of-exercise-on-telomere-length-and-telomere-related-proteins/
*  Werner Syndrome - GeneReviews® - NCBI Bookshelf
Individuals with Werner syndrome develop normally until the end of the first decade. The first sign is the lack of a growth ... Myocardial infarction and cancer are the most common causes of death; the mean age of death in individuals with Werner syndrome ... Werner syndrome is characterized by the premature appearance of features associated with normal aging and cancer predisposition ... Werner syndrome ATP-dependent helicase. Werner Syndrome Mutational Database. WRN database. WRN. WRN. ...
https://www.ncbi.nlm.nih.gov/books/NBK1514/
*  Progeria: Werner's Syndrome | HubPages
Collectively, they are called progeroid syndromes. But they... ... Werner's Syndrome. Werner's syndrome was named after Otto ... Werner's syndrome is also known as adult progeria. This is one of the most common progeria cases. It is a less known form of ... To date, there are about 1300 recorded cases about this syndrome since Otto Werner first described it in 1904. ... Werner. He was a German scientist who described the syndrome in 1904 in his doctoral thesis. ...
https://hubpages.com/health/Progeria-Werners-Syndrome
*  Werner's Syndrome
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC2081163/
*  Werner syndrome - ONA
Werner syndrome OMIM #277700. Are You Confident of the Diagnosis?. What you should be alert for in the history. Werner syndrome ... A detailed discussion of the molecular and genetic basis of the progeroid syndromes including Werner syndrome is presented to ... aging syndromes is presented with a detailed discussion of both Hutchinson-Gilford progeria syndrome and Werner syndrome, their ... Management of the Systemic Complications of Werner Syndrome. Complications. Management Strategies. Diabetes. Smoking cessation ...
https://www.oncologynurseadvisor.com/dermatology/werner-syndrome/article/592161/
*  'werner syndrome' Protocols and Video...
... werner syndrome' include 'A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN ... Werner Syndrome: An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin ...
https://www.jove.com/keyword/werner+syndrome
*  Werner's Syndrome | Annals of Internal Medicine | American College of Physicians
A REVIEW OF WERNER'S SYNDROME, WITH A REPORT OF THE SECOND AUTOPSIED CASE1 Annals of Internal Medicine; 48 (6): 1205-1220 ... In his classic review on Werner's syndrome published in the ANNALS in 1945, Thannhauser (1) was the first to define clearly the ... Treating a Patient with the Werner Syndrome and Osteoporosis Using Recombinant Human Insulin-like Growth Factor Annals of ... The principal characteristics, as first described by Werner in 1904 (2) and expanded by Thannhauser and others (1, 3-6), are [1 ...
http://annals.org/aim/article-abstract/680174/werner-s-syndrome
*  Werner's Syndrome (Progeria of the Adult)
Werner's syndrome (progeria in the adult). Ulster Med J. 1957 May 1;26(1):65-70. [PMC free article] [PubMed] ... Werner's syndrome: a study of adrenocortical and hepatic steroidal metabolism. Tex State J Med. 1953 Dec;49(12):882-888. [ ... Werner's syndrome. Br Med J. 1955 Jul 23;2(4933):237-239. [PMC free article] [PubMed] ... Werner's syndrome; with a report of two cases. Am J Med. 1953 Aug;15(2):266-271. [PubMed] ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC1990635/?lang=en-ca
*  International Registry of Werner Syndrome - NORD (National Organization for Rare Disorders)
International Registry of Werner Syndrome. Address. University of Washington Department of Pathology. Box 357470. Seattle, WA ... Werner syndrome, a rare autosomal recessive disorder, is characterized by abnormally short stature in childhood and premature ... Home / For Patients and Families / Find a Patient Organization / International Registry of Werner Syndrome ... Established in 1986, IRWS works to ascertain and genotype individuals with Werner syndrome from around the world and to ...
https://rarediseases.org/organizations/international-registry-of-werner-syndrome/
*  Vitamin C alleviates aging defects in a stem cell model for Werner syndrome | SpringerLink
Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently ... Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome? Rejuvenation Res 9 ... A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science 348:1160-1163CrossRef ... Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently ...
https://link.springer.com/article/10.1007/s13238-016-0278-1
*  Atypical Werner syndrome | definition of Atypical Werner syndrome by Medical dictionary
What is Atypical Werner syndrome? Meaning of Atypical Werner syndrome medical term. What does Atypical Werner syndrome mean? ... Looking for online definition of Atypical Werner syndrome in the Medical Dictionary? Atypical Werner syndrome explanation free ... Werner syndrome. (redirected from Atypical Werner syndrome). Also found in: Dictionary. Wer·ner syn·drome. (wĕr'nĕr), [MIM* ... Werner syndrome. (vĕr′nər) or Werner's syndrome. (-nərz). n.. An autosomal recessive disorder characterized by short stature ...
https://medical-dictionary.thefreedictionary.com/Atypical+Werner+syndrome
*  Homologous Recombination Resolution Defect in Werner Syndrome | Molecular and Cellular Biology
... and genetic aspects of this syndrome following Otto Werner's initial description has led to the recognition of Werner syndrome ... report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome. Am. J. Med. Genet. 90:223-228. ... Werner syndrome, p. 785-797. In C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle (ed.), The metabolic and molecular basis ... Homologous Recombination Resolution Defect in Werner Syndrome. Yannick Saintigny, Kate Makienko, Cristina Swanson, Mary J. ...
https://mcb.asm.org/content/22/20/6971
*  WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers. - PubMed - NCBI
WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers.. Lee JH1, Kim SS2, Kim MS1, Yoo ...
https://www.ncbi.nlm.nih.gov/pubmed/28012115
*  Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient
Werner syndrome (WS) is a progeroid or premature aging syndrome characterized by early onset of age-related pathologies and ... Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient. Tiphaine Goletto,1 Flora Crockett,1 ...
https://www.hindawi.com/journals/cripu/2015/361694/abs/
*  Werner syndrome helicase - Wikipedia
Werner syndrome is caused by mutations in the WRN gene. More than 20 mutations in the WRN gene are known to cause Werner ... "Werner syndrome ATP-dependent helicase" also known as DNA helicase, RecQ-like type 3 is an enzyme that in humans is encoded by ... Werner syndrome ATP-dependent helicase has been shown to interact with: BLM DNA-PKcs, FEN1, Ku70, Ku80, P53, PCNA, TERF2, and ... Lebel M (2001). "Werner syndrome: genetic and molecular basis of a premature aging disorder". Cell. Mol. Life Sci. 58 (7): 857- ...
https://en.wikipedia.org/wiki/Werner_syndrome_helicase